Tag: 200-300

In 2012,Takahashi, Michiko; Kawamura, Akie; Kato, Nobuo; Nishi, Tsuyoshi; Hamachi, Itaru; Ohkanda, Junko published 《Phosphopeptide-Dependent Labeling of 14-3-3 ζ Proteins by Fusicoccin-Based Fluorescent Probes》.Angewandte Chemie, International Edition published the findings.Reference of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate The information in the text is summarized as follows:

The authors hypothesized that a chem. modified fusicoccin (FC) bearing a fluorescent tag that is attached by a reactive spacer, and a phosphopeptide that contains a V residue at position i+1 would bind to 14-3-3 and form a ternary complex. The formation of the complex would in turn trigger the spacer to react with nucleophilic residues on the protein surface to covalently attach the tag. Labeling through formation of a ternary complex with the consensus peptide should be kinetically more favorable than labeling with the probe alone, because of the stabilizing effect imparted by van der Waals interactions. The authors developed such fluorescent probes that are capable of labeling 14-3-3ζ, in a site-specific, 14-3-3-selective, and most importantly, highly ligand-dependent manner. The FC anchor precisely recognizes the structural difference of the residue at position i+1 in the phosphopeptide, thus enabling selective 14-3-3 labeling which depends on the shape of the ligand.tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Reference of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate) was used in this study.

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.Oxygen is more electronegative than carbon, thus the alpha hydrogens of ethers are more acidic than those of simple hydrocarbons. They are far less acidic than alpha hydrogens of carbonyl groups (such as in ketones or aldehydes), however. Reference of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Fukasawa, Yuto; Kaneko, Masashi; Nakashima, Satoru published their research in Journal of Radioanalytical and Nuclear Chemistry in 2021. The article was titled 《Density functional study on Am(III)/Eu(III) selectivity using crown ether type ligands》.COA of Formula: C10H20O5 The article contains the following contents:

D. functional theory calculations were applied to understand the selectivity between Am3+ and Eu3+ ions with the crown ethers type ligands. 18C6 is predicted to form the most stable complex with Eu3+ and show the higher stability for Am3+ over Eu3+, being consistent with previously reported Am3+/Eu3+ selectivity. The authors modeled N- and S-donor complexes by using framework of 18C6 complex and analyzed the complexation Gibbs energies, indicating that 18C6 with N-donor atoms is suitable for both complexation and higher Am3+ stability over Eu3+ due to the stronger covalent interaction. In the experimental materials used by the author, we found 1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5COA of Formula: C10H20O5)

1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5) is a member of crown ether Ligands. Crown-ethers are macrocyclic polyethers capable of forming host-guest complexes, especially with inorganic and organic cations. Crown-ethers can incorporate protonated primary amine compounds by formation of ion-dipole bonds with the oxygen atoms of the chiral selector. Crown-ethers have been widely used for the separation of several pharmaceuticals both in aqueous and non-aqueous media. COA of Formula: C10H20O5

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Construction of sequence-defined polytriazoles by IrAAC and CuAAC reactions》 was published in Chemical Communications (Cambridge, United Kingdom) in 2020. These research results belong to Ju, Changhong; Meng, Congcong; Ma, Jiahao; Zhang, Xueyan; Ding, Shengtao. Application In Synthesis of 1,2-Diphenyldisulfane The article mentions the following:

Here we report the first synthesis of sequence-defined polytriazoles, in which different side groups are sequentially anchored to the C-5 position of 1,2,3-triazole rings. By using efficient synthetic strategies based on IrAAC and CuAAC, different monodispersed polytriazoles with up to ∼5.3 kDa and 31-mer were constructed. Structural characterization via NMR, SEC, MALDI-TOF-MS, tandem MS and FTICR-MS evidenced the formation of polytriazoles with the desired specified sequences and exact chain lengths.1,2-Diphenyldisulfane(cas: 882-33-7Application In Synthesis of 1,2-Diphenyldisulfane) was used in this study.

1,2-Diphenyldisulfane(cas: 882-33-7) belongs to ethers.Application In Synthesis of 1,2-DiphenyldisulfaneAlthough ethers resist hydrolysis, they are cleaved by hydrobromic acid and hydroiodic acid. Hydrogen chloride cleaves ethers only slowly.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Recommanded Product: 139115-91-6In 2017 ,《NanoSOSG: a Nanostructured Fluorescent Probe for the Detection of Intracellular Singlet Oxygen》 was published in Angewandte Chemie, International Edition. The article was written by Ruiz-Gonzalez, Ruben; Bresoli-Obach, Roger; Gulias, Oscar; Agut, Montserrat; Savoie, Huguette; Boyle, Ross W.; Nonell, Santi; Giuntini, Francesca. The article contains the following contents:

A biocompatible fluorescent nanoprobe for singlet oxygen (1O2) detection in biol. systems was designed, synthesized, and characterized, that circumvents many of the limitations of the mol. probe Singlet Oxygen Sensor Green (SOSG). This widely used com. singlet oxygen probe was covalently linked to a polyacrylamide nanoparticle core using different architectures to optimize the response to 1O2. In contrast to its mol. counterpart, the optimum SOSG-based nanoprobe, which we call NanoSOSG, is readily internalized by E. coli cells and does not interact with bovine serum albumin. Furthermore, the spectral characteristics do not change inside cells, and the probe responds to intracellularly generated 1O2 with an increase in fluorescence. After reading the article, we found that the author used tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Recommanded Product: 139115-91-6)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.Oxygen is more electronegative than carbon, thus the alpha hydrogens of ethers are more acidic than those of simple hydrocarbons. They are far less acidic than alpha hydrogens of carbonyl groups (such as in ketones or aldehydes), however. Recommanded Product: 139115-91-6

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Jafari, Mehrafshan G.; Park, Yerin; Pudasaini, Bimal; Kurogi, Takashi; Carroll, Patrick J.; Kaphan, David M.; Kropf, Jeremy; Delferro, Massimiliano; Baik, Mu-Hyun; Mindiola, Daniel J. published their research in Angewandte Chemie, International Edition in 2021. The article was titled 《Phosphorus-Atom Transfer from Phosphaethynolate to an Alkylidyne》.Recommanded Product: 1,4,7,10,13-Pentaoxacyclopentadecane The article contains the following contents:

A low-spin and mononuclear V complex, (Menacnac)V(CO)(η2-PCtBu) (2) (Menacnac- = [ArNCMe]2CH, Ar = 2,6-iPr2C6H3), was prepared upon treatment of the V neopentylidyne complex (Menacnac)VCtBu(OTf) (1) with Na(OCP)(diox)2.5 (diox = 1,4-dioxane), while the isoelectronic ate-complex [Na(15-crown-5)]{([ArNC(CH2)]CH[CMeNAr])V(CO)(η2-PCtBu)} (4), was obtained via the reaction of Na(OCP)(diox)2.5 and ([ArNC(CH2)]CH[CMeNAr])VCtBu(OEt2) (3) in the presence of crown-ether. Computational studies suggest that the P-atom transfer proceeds by [2+2]-cycloaddition of the PC bond across the VCtBu moiety, followed by a reductive decarbonylation to form the V-CO linkage. The nature of the electronic ground state in diamagnetic complexes, 2 and 4, was further studied both theor. and exptl., using a combination of d. functional theory (DFT) calculations, UV/visible and NMR spectroscopies, cyclic voltammetry, x-ray absorption spectroscopy (XAS) measurements, and comparison of salient bond metrics derived from X-ray single-crystal structural characterization. In combination, these data are consistent with a low-valent V ion in complexes 2 and 4. This study represents the 1st example of a metathesis reaction between the P-atom of [PCO]- and an alkylidyne ligand.1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5Recommanded Product: 1,4,7,10,13-Pentaoxacyclopentadecane) was used in this study.

1,4,7,10,13-Pentaoxacyclopentadecane(cas: 33100-27-5) is a member of crown ether Ligands. Crown-ethers are macrocyclic polyethers capable of forming host-guest complexes, especially with inorganic and organic cations. Crown-ethers can incorporate protonated primary amine compounds by formation of ion-dipole bonds with the oxygen atoms of the chiral selector. Crown-ethers have been widely used for the separation of several pharmaceuticals both in aqueous and non-aqueous media. Recommanded Product: 1,4,7,10,13-Pentaoxacyclopentadecane

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Visible-light induced decarboxylative coupling of redox-active esters with disulfides to construct C-S bonds》 was published in Chemical Communications (Cambridge, United Kingdom) in 2020. These research results belong to Xiao, Zhiwei; Wang, Lu; Wei, Junjie; Ran, Chongzhao; Liang, Steven H.; Shang, Jingjie; Chen, Guang-Ying; Zheng, Chao. COA of Formula: C12H10S2 The article mentions the following:

A novel method was established for the construction of C-S bonds using redox-active esters with disulfides in the presence of Ru-photoredox catalyst. This method exhibited remarkable functional group tolerance across a wide scope of substrates. Under mild conditions, a structurally diverse array of aryl alkyl sulfides was successfully and efficiently obtained through decarboxylative cross-coupling. In the part of experimental materials, we found many familiar compounds, such as 1,2-Diphenyldisulfane(cas: 882-33-7COA of Formula: C12H10S2)

1,2-Diphenyldisulfane(cas: 882-33-7) belongs to ethers.COA of Formula: C12H10S2Although ethers resist hydrolysis, they are cleaved by hydrobromic acid and hydroiodic acid. Hydrogen chloride cleaves ethers only slowly.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2019,Chemical Communications (Cambridge, United Kingdom) included an article by Gao, Qianwen; Liu, Ze-Shui; Hua, Yu; Li, Lisha; Cheng, Hong-Gang; Cong, Hengjiang; Zhou, Qianghui. Application of 529-28-2. The article was titled 《A palladium/norbornene cooperative catalysis to access N-containing bridged scaffolds》. The information in the text is summarized as follows:

A palladium/norbornene cooperative catalysis promoted annulation involving an ortho-C-H amination and intramol. Heck cascade between aryl iodides ArI (Ar = 2-methylphenyl, 3-fluoro-2-methylphenyl, naphthalen-1-yl, etc.) and functionalized amination reagents I (R = Me, Et, benzyl, cyclopropylmethyl, 2-methylpropyl) is reported, thereby providing a highly convergent access to the unique N-containing bridged scaffolds: hexahydro-2,6-methano-1-benzazocine II (R1 = Me, F, C6H5, etc.; R2 = H, Me, F; R3 = H, F, C(O)2CH3, etc.; R1R2 = CH=CH-CH=CH). The salient features of the reaction include its broad substrate scope (with respect to aryl iodides), its high step economy, and good chemoselectivity. Preliminary studies underscore the future promise of rendering this Catellani-type annulation enantioselective.1-Iodo-2-methoxybenzene(cas: 529-28-2Application of 529-28-2) was used in this study.

1-Iodo-2-methoxybenzene(cas: 529-28-2) is a useful synthetic intermediate. It can be used in the synthesis of piperidinyl diaminopyrimidines as cyclin-dependent kinase inhibitors with antitumor activity and polysubstituted benzofuran derivatives as novel inhibitors of parasitic growth.Application of 529-28-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2018,Matsushita, Takahiko; Tsuchibuchi, Koji; Koyama, Tetsuo; Hatano, Ken; Matsuoka, Koji published 《A constraint scaffold enhances affinity of a bivalent N-acetylglucosamine ligand against wheat germ agglutinin》.Bioorganic & Medicinal Chemistry Letters published the findings.Recommanded Product: 139115-91-6 The information in the text is summarized as follows:

Bivalent glycoconjugates have a minimal valence with avidity potential on protein-carbohydrate interactions as well as simplicity of chem. structures enabling simple synthesis with low cost. Understanding the way to maximize the affinities of bivalent glycoconjugates is important for the development of cost-effective tools for therapeutic and diagnostic research. However, there has been little discussion about the effects of constraints imposed from ligand scaffolds on the binding abilities. The authors synthesized three kinds of biantennary N-acetylglucosamine glycosides with different scaffolds using isobutenyl bis(propargyl)ether as a common scaffold precursor. Decoration of the scaffold branches with GlcNAc moieties through copper-catalyzed azide-alkyne cycloaddition and grafting of the alkenyl focal point to another bivalent biotin dendron through thiol-ene and nucleophilic substitution reactions were successfully carried out in an orthogonal manner. The association constants of the ligands against wheat germ agglutinin were determined by a fluorometric titration assay. A bivalent biotin counterpart provided higher affinity than an iso-Bu scaffold, whereas an isobutenyl scaffold yielded more enhancement than a bivalent biotin counterpart. The present work suggested that the constraint and steric bulk of ligand scaffolds are possible factors for improving binding properties of glycoconjugates against lectins or proteins. In the part of experimental materials, we found many familiar compounds, such as tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Recommanded Product: 139115-91-6)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.Although ethers resist hydrolysis, they are cleaved by hydrobromic acid and hydroiodic acid. Hydrogen chloride cleaves ethers only slowly. Recommanded Product: 139115-91-6

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2013,Ke, Damei; Tang, Ailing; Zhan, Chuanlang; Yao, Jiannian published 《Conformation-variable PDI@β-sheet nanohelices show stimulus-responsive supramolecular chirality》.Chemical Communications (Cambridge, United Kingdom) published the findings.Recommanded Product: tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate The information in the text is summarized as follows:

A tripeptide-perylene diimide (PDI) conjugate self-assembles into PDI@β-sheet nanohelices, whose local conformations are sensitive to the external stimuli of concentration, heating and ultrasound, showing stimulus-responsive supramol. chirality. The experimental process involved the reaction of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Recommanded Product: tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.Ethers do have nonbonding electron pairs on their oxygen atoms, and they can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. Recommanded Product: tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2012,Richards, Sarah-Jane; Jones, Mathew W.; Hunaban, Mark; Haddleton, David M.; Gibson, Matthew I. published 《Probing Bacterial-Toxin Inhibition with Synthetic Glycopolymers Prepared by Tandem Post-Polymerization Modification: Role of Linker Length and Carbohydrate Density》.Angewandte Chemie, International Edition published the findings.Formula: C9H19NO4 The information in the text is summarized as follows:

The authors use tandem post-polymerization modification to obtain glycopolymers with precisely controlled chain length, carbohydrate d., and crucially, defined back-bone-carbohydrate linker lengths. This series of polymers was used to study the multivalent interactions between cholera toxin and peanut agglutinin, to probe the impact of modulating the binding site complementarity on the inhibitory activity of the glycopolymers. This unique combination of structural biol. with materials science gives insights into the cluster glycoside effect and will allow design of active inhibitors. The aim of this investigation was to probe the effect of carbohydrate-binding site accessibility on the measured affinity between multivalent glycopolymers and their target lectins. The B subunit domain of cholera toxin was chosen because it is nontoxic,and a report by Polizzotti and Kiick showed that longer linkers resulted in increased inhibitory activity of cholera toxin. A series of glycopolymers with varying saccharide d., linker length, and chain length were synthesized by tandem post-polymerization modification. Longer linkers were shown to result in increased inhibition of the B subunit of cholera toxin, which is attributed to the depth of the binding pocket. Comparison with peanut agglutinin, which has a shallower binding pocket, revealed no difference in inhibitory activity as a function of linker length. The tandem post-polymerization modification strategy also allowed the effect of carbohydrate d. to be studied. The experimental part of the paper was very detailed, including the reaction process of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Formula: C9H19NO4)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.The C-O bonds that comprise simple ethers are strong. Formula: C9H19NO4 They are unreactive toward all but the strongest bases. Although generally of low chemical reactivity, they are more reactive than alkanes.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem