Tag: 200-300

Ruthenium-Catalyzed Vinylene Carbonate Annulation by C-H/N-H Functionalizations: Step-Economical Access to Indoles was written by Yu, Yao;Wang, Yang;Li, Bo;Tan, Yuqiang;Zhao, Huan;Li, Zheyu;Zhang, Chunran;Ma, Wenbo. And the article was included in Advanced Synthesis & Catalysis in 2022.Formula: C12H17NO2 This article mentions the following:

A convenient and effective method of ruthenium-catalyzed C-H/N-H annulations using vinylene carbonate as oxidizing acetylene surrogate has been disclosed. This method is scalable and compatible with a wide range of functional groups, providing a step-economical access to indoles I (R = H, 5-Me, 7-Ph, 6-Br, etc.) and preliminary mechanistic studies provided support for a reversible, acetate-assisted C-H ruthenation, along with a subsequent olefin insertion. In the experiment, the researchers used many compounds, for example, N-(3-Methoxyphenyl)pivalamide (cas: 56619-93-3Formula: C12H17NO2).

N-(3-Methoxyphenyl)pivalamide (cas: 56619-93-3) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.Formula: C12H17NO2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Analysis of organic pollutants in a wastewater treatment plant was written by Lepri, Luciano;Desideri, Piergiorgio;Del Bubba, Massimo. And the article was included in Annali di Chimica (Rome) in 1997.Quality Control of 1-((1-((1-Methoxypropan-2-yl)oxy)propan-2-yl)oxy)propan-2-ol This article mentions the following:

A comprehensive anal. method to identify and quant. determine organic pollutants in domestic and industrial wastewater collected during different treatment phases at the Baciacavallo Plant, Prato, Italy, is outlined. Liquid-liquid extraction (LLE) with n-hexane and liquid-solid extraction (LSE) on a RP-18 column to recover a wide variety of dissolved compounds were evaluated. Organic extracts were divided into 4 fractions of increasing polarity by adsorption on silica gel and analyzed using HPLC and high resolution gas chromatog.-mass spectrometry. The distribution of these pollutants between dissolved and particulate phases and their fate during treatment are discussed. In the experiment, the researchers used many compounds, for example, 1-((1-((1-Methoxypropan-2-yl)oxy)propan-2-yl)oxy)propan-2-ol (cas: 20324-33-8Quality Control of 1-((1-((1-Methoxypropan-2-yl)oxy)propan-2-yl)oxy)propan-2-ol).

1-((1-((1-Methoxypropan-2-yl)oxy)propan-2-yl)oxy)propan-2-ol (cas: 20324-33-8) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.Quality Control of 1-((1-((1-Methoxypropan-2-yl)oxy)propan-2-yl)oxy)propan-2-ol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

π-Excess σ²P,O hybrid ligands: synthesis of the first 4-methoxy-1H-1,3-benzazaphospholes was written by Aluri, Bhaskar R.;Jones, Peter G.;Dix, Ina;Heinicke, Joachim W.. And the article was included in Synthesis in 2014.HPLC of Formula: 56619-93-3 This article mentions the following:

3-Pivaloylaminoanisole undergoes regioselective lithiation in 2-position, which enables introduction of phosphono and phosphino-groups in 2-position; the reduction product, phosphine 3-MeO-2-PH₂-1-NHCH₂^tBuC₆H₃ was cyclized into 1-neopentyl-4-methoxy-1H-1,3-benzazaphosphole with 86% yield. The synthesis of the first 4-methoxy-substituted 1,3-benzazaphosphole was accomplished by using a C,O-dilithium intermediate generated from N-(3-methoxyphenyl)-2,2-dimethylpropanamide and butyllithium. This intermediate was subjected either to direct phosphonylation or to a bromination and phosphonylation sequence; subsequent reductive cyclization with excess lithium aluminum hydride led to the desired product. In addition, N-(2,2-dimethylpropyl)-3-methoxy-2-phosphinoaniline, formed in a side reaction, was cyclized with (dimethoxymethyl)dimethylamine to give 1-(2,2-dimethylpropyl)-4-methoxy-1H-1,3-benzazaphosphole. The behavior of these +M-substituted π-excess aromatic σ²-P-heterocycles towards moisture is reported, together with their 1H, 13C, and 31P solution NMR spectra and a crystal-structure anal. The new compounds represent potential σ²-P,O hybrid or chelate ligands with a high π-d. at the phosphorus atom. In the experiment, the researchers used many compounds, for example, N-(3-Methoxyphenyl)pivalamide (cas: 56619-93-3HPLC of Formula: 56619-93-3).

N-(3-Methoxyphenyl)pivalamide (cas: 56619-93-3) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. But ether is more polar than alkenes. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.HPLC of Formula: 56619-93-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Palladium-Catalyzed Intermolecular C(sp³)-H Amidation was written by Iglesias, Alvaro;Alvarez, Rosana;de Lera, Angel R.;Muniz, Kilian. And the article was included in Angewandte Chemie, International Edition in 2012.Recommanded Product: 4-Iodo-1-methoxy-2-methylbenzene This article mentions the following:

Palladium-catalyzed intermol. C(SP³)-H activation/amination of alkyl group to give amine derivatives, e.g. I [X = H, Br, Me, etc.], was reported. N-Fluorobis(phenylsulfonyl)imide (NSFI) was identified as the decisive reagent for the development of a new palladium-catalyzed oxidative amidation od C(SP³)-H bonds. In the experiment, the researchers used many compounds, for example, 4-Iodo-1-methoxy-2-methylbenzene (cas: 75581-11-2Recommanded Product: 4-Iodo-1-methoxy-2-methylbenzene).

4-Iodo-1-methoxy-2-methylbenzene (cas: 75581-11-2) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. But ether is more polar than alkenes. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.Recommanded Product: 4-Iodo-1-methoxy-2-methylbenzene

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Composition of the essential oil of Rhanterium adpressum Coss. and Durieu. from Algeria was written by Kala, Ali;Gherraf, Noureddine;Belkacemi, Djebellah;Ladjel, Segni;Zellagui, Amar;Samir, Hameurelain;Chihi, Soumia;Brahim, Labed. And the article was included in Archives of Applied Science Research in 2009.Electric Literature of C10H22O4 This article mentions the following:

The water distilled essential oils from the aerial parts of Rhanterium adpressum Coss. & Durieu. was analyzed by GC/MS. The oil was characterized by the presence of high amounts of Spathulenol (19.6%), β-Eudesmol (15.2%), Bicyclo[4.4.0]dec-1-ene, 2-isopropyl-5-methyl-9-methylene (12.9%), β-Cadinol (11.3%), α-Cadinol (6.56%), α-Eudesmol (5.37%), Myristicin (5.05%), 2H-Pyran-3-ol, and tetrahydro-2-(1,7-nonadiene-3,5-diynyl) (4.81%). Nevertheless, some other compounds were only present in minor amounts such as n-Tridec-1-ene (0.54), n-Hexadecan-1-ol (0.52), 1-Bu 2-(2-ethylhexyl) phthalate (0.59). In total, volatile oil composition of Rhanterium adpressum was characterized as a rich source of sesquiterpeniod compounds In the experiment, the researchers used many compounds, for example, 1-((1-((1-Methoxypropan-2-yl)oxy)propan-2-yl)oxy)propan-2-ol (cas: 20324-33-8Electric Literature of C10H22O4).

1-((1-((1-Methoxypropan-2-yl)oxy)propan-2-yl)oxy)propan-2-ol (cas: 20324-33-8) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. Ethers can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Electric Literature of C10H22O4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Dihydro-7-benzofurancarboxylic acid: An intermediate in the synthesis of the enterokinetic agent R108512 was written by Willemsens, Bert;Copmans, Alex;Beerens, Dirk;Leurs, Stef;de Smaele, Dirk;Rey, Max;Farkas, Silke. And the article was included in ACS Symposium Series in 2004.Safety of N-(3-Methoxyphenyl)pivalamide This article mentions the following:

A facile and scalable method for the synthesis of 4-amino-5-chloro-2,3-dihydro-7-benzofurancarboxylic acid, an intermediate in the synthesis of the enterokinetic agent R108512, was developed. The key step in the synthesis is a Zn mediated ring closure of Me 4-(acetylamino)-3-bromo-2-(2-bromoethoxy)-5-chlorobenzoate. The ring closure can be achieved without preliminary activation of the Zn on condition that the O content in the reaction mixture is <0.5%. The new process eliminates hazardous chems. (ethylene oxide) and low temperature reactions (-70°, BuLi). In the experiment, the researchers used many compounds, for example, N-(3-Methoxyphenyl)pivalamide (cas: 56619-93-3Safety of N-(3-Methoxyphenyl)pivalamide).

N-(3-Methoxyphenyl)pivalamide (cas: 56619-93-3) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. Ethyl ether is an excellent solvent for extractions and for a wide variety of chemical reactions. It is also used as a volatile starting fluid for diesel engines and gasoline engines in cold weather. Dimethyl ether is used as a spray propellant and refrigerant. Methyl t-butyl ether (MTBE) is a gasoline additive that boosts the octane number and reduces the amount of nitrogen-oxide pollutants in the exhaust. The ethers of ethylene glycol are used as solvents and plasticizers.Safety of N-(3-Methoxyphenyl)pivalamide

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Intramolecular Anion Effect in Polyoxometalate-Based Organocatalysts: Reactivity Enhancement and Chirality Transfer by a Metal Oxide-Organic Cation Interaction was written by Brazel, Christian;Dupre, Nathalie;Malacria, Max;Hasenknopf, Bernold;Lacote, Emmanuel;Thorimbert, Serge. And the article was included in Chemistry – A European Journal in 2014.Recommanded Product: 3-(2,4-Dimethoxyphenyl)acrylic acid This article mentions the following:

An α₁-Dawson polyanion bearing a lateral side chain with a 4-aminopyridine end group was synthesized. This organopolyoxometalate catalyzes the addition of indenyl allyl silanes to cinnamoyl fluorides. The polyanionic framework influences the organocatalyst activity and selectivity. A moderate but nonzero chirality transfer from the chiral inorganic framework to the organic substrate was observed In the experiment, the researchers used many compounds, for example, 3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8Recommanded Product: 3-(2,4-Dimethoxyphenyl)acrylic acid).

3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.Recommanded Product: 3-(2,4-Dimethoxyphenyl)acrylic acid

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Efficient iron/copper-cocatalyzed O-arylation of phenols with bromoarenes was written by Liu, Xiaoyan;Zhang, Songlin. And the article was included in Synlett in 2011.Name: 1-(4-(4-Methoxyphenoxy)phenyl)ethanone This article mentions the following:

Low catalytic amount CuI and Fe(acac)₃ were found to effectively promote the C-O cross-coupling reaction in the presence of K₂CO₃ as the base. A series of diaryl ethers with different substituents can be synthesized in good to excellent yields. This efficient and economic method is attractive for applications on an industrial scale. In the experiment, the researchers used many compounds, for example, 1-(4-(4-Methoxyphenoxy)phenyl)ethanone (cas: 54916-28-8Name: 1-(4-(4-Methoxyphenoxy)phenyl)ethanone).

1-(4-(4-Methoxyphenoxy)phenyl)ethanone (cas: 54916-28-8) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom. Complexation of the magnesium atom stabilizes the Grignard reagent and helps to keep it in solution.Name: 1-(4-(4-Methoxyphenoxy)phenyl)ethanone

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Selective para-iodination of methoxyarenes, phenols, and anilines with iodine in the presence of poly(4-vinylpyridine)-supported peroxodisulfate was written by Tajik, Hassan;Mohammadpoor-Baltork, Iraj;Rasht-Abadi, Hassan Rafiee. And the article was included in Synthetic Communications in 2004.HPLC of Formula: 75581-11-2 This article mentions the following:

A mild and efficient method for the direct iodination of methoxyarenes, phenols, and anilines using iodine and poly (4-vinylpyridine)-supported peroxodisulfate in acetonitrile solution, is presented. Selective para-substitution and also, the rather general applicability of this system is the advantage of the method. In the experiment, the researchers used many compounds, for example, 4-Iodo-1-methoxy-2-methylbenzene (cas: 75581-11-2HPLC of Formula: 75581-11-2).

4-Iodo-1-methoxy-2-methylbenzene (cas: 75581-11-2) belongs to ethers. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides. Ethyl ether is an excellent solvent for extractions and for a wide variety of chemical reactions. It is also used as a volatile starting fluid for diesel engines and gasoline engines in cold weather. Dimethyl ether is used as a spray propellant and refrigerant. Methyl t-butyl ether (MTBE) is a gasoline additive that boosts the octane number and reduces the amount of nitrogen-oxide pollutants in the exhaust. The ethers of ethylene glycol are used as solvents and plasticizers.HPLC of Formula: 75581-11-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Complexation and structural studies of a sulfonamide aza-15-crown-5 derivative was written by Ioannidis, Marie;Gentleman, Alexander S.;Ho, Lam;Lincoln, Stephen F.;Sumby, Christopher J.. And the article was included in Inorganic Chemistry Communications in 2010.COA of Formula: C10H21NO4 This article mentions the following:

An aza-15-crown-5 derivative, N-[4-(phenyldiazo)benzenesulfonyl]-aza-15-crown-5, 1 was synthesized from com. available starting materials in 55% yield. Compound 1, which contains a sulfonamide link between the crown ether macroring and the azobenzene, readily binds alkali metals in buffered ethanol-water (75:25 volume/volume, pH 6.66). Titration data for both sodium and potassium were readily fitted to a 1:1 metal ion/ligand binding model to obtain stability constants (log K) of 4.7 ± 0.4 and 4.8 ± 0.2 dm³ mol^-1, resp. The authors also studied the structures of 1 and the sodium perchlorate salt of 1, [Na(1)(H₂O)]₂(ClO₄)₂, which were determined by x-ray crystallog. [Na(1)(H₂O)]₂(ClO₄)₂ is a dimer in the solid state whereby a sulfonamide oxygen atom from one of the [Na(1)(H₂O)] cations provides solvation of the adjacent macroring bound sodium cation. In the crystal structure, binding of a water mol. to the sodium cation is supported by hydrogen bonding to the sulfonamide oxygen, which represents a supramol. lariat ether-like interaction. In the experiment, the researchers used many compounds, for example, 1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3COA of Formula: C10H21NO4).

1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.COA of Formula: C10H21NO4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem