Tag: 200-300

In 2018,Beilstein Journal of Organic Chemistry included an article by Tarapdar, Abed; Norris, James K. S.; Sampson, Oliver; Mukamolova, Galina; Hodgkinson, James T.. Application In Synthesis of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate. The article was titled 《The design and synthesis of an antibacterial phenothiazine-siderophore conjugate》. The information in the text is summarized as follows:

Siderophore-antibiotic conjugates consist of an antibiotic covalently linked by a tether to a siderophore. Such conjugates can demonstrate enhanced uptake and internalisation to the bacterial cell resulting in significantly reduced MIC values and extended spectrum of activity. Phenothiazines are a class of small mols. that have been identified as a potential treatment for multidrug resistant tuberculosis and latent TB. Herein we report the design and synthesis of the first phenothiazine-siderophore conjugate. A convergent synthetic route was developed whereby the functionalised phenothiazine component was prepared in four steps and the siderophore component also prepared in four steps. In M. smegmatis the functionalised phenothiazine demonstrated an equipotent MIC value in direct comparison to the parent phenothiazine from which it was derived. The final conjugate was synthesized by amide bond formation between the two components and global deprotection of the PMB protecting groups to unmask the catechol iron chelating groups of the siderophore. The synthesis is readily amenable to the preparation of analogs whereby the siderophore component of the conjugate can be modified. The route will be used to prepare a library of siderophore-phenothiazine conjugates for full biol. evaluation of much needed new antibacterial agents. The results came from multiple reactions, including the reaction of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Application In Synthesis of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.The C-O bonds that comprise simple ethers are strong. Application In Synthesis of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate They are unreactive toward all but the strongest bases. Although generally of low chemical reactivity, they are more reactive than alkanes.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2018,Serebrenik, Yevgeniy V.; Hellerschmied, Doris; Toure, Momar; Lopez-Giraldez, Francesc; Brookner, Dennis; Crews, Craig M. published 《Targeted protein unfolding uncovers a Golgi-specific transcriptional stress response》.Molecular Biology of the Cell published the findings.Product Details of 139115-91-6 The information in the text is summarized as follows:

In eukaryotic cells, organelle-specific stress-response mechanisms are vital for maintaining cellular homeostasis. The Golgi apparatus, an essential organelle of the secretory system, is the major site of protein modification and sorting within a cell and functions as a platform for spatially regulated signaling. Golgi homeostasis mechanisms that regulate organelle structure and ensure precise processing and localization of protein substrates remain poorly understood. Using a chem. biol. strategy to induce protein unfolding, we uncover a Golgi-specific transcriptional response. An RNA-sequencing profile of this stress response compared with the current state-of-the-art Golgi stressors, nigericin and xyloside, demonstrates the enhanced precision of Golgi targeting achieved with our system. The data set further reveals previously uncharacterized genes that we find to be essential for Golgi structural integrity. These findings highlight the Golgi′s ability to sense misfolded proteins and establish new aspects of Golgi autoregulation. In addition to this study using tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate, there are many other studies that have used tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Product Details of 139115-91-6) was used in this study.

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.Ethers do have nonbonding electron pairs on their oxygen atoms, and they can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Product Details of 139115-91-6

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2013,Singh, Vijay; Wang, Shenliang; Kool, Eric T. published 《Genetically Encoded Multispectral Labeling of Proteins with Polyfluorophores on a DNA Backbone》.Journal of the American Chemical Society published the findings.Electric Literature of C9H19NO4 The information in the text is summarized as follows:

Genetically encoded methods for protein conjugation are of high importance as biol. tools. Here the authors describe the development of a new class of dyes for genetically encoded tagging that add new capabilities for protein reporting and detection via HaloTag methodol. Oligodeoxyfluorosides (ODFs) are short DNA-like oligomers in which the natural nucleic acid bases are replaced by interacting fluorescent chromophores, yielding a broad range of emission colors using a single excitation wavelength. The authors describe the development of an alkyl halide dehalogenase-compatible chloroalkane linker phosphoramidite derivative that enables the rapid automated synthesis of many possible dyes for protein conjugation. Experiments to test the enzymic self-conjugation of nine different DNA-like dyes to proteins with HaloTag domains in vitro were performed, and the data confirmed the rapid and efficient covalent labeling of the proteins. Notably, a number of the ODF dyes increase in brightness or change color upon protein conjugation. Tests in mammalian cellular settings revealed that the dyes are functional in multiple cellular contexts, both on the cell surface and within the cytoplasm, allowing protein localization to be imaged in live cells by epifluorescence and laser confocal microscopy. The experimental process involved the reaction of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Electric Literature of C9H19NO4)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.Oxygen is more electronegative than carbon, thus the alpha hydrogens of ethers are more acidic than those of simple hydrocarbons. They are far less acidic than alpha hydrogens of carbonyl groups (such as in ketones or aldehydes), however. Electric Literature of C9H19NO4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Underlying Polar and Nonpolar Modification MOF-Based Factors that Influence Permanent Porosity in Porous Liquids》 was written by Mahdavi, Hamidreza; Eden, Nathan T.; Doherty, Cara M.; Acharya, Durga; Smith, Stefan J. D.; Mulet, Xavier; Hill, Matthew R.. COA of Formula: C10H20O5This research focused onzirconium terephthalato MOF carbon dioxide adsorption; MOF modification; gas sorption; permanent porosity; porous liquids; zirconium-based metal−organic frameworks. The article conveys some information:

It is increasingly apparent that porous liquids (PLs) have unique use cases due to the combination of ready liquid handling and their inherently high adsorption capacity. Among the PL types, those with permanent porosity are the most promising. Although Type II and III PLs have economic synthetic methods and can be made from a huge variety of metal-organic frameworks (MOFs) and solvents, these nanocomposites still need to be stable to be useful. This work aims to systematically explore the possibilities of creating PLs using different MOF modification methods. This delivered underpinning insights into the mol.-level influence between solvent and MOF on the overall nanocomposite stability. Zirconium-based metal-organic frameworks were combined with two different solvents of varying chem. to deliver CO2 sorption capacities as high as 2.9 mmol g-1 at 10 bar. The results of the study could have far-reaching ramifications for future investigations in the PL field. After reading the article, we found that the author used 1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5COA of Formula: C10H20O5)

1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5) is a member of crown ether Ligands. Crown-ethers are macrocyclic polyethers capable of forming host-guest complexes, especially with inorganic and organic cations. Crown-ethers can incorporate protonated primary amine compounds by formation of ion-dipole bonds with the oxygen atoms of the chiral selector. Crown-ethers have been widely used for the separation of several pharmaceuticals both in aqueous and non-aqueous media. COA of Formula: C10H20O5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Effect of Propanol-1 on the Reaction between Thiophenol and N,N’-Diphenyl-1,4-Benzoquinone Diimine in Chlorobenzene》 was written by Varlamov, V. T.. Synthetic Route of C12H10S2This research focused onthiophenol diphenyl benzoquinone diimine addition reaction kinetics. The article conveys some information:

Abstract: It is found that the interaction between thiophenol and N,N’-diphenyl-1,4-benzoquinone diimine proceeds by two routes, one of which is a radical chain reaction and the other is a nonchain reaction between the reagents. The kinetic patterns of the reaction depend substantially on the concentration of propanol-1 in mixtures of it and chlorobenzene. It is shown that at 343 K, replacing chlorobenzene with propanol-1 results in an almost twentyfold increase in the total rate of the reaction. Increasing the concentration of propanol-1 raises the rate of both routes of the reaction, but that of the nonchain route grows more than that of the chain route. It is concluded that increasing the concentration of propanol-1 results in a simultaneous 20-30 times rise in the rate constants of both the stage of radical generation by the reaction between the reagents as well as the rate constant of the nonchain bimol. reaction, and the chain length of the chain reaction is shortened. When chlorobenzene is replaced with propanol-1, the rate constant of the limiting stage of chain propagation (the reaction of quinone diimine with a phenylthiyl radical) is halved, due to the formation of H complexes between the π system of quinone diimine and the proton of propanol-1.1,2-Diphenyldisulfane(cas: 882-33-7Synthetic Route of C12H10S2) was used in this study.

1,2-Diphenyldisulfane(cas: 882-33-7) belongs to ethers.Although ethers resist hydrolysis, they are cleaved by hydrobromic acid and hydroiodic acid. Hydrogen chloride cleaves ethers only slowly. Synthetic Route of C12H10S2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Name: 1,4,7,10,13-PentaoxacyclopentadecaneIn 2020 ,《Sorption of Metal Ions from Aqueous Solutions by Crown Ethers》 was published in Russian Journal of Physical Chemistry B. The article was written by Gromov, V. F.; Gerasimov, G. N.; Ikim, M. I.; Spiridonova, E. Yu.; Trakhtenberg, L. I.. The article contains the following contents:

The sorption of copper and lead ions by polymeric sorbents based on crosslinked polyacrylamide containing chem. bound or immobilized 15-crown-5 and 18-crown-6 was studied, as was the effect of various parameters on the efficiency of metal sorption from aqueous solutions It is shown that the sorption capacity of these sorbents increases dramatically with an increase in the content of crown ethers in them from 3 to 6 wt %. When aging sorbents containing 6 wt % 15-crown-5 or 18-crown-6, in an aqueous solution of copper chloride or lead acetate, resp., the salt concentration in the solution decreases by 3-4 orders of magnitude. When aging sorbents based on 18-crown-6 in a solution containing equivalent amounts of lead acetate or copper sulfate, the amount of absorbed copper did not exceed 5% of the amount of extracted lead, which indicates the high selectivity of such sorbents. In addition to this study using 1,4,7,10,13-Pentaoxacyclopentadecane, there are many other studies that have used 1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5Name: 1,4,7,10,13-Pentaoxacyclopentadecane) was used in this study.

1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5) is a member of crown ether Ligands. Crown-ethers are macrocyclic polyethers capable of forming host-guest complexes, especially with inorganic and organic cations. Crown-ethers can incorporate protonated primary amine compounds by formation of ion-dipole bonds with the oxygen atoms of the chiral selector. Crown-ethers have been widely used for the separation of several pharmaceuticals both in aqueous and non-aqueous media. Name: 1,4,7,10,13-Pentaoxacyclopentadecane

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

SDS of cas: 33100-27-5In 2020 ,《Transforming Porous Organic Cages into Porous Ionic Liquids via a Supramolecular Complexation Strategy》 appeared in Angewandte Chemie, International Edition. The author of the article were Jie, Kecheng; Onishi, Nicole; Schott, Jennifer A.; Popovs, Ilja; Jiang, De-en; Mahurin, Shannon; Dai, Sheng. The article conveys some information:

Porous liquids are a type of porous materials that engineer permanent porosity into unique flowing liquids, exhibiting promising functionalities for a variety of applications. Here a Type I porous liquid is synthesized by transforming porous organic cages into porous ionic liquids via a supramol. complexation strategy. Simple phys. mixing of 18-crown-6 with task-specific anionic porous organic cages affords a porous ionic liquid with anionic porous organic cages as the anionic parts and 18-crown-6/potassium ion complexes as the cationic parts. In contrast, mixing of 15-crown-5 and anionic porous organic cages in a 2:1 ratio gives only solids, while the addition of excess 15-crown-5 affords a Type II porous liquid The permanent porosity in the cage-based porous liquids has been also confirmed by mol. simulation, positron (e+) annihilation lifetime spectroscopy, and enhanced gas sorption capacity compared with pure crown ethers. In the experimental materials used by the author, we found 1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5SDS of cas: 33100-27-5)

1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5) is a member of crown ether Ligands. Crown-ethers are macrocyclic polyethers capable of forming host-guest complexes, especially with inorganic and organic cations. Crown-ethers can incorporate protonated primary amine compounds by formation of ion-dipole bonds with the oxygen atoms of the chiral selector. Crown-ethers have been widely used for the separation of several pharmaceuticals both in aqueous and non-aqueous media. SDS of cas: 33100-27-5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Thomas, Sajesh P.; Thomas, Reshmi; Groenbech, Thomas Bjoern E.; Bondesgaard, Martin; Mamakhel, Aref H.; Birkedal, Victoria; Iversen, Bo B. published their research in Journal of Physical Chemistry Letters in 2021. The article was titled 《Bandgap tuning in molecular alloy crystals formed by weak chalcogen interactions》.Related Products of 882-33-7 The article contains the following contents:

We demonstrate systematic tuning in the optical bandgaps of mol. crystals achieved by the generation of mol. alloys/solid solutions of a series of di-Ph dichalcogenides-characterized by weak chalcogen bonding interactions involving S, Se, and Te atoms. Despite the variety in chalcogen bonding interactions found in this series of dichalcogenide crystals, they show isostructural interaction topologies, enabling the formation of solid solutions The alloy crystals exhibit Vegard’s law-like trends of variation in their unit cell dimensions and a nonlinear trend for the variation in optical bandgaps with respect to their compositions Energy-dispersive X-ray and spatially resolved Raman spectroscopic studies indicate significant homogeneity in the domain structure of the solid solutions Quantum periodic calculations of the projected d. of states provide insights into the bandgap tuning in terms of the mixing of states in the alloy crystal phases. The results came from multiple reactions, including the reaction of 1,2-Diphenyldisulfane(cas: 882-33-7Related Products of 882-33-7)

1,2-Diphenyldisulfane(cas: 882-33-7) belongs to ethers. Ethers lack the hydroxyl groups of alcohols. Related Products of 882-33-7 Without the strongly polarized O―H bond, ether molecules cannot engage in hydrogen bonding with each other.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Unconventional Reactivity with DABCO-Bis(sulfur dioxide): C-H Bond Sulfenylation of Imidazopyridines》 was published in European Journal of Organic Chemistry in 2020. These research results belong to Le Bescont, Julie; Breton-Patient, Chloe; Piguel, Sandrine. Application In Synthesis of 1-Iodo-2-methoxybenzene The article mentions the following:

This work highlights the unexpected and unprecedented outcome of the reactivity with DABCO-bis(sulfur dioxide). The use of this reagent led to the exclusive introduction of a sulfur atom on the C-3 position of imidazopyridines instead of a sulfone group. The reaction methodol. turned out to be robust, scalable and suitable for various imidazopyridines and aryl iodides both bearing substituents with different electronic and steric properties (38 examples). Beyond the fact that this synthetic method complements the previously reported protocols for sulfenylation reactions, this work is meant to underline the unconventional role of DABCO-bis(sulfur dioxide). Thus, e.g., 2-phenylimidazo[1,2-a]pyridine + PhI + DABSO → I (68%) in presence of CuI/phenanthroline and tBuOK in DMF at 140°. A polemic in response to the work of D. Yang et al. (2018), who reported the preparation of sulfones under similar conditions. The results came from multiple reactions, including the reaction of 1-Iodo-2-methoxybenzene(cas: 529-28-2Application In Synthesis of 1-Iodo-2-methoxybenzene)

1-Iodo-2-methoxybenzene(cas: 529-28-2) participates in palladium catalyzed enantioselective Heck arylation of 2,3-dihydrofuran in the presence of chiral ionic liquids containing L-prolinate and L-lactate anions and non-chiral quaternary ammonium cations.Application In Synthesis of 1-Iodo-2-methoxybenzene

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthetic Route of C10H20O5In 2019 ,《Tunable Reduction of 2,4,6-Tri(4-pyridyl)-1,3,5-Triazine: From Radical Anion to Diradical Dianion to Radical Metal-Organic Framework》 appeared in Angewandte Chemie, International Edition. The author of the article were Tang, Shuxuan; Ruan, Huapeng; Feng, Rui; Zhao, Yue; Tan, Gengwen; Zhang, Li; Wang, Xinping. The article conveys some information:

The reduction of 2,4,6-tri(4-pyridyl)-1,3,5-triazine (TPT) with alkali metals resulted in four radical anion salts (1, 2, 4 and 5) and one diradical dianion salt (3). Single-crystal x-ray diffraction and ESR spectroscopy reveal that 1 contains the monoradical anion TPT.- stacked in one-dimensional (1D) with K+(18c6) and 2 can be viewed as a 1D magnetic chain of TPT.-, while 4 and 5 form radical metal-organic frameworks (RMOFs). 1D pore passages, with a diameter of 6.0 Å, containing solvent mols. were observed in 5. Variable-temperature EPR measurements show that 3 has an open-shell singlet ground state that can be excited to a triplet state, consistent with theor. calculation The work suggests that the direct reduction approach could lead to the formation of RMOFs. The results came from multiple reactions, including the reaction of 1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5Synthetic Route of C10H20O5)

1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5) is a member of crown ether Ligands. Crown-ethers are macrocyclic polyethers capable of forming host-guest complexes, especially with inorganic and organic cations. Crown-ethers can incorporate protonated primary amine compounds by formation of ion-dipole bonds with the oxygen atoms of the chiral selector. Crown-ethers have been widely used for the separation of several pharmaceuticals both in aqueous and non-aqueous media. Synthetic Route of C10H20O5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem