Tag: 200-300

The author of 《A photocatalytic sp3 C-S, C-Se and C-B bond formation through C-C bond cleavage of cycloketone oxime esters》 were Anand, Devireddy; He, Yuwei; Li, Linyong; Zhou, Lei. And the article was published in Organic & Biomolecular Chemistry in 2019. Quality Control of 1,2-Diphenyldisulfane The author mentioned the following in the article:

The photocatalytic thiolation, selenylation and borylation of cycloketone oxime esters through iminyl radical-triggered C-C bond cleavage were described. The reactions provide a unified approach to alkyl sulfur, selenium and boron compounds tethered to a synthetically useful nitrile group.1,2-Diphenyldisulfane(cas: 882-33-7Quality Control of 1,2-Diphenyldisulfane) was used in this study.

1,2-Diphenyldisulfane(cas: 882-33-7) belongs to ethers. Ethers lack the hydroxyl groups of alcohols. Quality Control of 1,2-Diphenyldisulfane Without the strongly polarized O―H bond, ether molecules cannot engage in hydrogen bonding with each other.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Kawashita, Seiji; Aoyagi, Koichi; Fukushima, Kyoko; Hantani, Rie; Naruoka, Shiori; Tanimoto, Atsuo; Hori, Yuji; Toyonaga, Yukiyo; Yamanaka, Hiroshi; Miyazaki, Susumu; Hantani, Yoshiji published an article in 2021. The article was titled 《SAR study of small molecule inhibitors of the programmed cell death-1/programmed cell death-ligand 1 interaction》, and you may find the article in Chemical Biology & Drug Design.Related Products of 139115-91-6 The information in the text is summarized as follows:

The development of small mol. inhibitors of programmed cell death-1/programmed cell death-ligand 1 (PD-1/PD-L1) has drawn research interest for the treatment of cancer. Recently, we reported the discovery of a novel dimeric core small mol. PD-1/PD-L1 inhibitor. In an effort to discover more potent inhibitors, we further explored the dimeric core scaffold. Our investigations of the structure-activity-relationship revealed that introduction of lipophilic substituents onto one of the di-alkoxylated Ph rings improved binding affinities to PD-L1, and inhibitory activities of PD-1/PD-L1 in cellular assays. Furthermore, conversion of the ether linker part to an olefin linker not only improved binding affinity but also led to slow dissociation binding kinetics. We also explored more potent, as well as downsized, scaffolds. Compounds bearing a linear chain in place of one of the di-alkoxylated Ph rings exhibited good binding affinity with improved ligand efficiency (LE). Representative compounds demonstrated potent inhibitory activities of PD-1/PD-L1 in the submicromolar range in cellular assays as well as cellular function in the mixed lymphocyte reaction (MLR) assay with efficacy comparable to anti-PD-1 antibody. Our results provide applicable information for the design of more potent inhibitors targeting PD-1/PD-L1 pathway. After reading the article, we found that the author used tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Related Products of 139115-91-6)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.Related Products of 139115-91-6Although ethers resist hydrolysis, they are cleaved by hydrobromic acid and hydroiodic acid. Hydrogen chloride cleaves ethers only slowly.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Jozwiak, Malgorzata; Urban, Aleksandra; Tyczynska, Magdalena published their research in Journal of Molecular Liquids in 2021. The article was titled 《Effect of properties of N,N-dimethylformamide + propan-1-ol mixtures on the solution enthalpy of selected cyclic ethers in these mixtures at 298.15 K. The contribution of solvent to the enthalpy of solvation of cyclic ethers》.COA of Formula: C10H20O5 The article contains the following contents:

The enthalpies of solution of cyclic ethers (1,4-dioxane, 12-crown-4, 15-crown-5 and 18-crown-6) in N,N-dimethylformamide+propan-1-ol mixtures have been measured over the range of composition of the mixture at 298.15 K. The preferential solvation process of cyclic ethers mols. in the investigated mixture has been discussed. The mole fraction of N,N-dimethylforamide in the solvation sphere of cyclic ethers and the contribution of solvent to the solvation enthalpy of cyclic ethers has been calculated On the basis of the obtained data, the effect of the structural and energetic properties N,N-dimethylformamide+propan-1-ol mixtures on the enthalpy of solution of cyclic ethers in these mixtures has been analyzed. The results obtained have been compared with analogous data of solvation enthalpy of selected glymes in N,N-dimethylformamide+propan-1-ol mixtures In the experiment, the researchers used 1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5COA of Formula: C10H20O5)

1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5) is a member of crown ether Ligands. Crown-ethers are macrocyclic polyethers capable of forming host-guest complexes, especially with inorganic and organic cations. Crown-ethers can incorporate protonated primary amine compounds by formation of ion-dipole bonds with the oxygen atoms of the chiral selector. Crown-ethers have been widely used for the separation of several pharmaceuticals both in aqueous and non-aqueous media. COA of Formula: C10H20O5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Tang, Shuai; Chen, Qiliang; Si, Yubing; Guo, Wei; Mao, Bingwei; Fu, Yongzhu published their research in Advanced Materials (Weinheim, Germany) in 2021. The article was titled 《Size Effect of Organosulfur and In Situ Formed Oligomers Enables High-Utilization Na-Organosulfur Batteries》.Application of 882-33-7 The article contains the following contents:

Organosulfurs are promising cathode materials for rechargeable metal batteries due to their high capacities, diverse structures, and electrochem. properties. Herein, the electrochem. behavior of three organosulfur compounds, i.e., 4,4′-thiobisbenzenethiol (TBBT), 1,4-benzenedithiol (1,4-BDT), and di-Ph disulfide (DPDS), is revealed in room-temperature rechargeable sodium (Na) batteries, which show significantly improved performances when sodiated Nafion membranes are used. Large oligomers of organosulfur can be formed during charging, and they are readily blocked by the nanosized ion-conducting clusters in the Nafion membrane. In addition, large organosulfur monomers can also be blocked. Only 5.4% of TBBT diffuses through the Nafion membrane after 800 h. The Na|TBBT cell sustains 77% of the theor. capacity after 300 cycles (2420 h). Moreover, the Na|TBBT redox flow cell shows promising rechargeability. Due to the medium mol. size, the organosulfur oligomers are expected to provide a new avenue to develop high-capacity chalcogen cathodes, besides inorganic S and S-containing polymers. The experimental process involved the reaction of 1,2-Diphenyldisulfane(cas: 882-33-7Application of 882-33-7)

1,2-Diphenyldisulfane(cas: 882-33-7) belongs to ethers.Application of 882-33-7Although ethers resist hydrolysis, they are cleaved by hydrobromic acid and hydroiodic acid. Hydrogen chloride cleaves ethers only slowly.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Zhang, Ming; Wang, Wentao; Mohammadniaei, Mohsen; Zheng, Tao; Zhang, Qicheng; Ashley, Jon; Liu, Shunjie; Sun, Yi; Tang, Ben Zhong published their research in Advanced Materials (Weinheim, Germany) in 2021. The article was titled 《Upregulating Aggregation-Induced-Emission Nanoparticles with Blood-Tumor-Barrier Permeability for Precise Photothermal Eradication of Brain Tumors and Induction of Local Immune Responses》.Application In Synthesis of Bis(4-methoxyphenyl)amine The article contains the following contents:

Compared to other tumors, glioblastoma (GBM) is extremely difficult to treat. Recently, photothermal therapy (PTT) has demonstrated advanced therapeutic efficacy; however, because of the relatively low tissue-penetration efficiency of laser light, its application in deep-seated tumors remains challenging. Herein, bradykinin (BK) aggregation-induced-emission nanoparticles (BK@AIE NPs) are synthesized; these offer selective penetration through the blood-tumor barrier (BTB) and strong absorbance in the near-IR region (NIR). The BK ligand can prompt BTB adenosine receptor activation, which enhances transportation and accumulation inside tumors, as confirmed by T1-weighted magnetic resonance and fluorescence imaging. The BK@AIE NPs exhibit high photothermal conversion efficiency under 980 nm NIR laser irradiation, facilitating the treatment of deep-seated tumors. Tumor progression can be effectively inhibited to extend the survival span of mice after spatiotemporal PTT. NIR irradiation can eradicate tumor tissues and release tumor-associated antigens. It is observed that the PTT treatment of GBM-bearing mice activates natural killer cells, CD3+ T cells, CD8+ T cells, and M1 macrophages in the GBM area, increasing the therapeutic efficacy. This study demonstrates that NIR-assisted BK@AIE NPs represent a promising strategy for the improved systematic elimination of GBMs and the activation of local brain immune privilege. In the experimental materials used by the author, we found Bis(4-methoxyphenyl)amine(cas: 101-70-2Application In Synthesis of Bis(4-methoxyphenyl)amine)

Bis(4-methoxyphenyl)amine(cas: 101-70-2) is a diphenylamine derivative used as a chemical additive for cured rubber.Bis(4-methoxyphenyl)amine is highly toxic and may potentially induce chromosome abberation.Application In Synthesis of Bis(4-methoxyphenyl)amine

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Copper(I)-Catalyzed Synthesis of Functionalized Indolizinones from Substituted Pyridine Homologated Ynones》 was written by Sahoo, Sushree Ranjan; Sarkar, Debayan; Henkel, Felix; Reuter, Hans. Quality Control of 1,2-Diphenyldisulfane And the article was included in Journal of Organic Chemistry in 2020. The article conveys some information:

An efficient two-component copper-catalyzed cyclization cascade approach toward highly functionalized indolizinone heterocycles has been developed from reactions of pyridine-, isoquinoline-, and quinoline ynones, via 5-exo-dig cyclization. The catalysis involves the activation by diorgano diselenide and diorgano disulfide and also their incorporation into the indolizinone core. In addition, the obtained substituted indolizinones were readily transformed into 1-(organochalcogenyl)indolizin-2-ols, which are important building blocks in organic synthesis. In addition to this study using 1,2-Diphenyldisulfane, there are many other studies that have used 1,2-Diphenyldisulfane(cas: 882-33-7Quality Control of 1,2-Diphenyldisulfane) was used in this study.

1,2-Diphenyldisulfane(cas: 882-33-7) belongs to ethers.The C-O bonds that comprise simple ethers are strong. Quality Control of 1,2-Diphenyldisulfane They are unreactive toward all but the strongest bases. Although generally of low chemical reactivity, they are more reactive than alkanes.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The author of 《Highly atom-economical, catalyst-free, and solvent-free phosphorylation of chalcogenides》 were Choudhary, Rakhee; Singh, Pratibha; Bai, Rekha; Sharma, Mahesh C.; Badsara, Satpal Singh. And the article was published in Organic & Biomolecular Chemistry in 2019. Synthetic Route of C12H10S2 The author mentioned the following in the article:

Silica gel promoted, catalyst-free and solvent-free S-P, Se-P and Te-P bond formations are described, giving chalcogen-substituted phosphorus esters. A variety of disulfides coupled with diarylphosphine oxides provide the corresponding phosphinothioates in excellent yields. For the first time, diselenides and ditellurides reacted with dialkyl phosphites under catalyst-free conditions to provide the corresponding phosphoroselenoates and phosphorotelluroates, resp., in good to excellent yields. The results came from multiple reactions, including the reaction of 1,2-Diphenyldisulfane(cas: 882-33-7Synthetic Route of C12H10S2)

1,2-Diphenyldisulfane(cas: 882-33-7) belongs to ethers.Oxygen is more electronegative than carbon, thus the alpha hydrogens of ethers are more acidic than those of simple hydrocarbons. Synthetic Route of C12H10S2 They are far less acidic than alpha hydrogens of carbonyl groups (such as in ketones or aldehydes), however.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The author of 《Analysis of lithium separation by modified zeolite using fuzzy logic: equilibrium, kinetics and thermodynamic》 were Farhadi, Mehraz; Rashidi, Abbas; Mallah, Mohammad Hassan. And the article was published in Desalination and Water Treatment in 2019. Product Details of 33100-27-5 The author mentioned the following in the article:

Modified natural zeolite with crown ethers such as 12crown4, 15crown5, 6crown18 and benzo- 15crown5 have been characterized using Fourier transform infra-red, scanning electron microscope and Brunauer-Emmett-Teller instruments. Concentration of 0.01 mg/L of complexing agent and modification time of 240 h were obtained as optimum parameters. Effective parameters such as pH, adsorbent dose, contact time, type and concentration of crown ethers, ion strength, and initial concentration of lithium ion and temperature of complex formation were also investigated and optimized in this adsorption process. Under the optimized exptl. conditions pH equal to 7, one gram of adsorbent in 2 mL solution of 0.01 mg/L and temperature of 40°C, the most lithium adsorption (87%) was acquired. The effect of interference ions on the adsorption process was also considered. The results showed that Freundlich model is one of the best descriptive models for this process. The adsorption kinetics of lithium on modified zeolite follows the pseudo second-order model. Thermodn. parameters were calculated and shown that adsorption process is an endothermic and spontaneous process. Statistical anal. of exptl. results was done by fuzzy logic tool of MATLAB software and three-dimensional diagrams of different parameters effect on the adsorption percentage were also presented. The experimental process involved the reaction of 1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5Product Details of 33100-27-5)

1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5) is a member of crown ether Ligands. Crown-ethers are macrocyclic polyethers capable of forming host-guest complexes, especially with inorganic and organic cations. Crown-ethers can incorporate protonated primary amine compounds by formation of ion-dipole bonds with the oxygen atoms of the chiral selector. Crown-ethers have been widely used for the separation of several pharmaceuticals both in aqueous and non-aqueous media. Product Details of 33100-27-5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The author of 《Selective Inhibition of Histone Deacetylase 10: Hydrogen Bonding to the Gatekeeper Residue is Implicated》 were Geraldy, Magalie; Morgen, Michael; Sehr, Peter; Steimbach, Raphael R.; Moi, Davide; Ridinger, Johannes; Oehme, Ina; Witt, Olaf; Malz, Mona; Nogueira, Mauro S.; Koch, Oliver; Gunkel, Nikolas; Miller, Aubry K.. And the article was published in Journal of Medicinal Chemistry in 2019. Formula: C9H19NO4 The author mentioned the following in the article:

The discovery of isoenzyme-selective histone deacetylase (HDAC) inhibitors is critical for understanding the biol. functions of individual HDACs and for validating HDACs as drug targets. The isoenzyme HDAC10 contributes to chemotherapy resistance and has recently been described to be a polyamine deacetylase, but no studies toward selective HDAC10 inhibitors have been published. Using two complementary assays, the authors found tubastatin A, an HDAC6 inhibitor, to potently bind HDAC10. The authors synthesized tubastatin A derivatives and found that a basic amine in the cap group was required for strong HDAC10 binding. HDAC10 inhibitors mimicked knockdown by causing dose-dependent accumulation of acidic vesicles in a neuroblastoma cell line. Furthermore, docking into human HDAC10 homol. models indicated that a hydrogen-bond between a cap group nitrogen and the gatekeeper residue Glu272 was responsible for potent HDAC10 binding. Taken together, the authors’ data provide an optimal platform for the development of HDAC10-selective inhibitors, as exemplified with the tubastatin A scaffold. In the experiment, the researchers used tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Formula: C9H19NO4)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.Oxygen is more electronegative than carbon, thus the alpha hydrogens of ethers are more acidic than those of simple hydrocarbons. They are far less acidic than alpha hydrogens of carbonyl groups (such as in ketones or aldehydes), however. Formula: C9H19NO4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The author of 《Farming thermoelectric paper》 were Abol-Fotouh, Deyaa; Dorling, Bernhard; Zapata-Arteaga, Osnat; Rodriguez-Martinez, Xabier; Gomez, Andres; Reparaz, J. Sebastian; Laromaine, Anna; Roig, Anna; Campoy-Quiles, Mariano. And the article was published in Energy & Environmental Science in 2019. Computed Properties of C10H20O5 The author mentioned the following in the article:

Waste heat to electricity conversion using thermoelec. generators is emerging as a key technol. in the forthcoming energy scenario. Carbon-based composites could unleash the as yet untapped potential of thermoelectricity by combining the low cost, easy processability, and low thermal conductivity of biopolymers with the mech. strength and good elec. properties of carbon nanotubes (CNTs). Here we use bacteria in environmentally friendly aqueous media to grow large area bacterial nanocellulose (BC) films with an embedded highly dispersed CNT network. The thick films (≈10μm) exhibit tuneable transparency and color, as well as low thermal and high elec. conductivity Moreover, they are fully bendable, can conformally wrap around heat sources and are stable above 500 K, which expands the range of potential uses compared to typical conducting polymers and composites. The high porosity of the material facilitates effective n-type doping, enabling the fabrication of a thermoelec. module from farmed thermoelec. paper. Because of vertical phase separation of the CNTs in the BC composite, the grown films at the same time serve as both the active layer and separating layer, insulating each thermoelec. leg from the adjacent ones. Last but not least, the BC can be enzymically decomposed, completely reclaiming the embedded CNTs. After reading the article, we found that the author used 1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5Computed Properties of C10H20O5)

1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5) is a member of crown ether Ligands. Crown-ethers are macrocyclic polyethers capable of forming host-guest complexes, especially with inorganic and organic cations. Crown-ethers can incorporate protonated primary amine compounds by formation of ion-dipole bonds with the oxygen atoms of the chiral selector. Crown-ethers have been widely used for the separation of several pharmaceuticals both in aqueous and non-aqueous media. Computed Properties of C10H20O5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem