Tag: 200-300

Selective radioactive decontamination employing dual stimuli responsive N-Aza crown ether containing polymer hydrogels was written by Deli, Dario;Crouch, David J.;Law, Kathleen;Yeates, Stephen G.;Livens, Francis. And the article was included in Materials Research Society Symposium Proceedings in 2010.Application of 66943-05-3 This article mentions the following:

We report the synthesis and properties of two different hydrogels based on N-isopropylacrylamide/acrylic acid and copolymers of oligo-ethylene glycol methacrylates incorporating N-Aza crown ethers. Both hydrogels show rapid response to environmental stimuli and their size can be tuned by pH and temperature Swollen states lead to high adsorption of water and high contact surface area with ions whereas in the collapsed state the material releases water and the ions not selectively retained by the polymer. Preliminary autoradiog. tests show that these materials strongly bind ⁹⁰Sr and both pH and temperature can be used to fine tune binding selectivity. This results in such materials being promising candidates for use as smart scavenging agents for radioactive decontamination. In the experiment, the researchers used many compounds, for example, 1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3Application of 66943-05-3).

1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. Ethers can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Application of 66943-05-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

N-Arylation of Sterically Hindered NH-Nucleophiles: Copper-Mediated Syntheses of Diverse N-Arylindole-2-carboxylates was written by Lee, Jinyong;Choi, Ji Hye;Shin, Seunghoon;Heo, Jung-Nyoung;Lim, Hwan Jung. And the article was included in Synthesis in 2015.Computed Properties of C7H5BrF2O This article mentions the following:

Indole-carboxylates are N-arylated with 2-bromopyridines using stoichiometric copper(II) oxide/potassium carbonate to give various N-(2-pyridyl)-substituted indole-2-carboxylates e. g., I, and with bromobenzenes using stoichiometric copper(I) iodide/N,N’-dimethylethylenediamine to give various N-(substituted phenyl)-substituted indole-2-carboxylates, e. g., II. These results expand the scope of metal-catalyzed N-arylation using heterocyclic amines with steric bulk and weak nucleophilicity. In the experiment, the researchers used many compounds, for example, 4-Bromo-2,6-difluoroanisole (cas: 104197-14-0Computed Properties of C7H5BrF2O).

4-Bromo-2,6-difluoroanisole (cas: 104197-14-0) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. But ether is more polar than alkenes. Ethers can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Computed Properties of C7H5BrF2O

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Diflunisal Analogues Stabilize the Native State of Transthyretin. Potent Inhibition of Amyloidogenesis was written by Adamski-Werner, Sara L.;Palaninathan, Satheesh K.;Sacchettini, James C.;Kelly, Jeffery W.. And the article was included in Journal of Medicinal Chemistry in 2004.Formula: C7H5BrF2O This article mentions the following:

Analogs of diflunisal, an FDA-approved nonsteroidal antiinflammatory drug (NSAID), were synthesized and evaluated as inhibitors of transthyretin (TTR) aggregation, including amyloid fibril formation. High inhibitory activity was observed for 26 of the compounds Of those, eight exhibited excellent binding selectivity for TTR in human plasma (binding stoichiometry >0.50, with a theor. maximum of 2.0 inhibitors bound per TTR tetramer). Biophys. studies reveal that these eight inhibitors dramatically slow tetramer dissociation (the rate-determining step of amyloidogenesis) over a duration of 168 h. This appears to be achieved through ground-state stabilization, which raises the kinetic barrier for tetramer dissociation Kinetic stabilization of WT TTR by these eight inhibitors is further substantiated by the decreasing rate of amyloid fibril formation as a function of increasing inhibitor concentration (pH 4.4). X-ray cocrystal structures of the TTR-3′,5′-difluorobiphenyl-4-carboxylic acid (I) and TTR-2′,6′-difluorobiphenyl-4-carboxylic acid (II) complexes reveal that I and II bind in opposite orientations in the TTR binding site. Moving the fluorines from the meta positions in I to the ortho positions in II reverses the binding orientation, allowing the hydrophilic aromatic ring of II to orient in the outer binding pocket where the carboxylate engages in favorable electrostatic interactions with the ε-ammonium groups of Lys 15 and 15′. The hydrophilic aryl ring of I occupies the inner binding pocket, with the carboxylate positioned to hydrogen bond to the serine 117 and 117′ residues. Diflunisal itself appears to occupy both orientations based on the electron d. in the TTR·1₂ structure. Structure-activity relationships reveal that para-carboxylate substitution on the hydrophilic ring and dihalogen substitution on the hydrophobic ring afford the most active TTR amyloid inhibitors. In the experiment, the researchers used many compounds, for example, 4-Bromo-2,6-difluoroanisole (cas: 104197-14-0Formula: C7H5BrF2O).

4-Bromo-2,6-difluoroanisole (cas: 104197-14-0) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.Formula: C7H5BrF2O

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Regioselective iodination of activated arenes using phenyl trimethylammonium dichloroiodate in ionic liquid under microwave irradiation was written by Tilve, Rutuja D.;Kanetkar, Vinod R.. And the article was included in Synthetic Communications in 2005.COA of Formula: C8H9IO This article mentions the following:

The regioselective iodination of activated arenes was achieved in the presence of phenyltrimethylammonium dichloroiodate and ionic liquid The reaction was carried out by both conventional heating as well as by microwave irradiation In the experiment, the researchers used many compounds, for example, 4-Iodo-1-methoxy-2-methylbenzene (cas: 75581-11-2COA of Formula: C8H9IO).

4-Iodo-1-methoxy-2-methylbenzene (cas: 75581-11-2) belongs to ethers. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides. The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom. Complexation of the magnesium atom stabilizes the Grignard reagent and helps to keep it in solution.COA of Formula: C8H9IO

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

An Efficient Polymer Supported Palladium Catalyst for ortho Selective C-H Olefination of Anilides was written by Saranya, Thachora Venu;Sruthi, Pambingal Rajan;Ayana, Nambokkil;Anas, Saithalavi. And the article was included in ChemistrySelect in 2021.Application In Synthesis of N-(3-Methoxyphenyl)pivalamide This article mentions the following:

The development of a novel heterogeneous polymer supported palladium catalyst for the oxidative C-H olefination of anilides was described. The catalyst was realized by immobilizing palladium acetate over ethylene diamine modifiedpolyacrylonitrile (PAN) and characterized by means of FTIR, XRD and XPS analyses which evidenced the complexation of Pd(OAc)₂ with the chelating groups in the polymer. The resulting supported complex (en-PAN-Pd) was then explored as an efficient and reusable heterogeneous catalyst for ortho selective C-H activation of anilides on reaction with a number of alkyl acrylates. This reaction protocol served as a useful and greener method for the synthesis of o-alkenyl anilides under mild reaction conditions. The catalyst also exhibited good recyclability and reusability without losing much catalytic activity. In the experiment, the researchers used many compounds, for example, N-(3-Methoxyphenyl)pivalamide (cas: 56619-93-3Application In Synthesis of N-(3-Methoxyphenyl)pivalamide).

N-(3-Methoxyphenyl)pivalamide (cas: 56619-93-3) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. Ethers can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Application In Synthesis of N-(3-Methoxyphenyl)pivalamide

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthesis of copper nanoparticles supported on a microporous covalent triazine polymer: an efficient and reusable catalyst for O-arylation reaction was written by Puthiaraj, Pillaiyar;Ahn, Wha-Seung. And the article was included in Catalysis Science & Technology in 2016.Recommanded Product: 1-(4-(4-Methoxyphenoxy)phenyl)ethanone This article mentions the following:

Copper nanoparticles were supported on a microporous covalent triazine polymer prepared by the Friedel-Crafts reaction (Cu@MCTP-1). The resulting material was characterized by powder X-ray diffraction, thermogravimetric anal., N₂ adsorption-desorption isotherms at 77 K, transmission electron microscopy, XPS, and inductively coupled plasma optical emission spectroscopy, and Cu particles with an average size of 3.0 nm and a BET total surface area of ca. 1002 m² g^-1 were obtained. Cu@MCTP-1 was evaluated as a heterogeneous catalyst for the Ullmann coupling of O-arylation over a series of aryl halides and phenols without employing expensive ligands or inert atm., which produced an excellent yield of the corresponding diaryl ethers. The catalyst could be recovered by simple centrifugation and was reusable at least five times with only a slight decrease in catalytic activity. In the experiment, the researchers used many compounds, for example, 1-(4-(4-Methoxyphenoxy)phenyl)ethanone (cas: 54916-28-8Recommanded Product: 1-(4-(4-Methoxyphenoxy)phenyl)ethanone).

1-(4-(4-Methoxyphenoxy)phenyl)ethanone (cas: 54916-28-8) belongs to ethers. The oxygen atom in ethers are more electronegative than carbon, thus the hydrogens which are alpha to the ethers are more acidic than the simple hydrocarbons. The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom. Complexation of the magnesium atom stabilizes the Grignard reagent and helps to keep it in solution.Recommanded Product: 1-(4-(4-Methoxyphenoxy)phenyl)ethanone

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Allelochemicals of barnyardgrass-infested soil and their activities on crops and weeds was written by Khanh, Tran Dang;Xuan, Tran Dang;Chung, Ill Min;Tawata, Shinkichi. And the article was included in Weed Biology and Management in 2008.Computed Properties of C11H12O4 This article mentions the following:

Barnyardgrass is one of the most noxious paddy weeds in the world and causes great trouble to many crops. In a bioassay, the aqueous extract of paddy soil infested with barnyardgrass showed phytotoxic action against the growth of the tested crops and paddy weeds, of which rice was the most suppressed among the crops. In contrast, barnyardgrass was the least affected paddy weed. By the use of a separation resin, 18 compounds belonging to terpenes, derivatives of cinnamic acid and ferulic acid, long-chain fatty acids, and steroids that were potentially involved in the phytotoxic activities in barnyardgrass-infested soil were isolated and identified by gas chromatog.-mass spectrometry anal. Of these, the quantities of linalool, 4-terpinenol, coumaran, Me phenethyl ketone, and Me ester cinnamic acid were 1.42, 0.37, 0.02, 3.12, and 4.59 μg g^-1 of the wet soil, resp. The herbicidal activity was varied among these qualified test compounds, in which Me phenethyl ketone and Me ester cinnamic acid were more herbicidal than coumaran, linalool, and 4-terpinenol. A mixture of these compounds was also the least inhibitive against the growth of barnyardgrass, but exerted strong suppression against that of rice and monochoria. The present study demonstrates that barnyardgrass possesses strong phytotoxic properties and releases plant growth inhibitors into the soil to compete with rice and other paddy weeds in its vicinity by a chem. pathway. In the experiment, the researchers used many compounds, for example, 3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8Computed Properties of C11H12O4).

3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive. Ethyl ether is an excellent solvent for extractions and for a wide variety of chemical reactions. It is also used as a volatile starting fluid for diesel engines and gasoline engines in cold weather. Dimethyl ether is used as a spray propellant and refrigerant. Methyl t-butyl ether (MTBE) is a gasoline additive that boosts the octane number and reduces the amount of nitrogen-oxide pollutants in the exhaust. The ethers of ethylene glycol are used as solvents and plasticizers.Computed Properties of C11H12O4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Copper-Mediated Sequential Cyanation of Aryl C-B and Arene C-H Bonds Using Ammonium Iodide and DMF was written by Kim, Jinho;Choi, Jiho;Shin, Kwangmin;Chang, Sukbok. And the article was included in Journal of the American Chemical Society in 2012.Quality Control of 2-(3,5-Dimethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane This article mentions the following:

The cyanation of aromatic boronic acids, boronate esters, and borate salts was developed under copper-mediated oxidative conditions using ammonium iodide and DMF as the source of nitrogen and carbon atom of the cyano unit, resp. The procedure was successfully extended to the cyanation of electron-rich benzenes, and regioselective introduction of a cyano group at the arene C-H bonds was also achieved. The observation that the reaction proceeds via a two-step process, initial iodination and then cyanation, led us to propose that ammonium iodide plays a dual role to provide iodide and nitrogen atom of the cyano moiety. In the experiment, the researchers used many compounds, for example, 2-(3,5-Dimethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 365564-07-4Quality Control of 2-(3,5-Dimethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane).

2-(3,5-Dimethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 365564-07-4) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive. The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom. Complexation of the magnesium atom stabilizes the Grignard reagent and helps to keep it in solution.Quality Control of 2-(3,5-Dimethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Thermal Properties of Macrocyclic Polyethers: Implications for the Design of Crown Ether-Based Ionic Liquids was written by Pawlak, Alan J.;Dietz, Mark L.. And the article was included in Separation Science and Technology (Philadelphia, PA, United States) in 2014.Application In Synthesis of 1,4,7,10-Tetraoxa-13-azacyclopentadecane This article mentions the following:

The most commonly studied classes of ionic liquids (ILs) comprise relatively large and asym. heterocyclic cations (e.g., diakylimidazolium or N-alkylpyridinium) in combination with any of a wide variety of inorganic (e.g., BF₄^–, Cl^–) or organic (e.g., bis[(trifluoromethyl-sulfonyl)imide], Tf₂N^–) anions. Recently it has been shown that ILs can also be formed by complexation reactions of metal cations (e.g., Li⁺, as its Tf₂N^– salt) with various neutral ligands (e.g., cyclohexano-15-crown-5 or alkylamines). Because the upper limit of the useful temperature range of any IL is governed by its thermal stability, and because the thermal stability of a neutral ligand (i.e., its propensity to either volatilize or decompose) is of obvious importance in determining that of an IL prepared from it, a systematic examination of the thermal properties of a series of macrocyclic polyethers of potential utility in the synthesis of new ILs has been undertaken. The results showed that the temperature corresponding to the onset of mass loss upon heating (i.e., evaporation and/or decomposition) varied with the ring size, substitution, nature of the donor atoms, and stereochem. of the macrocycle, but is most strongly influenced by the mol. weight and aromatic content of the compound In the experiment, the researchers used many compounds, for example, 1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3Application In Synthesis of 1,4,7,10-Tetraoxa-13-azacyclopentadecane).

1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.Application In Synthesis of 1,4,7,10-Tetraoxa-13-azacyclopentadecane

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

New fluorescent sensors based on 1H-pyrazolo[3,4-b]quinoline skeleton was written by Mac, Marek;Uchacz, Tomasz;Wrobel, Tomasz;Danel, Andrzej;Kulig, Ewa. And the article was included in Journal of Fluorescence in 2010.Synthetic Route of C10H21NO4 This article mentions the following:

Two novel fluorescing yellow dyes, 1,3,4-triphenyl-6-(1,4,7,10-tetraoxa-13-aza-cyclopentadec-13-ylmethyl)-1H-pyrazolo[3,4-b]quinoline and 2-[(2-hydroxyethyl)-(1,3,4-triphenyl-1H-pyrazolo[3,4-b]quinolin-6-ylmethyl)-amino]ethanol have been synthesized and investigated by the means of steady state and time-resolved fluorescence techniques. These compounds act as sensors for the fluorescence detection of small inorganic cations (lithium, sodium, barium, magnesium, and calcium) in solvents of different polarities (THF and acetonitrile). The mechanism, which allows application of these compounds as sensors, is an electron transfer from the electro-donative part of mol. to the acceptor part (fluorophore), which is retarded upon complexation of the electro-donative part by the inorganic cations. We found that the crown ether-containing compound is very sensitive to the addition of any investigated ions but the amino alc.-containing dye exhibits better selectivity to the addition of divalent cations. Two kinds of complexes were found in the investigated systems. In addition, the dyes may be used as fluorescence indicators in solvents of lower polarity like THF. In the experiment, the researchers used many compounds, for example, 1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3Synthetic Route of C10H21NO4).

1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3) belongs to ethers. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.Synthetic Route of C10H21NO4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem