Tag: 200-300

In 2019,Organic & Biomolecular Chemistry included an article by Phakdeeyothin, Kunita; Yotphan, Sirilata. Quality Control of 1,2-Diphenyldisulfane. The article was titled 《Metal-free regioselective direct thiolation of 2-pyridones》. The information in the text is summarized as follows:

A highly regioselective metal-free direct C-H thiolation of 2-pyridones with disulfides or thiols were developed. A combination of persulfate and a com. available halide source such as LiCl, NCS or I2 enabled the successful direct incorporation of a sulfide moiety into the 5-position of pyridone under mild conditions, providing a useful and convenient approach for the preparation of a diverse array of 5-thio-substituted pyridones in moderate to excellent yields. In the experimental materials used by the author, we found 1,2-Diphenyldisulfane(cas: 882-33-7Quality Control of 1,2-Diphenyldisulfane)

1,2-Diphenyldisulfane(cas: 882-33-7) belongs to ethers. Ethers lack the hydroxyl groups of alcohols. Without the strongly polarized O―H bond, ether molecules cannot engage in hydrogen bonding with each other. Quality Control of 1,2-Diphenyldisulfane

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2019,European Journal of Medicinal Chemistry included an article by Wang, Siwen; Yang, Dazhou; Singh, Mandeep; Joo, Hyun; Rangel, Vanessa M.; Tran, Aaron; Phan, Erich; Xue, Liang. Safety of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate. The article was titled 《Thiazole orange – Spermine conjugate: A potent human telomerase inhibitor comparable to BRACO-19》. The information in the text is summarized as follows:

In this report, we synthesized a series of TO conjugates containing different amino side chains and investigated their binding to telomeric G-quadruplex DNA (G4) using several biophys. methods including fluorometric titration and thermal denaturation monitored by fluorescence and CD. The composition of side chains strongly affects the binding of these mols. to G-quadruplex DNA. Incorporation of amino side chains increases the binding affinity of TO toward G4 but has a minimal effect on its selectivity for G4 over duplex DNA. The plausible binding modes are a synergistic effect of end-stacking and groove interactions as indicated by docking studies. Inhibition of human telomerase activity by TO derivatives was determined in vitro by the TRAP assay. Several derivatives can selectively inhibit the activity of telomerase over DNA polymerase at low concentrations More significantly, TO-spermine conjugate (16) exhibits a remarkable effect on telomerase inhibition in the submicromolar range, which is comparable to the inhibition effect of a well-known G4 ligand, BRACO-19. Our results here provide guidance of utilizing TO derivatives as a viable scaffold to design novel G4 ligands, G4 probes, and potent telomerase inhibitors. After reading the article, we found that the author used tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Safety of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.Ethers do have nonbonding electron pairs on their oxygen atoms, and they can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Safety of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2014,Mori, Ryota; Kato, Asako; Komenoi, Kousuke; Kurasaki, Haruaki; Iijima, Touru; Kawagoshi, Masashi; Kiran, Y. B.; Takeda, Sho; Sakai, Norio; Konakahara, Takeo published 《Synthesis and in vitro antitumor activity of novel 2-alkyl-5-methoxycarbonyl-11-methyl-6H-pyrido[4,3-b]carbazol-2-ium and 2-(alkyl)ellipticin-2-ium chloride derivatives》.European Journal of Medicinal Chemistry published the findings.Application In Synthesis of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate The information in the text is summarized as follows:

Twenty-one types of ellipticine derivatives [5,11-dimethyl-6H-pyrido[4,3-b]carbazole derivatives] and pyridocarbazole derivatives (5-methoxycarbonyl-11-methyl-6H-pyrido[4,3-b]carbazoles) with a (nitroso)urea group linked by an (oxy)bis[ethylene] unit at the 2-position, were designed and the synthesis of the target compounds was achieved by a multi-step pathway. Their cytotoxicity against HeLa S-3 cells (human uterine cervical carcinoma cell line) was evaluated. The title compounds thus formed included 2,5,11-trimethyl-6H-pyrido[4,3-b]carbazolium chloride and related substances. Some of these new compounds exhibited potent antitumor activity by comparison with that of ellipticine. In the experiment, the researchers used tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Application In Synthesis of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.Oxygen is more electronegative than carbon, thus the alpha hydrogens of ethers are more acidic than those of simple hydrocarbons. They are far less acidic than alpha hydrogens of carbonyl groups (such as in ketones or aldehydes), however. Application In Synthesis of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Category: ethers-buliding-blocksIn 2019 ,《Copper-Catalyzed Regioselective Direct C-H Thiolation and Thiocyanation of Uracils》 was published in European Journal of Organic Chemistry. The article was written by Noikham, Medena; Yotphan, Sirilata. The article contains the following contents:

A novel copper-catalyzed direct C-H thiolation and thiocyanation of uracils using disulfides and thiocyanate salts resp. as coupling partners are described. These reactions enable the C-H bond cleavage and C-S bond formation to proceed efficiently under relatively mild conditions, providing useful methods for a preparation of a series of thio-substituted at the C5 position of uracil derivatives These protocols exhibit several merits including simple exptl. procedures, readily accessible substrates and reagents, broad scopes, high yields, and excellent regioselectivity. Preliminary mechanistic studies revealed that a radical pathway is likely to be involved. The experimental part of the paper was very detailed, including the reaction process of 1,2-Diphenyldisulfane(cas: 882-33-7Category: ethers-buliding-blocks)

1,2-Diphenyldisulfane(cas: 882-33-7) belongs to ethers. Ethers lack the hydroxyl groups of alcohols. Category: ethers-buliding-blocks Without the strongly polarized O―H bond, ether molecules cannot engage in hydrogen bonding with each other.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ke, Quanli; Khalil, Ibrahim; Smeyers, Brent; Li, Zheng; de Oliveira-Silva, Rodrigo; Sels, Bert; Sakellariou, Dimitrios; Dusselier, Michiel published their research in Angewandte Chemie, International Edition in 2021. The article was titled 《A Cooperative OSDA Blueprint for Highly Siliceous Faujasite Zeolite Catalysts with Enhanced Acidity Accessibility》.Computed Properties of C10H20O5 The article contains the following contents:

A cooperative OSDA strategy is demonstrated, leading to novel high-silica FAU zeolites with a large potential for disruptive acid catalysis. In bottom-up synthesis, the symbiosis of choline ion (Ch+) and 15-crown-5 (CE) was evidenced, in a form of full occupation of the sodalite (sod) cages with the trans Ch+ conformer, induced by the CE presence. CE itself occupied the supercages along with addnl. gauche Ch+, but in synthesis without CE, no trans was found. The cooperation, and thus the fraction of trans Ch+, was closely related to the Si/Al ratio, a key measure for FAU stability and acidity. As such, a bottom-up handle for lowering the Al-content of FAU and tuning its acid site distribution is shown. A mechanistic study demonstrated that forming sod cages with trans Ch+ is key to the nucleation of high-silica FAU zeolites. The materials showed superior performances to com. FAU zeolites and those synthesized without cooperation, in the catalytic degradation of polyethylene. In the experiment, the researchers used 1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5Computed Properties of C10H20O5)

1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5) is a member of crown ether Ligands. Crown-ethers are macrocyclic polyethers capable of forming host-guest complexes, especially with inorganic and organic cations. Crown-ethers can incorporate protonated primary amine compounds by formation of ion-dipole bonds with the oxygen atoms of the chiral selector. Crown-ethers have been widely used for the separation of several pharmaceuticals both in aqueous and non-aqueous media. Computed Properties of C10H20O5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Application of 33100-27-5In 2020 ,《An electrospray ionization mass spectrometric study of beryllium chloride solutions and complexes with crown ether and cryptand macrocyclic ligands》 appeared in Journal of Coordination Chemistry. The author of the article were Raymond, Onyekachi; Henderson, William; Lane, Joseph R.; Brothers, Penelope J.; Plieger, Paul G.. The article conveys some information:

The speciation of beryllium chloride solutions was studied using electrospray ionization mass spectrometry in both pos. and neg. ion modes. The majority of observed species were mixed beryllium-chlorido-oxido-hydroxido species, with the degree of hydration of the observed ions depending on the number of chloride ions. The observed species contain between 1 and 6 Be ions. The interactions of BeCl2 with a selection of crown ether ligands and cryptand[2.2.2] were also studied using ESI MS. These ligands have low affinity for Be2+, instead the observed ions are dominated by species formed from adventitious Na+ or K+ ions. The crown ether 12-crown-4 showed the most complex spectra, as a result of greater interactions with Be2+, as evidenced by observed ions such as [BeX(12-crown-4)]+ (X = Cl or OH). The interactions of crown ethers with beryllium ions (as well as coordinated Cl- or OH- ancillary ligands) were studied using D. Functional Theory [B3LYP/6-311++G(dp)], where the species [BeX(crown ether)]+ (X = Cl or OH) are considerably more stable than [Be(crown ether)]2+ species, with 12-crown-4 forming the most stable complex. The combination of ESI MS and DFT studies indicates that full encapsulation of the Be2+ by crown ethers is unfavorable, and coordination with an accompanying hydroxide or chloride is preferred. The results came from multiple reactions, including the reaction of 1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5Application of 33100-27-5)

1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5) is a member of crown ether Ligands. Crown-ethers are macrocyclic polyethers capable of forming host-guest complexes, especially with inorganic and organic cations. Crown-ethers can incorporate protonated primary amine compounds by formation of ion-dipole bonds with the oxygen atoms of the chiral selector. Crown-ethers have been widely used for the separation of several pharmaceuticals both in aqueous and non-aqueous media. Application of 33100-27-5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Huang, Xianli; Zhuang, Dongmei; Chen, Zhihui; Gong, Hao; Wang, Tao; He, Jianping; Zhang, Xiaogang published their research in Journal of Electroanalytical Chemistry in 2021. The article was titled 《The investigation for electrodeposition behavior of lithium metal in a crown ether/propylene carbonate electrolyte》.Recommanded Product: 33100-27-5 The article contains the following contents:

It is so far an efficient way for depressing dendrite growth to adjust the electrolyte composition Therefore, the authors study the electrochem. behavior of Li metal electrodeposited in a LiPF6-propylene carbonate (PC) electrolyte by adding two kinds of crown ether. The effect of crown ether concentration on the Coulombic efficiency of Li electrodes has be evaluated, and the electrodeposition behavior of Li metal on neg. electrode has be analyzed by cyclic voltammetric curve, electrodeposition curve and Li metal deposition morphol. A certain amount of crown ether (15-crown-5 and 12-crown-4) can preferentially coordinate with Li ion in the electrolyte and form complex compounds, which reduce the Li ions concentration in the hot spot and level the Li electrode greatly by inhibiting the preferential growth of Li dendrite. A uniform and dense nano-columnar Li layer could be obtained at the c.d. of 2.0 mA cm-2 when the deposition amount is 1.0 mAh cm-2, and the concentration of 15-crown-5 and 12-crown-4 ether are 0.3M and 0.2M, resp. Gaussian calculation results show that the Li-crown complex has a relatively lower lowest unoccupied mol. orbit (LUMO), where electrons could be injected during the charging process, leading to decreased Coulombic efficiency. In the experiment, the researchers used many compounds, for example, 1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5Recommanded Product: 33100-27-5)

1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5) is a member of crown ether Ligands. Crown-ethers are macrocyclic polyethers capable of forming host-guest complexes, especially with inorganic and organic cations. Crown-ethers can incorporate protonated primary amine compounds by formation of ion-dipole bonds with the oxygen atoms of the chiral selector. Crown-ethers have been widely used for the separation of several pharmaceuticals both in aqueous and non-aqueous media. Recommanded Product: 33100-27-5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Gamez, Francisco; Aviles-Moreno, Juan R.; Berden, Giel; Oomens, Jos; Martinez-Haya, Bruno published their research in Physical Chemistry Chemical Physics in 2021. The article was titled 《Proton in the ring: spectroscopy and dynamics of proton bonding in macrocycle cavities》.Reference of 1,4,7,10,13-Pentaoxacyclopentadecane The article contains the following contents:

The proton bond is a paradigmatic quantum mol. interaction and a major driving force of supramol. chem. The ring cavities of crown ethers provide an intriguing environment, promoting competitive proton sharing with multiple coordination anchors. This study shows that protons confined in crown ether cavities form dynamic bonds that migrate to varying pairs of coordinating atoms when allowed by the flexibility of the macrocycle backbone. Prototypic native crown ethers (12-crown-4, 15-crown-5 and 18-crown-6) and aza-crown ethers (cyclen, 1-aza-18-crown-6 and hexacyclen) are investigated. For each system, IR action spectroscopy experiments and ab initio Mol. Dynamics computations are employed to elucidate the structural effects associated with proton diffusion and its entanglement with the conformational and vibrational dynamics of the protonated host. The experimental part of the paper was very detailed, including the reaction process of 1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5Reference of 1,4,7,10,13-Pentaoxacyclopentadecane)

1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5) is a member of crown ether Ligands. Crown-ethers are macrocyclic polyethers capable of forming host-guest complexes, especially with inorganic and organic cations. Crown-ethers can incorporate protonated primary amine compounds by formation of ion-dipole bonds with the oxygen atoms of the chiral selector. Crown-ethers have been widely used for the separation of several pharmaceuticals both in aqueous and non-aqueous media. Reference of 1,4,7,10,13-Pentaoxacyclopentadecane

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Li, Zezhong John; Srebnik, Simcha published their research in Physical Chemistry Chemical Physics in 2021. The article was titled 《Expanding carbon capture capacity: uncovering additional CO2 adsorption sites in imine-linked porous organic cages》.Related Products of 33100-27-5 The article contains the following contents:

With an increasing need to develop carbon capture technologies, research regarding the use of cage-based porous materials has garnered great interest. Typically, the study of gas adsorption in porous organic cages (POCs) has focused on the gas uptake inside the cage cavity. By using mol. dynamics simulation, this study reveals the presence of eight sites outside the cavity of a 15-crown-5 ether-substituted imine-linked POC which could enhance carbon dioxide adsorption capacity. Adsorption on these sites is likely stabilized by the functional groups on the cage vertices and the imine groups on the faces of the POC. These external adsorption sites have a higher CO2 adsorption capacity and greater sensitivity to temperature and pressure changes than the sites within the cage cavity. These characteristics are particularly favorable for applications based on pressure- and temperature-swing separation In the experimental materials used by the author, we found 1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5Related Products of 33100-27-5)

1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5) is a member of crown ether Ligands. Crown-ethers are macrocyclic polyethers capable of forming host-guest complexes, especially with inorganic and organic cations. Crown-ethers can incorporate protonated primary amine compounds by formation of ion-dipole bonds with the oxygen atoms of the chiral selector. Crown-ethers have been widely used for the separation of several pharmaceuticals both in aqueous and non-aqueous media. Related Products of 33100-27-5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Devulcanization of natural rubber industry waste in supercritical carbon dioxide combined with diphenyl disulfide》 was written by Asaro, Lucia; Gratton, Michel; Poirot, Nathalie; Seghar, Said; Ait Hocine, Nourredine. COA of Formula: C12H10S2 And the article was included in Waste Management (Oxford, United Kingdom) in 2020. The article conveys some information:

The elimination of rubber wastes without affecting the environment is one of the most important challenges of the 21st century waste management. Accordingly, the present work is focused on the recycling of natural rubber (NR) industry waste by means of devulcanization in supercritical carbon dioxide (scCO2) atm. With that aim, a novel device allowing to perform rubber devulcanization was developed. It consists of a triaxial compression reactor integrated into a dynamic hydraulic universal testing machine with a heating chamber. NR industry waste was devulcanized in the mentioned device at different temperatures, in scCO2 by using di-Ph disulfide (DD) as devulcanizing reagent. The devulcanization degree and quality of the treated materials were evaluated by the swelling test combined with the Horikx theory. It was appeared that a successful devulcanization, with almost no degradation, was obtained, and the devulcanization degree reached maximum value of ∼90%. Thermogravimetric tests and SEM (SEM) images strengthened these results. Finally, it was concluded that the developed device is appropriate to perform rubber recycling, which contributes to the progress in the environmental protection. In the experimental materials used by the author, we found 1,2-Diphenyldisulfane(cas: 882-33-7COA of Formula: C12H10S2)

1,2-Diphenyldisulfane(cas: 882-33-7) belongs to ethers.Ethers do have nonbonding electron pairs on their oxygen atoms, and they can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. COA of Formula: C12H10S2 The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem