Tag: 200-300

In 2019,Chinese Journal of Chemical Physics included an article by Yao, Yong-lin; Zhu, Mei-ying; Zhao, Zhuo; Liu, Wen-gang; Tong, Bi-hai; Li, Ming-yang. SDS of cas: 33100-27-5. The article was titled 《Density functional theory study of selectivity of crown ethers to Li+ in spent lithium-ion batteries leaching solutions》. The information in the text is summarized as follows:

It is a challenge to recover lithium from the leaching solution of spent lithium-ion batteries, and crown ethers are potential extractants due to their selectivity to alkali metal ions. The theor. calculations for the selectivity of crown ethers with different structures to Li ions in aqueous solutions were carried out based on the d. functional theory. The calculated results of geometries, binding energies, and thermodn. parameters show that 15C5 has the strongest selectivity to Li ions in the three crown ethers of 12C4, 15C5, and 18C6. B15C5 has a smaller binding energy but more neg. free energy than 15C5 when combined with Li+, leading to that the lithium ions in aqueous solutions will combine with B15C5 rather than 15C5. The exchange reactions between B15C5 and hydrated Li+, Co2+, and Ni2+ were analyzed and the results show that B15C5 is more likely to capture Li+ from the hydrated ions in an aqueous solution containing Li+, Co2+, and Ni2+. This study indicates that it is feasible to extract Li ions selectively using B15C5 as an extractant from the leaching solution of spent lithium-ion batteries. (c) 2019 American Institute of Physics. In the experiment, the researchers used 1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5SDS of cas: 33100-27-5)

1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5) is a member of crown ether Ligands. Crown-ethers are macrocyclic polyethers capable of forming host-guest complexes, especially with inorganic and organic cations. Crown-ethers can incorporate protonated primary amine compounds by formation of ion-dipole bonds with the oxygen atoms of the chiral selector. Crown-ethers have been widely used for the separation of several pharmaceuticals both in aqueous and non-aqueous media. SDS of cas: 33100-27-5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2018,Journal of the American Chemical Society included an article by Liu, Yu; Wolstenholme, Charles H.; Carter, Gregory C.; Liu, Hongbin; Hu, Hang; Grainger, Leeann S.; Miao, Kun; Fares, Matthew; Hoelzel, Conner A.; Yennawar, Hemant P.; Ning, Gang; Du, Manyu; Bai, Lu; Li, Xiaosong; Zhang, Xin. Product Details of 139115-91-6. The article was titled 《Modulation of Fluorescent Protein Chromophores To Detect Protein Aggregation with Turn-On Fluorescence》. The information in the text is summarized as follows:

We present a fluorogenic method to visualize misfolding and aggregation of a specific protein-of-interest in live cells using structurally modulated fluorescent protein chromophores. Combining photophys. anal., X-ray crystallog., and theor. calculation, we show that fluorescence is triggered by inhibition of twisted-intramol. charge transfer of these fluorophores in the rigid microenvironment of viscous solvent or protein aggregates. Bioorthogonal conjugation of the fluorophore to Halo-tag fused protein-of-interests allows for fluorogenic detection of both misfolded and aggregated species in live cells. Unlike other methods, our method is capable of detecting previously invisible misfolded soluble proteins. This work provides the first application of fluorescent protein chromophores to detect protein conformational collapse in live cells. In the experiment, the researchers used tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Product Details of 139115-91-6)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.Oxygen is more electronegative than carbon, thus the alpha hydrogens of ethers are more acidic than those of simple hydrocarbons. They are far less acidic than alpha hydrogens of carbonyl groups (such as in ketones or aldehydes), however. Product Details of 139115-91-6

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2018,Agrawalla, Bikram Keshari; Wang, Tao; Riegger, Andreas; Domogalla, Matthias P.; Steinbrink, Kerstin; Doerfler, Thilo; Chen, Xi; Boldt, Felix; Lamla, Markus; Michaelis, Jens; Kuan, Seah Ling; Weil, Tanja published 《Chemoselective Dual Labeling of Native and Recombinant Proteins》.Bioconjugate Chemistry published the findings.Name: tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate The information in the text is summarized as follows:

The attachment of two different functionalities in a site-selective fashion represents a great challenge in protein chem. The authors report site specific dual functionalization of peptides and proteins capitalizing on reactivity differences of cysteines in their free (thiol) and protected, oxidized (disulfide) forms. The dual functionalization of interleukin 2 and EYFP proceeded with no loss of bioactivity in a stepwise fashion applying maleimide and disulfide rebridging allyl-sulfone groups. In order to ensure broader applicability of the functionalization strategy, a novel, short peptide sequence that introduces a disulfide bridge was designed and site-selective dual labeling in the presence of biogenic groups was successfully demonstrated. After reading the article, we found that the author used tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Name: tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.Oxygen is more electronegative than carbon, thus the alpha hydrogens of ethers are more acidic than those of simple hydrocarbons. They are far less acidic than alpha hydrogens of carbonyl groups (such as in ketones or aldehydes), however. Name: tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2017,Liu, Yu; Fares, Matthew; Dunham, Noah P.; Gao, Zi; Miao, Kun; Jiang, Xueyuan; Bollinger, Samuel S.; Boal, Amie K.; Zhang, Xin published 《AgHalo: A Facile Fluorogenic Sensor to Detect Drug-Induced Proteome Stress》.Angewandte Chemie, International Edition published the findings.Reference of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate The information in the text is summarized as follows:

Drug-induced proteome stress that involves protein aggregation may cause adverse effects and undermine the safety profile of a drug. Safety of drugs is regularly evaluated using cytotoxicity assays that measure cell death. However, these assays provide limited insights into the presence of proteome stress in live cells. A fluorogenic protein sensor is reported to detect drug-induced proteome stress prior to cell death. An aggregation prone Halo-tag mutant (AgHalo) was evolved to sense proteome stress through its aggregation. Detection of such conformational changes was enabled by a fluorogenic ligand that fluoresces upon AgHalo forming soluble aggregates. Using 5 common anticancer drugs, we exemplified detection of differential proteome stress before any cell death was observed Thus, this sensor can be used to evaluate drug safety in a regime that the current cytotoxicity assays cannot cover and be generally applied to detect proteome stress induced by other toxins. In the experimental materials used by the author, we found tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Reference of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.Ethers do have nonbonding electron pairs on their oxygen atoms, and they can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. Reference of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Chen, Yen Ting; Seto, Christopher T. published an article in Bioorganic & Medicinal Chemistry. The title of the article was 《Parallel synthesis of a library of bidentate protein tyrosine phosphatase inhibitors based on the α-ketoacid motif》.Related Products of 660848-57-7 The author mentioned the following in the article:

Protein tyrosine phosphatases (PTPases) regulate intracellular signal transduction pathways by controlling the level of tyrosine phosphorylation in cells. These enzymes play an important role in a variety of diseases including type II diabetes and infection by the bacterium Yersinia pestis, which is the causative agent of bubonic plague. This report describes the synthesis, using parallel solution-phase methods, of a library of 104 potential inhibitors of PTPases. The library members are based on the bis(aryl α-ketocarboxylic acid) motif that incorporates a carboxylic acid on the central benzene linker. This carboxylic acid was coupled with a variety of different aromatic amines through an amide linkage. The aromatic component of the resulting amides is designed to make contacts with residues that surround the active site of the PTPase. The library was screened against the Yersinia PTPase and PTP1B. Based upon the screening results, four members of the library were selected for further study. These four compounds were evaluated against the Yersinia PTPase, PTP1B, TCPTP, CD45, and LAR. Compound 14 has an IC50 value of 590 nM against PTP1B and is a reversible competitive inhibitor. This affinity represents a greater than 120-fold increase in potency over compound 2, the parent structure upon which the library was based. A second inhibitor, compound 12, has an IC50 value of 240 nM against the Yersinia PTPase. In general, the selectivity of the inhibitors for PTP1B was good compared to LAR, but modest when compared to TCPTP and CD45. In addition to this study using 2-Methoxy-5-(trifluoromethoxy)aniline, there are many other studies that have used 2-Methoxy-5-(trifluoromethoxy)aniline(cas: 660848-57-7Related Products of 660848-57-7) was used in this study.

2-Methoxy-5-(trifluoromethoxy)aniline(cas: 660848-57-7) belongs to anime. Halogenation, in which one or more hydrogen atoms of an amine is replaced by a halogen atom, occurs with chlorine, bromine, and iodine, as well as with some other reagents, notably hypochlorous acid (HClO). With primary amines the reaction proceeds in two stages, producing N-chloro- and N,N-dichloro-amines, RNHCl and RNCl2, respectively. With tertiary amines, an alkyl group may be displaced by a halogen.Related Products of 660848-57-7

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Safety of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamateIn 2018 ,《Synthesis of thermo-responsive nanocomposites of superparamagnetic cobalt nanoparticles/poly(N-isopropylacrylamide)》 was published in Journal of Colloid and Interface Science. The article was written by Tan, Li; Liu, Bing; Siemensmeyer, Konrad; Glebe, Ulrich; Boeker, Alexander. The article contains the following contents:

Novel nanocomposites of superparamagnetic cobalt nanoparticles (Co NPs) and poly(N-isopropylacrylamide) (PNIPAM) were fabricated through surface-initiated atom-transfer radical polymerization (SI-ATRP). We firstly synthesized a functional ATRP initiator, containing an amine (as anchoring group) and a 2-bromopropionate group (SI-ATRP initiator). Oleic acid- and trioctylphosphine oxide-coated Co NPs were then modified with the initiator via ligand exchange. The process is facile and rapid for efficient surface functionalization and afterwards the Co NPs can be dispersed into polar solvent DMF without aggregation. Transmission electron microscopy, Fourier transform IR spectroscopy, XPS, and dynamic light scattering measurements confirmed the success of ligand exchange. The following polymerization of NIPAM was conducted on the surface of Co NPs. Temperature-dependent dynamic light scattering study showed the responsive behavior of PNIPAM-coated Co NPs. The combination of superparamagnetic and thermo-responsive properties in these hybrid nanoparticles is promising for future applications e.g. in biomedicine.tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Safety of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate) was used in this study.

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers. Ethers lack the hydroxyl groups of alcohols. Without the strongly polarized O―H bond, ether molecules cannot engage in hydrogen bonding with each other. Safety of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Reference of 1,2-DiphenyldisulfaneIn 2019 ,《Palladium(II)/Copper(II)-Catalyzed C-H Sulfidation or Selenation of Arenes Leading to Unsymmetrical Sulfides and Selenides》 was published in European Journal of Organic Chemistry. The article was written by Nishino, Kota; Tsukahara, Shouya; Ogiwara, Yohei; Sakai, Norio. The article contains the following contents:

A novel palladium(II)/copper(II)-catalyzed sulfidation of the C-H bond in electron-rich arenes and in pentafluorobenzene with disulfides was developed. This catalytic system can be used to efficiently produce various types of either unsym. aryl sulfides or alkyl aryl sulfides. The present protocol could also be applied to the direct preparation of unsym. aryl selenides via C-H selenation. In the part of experimental materials, we found many familiar compounds, such as 1,2-Diphenyldisulfane(cas: 882-33-7Reference of 1,2-Diphenyldisulfane)

1,2-Diphenyldisulfane(cas: 882-33-7) belongs to ethers.Oxygen is more electronegative than carbon, thus the alpha hydrogens of ethers are more acidic than those of simple hydrocarbons. Reference of 1,2-Diphenyldisulfane They are far less acidic than alpha hydrogens of carbonyl groups (such as in ketones or aldehydes), however.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Park, Sanghwan; Kim, Yun-Tae; Min, Hyegi; Moon, Seung Min; Lee, Seongwoo; Lee, Chang Young published their research in ACS Applied Materials & Interfaces in 2021. The article was titled 《Alkalide-Assisted Direct Electron Injection for the Noninvasive n-Type Doping of Graphene》.Application of 33100-27-5 The article contains the following contents:

Although the doping of graphene grown by chem. vapor deposition is crucial in graphene-based electronics, noninvasive methods of n-type doping have not been widely investigated in comparison with p-type doping methods. We developed a convenient and robust method for the noninvasive n-type doping of graphene, wherein electrons are directly injected from sodium anions into the graphene. This method involves immersing the graphene in solutions of [K(15-crown-5)2]Na prepared by dissolving a sodium-potassium (NaK) alloy in a 15-crown-5 solution The n-type doping of the graphene was confirmed by downshifted G and 2D bands in Raman spectra and by the Dirac point shifting to a neg. voltage. The electron-injected graphene showed no sign of structural damage, exhibited higher carrier mobilities than that of pristine graphene, and remained n-doped for over a month of storage in air. In addition, we demonstrated that electron injection enhances noncovalent interactions between graphene and metallomacrocycle mols. without requiring a linker, as used in previous studies, suggesting several potential applications of the method in modifying graphene with various functionalities. After reading the article, we found that the author used 1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5Application of 33100-27-5)

1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5) is a member of crown ether Ligands. Crown-ethers are macrocyclic polyethers capable of forming host-guest complexes, especially with inorganic and organic cations. Crown-ethers can incorporate protonated primary amine compounds by formation of ion-dipole bonds with the oxygen atoms of the chiral selector. Crown-ethers have been widely used for the separation of several pharmaceuticals both in aqueous and non-aqueous media. Application of 33100-27-5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Synthesis of Chiral-Substituted 2-Aryl-ferrocenes by the Catellani Reaction》 was written by Thorat, Raviraj Ananda; Jain, Saket; Sattar, Moh.; Yadav, Prateek; Mandhar, Yogesh; Kumar, Sangit. Formula: C7H7IO And the article was included in Journal of Organic Chemistry in 2020. The article conveys some information:

A Pd-catalyzed and norbornene-mediated methodol. was developed for the synthesis of chiral 2-aryl-ferroceneamides from chiral 2-iodo-N,N-diisopropylferrocencarboxamide, iodoarenes, and alkenes using a JohnPhos ligand and K carbonate as a base in DMF at 105°. The developed three-component coupling protocol allows the compatibility of electron-withdrawing fluoro, chloro, ester, and nitro and electron-donating Me, methoxy, dimethoxy, benzyl ether-substituted iodo-benzenes, other iodoarenes, such as iodo-naphthalene, heteroarenes, such as iodothiophene, and terminating substrates, such as Me, Et, tert-Bu acrylates, and substituted styrenes with 2-iodo-N,N-diisopropylferrocencarboxamide. Also, the developed three-component Catellani method proceeded with the retention of the configuration of the planar chiral ferrocene, which depends on the role of the participating C-I bond in ferrocene. Consequently, the developed protocol enabled the formation of densely substituted chiral 2-aryl ferroceneamides, exhibiting good to excellent enantioselectivity. The conversion of an ester of the synthesized chiral 2-aryl ferroceneamides also was carried out to further accommodate the easily expendable acid and alc. functionalities. In the experiment, the researchers used many compounds, for example, 1-Iodo-2-methoxybenzene(cas: 529-28-2Formula: C7H7IO)

1-Iodo-2-methoxybenzene(cas: 529-28-2) participates in palladium catalyzed enantioselective Heck arylation of 2,3-dihydrofuran in the presence of chiral ionic liquids containing L-prolinate and L-lactate anions and non-chiral quaternary ammonium cations.Formula: C7H7IO

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Hydroxide is not a Promoter of C2+ Product Formation in the Electrochemical Reduction of CO on Copper》 was written by Li, Jing; Wu, Donghuan; Malkani, Arnav S.; Chang, Xiaoxia; Cheng, Mu-Jeng; Xu, Bingjun; Lu, Qi. SDS of cas: 33100-27-5 And the article was included in Angewandte Chemie, International Edition in 2020. The article conveys some information:

Highly alk. electrolytes improve the formation rate of C2+ products in the electrochem. reduction of CO2 (CO2) and CO on Cu surfaces, with the assumption that higher OH- concentrations promote the C-C coupling chem. Herein, by systematically varying the concentration of Na+ and OH- at the same absolute electrode potential, higher concentrations of (Na+), rather than OH-, exert the main promotional effect on the production of C2+ products. The impact of the nature and the concentration of cations on the electrochem. reduction of CO is supported by experiments in which a fraction or all of Na+ is chelated by a crown ether. Chelation of Na+ leads to drastic decrease in the formation rate of C2+ products. The promotional effect of OH- determined at the same potential on the reversible H electrode scale is likely caused by larger overpotentials at higher electrolyte pH. In the experimental materials used by the author, we found 1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5SDS of cas: 33100-27-5)

1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5) is a member of crown ether Ligands. Crown-ethers are macrocyclic polyethers capable of forming host-guest complexes, especially with inorganic and organic cations. Crown-ethers can incorporate protonated primary amine compounds by formation of ion-dipole bonds with the oxygen atoms of the chiral selector. Crown-ethers have been widely used for the separation of several pharmaceuticals both in aqueous and non-aqueous media. SDS of cas: 33100-27-5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem