Tag: 200-300

Separation and identification of cinnamic acids by TLC was written by Bobbio, Florinda O.;Bobbio, Paulo A.;De Souza, Sandra C.. And the article was included in Journal of Chemical Education in 1987.Electric Literature of C11H12O4 This article mentions the following:

The Et₂O solutions of several cinnamic acids were spotted on silica gel plates, and the developed plates were sprayed with a 2% FeCl₃ solution acidified with 2N HCl for colorimetric detection. The R_f values of the acids with eluents consisting of different mixtures of toluene-HOAc-EtOH are given. In the experiment, the researchers used many compounds, for example, 3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8Electric Literature of C11H12O4).

3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.Electric Literature of C11H12O4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Kinetic study of the oxidation of catechols in the presence of some aza-crown ethers by digital simulation of cyclic voltammograms was written by Nematollahi, Davood;Mohammadi-Behzad, Leila;Davarani, Saied Saeed Hossainy. And the article was included in Electroanalysis in 2009.Electric Literature of C10H21NO4 This article mentions the following:

The electrochem. oxidation of catechols (1) were studied in the presence of diaza-18-crown-6 (DA18C6) (3a), diaza-15-crown-5 (DA15C5) (3b), and aza-15-crown-5 (A15C5) (3c) as nucleophiles in aqueous solution, by cyclic voltammetry and controlled-potential coulometry. The results indicate the participation of electrochem. generated o-benzoquinones (2) in Michael-type reaction with aza-crown ethers (3) to form the corresponding new o-benzoquinone-aza-crown ether adducts (5). Based on ECE mechanism, the observed homogeneous rate constants (k_obs) of the reaction of o-bezoquinones (2) with aza-crown ethers (3) were estimated by comparing the exptl. cyclic voltammograms with the digital simulated results. The calculated observed homogeneous rate constants (k_obs) was found to vary in the order DA18C6 > DA15C5 > A15C5. In the experiment, the researchers used many compounds, for example, 1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3Electric Literature of C10H21NO4).

1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. The unique properties of ethers (i.e., that they are strongly polar, with nonbonding electron pairs but no hydroxyl group) enhance the formation and use of many reagents. For example, Grignard reagents cannot form unless an ether is present to share its lone pair of electrons with the magnesium atom. Complexation of the magnesium atom stabilizes the Grignard reagent and helps to keep it in solution.Electric Literature of C10H21NO4

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Modulating the Elementary Steps of Methanol Carbonylation by Bridging the Primary and Secondary Coordination Spheres was written by Gregor, Lauren C.;Grajeda, Javier;Kita, Matthew R.;White, Peter S.;Vetter, Andrew J.;Miller, Alexander J. M.. And the article was included in Organometallics in 2016.Recommanded Product: 66943-05-3 This article mentions the following:

Kinetics and mechanism of methanol carbonylation catalyzed by iridium NCP-pincer 3-(diisopropylphosphinooxy)benzylamine complexes with N-pendant 15-crown-5 moiety was studied in dependence on secondary coordination of Lewis acidic centers. The rate of catalytic methanol carbonylation to acetic acid is typically limited by either the oxidative addition of Me iodide or the subsequent C-C bond-forming migratory insertion step. These elementary steps have been studied independently in acetonitrile solution for iridium aminophenylphosphinite (NCOP) complexes. The modular synthesis of NCOP ligands containing a macrocyclic aza-crown ether arm enables a direct comparison of two complementary catalyst optimization strategies: synthetic modification of the Ph backbone and noncovalent modification through cation-crown interactions with Lewis acids in the surrounding environment. The oxidative addition of Me iodide to iridium(I) carbonyl complexes proceeds readily at room temperature to form iridium(III) methylcarbonyl iodide complexes. The Me complexes undergo migratory insertion under 1 atm CO at 70° to produce iridium(III) acetyl species. Synthetic tuning, by incorporation of a methoxy group into the ligand backbone, had little influence on the rate. The addition of lithium and lanthanum salts, in contrast, enhanced the rate of C-C bond formation up to 25-fold. In the case of neutral iodide complexes, mechanistic studies suggest that Lewis acidic cations act as halide abstractors. In halide-free, cationic iridium complexes, the cations bind the macrocyclic ligand arm, further activating the iridium(III) center. The macrocyclic ligand is essential to the observed reactivity: complexes supported by acyclic diethylamine-containing ligands underwent migratory insertion slowly, Lewis acid effects were negligible, and the acetyl products decomposed over time. In the experiment, the researchers used many compounds, for example, 1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3Recommanded Product: 66943-05-3).

1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3) belongs to ethers. The oxygen atom in ethers are more electronegative than carbon, thus the hydrogens which are alpha to the ethers are more acidic than the simple hydrocarbons. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.Recommanded Product: 66943-05-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Metabolism of N-acylated and O-alkylated drugs by intestinal microflora during anaerobic incubation in vitro was written by Smith, G. E.;Griffiths, L. A.. And the article was included in Xenobiotica in 1974.Quality Control of 3-(2,4-Dimethoxyphenyl)acrylic acid This article mentions the following:

Phenacetin [62-44-2] and derivatives of acetanilide were N-deacylated by rat cecal microflora, the deacylation of the latter being dependent on the nature and position of the substituents. Thus, p-alkylated or o-, m-, or p-hydroxylated derivatives were deacylated, whereas a p-aromatic or halide substituent or an aromatic acyl grouping prevented deacylation. A few O-alkylated compounds with a simple benzenoid structure were dealkylated by cecal microflora, but none of the N-alkylated drugs were dealkylated. In the experiment, the researchers used many compounds, for example, 3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8Quality Control of 3-(2,4-Dimethoxyphenyl)acrylic acid).

3-(2,4-Dimethoxyphenyl)acrylic acid (cas: 6972-61-8) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.Quality Control of 3-(2,4-Dimethoxyphenyl)acrylic acid

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Zinc and magnesium complexes supported by bulky multidentate amino-ether phenolate ligands: potent pre-catalysts for the immortal ring-opening polymerization of cyclic esters was written by Poirier, Valentin;Roisnel, Thierry;Carpentier, Jean-Francois;Sarazin, Yann. And the article was included in Dalton Transactions in 2011.COA of Formula: C10H21NO4 This article mentions the following:

A family of heteroleptic complexes of zinc and magnesium supported by bulky multidentate amino-ether phenolate ligands has been developed; in combination with external chain transfer agents, they constitute efficient binary catalytic systems for the immortal ring-opening polymerization of cyclic esters. In the experiment, the researchers used many compounds, for example, 1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3COA of Formula: C10H21NO4).

1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3) belongs to ethers. Of all the functional groups, ethers are the least reactive ones. Ether bonds are quite stable towards bases, oxidizing agents and reducing agents. But on the other hand, ethers undergo cleavage by reaction with acids. Electron-deficient reagents are also stabilized by ethers. For example, borane (BH3) is a useful reagent for making alcohols. Pure borane exists as its dimer, diborane (B2H6), a toxic gas that is inconvenient and hazardous to use. Borane forms stable complexes with ethers, however, and it is often supplied and used as its liquid complex with tetrahydrofuran (THF).COA of Formula: C10H21NO4

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Boosting the triplet activity of heavy-atom-free difluoroboron dibenzoylmethane via sp³ oxygen-bridged electron donors was written by Huang, Wenhuan;Zhang, Xuepeng;Chen, Biao;Miao, Hui;Trindle, Carl O.;Wang, Yucai;Luo, Yi;Zhang, Guoqing. And the article was included in Chemical Communications (Cambridge, United Kingdom) in 2019.HPLC of Formula: 54916-28-8 This article mentions the following:

Purely organic phosphors have important applications in imaging, sensing, informatics and illumination. Methoxy-substituted difluoroboron dibenzoylmethane (BF₂dbm) complexes exhibit intense fluorescence with an almost unity quantum yield. Here, we show that by simply introducing an sp³ oxygen-bridged methoxylphenyl group as a pendant to BF₂dbm, the boron complex exhibits a triplet quantum yield of 0.16, a more than 100-fold increase compared to that of BF₂dbm. In the experiment, the researchers used many compounds, for example, 1-(4-(4-Methoxyphenoxy)phenyl)ethanone (cas: 54916-28-8HPLC of Formula: 54916-28-8).

1-(4-(4-Methoxyphenoxy)phenyl)ethanone (cas: 54916-28-8) belongs to ethers. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides. At room temperature, ethers are pleasant-smelling colourless liquids. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil.HPLC of Formula: 54916-28-8

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Unveiling the nature of supramolecular crown ether-C₆₀ interactions was written by Moreira, Luis;Calbo, Joaquin;Krick Calderon, Rafael M.;Santos, Jose;Illescas, Beatriz M.;Arago, Juan;Nierengarten, Jean-Francois;Guldi, Dirk M.;Orti, Enrique;Martin, Nazario. And the article was included in Chemical Science in 2015.Category: ethers-buliding-blocks This article mentions the following:

A series of exTTF-(crown ether)₂ receptors, designed to host C₆₀, has been prepared The size of the crown ether and the nature of the heteroatoms have been systematically changed to fine tune the association constants Electrochem. measurements and transient absorption spectroscopy assisted in corroborating charge transfer in the ground state and in the excited state, leading to the formation of radical ion pairs featuring lifetimes in the range from 12 to 21 ps. To rationalize the nature of the exTTF-(crown ether)₂·C₆₀ stabilizing interactions, theor. calculations have been carried out, suggesting a synergetic interplay of donor-acceptor, π-π, n-π and CH···π interactions, which is the basis for the affinity of our novel receptors towards C₆₀. In the experiment, the researchers used many compounds, for example, 1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3Category: ethers-buliding-blocks).

1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides.Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Study on synthetic process of 4-bromine-2,6-difluorine-trifluorinemethoxybenzene was written by Qi, Su-zhong;Shi, Jun-jie;Chen, Ya-peng;Li, Jing. And the article was included in Meitan Yu Huagong in 2013.Application In Synthesis of 4-Bromo-2,6-difluoroanisole This article mentions the following:

A synthetic method of 4-bromine-2,6-difluorine-trifluorinemethoxybenzene was provided using 3,4,5-trifluorinebromobenzene as raw material through substitution reaction, dealkylation reaction, trifluoromethylation reaction, and finally the target product 4-bromine-2,6-difluoro-trifluoromethoxybenzene was gotten. This method had the characteristics which were the synthetic process was simplified, synthetic technol. was reasonable, synthetic steps were shorter, the yield of target product was high, the cost was low, the synthetic process was conductive to large-scale industrial production etc. Therefore, the synthesis method was suitable for large scale preparation of target compounds In the experiment, the researchers used many compounds, for example, 4-Bromo-2,6-difluoroanisole (cas: 104197-14-0Application In Synthesis of 4-Bromo-2,6-difluoroanisole).

4-Bromo-2,6-difluoroanisole (cas: 104197-14-0) belongs to ethers. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.Application In Synthesis of 4-Bromo-2,6-difluoroanisole

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Non-Covalent Immobilization of Rare Earth Heterobimetallic Frameworks and their Reactivity in an Asymmetric Michael Addition was written by Robinson, Jerome R.;Yadav, Jagjit;Fan, Xinyuan;Stanton, Gretchen R.;Schelter, Eric J.;Pericas, Miquel A.;Walsh, Patrick J.. And the article was included in Advanced Synthesis & Catalysis in 2014.SDS of cas: 66943-05-3 This article mentions the following:

Nonracemic rare earth binaphthalenediolate sodium complexes were immobilized on Merrifield resin by complexation with pyridinyl, amino, cyclen-, and aza-crown-functionalized Merrifield resins; the supported complexes were tried as recyclable catalysts for the enantioselective Michael addition of dibenzyl malonate to 2-cyclohexen-1-one. In the experiment, the researchers used many compounds, for example, 1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3SDS of cas: 66943-05-3).

1,4,7,10-Tetraoxa-13-azacyclopentadecane (cas: 66943-05-3) belongs to ethers. Ethers are good solvents partly because they are not very reactive. Most ethers can be cleaved, however, by hydrobromic acid (HBr) to give alkyl bromides or by hydroiodic acid (HI) to give alkyl iodides. Ethers can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.SDS of cas: 66943-05-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Salicylic Acid Derivatives Inhibit Oxalate Production in Mouse Hepatocytes with Primary Hyperoxaluria Type 1 was written by Moya-Garzon, Maria Dolores;Martin Higueras, Cristina;Penalver, Pablo;Romera, Manuela;Fernandes, Miguel X.;Franco-Montalban, Francisco;Gomez-Vidal, Jose A.;Salido, Eduardo;Diaz-Gavilan, Monica. And the article was included in Journal of Medicinal Chemistry in 2018.HPLC of Formula: 156635-90-4 This article mentions the following:

Primary hyperoxaluria type 1 (PH1) is a rare life-threatening genetic disease related to glyoxylate metabolism and characterized by accumulation of calcium oxalate crystals. Current therapies involve hepatic and/or renal transplantation, procedures that have significant morbidity and mortality and require long-term immunosuppression. Thus, a pharmacol. treatment is urgently needed. We introduce here an unprecedented activity of salicylic acid derivatives as agents capable of decreasing oxalate output in hyperoxaluric hepatocytes at the low micromolar range, which means a potential use in the treatment of PH1. Though correlation of this phenotypic activity with glycolate oxidase (GO) inhibition is still to be verified, most of the salicylic acids described here are GO inhibitors with IC₅₀ values down to 3 μM. Binding mode of salicylic acids inside GO has been studied using in silico methods, and preliminary structure-activity relationships have been established. The drug-like structure and ease of synthesis of our compounds make them promising hits for structural optimization. In the experiment, the researchers used many compounds, for example, (4-((4-Methoxybenzyl)oxy)phenyl)boronic acid (cas: 156635-90-4HPLC of Formula: 156635-90-4).

(4-((4-Methoxybenzyl)oxy)phenyl)boronic acid (cas: 156635-90-4) belongs to ethers. Relative to alcohols, ethers are generally less dense, are less soluble in water, and have lower boiling points. They are relatively unreactive, and as a result they are useful as solvents for fats, oils, waxes, perfumes, resins, dyes, gums, and hydrocarbons. Vapours of certain ethers are used as insecticides, miticides, and fumigants for soil. Autoxidation is the spontaneous oxidation of a compound in air. In the presence of oxygen, ethers slowly autoxidize to form hydroperoxides and dialkyl peroxides. If concentrated or heated, these peroxides may explode. To prevent such explosions, ethers should be obtained in small quantities, kept in tightly sealed containers, and used promptly.HPLC of Formula: 156635-90-4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem