Tag: 200-300

Structure of a dihydroquinaldine dimer from electrolytic reduction was written by Elliott, I. W. Jr.;McCaskill, E. S.;Robertson, M. S.;Kirksey, C. H.. And the article was included in Tetrahedron Letters in 1962.Name: 3-(2,4-Dimethoxyphenyl)acrylic acid This article mentions the following:

Quinaldine in 10% alc. KOH reduced at a Hg cathode at 8 v. and current density 5.3 amp./sq. cm. for 4 hrs. at 15° (the cathode stirred magnetically and the anode compartment separated by a porous thimble) and the product isolated according to Levchenko (CA 43, 955g) gave I (a dihydroquinaldine dimer), C₂₀H₂₀N₂, m. 138-40°, mol. weight 330 (Rast); diperchlorate, C₂₀H₂₂Cl₂O₈.0.5 H₂O, m. 220-1°, spectra indicating enamine-iminium changes (Witkop, CA 50, 14595i). Details of infrared and nuclear magnetic resonance spectra, consistent with the given structure were tabulated. In the experiment, the researchers used many compounds, for example, 3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8Name: 3-(2,4-Dimethoxyphenyl)acrylic acid).

3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.Name: 3-(2,4-Dimethoxyphenyl)acrylic acid

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Influence of aza-15-crown-5 with nootropic activity on protein metabolism in various regions of rat brain and blood was written by Karaseva, T. L.;Zapenko, G. N.;Basok, S. S.;Kulygina, K. Yu.;Luk’yanenko, N. G.. And the article was included in Ukrainica Bioorganica Acta in 2010.Category: ethers-buliding-blocks This article mentions the following:

The influence of crown-ether (CE), possessing nootropic activity on the protein metabolism in various structures of mice brain and rats blood in comparison with piracetam were studied. It was found, that CE was able to increase the protein content, activate the synthesis of total protein and its fractions in different regions of brain. The distinct inclusion of ³H-leucine and ³⁵S-methionine in total content of blood proteins were found. In the experiment, the researchers used many compounds, for example, 1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3Category: ethers-buliding-blocks).

1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3) belongs to ethers. The oxygen atom in ethers are more electronegative than carbon, thus the hydrogens which are alpha to the ethers are more acidic than the simple hydrocarbons. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.Category: ethers-buliding-blocks

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthesis of the benzofuran analog of ILV, a new protein kinase C (PKC) activator was written by Kozikowski, Alan P.;Ma, Dawei;Du, Linh;Lewin, Nancy E.;Blumberg, Peter M.. And the article was included in Bioorganic & Medicinal Chemistry Letters in 1994.Computed Properties of C12H17NO2 This article mentions the following:

To probe the effect of small structural changes on the PKC activity of the natural product indolactam V (ILV), a synthesis of its benzofuran analog was developed. This compound was similar in its activity to ILV, exhibiting a K_i of 17.3 nM in the displacement of [³H]PDBU from PKCα. In the experiment, the researchers used many compounds, for example, N-(3-Methoxyphenyl)pivalamide (cas: 56619-93-3Computed Properties of C12H17NO2).

N-(3-Methoxyphenyl)pivalamide (cas: 56619-93-3) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.Computed Properties of C12H17NO2

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

A molecular gate based on a porphyrin and a silver lock was written by Guenet, Aurelie;Graf, Ernest;Kyritsakas, Nathalie;Allouche, Lionel;Hosseini, Mir Wais. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2007.Safety of 2-(2-(2-((Tetrahydro-2H-pyran-2-yl)oxy)ethoxy)ethoxy)ethan-1-ol This article mentions the following:

A Sn(IV) metallaporphyrin, bearing a 4-pyridyl group on one meso position and a handle equipped also with a pyridyl unit, functions in solution as a mol. gate in the presence of Ag cation. The complexation-decomplexation of Ag(I) corresponds to the opening and closing motions of the gate. The crystal structure of the Sn metallaporphyrin was determined In the experiment, the researchers used many compounds, for example, 2-(2-(2-((Tetrahydro-2H-pyran-2-yl)oxy)ethoxy)ethoxy)ethan-1-ol (cas: 60221-37-6Safety of 2-(2-(2-((Tetrahydro-2H-pyran-2-yl)oxy)ethoxy)ethoxy)ethan-1-ol).

2-(2-(2-((Tetrahydro-2H-pyran-2-yl)oxy)ethoxy)ethoxy)ethan-1-ol (cas: 60221-37-6) belongs to ethers. The oxygen atom in ethers are more electronegative than carbon, thus the hydrogens which are alpha to the ethers are more acidic than the simple hydrocarbons. Ethers can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Safety of 2-(2-(2-((Tetrahydro-2H-pyran-2-yl)oxy)ethoxy)ethoxy)ethan-1-ol

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

A Novel Ligand-free Manganese-catalyzed C-O Coupling Protocol for the Synthesis of Biaryl Ethers was written by Rohit, K. R.;Saranya, Salim;Harry, Nissy Ann;Anilkumar, Gopinathan. And the article was included in ChemistrySelect in 2019.Application of 54916-28-8 This article mentions the following:

Manganese catalyst was employed for the first time in the synthesis of biaryl ethers using various aryl alcs. and electron deficient aryl iodides as the coupling partners. This protocol does not require any ligand and employs relatively cheap, less toxic and easy to handle manganese chloride tetrahydrate as the metal catalyst. Aryl iodides having electron withdrawing groups provide a wide range of substrate scope for different phenols with moderate to excellent yields. In the experiment, the researchers used many compounds, for example, 1-(4-(4-Methoxyphenoxy)phenyl)ethanone (cas: 54916-28-8Application of 54916-28-8).

1-(4-(4-Methoxyphenoxy)phenyl)ethanone (cas: 54916-28-8) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. But ether is more polar than alkenes. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.Application of 54916-28-8

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

CuCl-catalyzed ortho trifluoromethylation of arenes and heteroarenes with a pivalamido directing group was written by Cai, Shangjun;Chen, Chao;Sun, Zelin;Xi, Chanjuan. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2013.Application In Synthesis of N-(3-Methoxyphenyl)pivalamide This article mentions the following:

The CuCl catalyzed direct trifluoromethylation of sp² C-H bonds has been realized, using the Togni reagent as the CF₃ source. This reaction achieves the goal of regio-selectively converting C-H into C-CF₃ with ecol. and readily available starting materials. In the experiment, the researchers used many compounds, for example, N-(3-Methoxyphenyl)pivalamide (cas: 56619-93-3Application In Synthesis of N-(3-Methoxyphenyl)pivalamide).

N-(3-Methoxyphenyl)pivalamide (cas: 56619-93-3) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. Ethers can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.Application In Synthesis of N-(3-Methoxyphenyl)pivalamide

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Structure-Reactivity Relationships on Substrates and Inhibitors of the Lysine Deacylase Sirtuin 2 from Schistosoma mansoni (SmSirt2) was written by Monaldi, Daria;Rotili, Dante;Lancelot, Julien;Marek, Martin;Woessner, Nathalie;Lucidi, Alessia;Tomaselli, Daniela;Ramos-Morales, Elizabeth;Romier, Christophe;Pierce, Raymond J.;Mai, Antonello;Jung, Manfred. And the article was included in Journal of Medicinal Chemistry in 2019.Application of 54916-28-8 This article mentions the following:

The only drug currently available for treatment of the neglected disease Schistosomiasis is Praziquantel, and the possible emergence of resistance makes research on novel therapeutic agents necessary and urgent. To this end, the targeting of Schistosoma mansoni epigenetic enzymes, which regulate the parasitic life cycle, emerged as a promising approach. Due to the strong effects of human sirtuin inhibitors on parasite survival and reproduction, Schistosoma sirtuins were postulated as potential therapeutic targets. In vitro testing of synthetic substrates of S. mansoni sirtuin 2 (SmSirt2) and kinetic experiments on a myristoylated peptide demonstrated lysine long-chain deacylation as an intrinsic SmSirt2 activity in addition to its known deacetylase activity for the first time. Focused in vitro screening of the GSK Kinetobox library and structure-activity relationships of identified hits led to the first SmSirt2 inhibitors with activity in the low micromolar range. Several SmSirt2 inhibitors showed potency against both larval schistosomes (viability) and adult worms (pairing, egg laying) in culture without general toxicity to human cancer cells. In the experiment, the researchers used many compounds, for example, 1-(4-(4-Methoxyphenoxy)phenyl)ethanone (cas: 54916-28-8Application of 54916-28-8).

1-(4-(4-Methoxyphenoxy)phenyl)ethanone (cas: 54916-28-8) belongs to ethers. Ether is less polar than esters, alcohols or amines because of the oxygen atom that is unable to participate in hydrogen bonding due to the presence of bulky alkyl groups on both sides of the oxygen atom. But ether is more polar than alkenes. The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom. Complexation of the magnesium atom stabilizes the Grignard reagent and helps to keep it in solution.Application of 54916-28-8

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Comparative analysis of the PET and ICT sensor properties of 1,8-naphthalimides containing aza-15-crown-5 ether moiety was written by Panchenko, Pavel A.;Fedorov, Yuri V.;Fedorova, Olga A.;Jonusauskas, Gediminas. And the article was included in Dyes and Pigments in 2013.Reference of 66943-05-3 This article mentions the following:

Novel 4-amino- and 4-(acetyl)amino-N-aryl-1,8-naphthalimides containing aza-15-crown-5 ether receptor unit in the N-aryl fragment and at C-4 of the naphthalimide residue were designed and prepared Significant internal charge transfer from electron donating amino or amido group at C-4 of the naphthalene ring to the acceptor carboxyimide moiety as well as photoinduced electron transfer between N-aryl receptor and the naphthalimide fragment was revealed by the UV/Vis absorption spectroscopy and considerable fluorescence quenching. The addition of calcium perchlorate to an acetonitrile solution of naphthalimides with the receptor at imide nitrogen hindered the photoinduced electron transfer process and accordingly restored the quenched fluorescence of the free ligands. In the case of the compound in which the aza-15-crown-5 receptor is located at C-4, the coordination with Ca²⁺ reduced the internal charge transfer interaction in the chromophore and caused a significant blue-shift of the absorption and emission peak. The observed spectral effects were analyzed using PM6 semiempirical calculations Formation of complexes was also confirmed by ¹H NMR spectroscopy. In the experiment, the researchers used many compounds, for example, 1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3Reference of 66943-05-3).

1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil. Electron-deficient reagents are also stabilized by ethers. For example, borane (BH3) is a useful reagent for making alcohols. Pure borane exists as its dimer, diborane (B2H6), a toxic gas that is inconvenient and hazardous to use. Borane forms stable complexes with ethers, however, and it is often supplied and used as its liquid complex with tetrahydrofuran (THF).Reference of 66943-05-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Rhodium-catalyzed oxidative coupling of N-acyl anilines with alkynes using an acylamino moiety as the traceless directing group was written by Geng, Kaijun;Fan, Zhoulong;Zhang, Ao. And the article was included in Organic Chemistry Frontiers in 2016.Application In Synthesis of N-(3-Methoxyphenyl)pivalamide This article mentions the following:

A rhodium-catalyzed oxidative annulation of N-acyl anilines with alkynes was developed by using the acylamino group as a traceless directing group for the first time. Various N-acyl anilines and para- or meta-substituted diphenylacetylenes were well tolerated, and a series of 1,2,3,4-tetrasubstituted naphthalenes were readily synthesized in good to excellent yields. Meanwhile, this method also provided a new strategy for the N-dearylation of N-phenylamides. In the experiment, the researchers used many compounds, for example, N-(3-Methoxyphenyl)pivalamide (cas: 56619-93-3Application In Synthesis of N-(3-Methoxyphenyl)pivalamide).

N-(3-Methoxyphenyl)pivalamide (cas: 56619-93-3) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil. Ethers feature bent C–O–C linkages. In dimethyl ether, the bond angle is 111° and C–O distances are 141 pm. The barrier to rotation about the C–O bonds is low. The bonding of oxygen in ethers, alcohols, and water is similar. In the language of valence bond theory, the hybridization at oxygen is sp3.Application In Synthesis of N-(3-Methoxyphenyl)pivalamide

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Methods for Preparing Metal Ion Photocages: Application to the Synthesis of CrownCast was written by Kennedy, Daniel P.;Gwizdala, Celina;Burdette, Shawn C.. And the article was included in Organic Letters in 2009.HPLC of Formula: 66943-05-3 This article mentions the following:

Three different synthetic strategies were utilized in the construction of a representative of a novel class of macrocyclic containing o-nitrobenzhydrol group II cation cages I (X = 1-aza-15-crown-5). The binding properties of I and its photoproduct II to several alk. earth metal cations have been studied. In the experiment, the researchers used many compounds, for example, 1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3HPLC of Formula: 66943-05-3).

1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom. Complexation of the magnesium atom stabilizes the Grignard reagent and helps to keep it in solution.HPLC of Formula: 66943-05-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem