Tag: 200-300

In 2022,Durrant, James P.; Day, Benjamin M.; Tang, Jinkui; Mansikkamaki, Akseli; Layfield, Richard A. published an article in Angewandte Chemie, International Edition. The title of the article was 《Dominance of Cyclobutadienyl Over Cyclopentadienyl in the Crystal Field Splitting in Dysprosium Single-Molecule Magnets》.Product Details of 33100-27-5 The author mentioned the following in the article:

Replacing a monoanionic cyclopentadienyl (Cp) ligand in Dy single-mol. magnets (SMMs) with a dianionic cyclobutadienyl (Cb) ligand in the sandwich complexes [(η4-Cb””)Dy(η5-C5Me4tBu)(BH4)]- (1), [(η4-Cb””)Dy(η8-Pn )K(THF)] (2) and [(η4-Cb””)Dy(η8-Pn )]- (3) leads to larger energy barriers to magnetization reversal (Cb”” = C4(SiMe3)4, Pn = 1,4-di(tri-isopropylsilyl)pentalenyl). Short distances to the Cb”” ligands and longer distances to the Cp ligands in 1-3 are consistent with the crystal field splitting being dominated by the former. Theor. anal. shows that the magnetic axes in the ground Kramers doublets of 1-3 are oriented towards the Cb”” ligands. The theor. axiality parameter and the relative axiality parameter Z and Zrel are introduced to facilitate comparisons of the SMM performance of 1-3 with a benchmark SMM. Increases in Z and Zrel when Cb”’ replaces Cp signposts a route to SMMs with properties that could surpass leading systems. In the experiment, the researchers used 1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5Product Details of 33100-27-5)

1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5) is a member of crown ether Ligands. Crown-ethers are macrocyclic polyethers capable of forming host-guest complexes, especially with inorganic and organic cations. Crown-ethers can incorporate protonated primary amine compounds by formation of ion-dipole bonds with the oxygen atoms of the chiral selector. Crown-ethers have been widely used for the separation of several pharmaceuticals both in aqueous and non-aqueous media. Product Details of 33100-27-5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Potentiometric screen-printed sensor for determination of oxybutynin hydrochloride》 was written by El-Attar, Rehab O.; Hendawy, Hassan A. M.; Khaled, Elmorsy. Application of 33100-27-5 And the article was included in Journal of the Iranian Chemical Society in 2020. The article conveys some information:

Abstract: The present work describes the fabrication of disposable screen-printed oxybutynin hydrochloride (OXB) potentiometric sensors. The electrode matrix composition was investigated on the basis of the effect of the nature and concentration of sensing ionophores, anionic sites, plasticizers and nanomaterials. Incorporation of single-walled carbon nanotubes (SWCNTs) as transducer and (2, 3, 6-tri-O-methyl)-β-cyclodextrin as mol. recognition elements in the electrode matrix improved both the sensitivity and selectivity of the sensor towards oxybutynin hydrochloride. The fabricated sensors showed Nernstian slope of 57.5 ± 1.0 mV decade-1 in the concentration range from 10-6 to 10-2 mol L-1 OXB with detection limit of 8 x 10-7 mol L-1. Moreover, the presence of SWCNTs in the electrode matrix enhanced the potential reading stability, response time (< 4 s) and increased life time of the sensors (5 mo). The developed sensors were successfully applied for determination of OXB in pharmaceutical formulations and biol. fluids with agreeable average recoveries compared with the official methods. The experimental part of the paper was very detailed, including the reaction process of 1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5Application of 33100-27-5)

1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5) is a member of crown ether Ligands. Crown-ethers are macrocyclic polyethers capable of forming host-guest complexes, especially with inorganic and organic cations. Crown-ethers can incorporate protonated primary amine compounds by formation of ion-dipole bonds with the oxygen atoms of the chiral selector. Crown-ethers have been widely used for the separation of several pharmaceuticals both in aqueous and non-aqueous media. Application of 33100-27-5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Zimmermann, Birte M.; Ngoc, Trung Tran; Tzaras, Dimitrios-Ioannis; Kaicharla, Trinadh; Teichert, Johannes F. published their research in Journal of the American Chemical Society in 2021. The article was titled 《A Bifunctional Copper Catalyst Enables Ester Reduction with H2: Expanding the Reactivity Space of Nucleophilic Copper Hydrides》.Quality Control of 1,4,7,10,13-Pentaoxacyclopentadecane The article contains the following contents:

Employing a bifunctional catalyst based on a copper(I)/NHC complex and a guanidine organocatalyst, catalytic ester reductions to alcs. with H2 as terminal reducing agent are facilitated. The approach taken here enables the simultaneous activation of esters through hydrogen bonding and formation of nucleophilic copper(I) hydrides from H2, resulting in a catalytic hydride transfer to esters. The reduction step is further facilitated by a proton shuttle mediated by the guanidinium subunit. This bifunctional approach to ester reductions for the first time shifts the reactivity of generally considered “”soft”” copper(I) hydrides to previously unreactive “”hard”” ester electrophiles and paves the way for a replacement of stoichiometric reducing agents by a catalyst and H2. In the experiment, the researchers used many compounds, for example, 1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5Quality Control of 1,4,7,10,13-Pentaoxacyclopentadecane)

1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5) is a member of crown ether Ligands. Crown-ethers are macrocyclic polyethers capable of forming host-guest complexes, especially with inorganic and organic cations. Crown-ethers can incorporate protonated primary amine compounds by formation of ion-dipole bonds with the oxygen atoms of the chiral selector. Crown-ethers have been widely used for the separation of several pharmaceuticals both in aqueous and non-aqueous media. Quality Control of 1,4,7,10,13-Pentaoxacyclopentadecane

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Distinctive Viewpoint on the Rapid Dissolution Mechanism of α-Chitin in Aqueous Potassium Hydroxide-Urea Solution at Low Temperatures》 was published in Macromolecules (Washington, DC, United States) in 2020. These research results belong to Huang, Junchao; Zhong, Yi; Zhang, Lina; Cai, Jie. Recommanded Product: 33100-27-5 The article mentions the following:

To develop a green solvent for chitin dissolution, the most fundamental aspects of its mechanism must be elucidated. In this work, an aqueous KOH/urea solution was utilized for the rapid dissolution of α-chitin without performing freeze-thaw cycles. It was found that the mechanism of α-chitin dissolution involved not only the fast expansion of its crystalline regions and hierarchical structure but also direct and strong interactions between K+ ions and chitin carbonyl oxygens. The relatively high flexibility and deformability of the K+ hydration shells allowed fast exchange between water mols. and carbonyl oxygens, which induced the cleavage of strong inter- and intramol. hydrogen bonds, resulting in the rapid swelling and destruction of the chitin crystal and dissolution of α-chitin. Moreover, the addnl. urea mitigated the hydrophobicity of chitin chains, which prevented self-aggregation and increased the mobility of chitin chains. The described α-chitin dissolution mechanism can help achieve a better understanding of biomacromol. dissolution The experimental part of the paper was very detailed, including the reaction process of 1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5Recommanded Product: 33100-27-5)

1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5) is a member of crown ether Ligands. Crown-ethers are macrocyclic polyethers capable of forming host-guest complexes, especially with inorganic and organic cations. Crown-ethers can incorporate protonated primary amine compounds by formation of ion-dipole bonds with the oxygen atoms of the chiral selector. Crown-ethers have been widely used for the separation of several pharmaceuticals both in aqueous and non-aqueous media. Recommanded Product: 33100-27-5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The author of 《Chain-growth horner-wadsworth-emmons condensation polymerization initiated with an aliphatic aldehyde》 were Sato, Keichiro; Goto, Eisuke; Ochiai, Yuto; Higashihara, Tomoya. And the article was published in Journal of Photopolymer Science and Technology in 2019. Safety of 1,4,7,10,13-Pentaoxacyclopentadecane The author mentioned the following in the article:

The effective initiation for the chain-growth Horner-Wadsworth-Emmons (HWE) condensation polymerization was succeeded by utilizing an aliphatic aldehyde. Due to the higher electrophilicity of the aliphatic aldehyde compared with the aromatic one, the reactivity of the initiation might be accelerated, producing uniform intermediates to result in the formation of well-defined poly(3-(2-ethylhexyl)thienylene vinylene) (P3EHTV). Consequently, P3EHTV possessed the predictable mol. weight and lower molar-mass dispersity (ETHM = 1.16) value than that of P3EHTV obtained by employing aromatic aldehyde compounds as the initiators. In this polymerization system, neither transition metals nor halogens are utilized to realize low environmental-load synthesis of well-defined π-conjugated polymers. The results came from multiple reactions, including the reaction of 1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5Safety of 1,4,7,10,13-Pentaoxacyclopentadecane)

1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5) is a member of crown ether Ligands. Crown-ethers are macrocyclic polyethers capable of forming host-guest complexes, especially with inorganic and organic cations. Crown-ethers can incorporate protonated primary amine compounds by formation of ion-dipole bonds with the oxygen atoms of the chiral selector. Crown-ethers have been widely used for the separation of several pharmaceuticals both in aqueous and non-aqueous media. Safety of 1,4,7,10,13-Pentaoxacyclopentadecane

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Zhang, Kan; Yao, Yanxiu; Sun, Wenjin; Wen, Rui; Wang, Yanyan; Sun, Huaming; Zhang, Weiqiang; Zhang, Guofang; Gao, Ziwei published an article in 2021. The article was titled 《Triazine-wingtips accelerated NHC-Pd catalysed carbonylative Sonogashira cross-coupling reaction》, and you may find the article in Chemical Communications (Cambridge, United Kingdom).Formula: C7H7IO The information in the text is summarized as follows:

By using a ppm-level precatalyst T-NHC-Pd, the highly efficient coupling of aryl iodide, alkyne and carbon monoxide furnished a variety of ynone compounds T-NHC-Pd, which deprotonated 4-methyl-phenylacetylene under mild conditions, converted into alkynyl-coordinated catalytic active species PdCl(T-NHC)(Py)(alkynyl). In the putative Pd/Pd catalytic cycle, both triazine-wingtips and NHCs were key players for establishing the carbonylative cross-couplings with high TON and TOF. After reading the article, we found that the author used 1-Iodo-2-methoxybenzene(cas: 529-28-2Formula: C7H7IO)

1-Iodo-2-methoxybenzene(cas: 529-28-2) participates in palladium catalyzed enantioselective Heck arylation of 2,3-dihydrofuran in the presence of chiral ionic liquids containing L-prolinate and L-lactate anions and non-chiral quaternary ammonium cations.Formula: C7H7IO

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Zhang, Shunyao; Tamura, Atsushi; Yui, Nobuhiko published their research in Science and Technology of Advanced Materials in 2021. The article was titled 《Weakly acidic carboxy group-grafted β-cyclodextrin-threaded acid-degradable polyrotaxanes for modulating protein interaction and cellular internalization》.Formula: C9H19NO4 The article contains the following contents:

To improve the therapeutic potential of β-cyclodextrin (β-CD)-threaded acid-degradable polyrotaxanes (β-CD PRXs) in cholesterol-related metabolic disorders, we investigated the effect of carboxylation of β-CD PRXs on intracellular uptake. In this study, we established a synthetic method for the modification of carboxylalkyl carbamates on β-CD PRXs without degradation and synthesized three series of carboxyalkyl carbamate group-modified β-CD PRXs with different alkyl spacer lengths. The modification of carboxymethyl carbamate (CMC), carboxyethyl carbamate (CEC), and carboxypropyl carbamate (CPC) on the β-CD PRXs slightly reduced the interaction of the PRXs with the lipid layer model compared with the modification of 2-(2-hydroxyethoxy)ethyl carbamate (HEE-PRX), which was used in our previous studies. However, all the carboxylated β-CD PRXs showed a significantly stronger interaction with a protein model compared with HEE-PRX. The carboxylated β-CD PRXs showed significantly high intracellular uptake, through macrophage scavenger receptor A (MSR-A)-mediated endocytosis, in MSR-A-pos. RAW 264.7 cells compared with HEE-PRX. Interestingly, the carboxylated β-CD PRXs also showed significantly higher intracellular uptake even in MSR-A-neg. cells compared with HEE-PRX. Carboxylated β-CD PRXs are considered to strongly interact with other membrane proteins, resulting in high intracellular uptake. The length of the alkyl spacer affected the intracellular uptake levels of carboxylated PRXs, however, this relationship was varied for different cell types. Furthermore, none of the carboxylated β-CD PRXs exhibited cytotoxicity in the RAW 264.7 and NIH/3T3 cells. Altogether, carboxylation of β-CD PRXs is a promising chem. modification approach for their therapeutic application because carboxylated β-CD PRXs exhibit high cellular internalization efficiency in MSR-A-neg. cells and negligible toxicity. In the part of experimental materials, we found many familiar compounds, such as tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Formula: C9H19NO4)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.Although ethers resist hydrolysis, they are cleaved by hydrobromic acid and hydroiodic acid. Hydrogen chloride cleaves ethers only slowly. Formula: C9H19NO4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Glycan-Gold Nanoparticles as Multifunctional Probes for Multivalent Lectin-Carbohydrate Binding: Implications for Blocking Virus Infection and Nanoparticle Assembly》 was written by Budhadev, Darshita; Poole, Emma; Nehlmeier, Inga; Liu, Yuanyuan; Hooper, James; Kalverda, Elizabeth; Akshath, Uchangi Satyaprasad; Hondow, Nicole; Turnbull, W. Bruce; Pohlmann, Stefan; Guo, Yuan; Zhou, Dejian. Computed Properties of C9H19NO4 And the article was included in Journal of the American Chemical Society in 2020. The article conveys some information:

Multivalent lectin-glycan interactions are widespread in biol. and are often exploited by pathogens to bind and infect host cells. Glycoconjugates can block such interactions and thereby prevent infection. The inhibition potency strongly depends on matching the spatial arrangement between the multivalent binding partners. However, the structural details of some key lectins remain unknown and different lectins may exhibit overlapping glycan specificity. This makes it difficult to design a glycoconjugate that can potently and specifically target a particular multimeric lectin for therapeutic interventions, especially under the challenging in vivo conditions. Conventional techniques such as surface plasmon resonance (SPR) and isothermal titration calorimetry (ITC) can provide quant. binding thermodn. and kinetics. However, they cannot reveal key structural information, e.g., lectin’s binding site orientation, binding mode, and interbinding site spacing, which are critical to design specific multivalent inhibitors. Herein we report that gold nanoparticles (GNPs) displaying a dense layer of simple glycans are powerful mechanistic probes for multivalent lectin-glycan interactions. They can not only quantify the GNP-glycan-lectin binding affinities via a new fluorescence quenching method, but also reveal drastically different affinity enhancing mechanisms between two closely related tetrameric lectins, DC-SIGN (simultaneous binding to one GNP) and DC-SIGNR (intercross-linking with multiple GNPs), via a combined hydrodynamic size and electron microscopy anal. Moreover, a new term, potential of assembly formation (PAF), has been proposed to successfully predict the assembly outcomes based on the binding mode between GNP-glycans and lectins. Finally, the GNP-glycans can potently and completely inhibit DC-SIGN-mediated augmentation of Ebola virus glycoprotein-driven cell entry (with IC50 values down to 95 pM), but only partially block DC-SIGNR-mediated virus infection. Our results suggest that the ability of a glycoconjugate to simultaneously block all binding sites of a target lectin is key to robust inhibition of viral infection. In addition to this study using tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate, there are many other studies that have used tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Computed Properties of C9H19NO4) was used in this study.

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.The C-O bonds that comprise simple ethers are strong. Computed Properties of C9H19NO4 They are unreactive toward all but the strongest bases. Although generally of low chemical reactivity, they are more reactive than alkanes.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Electrolyte additives to enable nonaqueous polyelectrolyte solutions for lithium ion batteries》 was published in Molecular Systems Design & Engineering in 2020. These research results belong to Diederichsen, Kyle M.; McCloskey, Bryan D.. Safety of 1,4,7,10,13-Pentaoxacyclopentadecane The article mentions the following:

Nonaqueous polyelectrolyte solutions, in which a neg. charged macromol. neutralized by lithium is dissolved in nonaqueous solvents, have shown promise as potential high transference number electrolytes. However, in battery-relevant carbonate solvents (ethylene carbonate/dimethyl carbonate blends), it has been shown that lithium ions do not readily dissociate from easily synthesized sulfonated polymers, despite the solvent’s high dielec. constant (∼50). In this work, a range of additives are screened to improve conductivity, and we demonstrate that the addition of less than 5 vol% of 15-crown-5 achieves an order of magnitude conductivity increase by selectively improving lithium dissociation Utilizing the optimized electrolyte, we show that polyelectrolyte solutions may be directly substituted for a standard electrolyte with com. electrodes in a graphite/LiFePO4 cell, providing further motivation for future study of these new electrolytes. In the part of experimental materials, we found many familiar compounds, such as 1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5Safety of 1,4,7,10,13-Pentaoxacyclopentadecane)

1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5) is a member of crown ether Ligands. Crown-ethers are macrocyclic polyethers capable of forming host-guest complexes, especially with inorganic and organic cations. Crown-ethers can incorporate protonated primary amine compounds by formation of ion-dipole bonds with the oxygen atoms of the chiral selector. Crown-ethers have been widely used for the separation of several pharmaceuticals both in aqueous and non-aqueous media. Safety of 1,4,7,10,13-Pentaoxacyclopentadecane

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2015,Pulsipher, Abigail; Griffin, Matthew E.; Stone, Shannon E.; Hsieh-Wilson, Linda C. published 《Long-Lived Engineering of Glycans to Direct Stem Cell Fate》.Angewandte Chemie, International Edition published the findings.Quality Control of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate The information in the text is summarized as follows:

Glycans mediate many critical, long-term biol. processes, such as stem cell differentiation. However, few methods are available for the sustained remodeling of cells with specific glycan structures. A new strategy that enables the long-lived presentation of defined glycosaminoglycans on cell surfaces using HaloTag proteins (HTPs) as anchors is reported. By controlling the sulfation patterns of heparan sulfate (HS) on pluripotent embryonic stem cell (ESC) membranes, it is demonstrated that specific glycans cause ESCs to undergo accelerated exit from self-renewal and differentiation into neuronal cell types. Thus, the stable display of glycans on HTP scaffolds provides a powerful, versatile means to direct key signaling events and biol. outcomes such as stem cell fate. In the experiment, the researchers used many compounds, for example, tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Quality Control of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.The C-O bonds that comprise simple ethers are strong. They are unreactive toward all but the strongest bases. Although generally of low chemical reactivity, they are more reactive than alkanes. Quality Control of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem