Tag: 200-300

Nanoliter-scale, regenerable ion sensor: sensing with a surface functionalized microstructured optical fiber was written by Heng, Sabrina;Nguyen, Mai-Chi;Kostecki, Roman;Monro, Tanya M.;Abell, Andrew D.. And the article was included in RSC Advances in 2013.Application In Synthesis of 1,4,7,10-Tetraoxa-13-azacyclopentadecane This article mentions the following:

The 1st nanoliter-scale regenerable ion sensor based on a microstructured optical fiber (MOF) is reported. The air holes of the MOF are functionalized with a monoazacrown bearing spiropyran to give a switchable sensor that detects lithium ions down to 100 nM in nanoliter-scale volumes Ion binding is turned on and off on upon irradiation with light, with the sensor being unaffected by multiple rounds of photoswitching. Unbound ions are flushed from the fiber in the off’ state to allow the sensor to be reused. The integration of an ionophore into the sensor paves the way for the development of highly specific light-based sensing platforms that are readily adaptable to sense a particular ion simply by altering the ionophore design. In the experiment, the researchers used many compounds, for example, 1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3Application In Synthesis of 1,4,7,10-Tetraoxa-13-azacyclopentadecane).

1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil. Electron-deficient reagents are also stabilized by ethers. For example, borane (BH3) is a useful reagent for making alcohols. Pure borane exists as its dimer, diborane (B2H6), a toxic gas that is inconvenient and hazardous to use. Borane forms stable complexes with ethers, however, and it is often supplied and used as its liquid complex with tetrahydrofuran (THF).Application In Synthesis of 1,4,7,10-Tetraoxa-13-azacyclopentadecane

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Sequential Ir/Cu-Mediated Method for the Meta-Selective C-H Radiofluorination of (Hetero)Arenes was written by Wright, Jay S.;Sharninghausen, Liam S.;Preshlock, Sean;Brooks, Allen F.;Sanford, Melanie S.;Scott, Peter J. H.. And the article was included in Journal of the American Chemical Society in 2021.Category: ethers-buliding-blocks This article mentions the following:

This article describes a sequential Ir/Cu-mediated process for the meta-selective C-H radiofluorination of (hetero)arene substrates. In the first step, Ir-catalyzed C(sp²)-H borylation affords (hetero)aryl pinacolboronate (BPin) esters. The intermediate organoboronates are then directly subjected to copper-mediated radiofluorination with [¹⁸F]tetrabutylammonium fluoride to afford fluorine-18 labeled (hetero)arenes in high radiochem. yield and radiochem. purity. This entire process is performed on a bench top without Schlenk or glove box techniques and circumvents the need to isolate (hetero)aryl boronate esters. The reaction was automated on a TracerLab FX_FN module with 1,3-dimethoxybenzene and a meta-tyrosine derivative The products, [¹⁸F]1-fluoro-3,5-dimethoxybenzene and an ¹⁸F-labeled meta-tyrosine derivative, were obtained in 37 ± 5% isolated radiochem. yield and >99% radiochem. purity and 25% isolated radiochem. yield and 99% radiochem. purity, and 0.52 Ci/μmol (19.24 GBq/μmol) molar activity (A_m), resp. In the experiment, the researchers used many compounds, for example, 2-(3,5-Dimethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 365564-07-4Category: ethers-buliding-blocks).

2-(3,5-Dimethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 365564-07-4) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. But ether is more polar than alkenes. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.Category: ethers-buliding-blocks

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

A strategy for effective recovery of salvianolic acid a from Salvia miltiorrhiza (Danshen) through multiple interactions was written by Qian, Jun;Xu, Xiaoqian;Su, Jiajia;Zeng, Weihuan;Han, Bing;Hao, Xiaolong;Kai, Guoyin. And the article was included in Composites, Part B: Engineering in 2022.Computed Properties of C14H15BO4 This article mentions the following:

Salvianolic acid A (SAA) has high pharmacol. activity and is widely used in the treatment of various diseases. We reported herein a strategy for effective adsorption of SAA from aqueous solution by surface molecularly imprinted magnetic nanoparticle (SIMNP). 4-(acryloyloxy)phenylboronic acid, 1-vinylimidazole and methacrylamido Pr tri-Me ammonium chloride were chosen as functional monomers. 1-vinylimidazole not only neutralizes the acidity of SAA solution to help phenylboronic acid react with ortho-phenolic hydroxyl groups of SAA quickly and stably, but also captures SAA through electrostatic interaction and hydrogen bond. Besides, the introduction of pos. charged methacrylamido Pr tri-Me ammonium chloride can accelerate the adsorption kinetics. Adsorption kinetically follows a pseudo-second-order model and achieves equilibrium within 10 min at 298.15 K with high selectivity. And the maximum adsorption capacity can be determined to be 1117.6 mg/g by Langmuir adsorption model. Adsorption mechanism involves the formation of covalent bond, electrostatic interaction and hydrogen bond. This work indicates that SIMNP is a promising adsorbent to realize effective capture of SAA from aqueous solution In the experiment, the researchers used many compounds, for example, (4-((4-Methoxybenzyl)oxy)phenyl)boronic acid (cas: 156635-90-4Computed Properties of C14H15BO4).

(4-((4-Methoxybenzyl)oxy)phenyl)boronic acid (cas: 156635-90-4) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.Computed Properties of C14H15BO4

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Ether – Wikipedia,
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A spiropyran with enhanced fluorescence: A bright, photostable and red-emitting calcium sensor was written by Sylvia, Georgina M.;Heng, Sabrina;Bachhuka, Akash;Ebendorff-Heidepriem, Heike;Abell, Andrew D.. And the article was included in Tetrahedron in 2018.COA of Formula: C10H21NO4 This article mentions the following:

A rationally designed, pyrene-spiropyran hybrid Ca²⁺ sensor 1′,3′-dihydro-3′,3′-dimethyl-6-nitro-1′-(2-pyrenylmethyl)-8-(1,4,7,10-tetraoxa-13-azacyclopentadec-13-ylmethyl)spiro[2H-1-benzopyran-2,2′-[2H]indole], Py-1 (I), with enhanced fluorescence intensity compared to a standalone spiropyran analog is presented. Importantly, I retains the characteristic red emission profile of the spiropyran, while fiber-based photostability studies show the sensor is stable after multiple cycles of photoswitching, without any sign of photodegradation Such properties are of real advantage for cell-based sensing applications. An interesting observation is that, I presents with two excitation options; direct green excitation (532 nm) of the photoswitch for a red emission, and UV excitation (344 nm) of the component pyrene, which gives rise to distinct blue and red emissions. This proof-of-concept hybrid sensing system presents as a more general approach to brighter spiropyran-based sensors. In the experiment, the researchers used many compounds, for example, 1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3COA of Formula: C10H21NO4).

1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive. The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom. Complexation of the magnesium atom stabilizes the Grignard reagent and helps to keep it in solution.COA of Formula: C10H21NO4

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Dihydroquinoline Carbamate DQS1-02 as a Prodrug of a Potent Acetylcholinesterase Inhibitor for Alzheimer’s Disease Therapy: Multigram-Scale Synthesis, Mechanism Investigations, in Vitro Safety Pharmacology, and Preliminary in Vivo Toxicology Profile was written by Alix, Florent;Gembus, Vincent;Coquet, Laurent;Hubert-Roux, Marie;Chan, Philippe;Truong, Lina;Sebban, Muriel;Coadou, Gael;Oulyadi, Hassan;Papamicael, Cyril;Levacher, Vincent. And the article was included in ACS Omega in 2018.Recommanded Product: 56619-93-3 This article mentions the following:

The (dimethylcarbamoyloxy)dihydroquinolinecarboxamide I, a prodrug for an irreversible inhibitor of acetylcholinesterase (AChE), was prepared on multigram scale in nine steps and 18% overall yield from m-anisidine. The conversion of I to the active (carbamoyloxy)(methylaminocarbonyl)quinolinium was observed in vitro; O-dimethylcarbamoylated human AChE was detected and sequenced using tandem mass spectrometry to determine the site of dimethylcarbamoylation, and the kinetics of dimethylcarbamoylation were determined The physicochem. properties of I, its selectivity for AChE over other enzymes, and its inhibition of cytochrome P₄₅₀ isoenzymes and hERG and Na_V1.5 ion channels, and its toxicity in rats were determined In the experiment, the researchers used many compounds, for example, N-(3-Methoxyphenyl)pivalamide (cas: 56619-93-3Recommanded Product: 56619-93-3).

N-(3-Methoxyphenyl)pivalamide (cas: 56619-93-3) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive. Electron-deficient reagents are also stabilized by ethers. For example, borane (BH3) is a useful reagent for making alcohols. Pure borane exists as its dimer, diborane (B2H6), a toxic gas that is inconvenient and hazardous to use. Borane forms stable complexes with ethers, however, and it is often supplied and used as its liquid complex with tetrahydrofuran (THF).Recommanded Product: 56619-93-3

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Crown-templated assembling of the inorganic binuclear fluoro-containing anions in the system ZrO₂/HfO₂ (Nb₂O₅/Ta₂O₅)-HF-H₂O-azacrown ether was written by Fonari, Marina S.;Kravtsov, Victor Ch.;Simonov, Yurii A.;Basok, Stepan S.;Ganin, Eduard V.;Gelmboldt, Vladimir O.;Suwinska, Kinga;Lipkowski, Janusz;Alekseeva, Olga A.;Furmanova, Nina G.. And the article was included in Polyhedron in 2008.Recommanded Product: 66943-05-3 This article mentions the following:

The interaction of ZrO₂/HfO₂ or Nb₂O₅/Ta₂O₅ with an aqueous solution of hydrofluoric acid in the presence of aza-crown ether resulted in novel organically templated metal oxyfluorides [(HA15C5)₂][Ta₂F₁₀O] (1), [(HA18C6·H₂O)(A18C6·H₂O)][(H₂O)Nb₂F₉O]·H₂O (2), [(HA18C6·H₂O)(M₂F₁₀·2H₂O)·(H₃O)·H₂O] (3, 4) and [(H₂DA18C6)(M₂F₁₀·2H₂O)·2H₂O] (5, 6) (M = Zr, Hf, A15C5 = aza-15-crown-5, A18C6 = aza-18-crown-6, DA18C6 = diaza-18-crown-6). Complexes 1–6 were identified by single crystal x-ray diffraction. In 1, the neg. charge of the [(TaF₅)₂O]^2- centrosym. dianion is balanced by two azonia-15C5 cations, while in 2 the charge of asym. [(H₂O)NbF₄ONbF₅]^– monoanion is compensated by azonia-18C6 cation. The crystal of 2 revealed an extensive hydrogen bonding between the anions, protonated and neutral macrocycles and water mols. that combine the components into 2-dimensional sheets. Complexes 3–4 and 5–6 are isostructural in pairs; in all of them the rigid 2-dimensional inorganic motif is formed through the association of the [(M₂F₁₀·2H₂O)]^2- anions by OH···F hydrogen bonds. The similar 3-dimensional supramol. architecture in 3–6 represents an alternation of the neg.-charged inorganic sheets and the columns of (HA18C6)⁺ or (DA18C6)²⁺ organic cations glued by oxonium cations or water mols. In the experiment, the researchers used many compounds, for example, 1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3Recommanded Product: 66943-05-3).

1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3) belongs to ethers. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.Recommanded Product: 66943-05-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Direct iodination of aromatic compounds with iodine and alumina-supported copper(II) chloride or sulfate was written by Kodomari, Mitsuo;Amanokura, Natsuki;Takeuchi, Kiyoshi;Yoshitomi, Suehiko. And the article was included in Bulletin of the Chemical Society of Japan in 1992.Recommanded Product: 75581-11-2 This article mentions the following:

The iodination of aromatic compounds (polymethylbenzenes, alkyl Ph ethers, and polynuclear aromatic hydrocarbons) with iodine in combination with copper(II) chloride or sulfate supported on alumina proceeds well under mild conditions to selectively give monoiodinated compounds in high yields. In the experiment, the researchers used many compounds, for example, 4-Iodo-1-methoxy-2-methylbenzene (cas: 75581-11-2Recommanded Product: 75581-11-2).

4-Iodo-1-methoxy-2-methylbenzene (cas: 75581-11-2) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.Recommanded Product: 75581-11-2

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthesis of actinomycin D analogs: XXIII. Actinocin derivatives containing azacrown fragments was written by Ovchinnikov, D. V.;Glibin, E. N.;Garabadzhiu, A. V.;Plekhanova, N. G.. And the article was included in Russian Journal of General Chemistry in 2010.Electric Literature of C10H21NO4 This article mentions the following:

A number of actinocin amides containing residues of aza-15-crown-5 and aza-18-crown-6 where crown fragments, e.g. I, were separated from the heterocyclic chromophore by the residues of ω-amino acids were obtained as actinomycin D models. In the experiment, the researchers used many compounds, for example, 1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3Electric Literature of C10H21NO4).

1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.Electric Literature of C10H21NO4

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Efficient synthesis of oxygenated terphenyls and other oligomers: sequential arylation reactions through phenol oxidation-rearomatization was written by Dohi, Toshifumi;Kamitanaka, Tohru;Watanabe, Shohei;Hu, Yinjun;Washimi, Naohiko;Kita, Yasuyuki. And the article was included in Chemistry – A European Journal in 2012.Application of 365564-07-4 This article mentions the following:

A sequential arylation method involving the oxidation/rearomatization of phenols is developed. Quinone monoacetalsthe key intermediates, can be used for preparation of oxygenated terphenyls and other oligomers. The reaction employed hypervalent iodine compounds as the oxidant and montmorillonite clay as the acid promoter. In the experiment, the researchers used many compounds, for example, 2-(3,5-Dimethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 365564-07-4Application of 365564-07-4).

2-(3,5-Dimethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 365564-07-4) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. Ethyl ether is an excellent solvent for extractions and for a wide variety of chemical reactions. It is also used as a volatile starting fluid for diesel engines and gasoline engines in cold weather. Dimethyl ether is used as a spray propellant and refrigerant. Methyl t-butyl ether (MTBE) is a gasoline additive that boosts the octane number and reduces the amount of nitrogen-oxide pollutants in the exhaust. The ethers of ethylene glycol are used as solvents and plasticizers.Application of 365564-07-4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Redox-Divergent Construction of (Dihydro)thiophenes with DMSO was written by Liu, Heng;He, Gu-Cheng;Zhao, Chao-Yang;Zhang, Xiang-Xin;Ji, Ding-Wei;Hu, Yan-Cheng;Chen, Qing-An. And the article was included in Angewandte Chemie, International Edition in 2021.Formula: C14H21BO4 This article mentions the following:

Thiophene-based rings are one of the most widely used building blocks for the synthesis of sulfur-containing mols. Inspired by the redox diversity of these features in nature, herein a redox-divergent construction of dihydrothiophenes, thiophenes, and bromothiophenes from the resp. readily available allylic alcs., DMSO (DMSO), and HBr is reported. The redox-divergent selectivity could be manipulated mainly by controlling the dosage of DMSO and HBr. Mechanistic studies suggest that DMSO simultaneously acts as an oxidant and a sulfur donor. The synthetic potentials of the products as platform mols. were also demonstrated by various derivatizations, including the preparation of bioactive and functional mols. In the experiment, the researchers used many compounds, for example, 2-(3,5-Dimethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 365564-07-4Formula: C14H21BO4).

2-(3,5-Dimethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 365564-07-4) belongs to ethers. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides. Ethers can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Formula: C14H21BO4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem