Tag: 200-300

Side-product in methylation of 2′,4”-O-bis (trimethylsilyl) erythromycin A 9-O-(1-isopropoxycyclohexyl) oxime was written by Liang, Jianhua;Yao, Guowei. And the article was included in Zhongguo Yaowu Huaxue Zazhi in 2006.Related Products of 1132-95-2 This article mentions the following:

A side-product of methylation was identified and the influence of the reaction condition on it was investigated. The side-product was E-2′-O-trimethylsilyl-6-O-methylerythromyein A 9-O-(1-isopropoxyeyelohexyl) oxime (1). Higher temperature, longer reaction time, the addition of triethylamine, and an excessive deproton reagent would lead to the increase of 1, whereas the order of adding methylating reagents followed by deproton reagents, an excessive methylating reagent, the mixture of tetrahydrofuran/dimethyl sulfoxide (THF/DMSO) and toluene/DMSO are detrimental to the production of 1. By optimizing the reaction condition, the yield of the methylation was 100.2% with 0.76% of 1. In the experiment, the researchers used many compounds, for example, 1,1-Diisopropoxycyclohexane (cas: 1132-95-2Related Products of 1132-95-2).

1,1-Diisopropoxycyclohexane (cas: 1132-95-2) belongs to ethers. The oxygen atom in ethers are more electronegative than carbon, thus the hydrogens which are alpha to the ethers are more acidic than the simple hydrocarbons. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.Related Products of 1132-95-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Aerobic oxyiodination of activated aromatics using HCl/NaNO₂/I₂ was written by Wang, Kaiyang;Wang, Xinliang;Zhang, Guofu;Liang, Xinmiao. And the article was included in Jingxi Huagong in 2009.HPLC of Formula: 75581-11-2 This article mentions the following:

Hydrochloric acid/NaNO₂, were the inexpensive and available catalyst system, which can be developed to cooperate exquisitely with I₂ in catalyzing the aerobic oxyiodination of arenes, aryl ethers and phenols to the corresponding aromatic iodides under mild conditions. Based on the systematic investigation of reaction conditions using anisole as model substrate, the optimal conditions showed that n(substrate):n(I₂):n(NaNO₂):n(HCl) = 1:0.515:0.05:0.1, while 1,2-dichlorethane (DCE) as solvent and O₂ as oxidant at 20°C. The newly developed catalyst system exhibited many advantages: 100% iodine atom economy, high efficiency, excellent selectivity and conversion and innocuous water as the only byproduct, environment-friendly and easily industrialized production Furthermore, the mechanism for the catalytic oxyiodination reaction was proposed in this paper. In the experiment, the researchers used many compounds, for example, 4-Iodo-1-methoxy-2-methylbenzene (cas: 75581-11-2HPLC of Formula: 75581-11-2).

4-Iodo-1-methoxy-2-methylbenzene (cas: 75581-11-2) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. But ether is more polar than alkenes. Electron-deficient reagents are also stabilized by ethers. For example, borane (BH3) is a useful reagent for making alcohols. Pure borane exists as its dimer, diborane (B2H6), a toxic gas that is inconvenient and hazardous to use. Borane forms stable complexes with ethers, however, and it is often supplied and used as its liquid complex with tetrahydrofuran (THF).HPLC of Formula: 75581-11-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

A highly Hg(II)-selective chemosensor with unique diarylethene fluorophore was written by Ji, Heesun;Kim, Jinho;Yoo, Jung Whan;Lee, Hyeong Seok;Park, Ki-Min;Kang, Youngjin. And the article was included in Bulletin of the Korean Chemical Society in 2010.Recommanded Product: 66943-05-3 This article mentions the following:

A systematic investigation into photophys. and coordinative properties to varied metal ions of 1,2-bis[9,9-diethyl-7-(1,4,7,10-tetraoxa-13-azacyclopentadecane)fluoren-2-yl]-3,3,4,4,5,5-hexafluorocyclopentene (L1) is reported. A novel fluorene and perfluorocyclopentene based ligand L1 with NO4 donor set was synthesized and was evaluated as fluorometric sensor for Ni²⁺, Ag⁺, Co²⁺, Zn²⁺, Cd²⁺, and Hg²⁺. This ligand exhibits enhanced fluorescence intensity upon addition of all metal ions through the CHEF effect and the formation of 1:2 complexes. In particular, ligand L1 was demonstrated highly selectivity and sensitivity for the Hg²⁺ ion due to the strong interactions between NO donor set and metal ion. In the experiment, the researchers used many compounds, for example, 1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3Recommanded Product: 66943-05-3).

1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. Electron-deficient reagents are also stabilized by ethers. For example, borane (BH3) is a useful reagent for making alcohols. Pure borane exists as its dimer, diborane (B2H6), a toxic gas that is inconvenient and hazardous to use. Borane forms stable complexes with ethers, however, and it is often supplied and used as its liquid complex with tetrahydrofuran (THF).Recommanded Product: 66943-05-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

A convenient method for the preparation of 4-aryloxyphenols was written by Yeager, Gary W.;Schissel, David N.. And the article was included in Synthesis in 1991.Formula: C15H14O3 This article mentions the following:

The treatment of p-RC₆H₄OH (R = H, Cl, Br, CMe₃, OMe, OPh, CO₂Et) with p-FC₆H₄COR¹ (I; R¹ = H, Me) in the presence of K₂CO₃ gave di-Ph ethers II. The Baeyer-Villiger oxidation of II followed by acid hydrolysis gave 4-aryloxyphenols III. Bisphenols IV (X = p-C₆H₄, 4,4′-C₆H₄OC₆H₄, 4,4′-biphenylene) were prepared similarly from HOXOH and I. In the experiment, the researchers used many compounds, for example, 1-(4-(4-Methoxyphenoxy)phenyl)ethanone (cas: 54916-28-8Formula: C15H14O3).

1-(4-(4-Methoxyphenoxy)phenyl)ethanone (cas: 54916-28-8) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.Formula: C15H14O3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Determination of fatty acids and volatile compounds in fruits of rosehip (Rosa L.) species by HS-SPME/GC-MS and Im-SPME/GC-MS techniques was written by Murathan, Zehra Tugba;Zarifikhosroshahi, Mozhgan;Kafkas, Nesibe Ebru. And the article was included in Turkish Journal of Agriculture and Forestry in 2016.COA of Formula: C11H12O4 This article mentions the following:

In this study, we aimed to compare fatty acid and volatile compound compositions of four rosehip species, namely Rosa pimpinellifolia, R. villosa, R. canina, and R. dumalis, by gas chromatog. with flame ionization detector (GC/FID) and headspace and immersion solid-phase microextraction gas chromatog.-mass spectrometry (HS-SPME/GC-MS and Im-SPME/GC-MS) techniques. The total lipid contents in fruits of the rosehip species varied from 5.83% (R. villosa) to 7.84% (R. dumalis). A total of 21 fatty acids were detected and quantified. In all species, except R. canina, polyunsaturated fatty acids (PUFAs) predominated over saturated fatty acids (SFAs) and monounsaturated fatty acids (MUFAs). Palmitic acid is the major SFA in R. villosa (5.50%), R. canina (8.27%), and R. dumalis (7.46%). Oleic acid is the most abundant MUFA, and linoleic and a-linolenic acids are the most abundant PUFAs. Sixtytwo volatile compounds were detected by the HS-SPME/GC-MS technique, and 54 volatile compounds were determined by the Im- SPME/GC-MS technique. Fifty-three volatile components of rosehips have been detected for the first time in this study. While 19 acids, 9 aldehydes, 6 ketones, 18 alcs., 5 esters, 2 terpenes, and 2 phenols were identified by HS-SPME/GC-MS, 20 acids, 5 aldehydes, 8 ketones, 13 alcs., 5 esters, 1 terpene, and 2 phenols were identified by Im-SPME/GC-MS. The HS-SPME/GC-MS technique allowed identification of a larger number of volatile compounds and thus is more efficient than the Im-SPME/GC-MS technique. In the experiment, the researchers used many compounds, for example, 3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8COA of Formula: C11H12O4).

3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.COA of Formula: C11H12O4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Thermodynamic Studies of Cation-Macrocycle Interactions in Nickel Pincer-Crown Ether Complexes Enable Switchable Ligation was written by Smith, Jacob B.;Kerr, Stewart H.;White, Peter S.;Miller, Alexander J. M.. And the article was included in Organometallics in 2017.Computed Properties of C10H21NO4 This article mentions the following:

The thermochem. of cation-macrocycle interactions in Ni pincer complexes bearing hemilabile aza-15-crown-5 or aza-18-crown-6 macrocycles was studied and applied to cation-controlled reversible ligand binding. Cation-crown interactions were examined in a noncoordinating, low polarity solvent (CH₂Cl₂) and a coordinating, polar solvent (acetonitrile). Structural studies provide solid-state information on cation-crown interactions, while binding affinity studies in solution provide quant. thermodn. information. The different hemilabile ligand coordination modes have vastly different cation binding affinities, with the tridentate pincer coordination mode binding cations >100,000 times more strongly than the tetradentate coordination mode with a crown ether O donating to Ni. CH₂Cl₂ enforces strong cation-crown interactions without disrupting the hemilabile ether ligand, whereas MeCN disrupts hemilability by displacing the ethers from the Ni center and supports weaker cation-crown interactions. In CH₂Cl₂, Li binding provides at least 7 kcal mol^-1 of stabilization to assist in ligand binding, and the extent of stabilization can be tuned by the choice of cation. The newfound thermodn. insight guided the development of in situ switchable ligand binding and release at Ni using cations. The Ni complex only binds pentafluorophenylnitrile upon addition of Li⁺ salts in CH₂Cl₂, and the nitrile ligand is readily released upon sequestration of the Li⁺ with 12-crown-4. In the experiment, the researchers used many compounds, for example, 1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3Computed Properties of C10H21NO4).

1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. Ethers can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Computed Properties of C10H21NO4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Highly selective detection of Hg²⁺ ion by push-pull-type purine nucleoside-based fluorescent sensor was written by Gao, Shao-Hua;Xie, Ming-Sheng;Wang, Hai-Xia;Niu, Hong-Ying;Qu, Gui-Rong;Guo, Hai-Ming. And the article was included in Tetrahedron in 2014.Recommanded Product: 66943-05-3 This article mentions the following:

Highly selective detection of Hg²⁺ ion was achieved using the push-pull-type purine nucleoside-based fluorescent sensor L1. The sensor L1 incorporating aza-18-crown-6 at C6 position of purine nucleoside, is highly sensitive and selective toward Hg²⁺ ion in CH₃CN-H₂O mixture (92/8, volume/volume). The detection limit for the fluorescent sensor L1 toward Hg²⁺ ion is 7.8 × 10^-8. In the experiment, the researchers used many compounds, for example, 1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3Recommanded Product: 66943-05-3).

1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3) belongs to ethers. The oxygen atom in ethers are more electronegative than carbon, thus the hydrogens which are alpha to the ethers are more acidic than the simple hydrocarbons. Ethyl ether is an excellent solvent for extractions and for a wide variety of chemical reactions. It is also used as a volatile starting fluid for diesel engines and gasoline engines in cold weather. Dimethyl ether is used as a spray propellant and refrigerant. Methyl t-butyl ether (MTBE) is a gasoline additive that boosts the octane number and reduces the amount of nitrogen-oxide pollutants in the exhaust. The ethers of ethylene glycol are used as solvents and plasticizers.Recommanded Product: 66943-05-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Study on reactivity of etherification protection for hydroxyl in erythromycin oxime was written by Liang, Jian-hua;Sun, Jing-guo;Deng, Zhi-hua;Yao, Guo-wei. And the article was included in Jingxi Huagong in 2003.HPLC of Formula: 1132-95-2 This article mentions the following:

Two kinds of etherification reagents, dialkyloxycyclohexanes ( II ) (1,1-dimethoxycyclohexane II a, 1,1-diethoxycyclohexane II b and 1,1-diisopropoxycyclohexane II c) and alkyloxycyclohexenes ( III ) (1-methoxycyclohexene III a, 1-ethoxycyclohexene III b and 1-isopropoxycyclohexene IIIc) were applied to the etherification protection of hydroxyl at the oxime group of erythromycin oxime ( I ). Exptl. results showed that the order of reactivity was IIc > IIb > IIa , IIIc > IIIb > IIIa, and IIIa > IIa, IIIb > IIb, IIIc > IIc. IIIc and IIIb have promising prospect for industrial application as compared with IIc which is used at present. Also the optimum conditions were given as follows: dichloromethane as solvent, n (pyridine hydrochloride)/n ( I ) = 1.5 – 2, n(II or III)/n ( I ) = 2 – 3, room temperature In the experiment, the researchers used many compounds, for example, 1,1-Diisopropoxycyclohexane (cas: 1132-95-2HPLC of Formula: 1132-95-2).

1,1-Diisopropoxycyclohexane (cas: 1132-95-2) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil. Electron-deficient reagents are also stabilized by ethers. For example, borane (BH3) is a useful reagent for making alcohols. Pure borane exists as its dimer, diborane (B2H6), a toxic gas that is inconvenient and hazardous to use. Borane forms stable complexes with ethers, however, and it is often supplied and used as its liquid complex with tetrahydrofuran (THF).HPLC of Formula: 1132-95-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Multigram preparation of 1,8-diethyl-7-hydroxy-1,3,4,9-tetrahydropyrano[3,4-b]indole-1-acetic acid, a phenolic metabolite of the analgesic and antiinflammatory agent etodolac was written by Soll, Richard M.;Guinosso, Charles;Asselin, Andre. And the article was included in Journal of Organic Chemistry in 1988.Name: N-(3-Methoxyphenyl)pivalamide This article mentions the following:

The title compound (I; R = OH), a phenolic human metabolite of the anti-inflammatory and analgesic agent etodolac (I; R = H), was prepared in 13 steps from 3-MeOC₆H₄NHCOCMe₃. The key step involves condensation of LiCH₂CO₂CMe₃ with isatin II to give 77% indoleacetate III. In the experiment, the researchers used many compounds, for example, N-(3-Methoxyphenyl)pivalamide (cas: 56619-93-3Name: N-(3-Methoxyphenyl)pivalamide).

N-(3-Methoxyphenyl)pivalamide (cas: 56619-93-3) belongs to ethers. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.Name: N-(3-Methoxyphenyl)pivalamide

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Design, Synthesis, and Evaluation of Enhanced DNA Binding New Lipopolythioureas was written by Leblond, Jeanne;Mignet, Nathalie;Leseurre, Lucie;Largeau, Celine;Bessodes, Michel;Scherman, Daniel;Herscovici, Jean. And the article was included in Bioconjugate Chemistry in 2006.Related Products of 60221-37-6 This article mentions the following:

Nonviral gene delivery is limited to a large extent by the cationic nature of most of the chem. vector. We have shown that lipopolythioureas interact with DNA. However, lipopolythioureas were not very efficient at transfecting cells, probably due to reduced interaction between the noncationic synthetic lipid and the cell membrane. Here, we report that liposomes made from a new thiourea lipid, DPPC, and a lipid bearing an RGD ligand allowed very efficient entry of the lipopolythioureas into integrin α_vβ₃ expressing cells. In addition, we show that a stable interaction between DNA and lipopolythiourea could be obtain with two thiourea groups. Moreover, the addition of a hydrophilic terminus improves the formulation of these new DNA binding agents. In the experiment, the researchers used many compounds, for example, 2-(2-(2-((Tetrahydro-2H-pyran-2-yl)oxy)ethoxy)ethoxy)ethan-1-ol (cas: 60221-37-6Related Products of 60221-37-6).

2-(2-(2-((Tetrahydro-2H-pyran-2-yl)oxy)ethoxy)ethoxy)ethan-1-ol (cas: 60221-37-6) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. But ether is more polar than alkenes. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.Related Products of 60221-37-6

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem