Tag: 200-300

Paper-Based Colorimetric Sensor System for High-Throughput Screening of C-H Borylation was written by Kim, Han-Sung;Eom, Min Sik;Han, Min Su;Lee, Sunwoo. And the article was included in Chemistry – A European Journal in 2017.Name: 2-(3,5-Dimethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane This article mentions the following:

A paper-based colorimetric sensor system (PBCSS) was developed to detect the amount of bis(pinacolato)diboron (B₂Pin₂) and applied as a high-throughput screening protocol in Ir-catalyzed C-H borylation. First, 96 ligands were screened for the borylation of benzene, and then 12 of them were selected and tested for five substrates. These reaction mixtures were spotted in the PBCSS, showing a blue-violet color. The value of the gray scale of each reaction was obtained from these colored spots and converted to the extent of conversion of B₂Pin₂. The extents of conversion of B₂Pin₂ obtained from the PBCSS showed good correlation with those obtained from gas chromatog. anal. The modified conversion using blank data showed good correlation with the yield of products. In the experiment, the researchers used many compounds, for example, 2-(3,5-Dimethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 365564-07-4Name: 2-(3,5-Dimethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane).

2-(3,5-Dimethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 365564-07-4) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil. Ethyl ether is an excellent solvent for extractions and for a wide variety of chemical reactions. It is also used as a volatile starting fluid for diesel engines and gasoline engines in cold weather. Dimethyl ether is used as a spray propellant and refrigerant. Methyl t-butyl ether (MTBE) is a gasoline additive that boosts the octane number and reduces the amount of nitrogen-oxide pollutants in the exhaust. The ethers of ethylene glycol are used as solvents and plasticizers.Name: 2-(3,5-Dimethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Pyrroloquinoline Quinone Aza-Crown Ether Complexes as Biomimetics for Lanthanide and Calcium Dependent Alcohol Dehydrogenases was written by Vetsova, Violeta A.;Fisher, Katherine R.;Lumpe, Henning;Schafer, Alexander;Schneider, Erik K.;Weis, Patrick;Daumann, Lena J.. And the article was included in Chemistry – A European Journal in 2021.HPLC of Formula: 66943-05-3 This article mentions the following:

Understanding the role of metal ions in biol. can lead to the development of new catalysts for several industrially important transformations. Lanthanides are the most recent group of metal ions that have been shown to be important in biol., i.e., in quinone-dependent methanol dehydrogenases (MDH). Here we evaluate a literature-known pyrroloquinoline quinone (PQQ) and 1-aza-15-crown-5 based ligand platform as scaffold for Ca²⁺, Ba²⁺, La³⁺ and Lu³⁺ biomimetics of MDH and we evaluate the importance of ligand design, charge, size, counterions and base for the alc. oxidation reaction using NMR spectroscopy. In addition, we report a new straightforward synthetic route (3 steps instead of 11 and 33% instead of 0.6% yield) for biomimetic ligands based on PQQ. We show that when studying biomimetics for MDH, larger metal ions and those with lower charge in this case promote the dehydrogenation reaction more effectively and that this is likely an effect of the ligand design which must be considered when studying biomimetics. To gain more information on the structures and impact of counterions of the complexes, we performed collision induced dissociation (CID) experiments and observe that the nitrates are more tightly bound than the triflates. To resolve the structure of the complexes in the gas phase we combined DFT-calculations and ion mobility measurements (IMS). Furthermore, we characterized the obtained complexes and reaction mixtures using ESR (EPR) spectroscopy and show the presence of a small amount of quinone-based radical. In the experiment, the researchers used many compounds, for example, 1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3HPLC of Formula: 66943-05-3).

1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.HPLC of Formula: 66943-05-3

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Quantitative structure-activity relationship (QSAR) studies on the inhibition of porcine pancreatic amylase by cinnamic acid derivatives was written by Ramanan, P. N.;Kutty, A. V. Moiden;Rao, M. N. A.. And the article was included in Indian Journal of Biochemistry & Biophysics in 1987.Recommanded Product: 6972-61-8 This article mentions the following:

The inhibition of porcine pancreatic α-amylase by cinnamic acid derivatives with various substitutions on the Ph ring was studied. Quant. correlation by regression anal. showed that hydrophobicity of the substituents was important for the inhibitory activity. Ionization studies showed that all of the compounds were present in highly ionized form at pH 7.4. In the experiment, the researchers used many compounds, for example, 3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8Recommanded Product: 6972-61-8).

3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. Ethers can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Recommanded Product: 6972-61-8

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Biological synthesis and anti-inflammatory activity of arylalkylamine was written by Song, Min Kyung;Lee, Su Jin;Kang, Yoon Young;Lee, Youngshim;Mok, Hyejung;Ahn, Joong-Hoon. And the article was included in Applied Biological Chemistry in 2017.Product Details of 6972-61-8 This article mentions the following:

Hydroxycinnamic acid amides (HCAAs) are natural compounds with antifungal, anticancer, and anti-inflammatory activities. Extraction from plants and chem. synthesis have been the major approaches to obtain these compounds We used a biol. method to synthesize HCAA derivatives (arylalkylamines). Two genes, SHT encoding serotonin N-hydroxycinnamoyl transferase and 4CL encoding 4-coumaroyl-CoA ligase, were introduced into Escherichia coli. Using this E. coli transformant as a biocatalyst, 24 arylalkylamines were synthesized. The anti-inflammatory activities of five synthesized compounds, including N-p-coumaroyl phenethylamine, N-caffeoyl phenethylamine, N-p-coumaroyl 3-phenylpropylamine, N-p-coumaroyl 4-phenylbutylamine, and N-p-coumaroyl 4-methoxyphenethylamine, were measured. Among them, N-p-coumaroyl 4-phenylbutylamine showed the best anti-inflammatory activity. In the experiment, the researchers used many compounds, for example, 3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8Product Details of 6972-61-8).

3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.Product Details of 6972-61-8

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Complementary site-selectivity in arene functionalization enabled by overcoming the ortho constraint in palladium/norbornene catalysis was written by Wang, Jianchun;Li, Renhe;Dong, Zhe;Liu, Peng;Dong, Guangbin. And the article was included in Nature Chemistry in 2018.Name: 4-Iodo-1-methoxy-2-methylbenzene This article mentions the following:

Achieving site-selectivity in arene functionalization that is complementary to the site-selectivity from electrophilic aromatic substitution reactions has been a long-standing quest in organic synthesis. Palladium/norbornene cooperative catalysis potentially offers a unique approach to this problem, but its use has been hampered by the ortho constraint, which is the requirement of an ortho substituent for mono ortho functionalization of haloarenes. Here, we show that such a challenge could be addressed using a new class of bridgehead-modified norbornenes, thereby enabling a broadly useful strategy for arene functionalization with complementary site-selectivity. A range of ortho-unsubstituted aryl iodides, previously problematic substrates, can now be employed to provide mono ortho-functionalized products effectively. This method is applicable for late-stage functionalization of complex bioactive mols. at positions that are difficult to reach by conventional approaches. In the experiment, the researchers used many compounds, for example, 4-Iodo-1-methoxy-2-methylbenzene (cas: 75581-11-2Name: 4-Iodo-1-methoxy-2-methylbenzene).

4-Iodo-1-methoxy-2-methylbenzene (cas: 75581-11-2) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. But ether is more polar than alkenes. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.Name: 4-Iodo-1-methoxy-2-methylbenzene

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

An ion-responsive fluorescent compound based on NO-photoisomerisation styryl derivative linked to monoaza-15-crown-5 was written by Cao, Jing;Feng, Jun Xiang;Wu, Yong Xiang;Pei, Xue Qun;Yan, Jiao Jiao;Liu, Yang;Qin, Wen Jie;Zhang, Xiao Bin. And the article was included in Supramolecular Chemistry in 2011.Computed Properties of C10H21NO4 This article mentions the following:

A novel 15-aza-5-crown ether linked to styryl chemosensory 13-(4-((9H-fluoren-9-ylidene)methyl)-2-nitrophenyl)-1,4,7,10-tetraoxa-13-azacyclopentadecane was designed and synthesized, it would not occur during photoisomerization under radiation of light but shows special capability of selectively recognizing for Sr²⁺. In the experiment, the researchers used many compounds, for example, 1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3Computed Properties of C10H21NO4).

1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive. Electron-deficient reagents are also stabilized by ethers. For example, borane (BH3) is a useful reagent for making alcohols. Pure borane exists as its dimer, diborane (B2H6), a toxic gas that is inconvenient and hazardous to use. Borane forms stable complexes with ethers, however, and it is often supplied and used as its liquid complex with tetrahydrofuran (THF).Computed Properties of C10H21NO4

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Evaluation of acrylophenones and related bis-Mannich bases against murine P388 leukemia was written by Dimmock, Jonathan R.;Patil, Shirish A.;Leek, Donald M.;Warrington, Robert C.;Fang, Wei D.. And the article was included in European Journal of Medicinal Chemistry in 1987.HPLC of Formula: 54916-28-8 This article mentions the following:

Mannich reaction of acetophenones with bases gave acrylophenones and bis-Mannich bases I and II (R = H, Me, Cl, OMe; R¹ = H, Cl; R² = H, OMe, Me, OPh, OC₆H₄OMe-4, OC₆H₄Me-4, OC₆H₄Cl-4; R³ = H, OMe, Me). I and II were tested against P388 lymphocyte leukemia in mice. I (R = R¹ = R³ = H, R² = OMe) shows potent activity against P388 cells in vitro. In the experiment, the researchers used many compounds, for example, 1-(4-(4-Methoxyphenoxy)phenyl)ethanone (cas: 54916-28-8HPLC of Formula: 54916-28-8).

1-(4-(4-Methoxyphenoxy)phenyl)ethanone (cas: 54916-28-8) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive. Electron-deficient reagents are also stabilized by ethers. For example, borane (BH3) is a useful reagent for making alcohols. Pure borane exists as its dimer, diborane (B2H6), a toxic gas that is inconvenient and hazardous to use. Borane forms stable complexes with ethers, however, and it is often supplied and used as its liquid complex with tetrahydrofuran (THF).HPLC of Formula: 54916-28-8

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Room-Temperature Direct Arylation of Anilides under External Oxidant-Free Conditions Using CO₂-Derived Dimethyl Carbonate (DMC) as a ‘Green’ Solvent was written by Sahoo, Manoj K.;Rana, Jagannath;Subaramanian, Murugan;Balaraman, Ekambaram. And the article was included in ChemistrySelect in 2017.Reference of 56619-93-3 This article mentions the following:

Here, an efficient catalytic protocol for direct C-H bond arylation of anilides under base- and external oxidant-free conditions is reported. This reaction proceeds readily at room temperature using CO₂-derived di-Me carbonate (DMC) as a ‘green’ solvent under visible-light dual catalysis. Later, application of this strategy for the gram-scale synthesis of Boscalid has been successfully shown. An unprecedented unsym. bis-arylation of anilides is also demonstrated under mild, redox-neutral conditions. In the experiment, the researchers used many compounds, for example, N-(3-Methoxyphenyl)pivalamide (cas: 56619-93-3Reference of 56619-93-3).

N-(3-Methoxyphenyl)pivalamide (cas: 56619-93-3) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.Reference of 56619-93-3

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Intercalation/De-Intercalation Reactions of Lithium Ion at Graphite in Electrolyte Solutions Containing 3D-Transition-Metal Ions and Cyclic Ethers was written by Domi, Yasuhiro;Doi, Takayuki;Ochida, Manabu;Yamanaka, Toshiro;Abe, Takeshi;Ogumi, Zempachi. And the article was included in Journal of the Electrochemical Society in 2016.Name: 1,4,7,10-Tetraoxa-13-azacyclopentadecane This article mentions the following:

The effects of 3d-transition-metal ions in the electrolyte on the intercalation/de-intercalation reactions of Li⁺ at graphite neg.-electrodes were investigated. The edge plane of highly oriented pyrolytic graphite (HOPG) was used as a model electrode, and electrochem. properties were investigated by cyclic voltammetry and electrochem. impedance spectroscopy. A drastic decrease in redox current due to intercalation/de-intercalation reactions of Li⁺ was observed in electrolyte solutions containing Fe, Co, Ni, and Mn ions. In addition, interfacial resistance between the edge plane HOPG electrode and the electrolyte increased significantly. The effects of cyclic ethers, such as crown ether, aza crown ether, and cryptand, as electrolyte additives were applied to suppress the degradation of graphite neg.-electrodes. As a result, specific cyclic ethers greatly suppressed the degradation of edge plane HOPG neg.-electrodes in electrolyte solutions containing the above transition-metal ions. In the experiment, the researchers used many compounds, for example, 1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3Name: 1,4,7,10-Tetraoxa-13-azacyclopentadecane).

1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. But ether is more polar than alkenes. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.Name: 1,4,7,10-Tetraoxa-13-azacyclopentadecane

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Development of MAP4 Kinase Inhibitors as Motor Neuron-Protecting Agents was written by Bos, Pieter H.;Lowry, Emily R.;Costa, Jonathon;Thams, Sebastian;Garcia-Diaz, Alejandro;Zask, Arie;Wichterle, Hynek;Stockwell, Brent R.. And the article was included in Cell Chemical Biology in 2019.Safety of (4-((4-Methoxybenzyl)oxy)phenyl)boronic acid This article mentions the following:

Disease-causing mutations in many neurodegenerative disorders lead to proteinopathies that trigger endoplasmic reticulum (ER) stress. However, few therapeutic options exist for patients with these diseases. Using an in vitro screening platform to identify compounds that protect human motor neurons from ER stress-mediated degeneration, we discovered that compounds targeting the mitogen-activated protein kinase kinase kinase kinase (MAP4K) family are neuroprotective. The kinase inhibitor URMC-099 (compound 1) stood out as a promising lead compound for further optimization. We coupled structure-based compound design with functional activity testing in neurons subjected to ER stress to develop a series of analogs with improved MAP4K inhibition and concomitant increases in potency and efficacy. Further structural modifications were performed to enhance the pharmacokinetic profiles of the compound 1 derivatives Prostetin/12k emerged as an exceptionally potent, metabolically stable, and blood-brain barrier-penetrant compound that is well suited for future testing in animal models of neurodegeneration. In the experiment, the researchers used many compounds, for example, (4-((4-Methoxybenzyl)oxy)phenyl)boronic acid (cas: 156635-90-4Safety of (4-((4-Methoxybenzyl)oxy)phenyl)boronic acid).

(4-((4-Methoxybenzyl)oxy)phenyl)boronic acid (cas: 156635-90-4) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.Safety of (4-((4-Methoxybenzyl)oxy)phenyl)boronic acid

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem