Tag: 200-300

Reference of Dimethoxydiphenylmethane《Reduction of ketones with LiAlH₄ complexes of α,α,α’,α’-tetraaryl-1,3-dioxolane-4,5-dimethanols (TADDOLs). A combination of enantioselective reduction and clathrate formation with a discussion of LAH reagents bearing C₂-symmetrical ligands》 was published in 1996. The authors were Seebach, Dieter;Beck, Albert K.;Dahinden, Robert;Hoffmann, Matthias;Kuehnle, Florian N. M., and the article was included in《Croatica Chemica Acta》. The author mentioned the following in the article:

A complex prepared from one equivalent each of LiAlH₄, EtOH and a TADDOL (α,α,α’,α’-tetraaryl-1,3-dioxolane-4,5-dimethanol) reduces aryl alkyl ketones to sec. alcs. with enantiomer ratios (er) up to 96:4. The chiral LAH derivative is used in two-fold excess in THF solution and at dry ice temperatures The ability of TADDOLs to form clathrates diastereoselectivity can be exploited to increase the er of the initially formed alcs. by a simple modification of the work-up procedure and hence, products of very high enantiopurity (er 99:1) can be isolated. When (R,R)-TADDOLs (from (R,R)-tartrate) are applied in the reaction, the 1-aryl-alkanols formed preferentially have (S) configuration, as for the products obtained with the corresponding (P)-BINOL and (P)-BIPHENOL derivatives A common mechanistic model is discussed. And Dimethoxydiphenylmethane (cas: 2235-01-0) was used in the research process.

Dimethoxydiphenylmethane is one of ethers-buliding-blocks. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. Reference of Dimethoxydiphenylmethane The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Recommanded Product: 2235-01-0In 2008, Van Orden, L. J.;Jasti, R.;Rychnovsky, S. D. published 《Product class 1: dialkyl ethers. Synthesis from esters, aldehydes, ketones, and acetals by reduction or alkylation》. 《Science of Synthesis》published the findings. The article contains the following contents:

A review of methods to prepare dialkyl ethers via reduction or alkylation of esters, aldehydes, ketones, and acetals. And Dimethoxydiphenylmethane (cas: 2235-01-0) was used in the research process.

Dimethoxydiphenylmethane is one of ethers-buliding-blocks. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. Recommanded Product: 2235-01-0 The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Electric Literature of C15H16O2In 2011, Sinhamahapatra, Apurba;Sutradhar, Narottom;Ghosh, Malay;Bajaj, Hari C.;Panda, Asit B. published 《Mesoporous sulfated zirconia mediated acetalization reactions》. 《Applied Catalysis, A: General》published the findings. The article contains the following contents:

A novel, convenient, one step synthetic procedure for the synthesis of mesoporous sulfated zirconia (m-SZ) using zirconium carbonate complex and its use as solid acid catalyst for the acetalization of different carbonyl compound is reported. The high specific BET surface area (234 m² g^-1) of m-SZ is achieved after the removal of the surfactant (cetyltrymethylammonium bromide, CTAB) through calcination at 550 °C for 6 h. Microscopic anal. indicated the presence of spherical particles with worm like pores. DRIFT (diffuse reflectance FTIR) of pyridine adsorbed m-SZ and NH₃-TPD (temperature programmed desorption) anal. suggested the presence of appreciable amount of Broensted acid sites. The synthesized m-SZ showed high catalytic activity towards protection of carbonyl compounds through acetal/ketal formation. For the open ketal (from cyclohexanone and methanol) 97% conversion with 100% selectivity was obtained in 1 h at room temperature under solvent free condition. The catalyst can be easily recycled after separation from the reaction system without considerable loss in catalytic activity. To complete the study, the researchers used Dimethoxydiphenylmethane (cas: 2235-01-0) .

The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom.Electric Literature of C15H16O2

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Acar, Oktay;Varis, Serhat;Isik, Tugba;Tirkes, Seha;Demir, Mustafa M. published 《Synthesis and characterization of novel high temperature structural adhesives based on nadic end capped MDA-BTDA-ODA copolyimide》. The research results were published in《Materials Research Express》 in 2018.Product Details of 2657-87-6 The article conveys some information:

A series of novel copolyimide structural adhesives were synthesized using 4,4′-diaminodiphenyl- methane (MDA), 3,4′-oxydianiline (ODA) and 3,3′,4,4′-benzophenonetetracarboxylic acid dianhydride (BTDA) as co-monomers, and nadic anhydride as an end cap reagent. The adhesives with different MDA and ODA contents were examined in terms of their structure, thermal stability, mech. properties, and adhesive performance. They have glass transition temperatures (Tg) about 400 °C, with thermal stability up to 500 °C. The effect of diamine monomer compositions on adhesion performance and processability of the copolyimides were studied. The copolyimides exhibited adhesion strength up to 16.3 MPa at room temperature Nadic end capped MDA-BTDA-ODA copolyimide resins gained adjustable and controllable processability with the addition of ether bridged aromatic segments. The copolyimide adhesive with equimolar composition of MDA:ODA is distinguished form the both com. PMR-15 and LARC RP-46 polyimides in terms of its better processability and mech. performance. And 3-(4-Aminophenoxy)aniline (cas: 2657-87-6) was used in the research process.

3-(4-Aminophenoxy)aniline is one of ethers-buliding-blocks. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. Product Details of 2657-87-6 The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Previtali, Viola;Mihigo, Helene B.;Amet, Rebecca;McElligott, Anthony M.;Zisterer, Daniela M.;Rozas, Isabel published 《Exploring the anti-cancer mechanism of novel 3,4′-substituted diaryl guanidinium derivatives》 in 2020. The article was appeared in 《Pharmaceuticals》. They have made some progress in their research.Recommanded Product: 2657-87-6 The article mentions the following:

We previously identified a guanidinium-based lead compound that inhibited BRAF through a hypothetic type-III allosteric mechanism. Considering the pharmacophore identified in this lead compound (i.e., “lipophilic group”, “di-substituted guanidine”, “phenylguanidine polar end”), several modifications were investigated to improve its cytotoxicity in different cancer cell lines. Thus, several lipophilic groups were explored, the di-substituted guanidine was replaced by a secondary amine and the Ph ring in the polar end was substituted by a pyridine. In a structure-based design approach, four representative derivatives were docked into an inhouse model of an active triphosphate-containing BRAF protein, and the interactions established were analyzed. Based on these computational studies, a variety of derivatives was synthesized, and their predicted drug-like properties calculated Next, the effect on cell viability of these compounds was assessed in cell line models of promyelocytic leukemia and breast, cervical and colorectal carcinomas. The potential of a selection of these compounds as apoptotic agents was assessed by screening in the promyelocytic leukemia cell line HL-60. The toxicity against non-tumorigenic epithelial MCF10A cells was also investigated. These studies allowed for several structure-activity relationships to be derived. Investigations on the mechanism of action of representative compounds suggest a divergent effect on inhibition of the MAPK/ERK signaling pathway. The experimental procedure involved many compounds, such as 3-(4-Aminophenoxy)aniline (cas: 2657-87-6) .

3-(4-Aminophenoxy)aniline is one of ethers-buliding-blocks. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. Recommanded Product: 2657-87-6 The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Product Details of 2235-01-0《Fe(III)-Exchanged Montmorillonite as Reusable Heterogeneous Protonic Acid Catalyst for Michael Addition of Indole in Water》 was published in 2017. The authors were Matsuzawa, Ryosuke;Nishimura, Shun;Ebitani, Kohki, and the article was included in《ChemistrySelect》. The author mentioned the following in the article:

Fe³⁺-exchanged montmorillonite (Fe³⁺-mont) was found to be an effective and a reusable heterogeneous acid catalyst for the Michael addition of indole with Me vinyl ketone at 333 K in H₂O to afford 4-(1H-indol-3-yl)butan-2-one in high yields. Investigations on activity of the Fe³⁺-mont catalyst for deprotection of benzophenone dimethylketal and Meerwein-Ponndorf-Verley reduction of furfural suggested that protonic acid sites of the Fe³⁺-mont catalyst were responsible for the present Michael addition of indole. The experimental procedure involved many compounds, such as Dimethoxydiphenylmethane (cas: 2235-01-0) .

For example, the most common synthesis of ethers involves the attack of an alkoxide ion on an alkyl halide. This method is called Williamson ether synthesis.Product Details of 2235-01-0

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Hamada, Nao;Kazahaya, Kiyoshi;Shimizu, Hisashi;Sato, Tsuneo published 《An efficient and versatile procedure for the synthesis of acetals from aldehydes and ketones catalyzed by lithium tetrafluoroborate》. The research results were published in《Synlett》 in 2004.SDS of cas: 2235-01-0 The article conveys some information:

Acetals, e.g., I, were obtained, in good yields, by treatment of aldehydes and ketones with trialkyl orthoformate, and the corresponding alc., in the presence of a catalytic amount of lithium tetrafluoroborate. Due to the mild reaction conditions, this method was compatible with acid-sensitive substrates. And Dimethoxydiphenylmethane (cas: 2235-01-0) was used in the research process.

Dimethoxydiphenylmethane is one of ethers-buliding-blocks. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. SDS of cas: 2235-01-0 The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Iacazio, Gilles;Perissol, Claude;Faure, Bruno published 《A new tannase substrate for spectrophotometric assay》. The research results were published in《Journal of Microbiological Methods》 in 2000.Product Details of 2235-01-0 The article conveys some information:

A new tannase substrate, protocatechuic acid p-nitrophenyl ester, I, was synthesized using modern synthetic methods. The synthesis was designed to be performed by non-specialized chemists. It only involves four steps, three of which are protection-deprotection, and uses standard methods of separation and purification, such as recrystallization and column chromatog. over silica. Under tannase action, protocatechuic acid p-nitrophenyl ester, I, releases p-nitrophenol, which is easily measured spectrophotometrically either at 350 nm for pH values < 6 or at 400 nm for pH values of 6-7 (yellow). The pH-response and the catalytic parameters of a crude Penicillium sp. tannase preparation were determined using I as substrate, thus showing the usefulness of this substrate in determining tannase activity. To complete the study, the researchers used Dimethoxydiphenylmethane (cas: 2235-01-0) .

The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom.Product Details of 2235-01-0

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Wang, Wei;Wang, Zijun;Zhang, Li;Liu, Yuntao;Chen, Dongfeng published 《Effect of isomeric oxydianiline on crystalline behavior and properties of semicrystalline copolyimides》 in 2014. The article was appeared in 《Gaofenzi Cailiao Kexue Yu Gongcheng》. They have made some progress in their research.Related Products of 2657-87-6 The article mentions the following:

To investigate the effect of isomer on crystallinities of copolyimides, two copolyimides were synthesized by introducing 4,4′-oxydianiline (4,4′-ODA) or 3,4′-oxydianiline (3,4′-ODA) to 3,3′,4,4′-biphenyltetracarboxylic dianhydride (s-BPDA)/1,3-bis (4-aminophenoxy) benzene (TPER). And the mole ratio of ODA and TPER is both 1:9. The homopolyimide based on s-BPDA/TPER/phthalic anhydride (PA) was also prepared and it was abbreviated as TPER PI. Copolyimide containing 4,4′-ODA or 3,4′-ODA was abbreviated as PI a and PI b, resp. TGA, DSC, DMA and WXRD were used to study the crystalline behaviors and properties of the polymers. Three polymers display different cold crystallization temperatures and melting temperatures after being quenched from melts by DSC and they also display different melting behaviors after being slowly cooled from melts. Since 3,4′-ODA has more twisted structure, PI b displays the lowest melting temperature (T_m), the lowest crystallization rate, and the lowest storage modulus above T_g. After being isothermally crystallized at different temperatures for 1 h, PI a displays a triple-melting behaviors as same as TPER PI, however, PI b displays a duple-melting behaviors. Positions of some diffraction peaks of PI b were found to be changed after being isothermally crystallized at different temperatures In a word, introduction of 4,4′-ODA and 3,4′-ODA greatly affects crystalline behaviors of the copolyimides.3-(4-Aminophenoxy)aniline (cas: 2657-87-6) were involved in the experimental procedure.

3-(4-Aminophenoxy)aniline is one of ethers-buliding-blocks. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. Related Products of 2657-87-6 The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Meng, Xiangsheng;Yan, Jingling;Fan, Weifeng;Liu, Jingfeng;Wang, Zhen;Li, Guodong published 《Thermosetting polyimides and composites based on highly soluble phenylethynyl-terminated isoimide oligomers》 in 2014. The article was appeared in 《RSC Advances》. They have made some progress in their research.Application of 2657-87-6 The article mentions the following:

Highly soluble phenylethynyl-endcapped isoimide oligomers were synthesized using 2,3,3′,4′-biphenyltetracarboxylic dianhydride and aromatic diamines as the monomers, 4-phenylethynyl phthalic anhydride as the end-capping reagent, and trifluoroacetic anhydride as the dehydrating agent; then high performance thermosetting polyimides and composites were produced from these oligomers via the thermal crosslinking reaction of the phenylethylnyl group and the material properties were fully investigated. A series of isoimide oligomers with different mol. weights and a variety of chem. architectures were prepared by polycondensation of 3,4′-BPDA, 4-PEPA, and aromatic diamines including m-phenylenediamine (m-PDA), 2,2′-bis(trifluoromethyl)benzidine and 3,4′-oxydianiline followed by cyclization with trifluoroacetic anhydride. Compared to their imide analogs, isoimide oligomers showed much higher solubility in low b.p. solvents, and slightly lower melt viscosity, which can be attributed to their unique asym. architecture. These resins were formulated into thermosetting polyimides and composites by thermal crosslinking of the phenylethynyl group and conversion from isoimide to imide at elevated temperatures The properties of the thermosets and composites were studied using mech. property measurements, dynamic mech. thermal anal. and thermogravimetric anal. The polyimide/quartz fiber composites possessed excellent high temperature mech. properties due to the high glass transition temperatures of matrix resins. And 3-(4-Aminophenoxy)aniline (cas: 2657-87-6) was used in the research process.

3-(4-Aminophenoxy)aniline is one of ethers-buliding-blocks. Ethers lack the hydroxyl groups of alcohols. Without the strongly polarized O―H bond, ether molecules cannot engage in hydrogen bonding with each other. Application of 2657-87-6Ethers do have nonbonding electron pairs on their oxygen atoms, however, and they can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds.

Reference:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem