Tag: 200-300

Synthesis of tethered bis-macrocycles by cross-coupling of N-(3,5-dibromobenzyl)azacrowns with α,ω-diamino compounds was written by Anokhin, Maksim V.;Averin, Alexei D.;Buryak, Alexei K.;Beletskaya, Irina P.. And the article was included in Mendeleev Communications in 2011.Name: 1,4,7,10-Tetraoxa-13-azacyclopentadecane This article mentions the following:

Palladium-catalyzed cross-coupling of N-(3,5-dibromobenzyl) derivatives of 1-aza-15-crown-5 and 1-aza-18-crown-6 with a,w-diamino compounds afforded macrocyclization products comprising two tethered different azacrowns. In the experiment, the researchers used many compounds, for example, 1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3Name: 1,4,7,10-Tetraoxa-13-azacyclopentadecane).

1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.Name: 1,4,7,10-Tetraoxa-13-azacyclopentadecane

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A short efficient synthesis of 4-amino-2,3-dihydrobenzofuran was written by Marburg, S.;Tolman, R. L.. And the article was included in Journal of Heterocyclic Chemistry in 1980.Recommanded Product: 56619-93-3 This article mentions the following:

3-MeOC₆H₄NHCOCMe₃ was treated with BuLi and ethylene oxide and the 2-(hydroxyethyl) derivative cyclized by HBr to give the title compound (I; R = NH₂, R¹ = H), which underwent chlorination to give I (R = NH₂, R¹ = Cl). Sandmeyer reaction of I (R = NH₂, R¹ = H) gave I (R = CN, R¹ = H). In the experiment, the researchers used many compounds, for example, N-(3-Methoxyphenyl)pivalamide (cas: 56619-93-3Recommanded Product: 56619-93-3).

N-(3-Methoxyphenyl)pivalamide (cas: 56619-93-3) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. But ether is more polar than alkenes. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.Recommanded Product: 56619-93-3

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Nickel-catalyzed (E)-selective semihydrogenation of internal alkynes with hypophosphorous acid was written by Chen, Tieqiao;Xiao, Jing;Zhou, Yongbo;Yin, Shuangfeng;Han, Li-Biao. And the article was included in Journal of Organometallic Chemistry in 2014.Application of 39969-26-1 This article mentions the following:

A facile Ni-catalyzed semihydrogenation of internal alkynes to (E)-alkenes using the cheap and easily handled hypophosphorous acid as a hydrogen donor was described. This reaction is featured by high reaction efficiency to produce the corresponding (E)-alkenes selectively. In the experiment, the researchers used many compounds, for example, 1-Methoxy-4-((4-propylphenyl)ethynyl)benzene (cas: 39969-26-1Application of 39969-26-1).

1-Methoxy-4-((4-propylphenyl)ethynyl)benzene (cas: 39969-26-1) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.Application of 39969-26-1

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Ether – Wikipedia,
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A highly efficient Pd-catalyzed decarboxylative ortho-arylation of amides with aryl acylperoxides was written by Li, Dengke;Xu, Ning;Zhang, Yicheng;Wang, Lei. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2014.Electric Literature of C12H17NO2 This article mentions the following:

An efficient palladium-catalyzed decarboxylative ortho-arylation of amides with aryl acylperoxides was developed. A variety of anilide derivatives reacted with aryl acyl peroxides to afford the corresponding ortho-arylation products. N-methoxyarylamide reactants led to the formation of phenanthridinone derivatives (i.e., cyclic Weinreb N-(alkoxy)alkanamide analogs). Under optimized conditions the synthesis of the target compounds was achieved using palladium(II) acetate as a catalyst. Starting materials included N-(phenyl)propanamide derivatives, bis(benzoyl)peroxide, N-(methoxy)benzamide derivatives The title compounds thus formed included biaryl-amide derivatives, such as N-[1,1′-biphenyl]-2-yl-2,2-dimethylpropanamide, 1-[[1,1′-biphenyl]-2-yl]-2-pyrrolidinone (cyclic amide analog), and 5-methoxy-6(5H)-phenanthridinone derivatives (Weinreb amide analogs). In the experiment, the researchers used many compounds, for example, N-(3-Methoxyphenyl)pivalamide (cas: 56619-93-3Electric Literature of C12H17NO2).

N-(3-Methoxyphenyl)pivalamide (cas: 56619-93-3) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. But ether is more polar than alkenes. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.Electric Literature of C12H17NO2

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Ether – Wikipedia,
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Benzylpiperazine derivatives. VI. Design and syntheses of vinylogs of 1-benzyl-4-diphenylmethylpiperazine derivatives and their cerebral vasodilating activities was written by Ohtaka, Hiroshi;Kanazawa, Toshiro;Ito, Keizo;Tsukamoto, Goro. And the article was included in Chemical & Pharmaceutical Bulletin in 1987.HPLC of Formula: 6972-61-8 This article mentions the following:

Based on previous quant. structure-activity relationship (QSAR) results on cerebral vasodilating activities of 1-benzyl-4-diphenylmethylpiperazines, 1–cinnamyl-4-diphenylmethylpiperazines I (R = H, MeO; R¹ = H, F), having electron-donating groups on the cinnamyl moiety, were designed. Two methods of synthesis are reported. Thus, 2,3,4-(MeO)₃C₆H₂CH:CHCO₂H was treated sequentially with Et₃N, ClCO₂Et and then bis(fluorophenyl)methylpiperazine (II) in Me₃COH-MeCN to give the [bis(fluorophenyl)methyl](trimethoxycinnamoyl)piperazine III. Reducing III with NaAlH₂(OCH₂CH₂OMe)₂ gave 56% I (R = MeO, R¹ = F). As expected from the QSAR results, these compounds exhibited stronger potency and longer-lasting effects than cinnarizine and flunarizine. In the experiment, the researchers used many compounds, for example, 3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8HPLC of Formula: 6972-61-8).

3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.HPLC of Formula: 6972-61-8

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Engaging Ag(0) single atoms in silver(I) salts-mediated C-B and C-S coupling under visible light irradiation was written by Cui, Enxin;Qiao, Dan;Li, Haibin;Guo, Lirong;Tung, Chen-Ho;Wang, Yifeng. And the article was included in Journal of Catalysis in 2021.Related Products of 365564-07-4 This article mentions the following:

Silver(I) salts were found active in the borylation and sulfenylation of aryl iodides under visible light irradiation The optimized borylation protocol using AgF did not need any additive, operated under very mild conditions, and well tolerated a broad scope of substrates and boron sources. Formation of Ag(0) single atoms (AgSAs) during the borylation reactions was examined using high-angle annular dark field aberration-corrected scanning transmission electron microscope (HAADF AC-STEM) and ESR (EPR). The activities of the silver(I) salts were affected by the anions and could be associated with their abilities in formation of AgSAs during the reactions. Kinetic studies showed that the deiodination rate was linearly correlated with the loading of AgSAs, and hence AgSAs were the true catalytic centers for the 1e^–-reduction of the C-I moieties. The oxidation state of AgSAs kept 0 in both the resting and the working states. A “work-in-tandem” mechanism involving AgSAs as the catalytic centers and AgNPs as the light absorber to achieve the borylation of aryl iodides under visible light irradiation is proposed. The current approach not only provides an alternative system for borylation and sulfenylation of aryl iodides, but also reveals a new activity of silver(I) salts involving AgSAs under visible light irradiation In the experiment, the researchers used many compounds, for example, 2-(3,5-Dimethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 365564-07-4Related Products of 365564-07-4).

2-(3,5-Dimethoxyphenyl)-4,4,5,5-tetramethyl-1,3,2-dioxaborolane (cas: 365564-07-4) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.Related Products of 365564-07-4

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Use of mechanism-based structure-activity relationships analysis in carcinogenic potential ranking for drinking water disinfection by-products was written by Woo, Yin-Tak;Lai, David;McLain, Jennifer L.;Manibusan, Mary Ko;Dellarco, Vicki. And the article was included in Environmental Health Perspectives Supplements in 2002.Name: 1-((1-((1-Methoxypropan-2-yl)oxy)propan-2-yl)oxy)propan-2-ol This article mentions the following:

Disinfection byproducts (DBPs) are formed when disinfectants such as chlorine, chloramine, and ozone react with organic and inorganic matter in water. The observations that some DBPs such as trihalomethanes (THMs), di-/trichloroacetic acids, and 3-chloro-4-(dichloromethyl)-5-hydroxy-2(5H)-furanone (MX) are carcinogenic in animal studies have raised public concern over the possible adverse health effects of DBPs. To date, several hundred DBPs have been identified. To prioritize research efforts, an in-depth, mechanism-based structure-activity relationship anal., supplemented by extensive literature search for genotoxicity and other data, was conducted for ranking the carcinogenic potential of DBPs that met the following criteria: (a) detected in actual drinking water samples, (b) have insufficient cancer bioassay data for risk assessment, and (c) have structural features/alerts or short-term predictive assays indicative of carcinogenic potential. A semiquant. concern rating scale of low, marginal, low-moderate, moderate, high-moderate, and high was used along with delineation of scientific rationale. Of the 209 DBPs analyzed, 20 were of priority concern with a moderate or high-moderate rating. Of these, four were structural analogs of MX and five were haloalkanes that presumably will be controlled by existing and future THM regulations. The other eleven DBPs, which included halonitriles (6), haloketones (2), haloaldehyde (1), halonitroalkane (1), and dialdehyde (1), are suitable priority candidates for future carcinogenicity testing and/or mechanistic studies. In the experiment, the researchers used many compounds, for example, 1-((1-((1-Methoxypropan-2-yl)oxy)propan-2-yl)oxy)propan-2-ol (cas: 20324-33-8Name: 1-((1-((1-Methoxypropan-2-yl)oxy)propan-2-yl)oxy)propan-2-ol).

1-((1-((1-Methoxypropan-2-yl)oxy)propan-2-yl)oxy)propan-2-ol (cas: 20324-33-8) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.Name: 1-((1-((1-Methoxypropan-2-yl)oxy)propan-2-yl)oxy)propan-2-ol

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Polysubstituted Pyrimidines as mPGES-1 Inhibitors: Discovery of Potent Inhibitors of PGE₂ Production with Strong Anti-inflammatory Effects in Carrageenan-Induced Rat Paw Edema was written by Kalcic, Filip;Kolman, Viktor;Ajani, Haresh;Zidek, Zdenek;Janeba, Zlatko. And the article was included in ChemMedChem in 2020.Formula: C14H15BO4 This article mentions the following:

We report an extensive structure-activity relationship optimization of polysubstituted pyrimidines that led to the discovery of 5-butyl-4-(4-benzyloxyphenyl)-6-phenylpyrimidin-2-amine, and its difluorinated analog. These compounds are sub-micromolar inhibitors of PGE₂ production (IC₅₀ as low as 12 nM). In order to identify the mol. target of anti-inflammatory pyrimidines, we performed extensive studies including enzymic assays, homol. modeling and docking. The difluorinated analog simultaneously inhibits two key enzymes of the arachidonic acid cascade, namely mPGES-1 and COX-2, with mPGES-1 inhibition being the principal mechanism of action. Other pyrimidines studied are potent mPGES-1 inhibitors with no observed inhibition of COX-1/2 enzymes. Moreover, the two most potent compounds proved to be significantly effective in vivo in a model of acute inflammation, suppressing carrageenan-induced rat paw edema by 36 and 46%. The promising results of this study warrant further preclin. evaluation of selected anti-inflammatory candidates. In the experiment, the researchers used many compounds, for example, (4-((4-Methoxybenzyl)oxy)phenyl)boronic acid (cas: 156635-90-4Formula: C14H15BO4).

(4-((4-Methoxybenzyl)oxy)phenyl)boronic acid (cas: 156635-90-4) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.Formula: C14H15BO4

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Unravelling Some of the Key Transformations in the Hydrothermal Liquefaction of Lignin was written by Lui, Matthew Y.;Chan, Bun;Yuen, Alexander K. L.;Masters, Anthony F.;Montoya, Alejandro;Maschmeyer, Thomas. And the article was included in ChemSusChem in 2017.Related Products of 6972-61-8 This article mentions the following:

Using both exptl. and computational methods, focusing on intermediates and model compounds, some of the main features of the reaction mechanisms that operate during the hydrothermal processing of lignin were elucidated. Key reaction pathways and their connection to different structural features of lignin were proposed. Under neutral conditions, subcritical water was demonstrated to act as a bifunctional acid/base catalyst for the dissection of lignin structures. In a complex web of mutually dependent interactions, guaiacyl units within lignin were shown to significantly affect overall lignin reactivity. In the experiment, the researchers used many compounds, for example, 3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8Related Products of 6972-61-8).

3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. Ethyl ether is an excellent solvent for extractions and for a wide variety of chemical reactions. It is also used as a volatile starting fluid for diesel engines and gasoline engines in cold weather. Dimethyl ether is used as a spray propellant and refrigerant. Methyl t-butyl ether (MTBE) is a gasoline additive that boosts the octane number and reduces the amount of nitrogen-oxide pollutants in the exhaust. The ethers of ethylene glycol are used as solvents and plasticizers.Related Products of 6972-61-8

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

(2-Piperidine)- and (2-pyrrolidine)ethanones and -ethanols as inhibitors of blood platelets aggregation was written by Grisar, J. Martin;Claxton, George P.;Stewart, Kenneth T.;MacKenzie, Robert D.;Kariya, Takashi. And the article was included in Journal of Medicinal Chemistry in 1976.Quality Control of 1-(4-(4-Methoxyphenoxy)phenyl)ethanone This article mentions the following:

RMI 14133A [(E)-4-[4-(methylthio)phenyl]-1-(2-piperidinyl)-3-buten-2-one-HCl](I) [59999-96-1] inhibited ADP-induced aggregation of blood platelets. I was selected from a large series of (2-piperidinyl)- and (2-pyrrolidinyl)ethanones synthesized by a modified Schoepf reaction from enolate Mg salts of β-keto acids and 2,3,4,5-tetrahydropyridine trimer [27879-53-4] or 3,4-dihydro-2H-pyrrole trimer [54564-48-6], resp. Subacute toxicity evaluation in dogs and guinea pigs showed I to have an unfavorable therapeutic ratio. RMI 12436A [1-[4′-chloro(1,1′-biphenyl)-4-yl]-2-(2-piperidinyl)ethanone-HCl](II) [54916-69-7] lowered serum cholesterol [57-88-5] levels in rats with concurrent accumulation of (3β)-cholesta-5,7-dien-3-ol [434-16-2], suggesting inhibition of 7-dehydrocholesterol Δ7-reductase [9080-21-1]. In the experiment, the researchers used many compounds, for example, 1-(4-(4-Methoxyphenoxy)phenyl)ethanone (cas: 54916-28-8Quality Control of 1-(4-(4-Methoxyphenoxy)phenyl)ethanone).

1-(4-(4-Methoxyphenoxy)phenyl)ethanone (cas: 54916-28-8) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. Ethers can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Quality Control of 1-(4-(4-Methoxyphenoxy)phenyl)ethanone

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem