Tag: 200-300

Structure and Conformational Studies of Aza-Crown 8-Amino-BODIPY Derivatives: Influence of Steric Hindrance on Their Photophysical Properties was written by Costero, Ana M.;Betancourt-Mendiola, Maria L.;Gavina, Pablo;Ochando, Luis E.;Gil, Salvador;Chulvi, Katherine;Pena-Cabrera, Eduardo. And the article was included in European Journal of Organic Chemistry in 2017.Electric Literature of C10H21NO4 This article mentions the following:

Herein, the authors report the synthesis, x-ray crystal structure and photophys. studies of six new 8-amino-BODIPY derivatives containing crown or azo-crown ether moieties. The influence of steric hindrance, caused by the crown ether, on the planarity of the BODIPY core and its relation with the fluorescent properties has been established. ¹H NMR spectroscopic studies were undertaken to clarify the changes in fluorescence observed in the presence of Zn^II. In the experiment, the researchers used many compounds, for example, 1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3Electric Literature of C10H21NO4).

1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. But ether is more polar than alkenes. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.Electric Literature of C10H21NO4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Examination of the Perkin reaction under microwave irradiation was written by Veverkova, E.;Pacherova, E.;Toma, S.. And the article was included in Chemical Papers in 1999.Electric Literature of C11H12O4 This article mentions the following:

The microwave irradiation shortened the reaction time of the Perkin reaction by 60-fold over classical heating. Cesium salts (acetate, carbonate, fluoride) with a small amount of pyridine were found to be the best catalysts under all conditions tested. In the experiment, the researchers used many compounds, for example, 3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8Electric Literature of C11H12O4).

3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive. The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom. Complexation of the magnesium atom stabilizes the Grignard reagent and helps to keep it in solution.Electric Literature of C11H12O4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Demonstration of Selective Single-Barium Ion Detection with Dry Diazacrown Ether Naphthalimide Turn-on Chemosensors was written by Thapa, Pawan;Byrnes, Nicholas K.;Denisenko, Alena A.;Mao, James X.;McDonald, Austin D.;Newhouse, Charleston A.;Vuong, Thanh T.;Woodruff, Katherine;Nam, Kwangho;Nygren, David R.;Jones, Benjamin J. P.;Foss, Frank W. Jr.. And the article was included in ACS Sensors in 2021.Recommanded Product: 1,4,7,10-Tetraoxa-13-azacyclopentadecane This article mentions the following:

Single-mol. fluorescence imaging (SMFI) of gas-phase ions has been proposed for “barium tagging,” a burgeoning area of research in particle physics to detect individual barium daughter ions. This has potential to significantly enhance the sensitivity of searches for neutrinoless double-beta decay (0νββ) that is obscured by background radiation events. The chem. required to make such sensitive detection of Ba²⁺ by SMFI in dry Xe gas at solid interfaces has implications for solid-phase detection methods but has not been demonstrated. Here, we synthesized simple, robust, and effective Ba²⁺-selective chemosensors capable of function within ultrapure high-pressure ¹³⁶Xe gas. Turn-on fluorescent naphthalimide-(di)azacrown ether chemosensors were Ba²⁺-selective and achieved SMFI in a polyacrylamide matrix. Fluorescence and NMR experiments supported a photoinduced electron transfer mechanism for turn-on sensing. Ba²⁺ selectivity was achieved with computational calculations correctly predicting the fluorescence responses of sensors to barium, mercury, and potassium ions. With these mols., dry-phase single-Ba²⁺ ion imaging with turn-on fluorescence was realized using an oil-free microscopy technique for the first time-a significant advance toward single-Ba²⁺ ion detection within large volumes of ¹³⁶Xe, plausibly enabling a background-independent technique to search for the hypothetical process of 0νββ. In the experiment, the researchers used many compounds, for example, 1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3Recommanded Product: 1,4,7,10-Tetraoxa-13-azacyclopentadecane).

1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.Recommanded Product: 1,4,7,10-Tetraoxa-13-azacyclopentadecane

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Alkaline hydrolysis of nuclear-substituted ethyl cinnamates. Cumulative effects of substituents was written by Jones, Brynmor;Watkinson, J. G.. And the article was included in Journal of the Chemical Society in 1958.HPLC of Formula: 6972-61-8 This article mentions the following:

The introduction of substituents, even at the ο-position, causes no change in the nonexponential entropy term in the Arrhenius equation. The cumulative effect of 2 substituents in the 2- and 4-, and also in the 3- and 5-positions are additive, giving log₁₀A 9.8-10.0, but in other positions there are sometimes large significant variations in the energies of activation compared with that calculated by ΔE’ = 2.303 RT log₁₀k/k₀, e.g. the factor 100 k_calculated/k_obs. = 50 for Et 2,3-dimethoxycinnamate, and 58 for Et 2,3,4-trimethoxycinnamate, which indicates steric interference with mesomeric electron release from the 2-position, as confirmed by the analogous case of the 4-position in Et 3,4,5-trimethoxybenzoate where the factor = 25. Slight significant deviations for 3,4-dialkoxycinnamates may be due to steric and/or polar interactions. Hydrolyses were carried out at 24.8° and other temperatures in 85.4% aqueous EtOH, the initial concentrations of CO₂-free NaOH and ester were equal at 0.05M, and the reactions strictly 2nd order. New compounds prepared via the substituted BzH and esterification are Et m-methylcinnamate, b₁₀ 146°, Et 2,4-dichlorocinnamate, b₅ 162° and m. 53.5°, Et 3,5-dichlorocinnamate, b₁₂ 178°, and m. 74°, Et 3,6-dichlorocinnamate, b₂ 156° and m. 56°, Et 3-chloro-4-methoxycinnamate, b₄ 170° and m. 61° (3-chloro-4-methoxycinnamic acid m. 244°), Et 3-methyl-4-methoxycinnamate, b₁₁ 184° and m. 36.5° (3-methyl-4-methoxycinnamic acid m. 201°), Et 2,3,4-trimethoxycinnamate, b₁₄ 207° and m. 50°, and Et 4-ethoxy-3-methoxycinnamate, m. 109.5° [4-ethoxy-3-methoxycinnamic acid m. 200° (decomposition)]. In the experiment, the researchers used many compounds, for example, 3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8HPLC of Formula: 6972-61-8).

3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.HPLC of Formula: 6972-61-8

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Conjugation of a double bond with an aromatic nucleus. XXV. The Schiff base in the Diels-Alder reaction was written by Tamayo, M. Lora;Alvarez, Francisco. And the article was included in Anales de la Real Sociedad Espanola de Fisica y Quimica, Serie A: Fisica in 1952.HPLC of Formula: 51488-33-6 This article mentions the following:

Substituted Schiff bases containing the conjugated diene system C:C.C:N, the C:C being a part of the aromatic nucleus, are treated with various dienophiles such as maleic anhydride (I) and Et maleate (II). The substituted groups studied are MeO, Me, -OCH₂O- and NO₂. In none of the attempted condensations does a 1,4-addition occur. The Schiff bases RCH:NPh, where R = m-MeOC₆H₄, 3,4-Me₂C₆H₃ (VI), 3,4-CH₂O₂C₆H₃ (III), m-O₂NC₆H₄ (IV), and 3,4-(MeO)₂C₆H₃, are refluxed 3 hrs. with I in a solvent (C₆H₆ or PhMe). The only reaction product identified is PhNHCOCH:-CHCO₂H, m. 193°. Schiff bases containing hydroquinone (V) heated 3 hrs. at 160° with II under anhydrous conditions do not react. Only III and IV in the absence of V give brownish-black resinous substances which are infusible below 360°, insoluble in organic solvents, soluble in concentrated H₂SO₄ and hot 20% NaOH. An addnl. Schiff base, 3-(p-MeOC₆H₄N:)CH-C₆H₄NO₂ (VII) refluxed 3 hrs. with I in a solvent (C₆H₆ or PhMe) gives only p-(MeO)C₆H₄NHCOCH:CHCO₂H. VII and II heated 3 hrs. at 160° and then allowed to stand a day do not react in the presence of V; in the absence of V is obtained a yellowish brown amorphous solid, believed to be a copolymer with the empirical formula (C₂₂H₂₄O₇₂)_x, m. indefinitely 143-9°, soluble in alc. and NaOH, and precipitated by acids and H₂O. VI and VII are new. For VI, 4.5 g. 3,4-Me₂C₆H₃CHO and 3.1 g. PhNH₂ are stirred 0.5 hr., let stand 24 hrs., and distilled to give 75% VI, colorless oil, b₁₅ 182°. For VII 3 g. p-anisidine and 2.7 g. m-O₂NC₆H₄CHO are refluxed 3 hrs. in 20 cc. absolute alc. and let stand 24 hrs.; the pale green crystalline plates, filtered and recrystallized from alc. and H₂O, m. 72° (yield 85%). In the experiment, the researchers used many compounds, for example, 3,4-Dimethoxybenzimidamide hydrochloride (cas: 51488-33-6HPLC of Formula: 51488-33-6).

3,4-Dimethoxybenzimidamide hydrochloride (cas: 51488-33-6) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil. The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom. Complexation of the magnesium atom stabilizes the Grignard reagent and helps to keep it in solution.HPLC of Formula: 51488-33-6

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthesis and Structure-Activity Relationships of Novel 8a-Aza-8a-homoerythromycin A Ketolides was written by Pavlovic, Drazen;Mutak, Stjepan. And the article was included in Journal of Medicinal Chemistry in 2010.HPLC of Formula: 1132-95-2 This article mentions the following:

A series of novel 6-O-substituted 8a-aza-8a-homoerythromycin A ketolides was synthesized and evaluated for in vitro antibacterial activity. Key strategic elements of the synthesis include the base-induced E-Z isomerization of 3-O-descladinosyl-6-O-allylerythromycin A 9(E)-oxime followed by ring-expanding reaction of the resulting 9(Z)-oxime via Beckmann rearrangement. The ketolides showed potent activity against a variety of erythromycin-susceptible and macrolide-lincosamide-streptogramin B (MLS_B) resistant Gram-pos. and fastidious Gram-neg. pathogens. The best compounds in this series overcome all types of resistance in relevant clin. Gram-pos. pathogens and display in vitro activity comparable to telithromycin and cethromycin. In the experiment, the researchers used many compounds, for example, 1,1-Diisopropoxycyclohexane (cas: 1132-95-2HPLC of Formula: 1132-95-2).

1,1-Diisopropoxycyclohexane (cas: 1132-95-2) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.HPLC of Formula: 1132-95-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthesis and fluorescent properties of aza-crown ether tethered BODIPY fluorophores was written by Yang, Lijing;Liao, De-Jhong;Wu, An-tai;Yan, Hongbin. And the article was included in Tetrahedron Letters in 2017.HPLC of Formula: 66943-05-3 This article mentions the following:

Five BODIPY analogs modified at the meso-position were synthesized through a Mannich-type reaction. Among these derivatives, aza-12-crown-4 analog 3c was found to show Cu²⁺-specific behavior in UV/vis and fluorescent spectra, leading to blue shifts in absorption and effective fluorescent quenching in the presence of Cu²⁺. In the experiment, the researchers used many compounds, for example, 1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3HPLC of Formula: 66943-05-3).

1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive. Ethyl ether is an excellent solvent for extractions and for a wide variety of chemical reactions. It is also used as a volatile starting fluid for diesel engines and gasoline engines in cold weather. Dimethyl ether is used as a spray propellant and refrigerant. Methyl t-butyl ether (MTBE) is a gasoline additive that boosts the octane number and reduces the amount of nitrogen-oxide pollutants in the exhaust. The ethers of ethylene glycol are used as solvents and plasticizers.HPLC of Formula: 66943-05-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Copper-in-Charcoal (Cu/C) Promoted Diaryl Ether Formation was written by Lipshutz, Bruce H.;Unger, John B.;Taft, Benjamin R.. And the article was included in Organic Letters in 2007.Product Details of 54916-28-8 This article mentions the following:

Copper impregnated into charcoal efficiently catalyzes cross-couplings between aryl bromides and phenols to afford diaryl ethers, e.g., I, in good yields. The etherifications were conveniently promoted by microwave heating. In the experiment, the researchers used many compounds, for example, 1-(4-(4-Methoxyphenoxy)phenyl)ethanone (cas: 54916-28-8Product Details of 54916-28-8).

1-(4-(4-Methoxyphenoxy)phenyl)ethanone (cas: 54916-28-8) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom. Complexation of the magnesium atom stabilizes the Grignard reagent and helps to keep it in solution.Product Details of 54916-28-8

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthesis of Indoles through Palladium-Catalyzed Three-Component Reaction of Aryl Iodides, Alkynes, and Diaziridinone was written by Zhou, Bo;Wu, Zhuo;Ma, Ding;Ji, Xiaoming;Zhang, Yanghui. And the article was included in Organic Letters in 2018.Product Details of 75581-11-2 This article mentions the following:

The three-component reaction of aryl iodides, alkynes, and diaziridinone is described. The reaction provides an innovative synthetic approach for indoles. The approach features high efficiency, broad substrate scope, and excellent regioselectivity. C,C-Palladacycles should act as the intermediates. The C,C-palladacycles are obtained from simple aryl halides and alkynes and then reacted with diaziridinone to afford indoles. In the experiment, the researchers used many compounds, for example, 4-Iodo-1-methoxy-2-methylbenzene (cas: 75581-11-2Product Details of 75581-11-2).

4-Iodo-1-methoxy-2-methylbenzene (cas: 75581-11-2) belongs to ethers. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.Product Details of 75581-11-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Internalization of a peptide into multilamellar vesicles assisted by the formation of an α-oxo oxime bond was written by Richard, Antoine;Bourel-Bonnet, Line. And the article was included in Chemistry – A European Journal in 2005.Safety of 2-(2-(2-((Tetrahydro-2H-pyran-2-yl)oxy)ethoxy)ethoxy)ethan-1-ol This article mentions the following:

As part of a drug-delivery project, we designed and synthesized a novel hydroxylamine cholesterol-based anchor to ensure the chemoselective ligation of recognition patterns onto multilamellar vesicles by oxime ligation. The entry of a glyoxylyl peptide into the vesicles was unexpectedly assisted by the formation of the α-oxo oxime bond. We studied extensively the kinetic and thermodn. aspects of this phenomenon. Briefly, for a glyoxylyl peptide, the speed and ability to enter the vesicle were dependent upon (1) the presence of a hydroxyl-amine anchor of the type Chol-E₃ONH₂, (2) the amount of peptide engaged in the ligation and (3) the flip-flop motion permitted by the different formulations, in which the presence of cholesterol seems to play an important role. In the experiment, the researchers used many compounds, for example, 2-(2-(2-((Tetrahydro-2H-pyran-2-yl)oxy)ethoxy)ethoxy)ethan-1-ol (cas: 60221-37-6Safety of 2-(2-(2-((Tetrahydro-2H-pyran-2-yl)oxy)ethoxy)ethoxy)ethan-1-ol).

2-(2-(2-((Tetrahydro-2H-pyran-2-yl)oxy)ethoxy)ethoxy)ethan-1-ol (cas: 60221-37-6) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. Ethyl ether is an excellent solvent for extractions and for a wide variety of chemical reactions. It is also used as a volatile starting fluid for diesel engines and gasoline engines in cold weather. Dimethyl ether is used as a spray propellant and refrigerant. Methyl t-butyl ether (MTBE) is a gasoline additive that boosts the octane number and reduces the amount of nitrogen-oxide pollutants in the exhaust. The ethers of ethylene glycol are used as solvents and plasticizers.Safety of 2-(2-(2-((Tetrahydro-2H-pyran-2-yl)oxy)ethoxy)ethoxy)ethan-1-ol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem