Tag: 200-300

Synthesis of 5-(3-tert-butylamino-2-hydroxy)propoxy-3,4-dihydrocarbostyril. was written by Chen, Ling Ching;Lin, Jen Hom;Wu, Shihn Sheng. And the article was included in Journal of the Chinese Chemical Society (Taipei, Taiwan) in 1984.Application In Synthesis of N-(3-Methoxyphenyl)pivalamide This article mentions the following:

The title compound ( carteolol, I) was prepared in 21% yield in 6 steps from m-Me₃CCOC₆H₄OMe via cyclization of the amino ester II to the carbostyril III. In the experiment, the researchers used many compounds, for example, N-(3-Methoxyphenyl)pivalamide (cas: 56619-93-3Application In Synthesis of N-(3-Methoxyphenyl)pivalamide).

N-(3-Methoxyphenyl)pivalamide (cas: 56619-93-3) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive. Ethers can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Application In Synthesis of N-(3-Methoxyphenyl)pivalamide

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

A general method for the synthesis of isatins: preparation of regiospecifically functionalized isatins from anilines was written by Hewawasam, Plyasena;Meanwell, Nicholas A.. And the article was included in Tetrahedron Letters in 1994.Related Products of 56619-93-3 This article mentions the following:

A new method has been developed for regiospecific conversion of substituted anilines to isatins. The method utilizes the reaction of an ortho-lithiated, protected aniline derivative with di-Et oxalate to furnish an α-ketoester. Hydrolytic deprotection of the amino moiety is accompanied by cyclization to provide the isatin. In the experiment, the researchers used many compounds, for example, N-(3-Methoxyphenyl)pivalamide (cas: 56619-93-3Related Products of 56619-93-3).

N-(3-Methoxyphenyl)pivalamide (cas: 56619-93-3) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. Ethers can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Related Products of 56619-93-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Crowned spiropyran fluoroionophores with a carboxyl moiety for the selective detection of lithium ions was written by Stubing, D. B.;Heng, S.;Abell, A. D.. And the article was included in Organic & Biomolecular Chemistry in 2016.Category: ethers-buliding-blocks This article mentions the following:

The absorbance and fluorescence spectra of carboxylated spiropyrans containing methyl-1-aza-12-crown-4, methyl-1-aza-15-crown-5, methyl-1-aza-18-crown-6 moieties are compared. Characteristic changes in spectra after addition of the alkali metal salts of Li⁺, Na⁺, K⁺ and Cs⁺ were observed Chromism induced by the binding of the metal cations was observed as an increase in absorbance and fluorescence. Of these metal cations, the Li⁺ ion produced the largest change in all three spiropyran systems. Reversible photoswitching of the spiropyran-metal complexes was observed on irradiation with alternating 352 nm UV and white light. This results in reversible fluorescence based sensing of lithium ions with potential for use in a biol. sensor device. In the experiment, the researchers used many compounds, for example, 1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3Category: ethers-buliding-blocks).

1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3) belongs to ethers. The oxygen atom in ethers are more electronegative than carbon, thus the hydrogens which are alpha to the ethers are more acidic than the simple hydrocarbons. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.Category: ethers-buliding-blocks

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Amine Activation: Synthesis of N-(Hetero)arylamides from Isothioureas and Carboxylic Acids was written by Zhu, Yan-Ping;Sergeyev, Sergey;Franck, Philippe;Orru, Romano V. A.;Maes, Bert U. W.. And the article was included in Organic Letters in 2016.Application In Synthesis of N-(3-Methoxyphenyl)pivalamide This article mentions the following:

A novel method for N-(hetero)arylamide synthesis based on rarely explored amine activation, rather than classical acid activation, is reported. The activated amines are easily prepared using a three-component reaction with com. reagents. The new method shows a broad scope including challenging amides not (efficiently) accessible via classical protocols. In the experiment, the researchers used many compounds, for example, N-(3-Methoxyphenyl)pivalamide (cas: 56619-93-3Application In Synthesis of N-(3-Methoxyphenyl)pivalamide).

N-(3-Methoxyphenyl)pivalamide (cas: 56619-93-3) belongs to ethers. The oxygen atom in ethers are more electronegative than carbon, thus the hydrogens which are alpha to the ethers are more acidic than the simple hydrocarbons. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.Application In Synthesis of N-(3-Methoxyphenyl)pivalamide

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Phytochemical, antimicrobial and mast cell stabilizing activity of ethanolic extract of Solanum trilobatum Linn. leaves was written by Parasuraman, Subramani;Ren, Lee Yu;Chuon, Bobby Lau Chik;Yee, Stephanie Wong Kah;Qi, Tan Ser;Ching, Jan Yong Shu;Christapher, Parayil Varghese;Venkateskumar, Krishnamoorthy;Raj, Palanimuthu Vasanth. And the article was included in Malaysian Journal of Microbiology in 2016.SDS of cas: 6972-61-8 This article mentions the following:

Aims:Solanum trilobatum Linn., (Solanaceae) is one of the most widely used plants as food supplement in southern part of India and some parts of Southeast Asia. This plant is traditionally used for the treatment of respiratory illness. In animal studies, the extract of S. trilobatum showed significant antimicrobial, hepatoprotective and anticancer activities. The complete phytochem. profile, antimicrobial and mast cell stabilizing activities of S. trilobatum remains unclear. This study tests the antimicrobial, antihistaminic and mast cell stabilizing activities of ethanolic extract of leaves of S. trilobatum (EEST). Methodol. and results: The phytochem. test was carried out using chem. and instrumental [Gas Chromatog. Mass Spectrometry (GC-MS)] anal. methods. Antimicrobial effect of EEST was tested against Streptococcus pneumonia, Escherichia coli and Staphylococcus aureus. Intestinal mesentery of Sprague Dawley (SD) rats was used to study the peritoneal mast cell stabilization activity of EEST. The rat intestinal mesentery was exposed to 50, 100, 200, 300, 400 and 600 μg/mL of EEST and the peritoneal mast cell stabilization activity was compared with that of standards (pheniramine 20 μg/mL and ketotifen 20 μg/mL). The phytochem. test showed the presence of carbohydrates, saponins, flavonoids, alkaloids, tannins and phenolic compounds GC-MS anal. indicated the presence of 45 fragmented compounds which included epoxylinalol, himachalol, illudol, epibuphanamine, baimuxinal and edulan IV. EEST exhibited antimicrobial activity at 10 mg/mL against S. aureus, S. pneumonia. Significant mast cell stabilizing activity was observed from the dose of 100 μg/mL to 600 μg/mL. Conclusion: Ethanolic extract of leaves of S. trilobatum possess significant antimicrobial and antihistaminic activity. In the experiment, the researchers used many compounds, for example, 3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8SDS of cas: 6972-61-8).

3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8) belongs to ethers. The oxygen atom in ethers are more electronegative than carbon, thus the hydrogens which are alpha to the ethers are more acidic than the simple hydrocarbons. Ethers can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.SDS of cas: 6972-61-8

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The synthesis and characterization of a porphyrazine bearing aza-15-crown-5 moieties in the peripheral positions and its cobalt(II) complex was written by Kantekin, Halit;Celenk, Elif;Biyiklioglu, Zekeriya;Karadeniz, Huelya. And the article was included in Transition Metal Chemistry (Dordrecht, Netherlands) in 2008.Formula: C10H21NO4 This article mentions the following:

Novel metal-free and metalloporphyrazines I (H₂Pz, MgPz, CoPz; M = 2H, Mg, Co, resp.; Q = 1,4,7,10-tetraoxa-13-azacyclopentadec-13-yl), peripherally substituted with eight aza-15-crown-5 moieties, were prepared by template reductive condensation of 2,3-[Q(CH₂)₃S]-maleodinitrile in the presence of met. Mg in n-PrOH, while MgPz (I, M = Mg) was obtained. Demetalation of MgPz by CF₃CO₂H gave metal-free porphyrazine H₂Pz, which was reacted with CoCl₂ to give CoPz (I, M = Co). The novel compounds were characterized by elemental anal., IR, ¹H and ¹³C-NMR, UV-vis. spectra and MS data. In the experiment, the researchers used many compounds, for example, 1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3Formula: C10H21NO4).

1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. But ether is more polar than alkenes. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.Formula: C10H21NO4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Molecularly Responsive Binding through Co-occupation of Binding Space: A Lock-Key Story was written by Awino, Joseph K.;Hu, Lan;Zhao, Yan. And the article was included in Organic Letters in 2016.Computed Properties of C9H13ClN2O2 This article mentions the following:

When two guest mols. co-occupy a binding pocket of a water-soluble host, the first guest could be used as a signal mol. to turn on the binding of the second. This type of molecularly responsive binding strongly depends on the size of the two guests and the location of the signal mol. In the experiment, the researchers used many compounds, for example, 3,4-Dimethoxybenzimidamide hydrochloride (cas: 51488-33-6Computed Properties of C9H13ClN2O2).

3,4-Dimethoxybenzimidamide hydrochloride (cas: 51488-33-6) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. But ether is more polar than alkenes. Ethyl ether is an excellent solvent for extractions and for a wide variety of chemical reactions. It is also used as a volatile starting fluid for diesel engines and gasoline engines in cold weather. Dimethyl ether is used as a spray propellant and refrigerant. Methyl t-butyl ether (MTBE) is a gasoline additive that boosts the octane number and reduces the amount of nitrogen-oxide pollutants in the exhaust. The ethers of ethylene glycol are used as solvents and plasticizers.Computed Properties of C9H13ClN2O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Environmentally friendly method for the iodination of moderately active arenes was written by Sathiyapriya, R.. And the article was included in Asian Journal of Chemistry in 2011.Recommanded Product: 75581-11-2 This article mentions the following:

An effective and environmentally friendly method for the iodination of various moderately active methoxy arenes, phenols and anilines using hydrogen peroxide and acidified sodium periodate in aqueous ethanol medium is reported. The extent of iodination is easily controlled by stoichiometry and excellent yields of mono iodinated products are obtained. In the experiment, the researchers used many compounds, for example, 4-Iodo-1-methoxy-2-methylbenzene (cas: 75581-11-2Recommanded Product: 75581-11-2).

4-Iodo-1-methoxy-2-methylbenzene (cas: 75581-11-2) belongs to ethers. The oxygen atom in ethers are more electronegative than carbon, thus the hydrogens which are alpha to the ethers are more acidic than the simple hydrocarbons. Electron-deficient reagents are also stabilized by ethers. For example, borane (BH3) is a useful reagent for making alcohols. Pure borane exists as its dimer, diborane (B2H6), a toxic gas that is inconvenient and hazardous to use. Borane forms stable complexes with ethers, however, and it is often supplied and used as its liquid complex with tetrahydrofuran (THF).Recommanded Product: 75581-11-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The synergistic copper/ppm Pd-catalyzed hydrocarboxylation of alkynes with formic acid as a CO surrogate as well as a hydrogen source: an alternative indirect utilization of CO₂ was written by Xia, Shu-Mei;Yang, Zhi-Wen;Yao, Xiang-Yang;Chen, Kai-Hong;Qiu, Li-Qi;He, Liang-Nian. And the article was included in Green Chemistry in 2021.SDS of cas: 39969-26-1 This article mentions the following:

An unprecedented strategy had been developed involving the earth-abundant Cu-catalyzed hydrocarboxylation of alkynes with HCOOH to (E)-acrylic derivatives I [R¹ = Ph, 4-FC₆H₄, 2-thienyl, etc.; R² = Me, 4-BrC₆H₄, 4-MeOC₆H₄, etc.] with high regio- and stereoselectivity via synergistic effects with ppm levels of a Pd catalyst. Both sym. and unsym. alkynes bearing various functional groups were successfully hydrocarboxylated with HCOOH and the modification of a pharmaceutical mol. exemplified the practicability of this process. This protocol employed HCOOH as both a CO surrogate and hydrogen donor with 100% atom economy and it could be viewed as an alternative approach for indirect CO₂ utilization. Mechanistic investigations indicate a Cu/ppm Pd cooperative catalysis mechanism via alkenylcopper species as potential intermediates formed from Cu-hydride active catalytic species with HCOOH as a hydrogen source. This bimetallic system involving inexpensive Cu and trace Pd provided a reliable and efficient hydrocarboxylation method to access industrially useful acrylic derivatives with HCOOH as a hydrogen source, and it provided novel clues for optimizing other Cu-H-related co-catalytic systems. In the experiment, the researchers used many compounds, for example, 1-Methoxy-4-((4-propylphenyl)ethynyl)benzene (cas: 39969-26-1SDS of cas: 39969-26-1).

1-Methoxy-4-((4-propylphenyl)ethynyl)benzene (cas: 39969-26-1) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. But ether is more polar than alkenes. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.SDS of cas: 39969-26-1

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Heterogeneous Pd/C-catalyzed ligand-free Suzuki-Miyaura coupling reaction using aryl boronic esters was written by Kitamura, Yoshiaki;Sakurai, Ai;Udzu, Takahiro;Maegawa, Tomohiro;Monguchi, Yasunari;Sajiki, Hironao. And the article was included in Tetrahedron in 2007.Related Products of 365564-07-4 This article mentions the following:

Heterogeneous Pd/C-catalyzed Suzuki-Miyaura cross-coupling reaction of aryl boronic esters with aryl bromides was successfully carried out in aqueous media at room temperature without the use of a ligand such as phosphine derivatives In the experiment, the researchers used many compounds, for example, 2-(3,5-Dimethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 365564-07-4Related Products of 365564-07-4).

2-(3,5-Dimethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 365564-07-4) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.Related Products of 365564-07-4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem