Tag: 200-300

Facile aromatic nucleophilic substitution (S_NAr) reactions in ionic liquids: an electrophile-nucleophile dual activation by [Omim]Br for the reaction was written by Zhang, Xiao;Lu, Guo-ping;Cai, Chun. And the article was included in Green Chemistry in 2016.Application of 54916-28-8 This article mentions the following:

A facile aromatic nucleophilic substitution (S_NAr) reaction in recyclable [Omim]Br under relatively mild conditions has been described. An electrophile-nucleophile dual activation by [Omim]Br is also discovered based on control experiments, ¹H NMR and IR spectroscopies. This chem. provides an efficient and metal-free approach for the generation of C_aryl-X (X=S, N, O) bonds, many of which are significant synthetic intermediates or drugs, making this methodol. attractive to both synthetic and medicinal chem. In the experiment, the researchers used many compounds, for example, 1-(4-(4-Methoxyphenoxy)phenyl)ethanone (cas: 54916-28-8Application of 54916-28-8).

1-(4-(4-Methoxyphenoxy)phenyl)ethanone (cas: 54916-28-8) belongs to ethers. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.Application of 54916-28-8

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Characterization of volatile compounds of Albertisia papuana Becc root extracts and cytotoxic activity in breast cancer cell line T47D was written by Kristiani, Elizabeth B. E.;Nugroho, Laurentius H.;Moeljopawiro, Sukarti;Widyarini, Sitarina. And the article was included in Tropical Journal of Pharmaceutical Research in 2016.Recommanded Product: 56619-93-3 This article mentions the following:

Purpose: To evaluate the cytotoxic activity of chloroform and water root extracts of Albertisia papuana Becc. on T47D cell line and identify the volatile compounds of the extracts Methods: The plant roots were extracted with chloroform and water using maceration and boiling methods, resp. The cytotoxicity of the extracts on T47D were determined using 3-(4,5- dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Doxorubicin was used as reference drug in the cytotoxicity test while Probit anal. was used to calculate the Median Growth Inhibitory Concentration IC50 of the extracts The volatile compounds in the chloroform and water root extracts were analyzed using Gas Chromatog.-Mass Spectrophotometry GC-MS. Results: The IC50 of the chloroform and water extracts were 28.0 ± 6.0 and 88.0 ± 5.5μg/mL, resp. whereas that of doxorubicin was 8.5 ± 0.1μg/mL. GC-MS results showed that there were 46 compounds in the chloroform extract, out of which the five major components are Et linoleate (49.68%), bicyclo (3.3.1) non-2-ene (29.29%), Et palmitate (5.06%), palmitic acid (3.67%) and Et heptadecanoate (1.57%).The water extract consisted of three compounds, butanoic acid (15.58%); Me cycloheptane (3.45%), and Me 2-O-methylpentofuranoside (80.96%). Conclusion: The chloroform root extract of A. papuana Becc. had a fairly potent anticancer activity against breast cancer cells and may be further developed as an anticancer agent. Its major components were fatty acids and fatty acid esters. In the experiment, the researchers used many compounds, for example, N-(3-Methoxyphenyl)pivalamide (cas: 56619-93-3Recommanded Product: 56619-93-3).

N-(3-Methoxyphenyl)pivalamide (cas: 56619-93-3) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.Recommanded Product: 56619-93-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Barium Chemosensors with Dry-Phase Fluorescence for Neutrinoless Double Beta Decay was written by Thapa, P.;Arnquist, I.;Byrnes, N.;Denisenko, A. A.;Foss, Jr. F. W.;Jones, B. J. P.;McDonald, A. D.;Nygren, D. R.;Woodruff, K.. And the article was included in Scientific Reports in 2019.Quality Control of 1,4,7,10-Tetraoxa-13-azacyclopentadecane This article mentions the following:

The nature of the neutrino is one of the major open questions in exptl. nuclear and particle physics. The most sensitive known method to establish the Majorana nature of the neutrino is detection of the ultra-rare process of neutrinoless double beta decay. However, identification of one or a handful of decay events within a large mass of candidate isotope, without obfuscation by backgrounds is a formidable exptl. challenge. One hypothetical method for achieving ultra- low-background neutrinoless double beta decay sensitivity is the detection of single ¹³⁶Ba ions produced in the decay of ¹³⁶Xe (“barium tagging”). To implement such a method, a single-ion-sensitive barium detector must be developed and demonstrated in bulk liquid or dry gaseous xenon. This paper reports on the development of two families of dry-phase barium chemosensor mols. for use in high pressure xenon gas detectors, synthesized specifically for this purpose. One particularly promising candidate, an anthracene substituted aza-18-crown-6 ether, is shown to respond in the dry phase with almost no intrinsic background from the unchelated state, and to be amenable to barium sensing through fluorescence microscopy. This interdisciplinary advance, paired with earlier work demonstrating sensitivity to single barium ions in solution, opens a new path toward single ion detection in high pressure xenon gas. In the experiment, the researchers used many compounds, for example, 1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3Quality Control of 1,4,7,10-Tetraoxa-13-azacyclopentadecane).

1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. Ethyl ether is an excellent solvent for extractions and for a wide variety of chemical reactions. It is also used as a volatile starting fluid for diesel engines and gasoline engines in cold weather. Dimethyl ether is used as a spray propellant and refrigerant. Methyl t-butyl ether (MTBE) is a gasoline additive that boosts the octane number and reduces the amount of nitrogen-oxide pollutants in the exhaust. The ethers of ethylene glycol are used as solvents and plasticizers.Quality Control of 1,4,7,10-Tetraoxa-13-azacyclopentadecane

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Amidines of pharmacological interest was written by Easson, Alexander P. T.;Pyman, Frank L.. And the article was included in Journal of the Chemical Society in 1931.Recommanded Product: 51488-33-6 This article mentions the following:

The following amidines and related compounds were prepared and characterized mainly for pharmacol. study, but none of them appears to be of sufficient value to warrant clin. trial: m-aminobenzamidine-HCl, C₇H₉N₃.-HCl, m. 162-3°, hygroscopic (dihydrate m. 79-85°); p-aminobenzamidine-HCl, m. 225-6° (di-HCl salt, m. 320° (decomposition); picrate, m. 231-2°); the free base is amorphous and m. about 125°. Et 3,4-dimethoxyimidobenzoate (HCl salt, C₁₁H₁₅O₃N.HCl, m. 142-3°); 3,4-dimethoxybenzamidine (HCl salt, C₉H₁₂O₂N₂.HCl, m. 237°; picrate m. 217-8°; free base forms yellow needles m. 110-20°). Et p-carbethoxyimidobenzoate (HCl salt, C₁₂H₁₅O₃N. HCl, m. 179°); p-carbethoxybenzamidine (HCl salt, C₁₀H₁₂O₂N₂. HCl, m. 217-8°). p-Carboxyphenylthiocarbamide, C₈H₈O₂N₂S, does not melt below 330°; p-carboxyphenyl-S-methylisothiocarbamide-HI, C₉H₈O₂N₂S,HI, m. 238-9°; p-carbethoxyphenylguanidine (HCl salt, C₁₀H₁₃O₂N₃. HCl, m. 166-7°; picrate. m. 224-5°; nitrate, m. 201-2°). p-Hydroxyphenyl-S-methylisothiocarbamide-HI, C₈H₁₀ON₂S. HI, m. 176-81°; p-hydroxyphenylguanidine-HCl, C₇H₉ON₃.HCl, m. 197-8° (picrate, m. 235-6°; nitrate, m.2-5-6°). Benzenylveratrylamidine, m. 121° (HCl salt, C₁₅H₁₆O₂N₂. -HCl, m. 217-8°; picrate, m. 217-8°). Veratroylveratrylamine, C₁₇H₁₉O₅N, m. 192-3°. Et p-hydroxyphenylimidoacetate-HCl, C₁₀H₁₃O₂N.HCl, faint reddish powder, m. 145-8°. p-Hydroxyphenylacetamidine-HCl, C₈H₁₀ON₂.HCl, m. 253-4° (picrate, m. 212-3°; nitrate, m. 175-6°). p-Hydroxyphenyl-N-methylacetamidine (HCl salt, C₉H₁₂ON₂. HCl, m. 229-30°; picrate, m. 167-8°). o-Hydroxyimidobenzoate-HCl, C₉H₁₁O₂N.HCl, m. 150-1°. o-Hydroxybenzamidine (sulfate, m. 285° (decomposition); picrate, m. 245-6°). Et m-hydroxyimidobenzoate-HCl, m. 161-4°. m-Hydroxybenzamidine (sulfate, C₇H₈ON₂.0.5 H₂SO₄, m. 245° (decomposition); picrate, m. 260-1°). Pimelamidine (HCl salt, C₇H₁₆N₄.2 HCl, m. 218-9°; picrate, m. 249-50° (decomposition)). Azelamidine sulfate, C₉H₂₀N₄.H₂SO₄, m. 3103-5 (decomposition); picrate, m. 260-1°. Sebacamidine picrate, C₁₀H₂₂N₄.2C₆H₃O₇N₃, m. 249-50°. Nonane-1,9-diamidine picrate, m. 245-6°; acid chloride, b₂₂ 191-2°. Decane-1,10-diamidine-HCl, C₁₂H₂₆N₄.2HCl, m. 174-5° (picrate, m. 227-8°). Undecane- 1,11-diamidine picrate, m. 192-3°. Valeramidine sulfate, m. 272-4°; picrate, m. 195-6°. In the experiment, the researchers used many compounds, for example, 3,4-Dimethoxybenzimidamide hydrochloride (cas: 51488-33-6Recommanded Product: 51488-33-6).

3,4-Dimethoxybenzimidamide hydrochloride (cas: 51488-33-6) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.Recommanded Product: 51488-33-6

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Tuning Zr(IV)-assisted peptide hydrolysis at near-neutral pH was written by Kassai, Miki;Grant, Kathryn B.. And the article was included in Inorganic Chemistry Communications in 2008.Synthetic Route of C10H21NO4 This article mentions the following:

The present study has compared the effects of a total of 17 ligands on Zr(IV)-assisted hydrolysis of dipeptide Gly-Gly (60°, pH 6.8-7.4, t = 4, 10 h). The macrocyclic azacrown ether ligands 1,4,10,13-tetraoxa-7,16-diazacyclooctadecane and 1,4,10-trioxa-7,13-diazacyclopentadecane produced the overall highest amounts of hydrolysis, followed by the open-chain ligand 2-(2-aminoethoxy)ethanol. While it was not necessary to have a ring structure to enhance Zr(IV) reactivity, the structural feature “ROCH₂CH₂OCH₂CH₂NR” in ligands appeared to contribute to increased levels of peptide cleavage. In the experiment, the researchers used many compounds, for example, 1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3Synthetic Route of C10H21NO4).

1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.Synthetic Route of C10H21NO4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Tire pyrolysis wastewater treatment by a combined process of coagulation detoxification and biodegradation was written by Shen, Xiao-ran;Geng, Chun-Xiang;Lv, Bing-Qian;Xu, Wei;Xu, Yi;Zhao, Hua-Zhang. And the article was included in Environmental Science and Ecotechnology in 2021.Formula: C10H22O4 This article mentions the following:

Recycling waste tires through pyrolysis technol. generates refractory wastewater, which is harmful to the environment if not disposed properly. In this study, a combined process of coagulation detoxification and biodegradation was used to treat tire pyrolysis wastewater. Organics removal characteristics at the mol. level were investigated using electrospray ionization (ESI) coupled with Fourier transform ion cyclotron resonance mass spectrometry (FT-ICR MS). The results showed that nearly 90% of the organic matter from the wastewater was removed through the process. Preference of the two coagulants for different classes of organics in tire pyrolysis wastewater was observed The covalently bound inorganic-organic hybrid coagulant (CBHyC) used in this work had a complementary relationship with biodegradation for the organics removal: this coagulant reduced toxicity and enhanced the biodegradation by preferentially removing refractory substances such as lignin with a high degree of oxidation (O/C > 0.3). This study provides mol. insight into the organics of tire pyrolysis wastewater removed by a combined treatment process, supporting the advancement and application of waste rubber recycling technol. It also contributes to the possible development of an effective treatment process for refractory wastewater. In the experiment, the researchers used many compounds, for example, 1-((1-((1-Methoxypropan-2-yl)oxy)propan-2-yl)oxy)propan-2-ol (cas: 20324-33-8Formula: C10H22O4).

1-((1-((1-Methoxypropan-2-yl)oxy)propan-2-yl)oxy)propan-2-ol (cas: 20324-33-8) belongs to ethers. The oxygen atom in ethers are more electronegative than carbon, thus the hydrogens which are alpha to the ethers are more acidic than the simple hydrocarbons. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.Formula: C10H22O4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Optimization of potent and selective dual mTORC1 and mTORC2 inhibitors: The discovery of AZD8055 and AZD2014 was written by Pike, Kurt G.;Malagu, Karine;Hummersone, Marc G.;Menear, Keith A.;Duggan, Heather M. E.;Gomez, Sylvie;Martin, Niall M. B.;Ruston, Linette;Pass, Sarah L.;Pass, Martin. And the article was included in Bioorganic & Medicinal Chemistry Letters in 2013.COA of Formula: C14H21BO4 This article mentions the following:

The optimization of a potent and highly selective series of dual mTORC1 and mTORC2 inhibitors is described. An initial focus on improving cellular potency while maintaining or improving other key parameters, such as aqueous solubility and margins over hERG IC₅₀, led to the discovery of the clin. candidate AZD8055. Further optimization, particularly aimed at reducing the rate of metabolism in human hepatocyte incubations, resulted in the discovery of the clin. candidate AZD2014. In the experiment, the researchers used many compounds, for example, 2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenemethanol (cas: 1009303-77-8COA of Formula: C14H21BO4).

2-Methoxy-5-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzenemethanol (cas: 1009303-77-8) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil. Ethyl ether is an excellent solvent for extractions and for a wide variety of chemical reactions. It is also used as a volatile starting fluid for diesel engines and gasoline engines in cold weather. Dimethyl ether is used as a spray propellant and refrigerant. Methyl t-butyl ether (MTBE) is a gasoline additive that boosts the octane number and reduces the amount of nitrogen-oxide pollutants in the exhaust. The ethers of ethylene glycol are used as solvents and plasticizers.COA of Formula: C14H21BO4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Photophysical and Complexation Properties of Benzenesulfonamide Derivatives with Different Donor and Acceptor Moieties was written by Oezturk, G.;Foerstel, M.;Ergun, Y.;Alp, S.;Rettig, W.. And the article was included in Journal of Fluorescence in 2008.Synthetic Route of C10H21NO4 This article mentions the following:

Pyrrolobenzosulfonamide, indolobenzosulfonamide and carbazolobenzosulfonamide derivatives with different acceptor groups were synthesized and their photophys. properties were compared. The electron donor linking sites are found to influence the emission characteristics of these compounds while acceptor linking sites have no noticeable effects on the spectral properties. P2-A5 which is a C-C linked pyrrole derivative exhibited different spectral properties from the C-N linked pyrrole derivatives The complexation properties of the mols. were also investigated employing Na (I), Ca (II), Li (I), Mg (II), Zn (II) and Cu (II) ions. In the experiment, the researchers used many compounds, for example, 1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3Synthetic Route of C10H21NO4).

1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.Synthetic Route of C10H21NO4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Metal-Cation Recognition in Water by a Tetrapyrazinoporphyrazine-Based Tweezer Receptor was written by Lochman, Lukas;Svec, Jan;Roh, Jaroslav;Kirakci, Kaplan;Lang, Kamil;Zimcik, Petr;Novakova, Veronika. And the article was included in Chemistry – A European Journal in 2016.Electric Literature of C10H21NO4 This article mentions the following:

A series of zinc azaphthalocyanines with two azacrowns in a rigid tweezer arrangement were prepared and the fluorescence sensing properties were studied. The size-driven recognition of alkali and alk. earth metal cations was significantly enhanced by the close cooperation of the two azacrown units, in which both donor nitrogen atoms need to be involved in analyte binding to switch the sensor on. The mono- or biphasic character of the binding isotherms, together with the binding stoichiometry and magnitude of association constants (K_A), indicated specific complexation of particular analytes. Water solvation was shown to play an important role and resulted in a strong quenching of sensor fluorescence in the ON state. The lead compound was embedded into silica nanoparticles and advantageous sensing properties towards K⁺ were demonstrated in water (λ_F = 671 nm, apparent K_A = 82 M^-1, increase of 17×), even in the presence of (supra)physiol. concentrations of Na⁺ and Ca²⁺. In the experiment, the researchers used many compounds, for example, 1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3Electric Literature of C10H21NO4).

1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.Electric Literature of C10H21NO4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Annulation-Induced Cascade Transformation of 5-Iodo-1,2,3-triazoles to 2-(1-Aminoalkyl)benzoxazoles was written by Kotovshchikov, Yury N.;Latyshev, Gennadij V.;Navasardyan, Mger A.;Erzunov, Dmitry A.;Beletskaya, Irina P.;Lukashev, Nikolay V.. And the article was included in Organic Letters in 2018.Recommanded Product: 66943-05-3 This article mentions the following:

Base-mediated cyclization of (5-iodo-1,2,3-triazolyl)phenols was proposed as a new synthetic strategy for the in situ generation of diazoimines via electrocyclic ring opening of the fused heterocycle. Cu-catalyzed amination of the intermediate diazoalkanes was employed to develop an efficient cascade approach to functionalized benzoxazoles. In the experiment, the researchers used many compounds, for example, 1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3Recommanded Product: 66943-05-3).

1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3) belongs to ethers. The oxygen atom in ethers are more electronegative than carbon, thus the hydrogens which are alpha to the ethers are more acidic than the simple hydrocarbons. The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom. Complexation of the magnesium atom stabilizes the Grignard reagent and helps to keep it in solution.Recommanded Product: 66943-05-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem