Tag: 200-300

Facile synthesis of 3,5-diaryl-1,2,4-triazoles via copper-catalyzed domino nucleophilic substitution/oxidative cyclization using amidines or imidates as substrates was written by Sudheendran, Kavitha;Schmidt, Dietmar;Frey, Wolfgang;Conrad, Juergen;Beifuss, Uwe. And the article was included in Tetrahedron in 2014.Recommanded Product: 3,4-Dimethoxybenzimidamide hydrochloride This article mentions the following:

Two methods for the synthesis of 3,5-diaryl-1,2,4-triazoles, both domino reactions, are reported. The first procedure, the Cu(OTf)₂-catalyzed reaction between two amidines using NaHCO₃ as a base, 1,10-phenanthroline as an additive and K₃[Fe(CN)₆]/atm. oxygen as the oxidant, delivers 3,5-diaryl-1,2,4-triazoles with yields up to 68%. The second procedure for the synthesis of 3,5-diaryl-1,2,4-triazoles with yields up to 64% rests on the Cu(OTf)₂-catalyzed reaction between two imidates and ammonium carbonate. This method features the formation of three bonds in a single synthetic step. In the experiment, the researchers used many compounds, for example, 3,4-Dimethoxybenzimidamide hydrochloride (cas: 51488-33-6Recommanded Product: 3,4-Dimethoxybenzimidamide hydrochloride).

3,4-Dimethoxybenzimidamide hydrochloride (cas: 51488-33-6) belongs to ethers. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides. Ethyl ether is an excellent solvent for extractions and for a wide variety of chemical reactions. It is also used as a volatile starting fluid for diesel engines and gasoline engines in cold weather. Dimethyl ether is used as a spray propellant and refrigerant. Methyl t-butyl ether (MTBE) is a gasoline additive that boosts the octane number and reduces the amount of nitrogen-oxide pollutants in the exhaust. The ethers of ethylene glycol are used as solvents and plasticizers.Recommanded Product: 3,4-Dimethoxybenzimidamide hydrochloride

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Palladium-Catalyzed Semihydrogenation of Alkynes with EtOH: Highly Stereoselective Synthesis of E – and Z -Alkenes was written by Wang, Chengniu;Dong, Jin;Li, Tingting;Zhao, Xi;Xu, Dawei. And the article was included in Synthesis in 2022.Computed Properties of C18H18O This article mentions the following:

A palladium-catalyzed semihydrogenation of alkynes to E- and Z-alkenes R¹CH=CHR² [R¹ = Ph, 4-MeC₆H₄, 4-FC₆H₄, etc.; R² = Ph, 2-ClC₆H₄, 3-pyridyl, etc.; stereo = E, Z] employing EtOH as the hydrogenating agent was reported. The selectivity of the reaction system was effectively controlled by ligand/additive and solvent regulation. The use of sodium acetate/triethanolamine, THF and (1R,2R)-bis[(2-methoxyphenyl)phenylphosphino]ethane [( R,R)-DIPAMP] in CH₃CN was critical for the stereoselective semihydrogenation of alkynes. The general applicability of this procedure was highlighted by the synthesis of more than alkenes, in good yields with high stereoselectivities. In the experiment, the researchers used many compounds, for example, 1-Methoxy-4-((4-propylphenyl)ethynyl)benzene (cas: 39969-26-1Computed Properties of C18H18O).

1-Methoxy-4-((4-propylphenyl)ethynyl)benzene (cas: 39969-26-1) belongs to ethers. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides. Electron-deficient reagents are also stabilized by ethers. For example, borane (BH3) is a useful reagent for making alcohols. Pure borane exists as its dimer, diborane (B2H6), a toxic gas that is inconvenient and hazardous to use. Borane forms stable complexes with ethers, however, and it is often supplied and used as its liquid complex with tetrahydrofuran (THF).Computed Properties of C18H18O

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Axially- and Meso-Substituted Aza-Crown-Ether-Incorporated B^III Subporphyrins: Control of Electron-Donating Ability by Metal Ion Chelation was written by Kise, Koki;Lee, Yu Jin;Tanaka, Takayuki;Kim, Dongho;Osuka, Atsuhiro. And the article was included in European Journal of Inorganic Chemistry in 2021.Computed Properties of C10H21NO4 This article mentions the following:

A series of subporphyrin-based fluorescent probes bearing 1-aza-15-crown-5 or 1-aza-18-crown-6 moieties at the meso or axial positions were prepared by Pd-catalyzed Buchwald-Hartwig amination reaction of the corresponding bromosubporphyrins. Both types of aza-crown-ether-incorporated subporphyrins were fluorescent in solution and exhibited cation-dependent absorption and fluorescence changes. In fluorescence titration experiments, opposite responses were observed for the two types of subporphyrins. Namely, fluorescence quenching occurred for the meso-substituted subporphyrins while fluorescence enhancement was observed for the axially-substituted subporphyrins. These results demonstrate the advantage of subporphyrins being viable to serve as turn-off-type or turn-on-type fluorescence probes, depending upon substitution pattern. In the experiment, the researchers used many compounds, for example, 1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3Computed Properties of C10H21NO4).

1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil. The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom. Complexation of the magnesium atom stabilizes the Grignard reagent and helps to keep it in solution.Computed Properties of C10H21NO4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthesis, characterization and cation-induced dimerization of new aza-crown ether-appended metalloporphyrins was written by Mikhalitsyna, Elena A.;Tyurin, Vladimir S.;Zamylatskov, Ilia A.;Khrustalev, Victor N.;Beletskaya, Irina P.. And the article was included in Dalton Transactions in 2012.Synthetic Route of C10H21NO4 This article mentions the following:

New metalloporphyrins bearing one or two aryl-aza-crown ether moieties at meso-positions were synthesized using a palladium catalyzed amination reaction and fully characterized by spectral techniques. X-ray structural data were presented for the zinc and copper complexes of mono-substituted aza-crown ether appended metalloporphyrins. UV-visible and ¹H NMR spectroscopic studies showed that addition of K⁺ cations to a solution of monomeric aza-crowned porphyrins in CHCl₃/MeOH led to cation-induced dimerization of these porphyrins, whereas addition of Na⁺ cations yielded a monomeric complex. Axial coordination of the exobidentate ligand (DABCO) to zinc complexes of aza-crowned porphyrins and following binding metal ions gave sandwich complexes with high stability constants In the experiment, the researchers used many compounds, for example, 1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3Synthetic Route of C10H21NO4).

1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3) belongs to ethers. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.Synthetic Route of C10H21NO4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Effects of cyclohexyl group on electro-optical properties of liquid crystal tolan was written by Chen, Xin-bing;Feng, Kai;Jia, Lin;An, Zhong-wei. And the article was included in Yejing Yu Xianshi in 2004.Electric Literature of C18H18O This article mentions the following:

As one of widely used liquid crystals, tolans are mainly used for improving birefringence of liquid crystal composition Effects of cyclohexyl group introduced into mol. on the electro-optical properties of tolan were investigated. The results show that the threshold voltage and birefringence of the composition can be increased by introducing cyclohexyl group into mol. In the experiment, the researchers used many compounds, for example, 1-Methoxy-4-((4-propylphenyl)ethynyl)benzene (cas: 39969-26-1Electric Literature of C18H18O).

1-Methoxy-4-((4-propylphenyl)ethynyl)benzene (cas: 39969-26-1) belongs to ethers. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.Electric Literature of C18H18O

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Structure-activity relationships of novel alkylides: 3-O-Arylalkyl clarithromycin derivatives with improved antibacterial activities was written by Liang, Jian-Hua;Li, Xiao-Li;Wang, He;An, Kun;Wang, Yue-Ying;Xu, Ying-Chun;Yao, Guo-Wei. And the article was included in European Journal of Medicinal Chemistry in 2012.Category: ethers-buliding-blocks This article mentions the following:

A series of novel alkylides, possessing 3-O-arylalkyl group instead of 3-O-cladinose, were designed, synthesized and evaluated for in vitro antibacterial activities. The increased potency clearly ranked by the order of 3-O-(3-aryl-2-propargyl), 3-O-(3-aryl-E-prop-2-enyl), 3-O-(3-aryl-propyl), and 3-O-(3-aryl-Z-prop-1-enyl) groups. Some alkylides, e.g. I, showed improved activities against inducible MLS_B resistance and efflux resistance compared to the second-generation macrolides. Among them, I possessed comparable activities against erythromycin-susceptible Staphylococcus aureus, Streptococcus pneumoniae and Streptococcus pyogenes (MICs of 0.016-0.5 μg/mL). Moreover, I displayed dramatically enhanced potency against both efflux resistant and MLS_B resistant strains (MICs of 0.125-0.5 μg/mL) resistant to clarithromycin and azithromycin (MICs of 1- >254 μg/mL), independent of methicillin-susceptible and methicillin-resistant pheno-types. In the experiment, the researchers used many compounds, for example, 1,1-Diisopropoxycyclohexane (cas: 1132-95-2Category: ethers-buliding-blocks).

1,1-Diisopropoxycyclohexane (cas: 1132-95-2) belongs to ethers. The oxygen atom in ethers are more electronegative than carbon, thus the hydrogens which are alpha to the ethers are more acidic than the simple hydrocarbons. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Application of Raman diffusion to the determination of alkyl chain order in two homologous series of nematogenic compounds was written by Destrade, C.;Guillon, F.;Gasparoux, H.. And the article was included in Molecular Crystals and Liquid Crystals in 1976.Computed Properties of C18H18O This article mentions the following:

The Raman spectra of the homologous series p-methoxy-p’-alkyltolanes (I) and p-methoxybenzilidene-p’-alkylanilines (II; R = C1-C5 alkyl) are determined in isotropic, nematic, and solid phases. The resonance lines of cis and trans bonds were located at âˆ?00 cm-1. From the relative intensity of these lines vs. temperature, one could define a parameter (f), useful in the understanding of the ordering within the alkyl chain. Pretransitional effects, at the I â†?N transition, were observed, and established the existence of intramol. chain ordering in the isotropic phase even far from the transition point. This ordering did not exist in the case of nonnematogenic compounds From f was calculated the value of the order parameter S3. In the experiment, the researchers used many compounds, for example, 1-Methoxy-4-((4-propylphenyl)ethynyl)benzene (cas: 39969-26-1Computed Properties of C18H18O).

1-Methoxy-4-((4-propylphenyl)ethynyl)benzene (cas: 39969-26-1) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. Electron-deficient reagents are also stabilized by ethers. For example, borane (BH3) is a useful reagent for making alcohols. Pure borane exists as its dimer, diborane (B2H6), a toxic gas that is inconvenient and hazardous to use. Borane forms stable complexes with ethers, however, and it is often supplied and used as its liquid complex with tetrahydrofuran (THF).Computed Properties of C18H18O

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Using high-throughput techniques to identify complexants for ¹³⁷Cs, ⁶⁰Co and ⁹⁰Sr was written by Demetriou, Anna M.;Crouch, David J.;Batey, Helen D.;Faulkner, Stephen;Yeates, Stephen G.;Livens, Francis R.. And the article was included in Journal of Materials Chemistry in 2008.Recommanded Product: 66943-05-3 This article mentions the following:

High-throughput synthetic and screening methods have been used to prepare and evaluate Cs, Co and Sr selective sequestering agents derived from aza-crown ethers. Storage phosphor autoradiog. was the screening method used to determine potential lead compounds The most effective complexants for Cs⁺ have a very high selectivity over K ions and will bind picomolar quantities of Cs⁺ in the presence of mM K⁺. The binding and selectivity of these compounds with ⁶⁰Co and ⁹⁰Sr have also been studied and selectivity was also determined with tap H₂O and Ca²⁺, resp. Experiments with tap H₂O spiked with ¹³⁷Cs and ⁶⁰Co were carried out to confirm the decontamination capabilities of some of the compounds and a good correlation between autoradiog. and these results were found. In the experiment, the researchers used many compounds, for example, 1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3Recommanded Product: 66943-05-3).

1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. Ethers can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Recommanded Product: 66943-05-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Use of molecular sieves in synthesis. Aldehyde and ketone di-sec-alkyl acetals was written by Roelofsen, D. P.;Van Bekkum, H.. And the article was included in Synthesis in 1972.Product Details of 1132-95-2 This article mentions the following:

Mol. sieves adsorbed H2O in reaction of secondary alcs. with aldehydes and ketones to give 62-94% (>98% purity) RR1η(OR2)2 (I). Thus, 40 g powd. type 5a com. mol. sieve was added to 0.10 mole RR1ηO, 0.40 mole R2OH, 150 ml cyclohexane, and 3.8 g p-MeC6H4SO3H.H2O, and the mixture stirred 2 hr at 0° to give I (R,R1..sigma.2 given): Me, Me, Me2CH; Me, Me, cyclohexyl; Me2CH, H, Me2CH; Me2CH, H, MeEtCH; Me2CH, H, cyclohexyl; Ph, H, Me2CH and I[RR1(CH2)5], R2 = Me2CH and MeEtCH. In the experiment, the researchers used many compounds, for example, 1,1-Diisopropoxycyclohexane (cas: 1132-95-2Product Details of 1132-95-2).

1,1-Diisopropoxycyclohexane (cas: 1132-95-2) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.Product Details of 1132-95-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ionic liquid/H₂SO₄ catalyzed aerobic iodination of alkoxyl-substituted benzenes and naphthalenes was written by Ren, Yun-lai;Wang, Pei;Tian, Xin-zhe;Li, Fu-wei;Wang, Bin-yu;Wang, Jian-ji. And the article was included in Fenzi Cuihua in 2015.Category: ethers-buliding-blocks This article mentions the following:

The ionic liquid 1-butyl-3-methylimidazolium nitrate ([Bmim][NO₃]) was introduced as both the solvent and catalyst for the activation of the mol. oxygen related to the aerobic iodination of arenes, which provides an effective and practical strategy for the synthesis of aryl iodides. The presented procedure allows a series of alkoxyl-substituted benzenes and naphthalenes to undergo the aerobic iodination in high yields and selectivities at an ambient temperature of 40°C. Almost all the atoms in the iodine source can be transferred to the final products. In the experiment, the researchers used many compounds, for example, 4-Iodo-1-methoxy-2-methylbenzene (cas: 75581-11-2Category: ethers-buliding-blocks).

4-Iodo-1-methoxy-2-methylbenzene (cas: 75581-11-2) belongs to ethers. The oxygen atom in ethers are more electronegative than carbon, thus the hydrogens which are alpha to the ethers are more acidic than the simple hydrocarbons. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem