Tag: 200-300

Constructing chiral bicyclo[3.2.1]octanes via palladium-catalyzed asymmetric tandem Heck/carbonylation desymmetrization of cyclopentenes was written by Yuan, Zhenbo;Zeng, Yuye;Feng, Ziwen;Guan, Zhe;Lin, Aijun;Yao, Hequan. And the article was included in Nature Communications in 2020.Related Products of 103-16-2 The following contents are mentioned in the article:

A palladium-catalyzed asym. tandem Heck/carbonylation desymmetrization of cyclopentenes I (R = COMe, CO₂Et; R¹ = H, F, Cl, Me, OMe; X = I, Br) has been described. Alcs., (such as., n-propanol, isopropanol, cyclohexanol, etc.) phenols (such as., 4-methylphenol, biphenyl-4-ol, naphthol, etc.) and amines (such as., pyrrolidine, morpholine, benzylamine, etc.) are employed as versatile coupling reagents for the construction of multifunctional chiral bicyclo[3.2.1]octanes II (R² = OMe, OEt, OPh, pyrrolidino, morpholino, thiomorpholino, etc.) with one all-carbon quaternary and two tertiary carbon stereogenic centers in high diastereo- and enantioselectivities. This study represents an important progress in both the asym. tandem Heck/carbonylation reactions and enantioselective difunctionalization of internal alkenes. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Related Products of 103-16-2).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Related Products of 103-16-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Stereospecific Cross Couplings To Set Benzylic, All-Carbon Quaternary Stereocenters in High Enantiopurity was written by Zhou, Qi;Cobb, Kelsey M.;Tan, Tianyu;Watson, Mary P.. And the article was included in Journal of the American Chemical Society in 2016.Reference of 1003858-50-1 The following contents are mentioned in the article:

Asym. preparation of all-carbon quaternary stereocenters is an important goal. Despite advances in formation of highly enantioenriched products with quaternary stereocenters proximal to a functional group, methods to install quaternary stereocenters isolated from functional groups are limited. Transition metal catalysis offers a potential solution, but prior cross couplings are limited to allylic substrates or deliver little to no enantiomeric enrichment. We report a stereospecific, nickel-catalyzed Suzuki-Miyaura arylation of tertiary benzylic acetates to deliver products with diaryl and triaryl quaternary stereocenters in high yields and ee’s. This reaction employs an inexpensive, air-stable Ni(II) salt and com. available phosphine ligand to transform tertiary alc. derivatives, which are easily available in exceptional ee, into valuable products with stereoretention. This study involved multiple reactions and reactants, such as 2-(3-Methoxyphenyl)-5,5-dimethyl-1,3,2-dioxaborinane (cas: 1003858-50-1Reference of 1003858-50-1).

2-(3-Methoxyphenyl)-5,5-dimethyl-1,3,2-dioxaborinane (cas: 1003858-50-1) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Reference of 1003858-50-1

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Beyond Directed Ortho Metalation: Ruthenium-Catalyzed Amide-Directed C_Ar-N Activation/C-C Coupling Reaction of Anthranilamides with Organoboronates was written by Zhao, Yigang;Snieckus, Victor. And the article was included in Organic Letters in 2014.Electric Literature of C12H17BO3 The following contents are mentioned in the article:

A new, catalytic, and general methodol. for the synthesis of biaryls and heterobiaryls by the cross coupling of anthranilamide derivatives (o-NMe₂ benzamides) with aryl boroneopentylates is described. The reaction proceeds under catalytic RuH₂(CO)(PPh₃)₃ conditions driven by the activation of the unreactive C-N bond by amide directing group (DG)-Ru catalyst chelation. E.g., in presence of RuH₂(CO)(PPh₃)₃ in toluene, reaction of aryl boroneopentylate (I) with 2-Me₂NC₆H₄CONEt₂ gave 99% biaryl derivative (II). High regioselectivity, orthogonality with the Suzuki-Miyaura reaction, operational simplicity, and convenient scale-up are features of these reactions which may lend themselves to industrial applications. This study involved multiple reactions and reactants, such as 2-(3-Methoxyphenyl)-5,5-dimethyl-1,3,2-dioxaborinane (cas: 1003858-50-1Electric Literature of C12H17BO3).

2-(3-Methoxyphenyl)-5,5-dimethyl-1,3,2-dioxaborinane (cas: 1003858-50-1) belongs to ethers. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Electric Literature of C12H17BO3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Access to Unexplored 3D Chemical Space: cis-Selective Arene Hydrogenation for the Synthesis of Saturated Cyclic Boronic Acids was written by Kaithal, Akash;Wagener, Tobias;Bellotti, Peter;Daniliuc, Constantin G.;Schlichter, Lisa;Glorius, Frank. And the article was included in Angewandte Chemie, International Edition in 2022.Product Details of 1132669-90-9 The following contents are mentioned in the article:

A new class of saturated boron-incorporated cyclic mols. has been synthesized employing an arene-hydrogenation methodol. Cis-Selective hydrogenation of easily accessible, and biol. important mols. comprising benzoxaborole, benzoxaborinin, and benzoxaboripin derivatives is reported. Among the various catalysts tested, rhodium cyclic(alkyl)(amino)carbene [Rh-CAAC] (1) pre-catalyst revealed the best hydrogenation activity confirming turnover number up to 1400 with good to high diastereoselectivity. A broad range of functional groups was tolerated including sensitive substituents such as -F, -CF₃, and -silyl groups. The utility of the synthesized products was demonstrated by the recognition of diols and sugars under physiol. conditions. These motifs can have a substantial importance in medicinal chem. as they possess a three-dimensional structure, are highly stable, soluble in water, form hydrogen bonds, and interact with diols and sugars. This study involved multiple reactions and reactants, such as 5-Methoxy-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde (cas: 1132669-90-9Product Details of 1132669-90-9).

5-Methoxy-2-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)benzaldehyde (cas: 1132669-90-9) belongs to ethers. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Product Details of 1132669-90-9

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

δ-Carbolines and their ring-opened analogs: Synthesis and evaluation against fungal and bacterial opportunistic pathogens was written by Mazu, Tryphon K.;Etukala, Jagan R.;Jacob, Melissa R.;Khan, Shabana I.;Walker, Larry A.;Ablordeppey, Seth Y.. And the article was included in European Journal of Medicinal Chemistry in 2011.Quality Control of N-(4-Methoxyphenyl)pyridin-3-amine The following contents are mentioned in the article:

Previous studies have indicated that the δ-carboline ring system derived from the natural product cryptolepine may represent a pharmacophore for anti-infective activity. The design and synthesis of a small library of substituted δ-carbolines and the evaluation of their antifungal and antibacterial activities is reported. An evaluation of the antibacterial activity of a previously reported library of ring-opened analogs was also conducted to provide an opportunity to test the hypothesis that both group of compounds may have the same biol. target. Results indicate that against a selected group of fungal pathogens, substituted δ-carbolinium analogs displayed higher potency and several fold lower cytotoxicity than cryptolepine the parent natural product. Both the δ-carbolinium compounds and their ring-opened analogs, exhibited equally high antibacterial activity against the selected pathogens and especially against the gram pos. bacteria evaluated. This study involved multiple reactions and reactants, such as N-(4-Methoxyphenyl)pyridin-3-amine (cas: 562085-85-2Quality Control of N-(4-Methoxyphenyl)pyridin-3-amine).

N-(4-Methoxyphenyl)pyridin-3-amine (cas: 562085-85-2) belongs to ethers. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Quality Control of N-(4-Methoxyphenyl)pyridin-3-amine

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Photoconductive bent-core liquid crystalline radicals with a paramagnetic polar switchable phase was written by Shivakumar, Kilingaru I.;Pociecha, Damian;Szczytko, Jacek;Kapuscinski, Szymon;Monobe, Hirosato;Kaszynski, Piotr. And the article was included in Journal of Materials Chemistry in 2020.Related Products of 103-16-2 The following contents are mentioned in the article:

A series of self-organizing bent-core derivatives 1[12,n] (I; n = 10, 12, 14, 16) containing a highly π-delocalized stable radical as the central angular structural element, is described. The planarity of the open-shell core permits efficient π-π stacking, which results in the formation of B2 and soft crystalline phases above 100°C. Optical, XRD and dielec. analyses of 1[12,12] indicate that the ground state of the observed B2 phase is polar antiferroelec. of type SmC_AP_A exhibiting tristable electro-optical switching. SQUID and EPR measurements revealed strong antiferromagnetic spin-spin exchange interactions below the isotropic phase, which have been estimated at θ = -46 cm^-1 with the Curie-Weiss law. Transient photoconductivity was observed in the B2 phase with a hole carrier mobility μ_h of 1.4 × 10^-4 cm² V^-1 s^-1. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Related Products of 103-16-2).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Related Products of 103-16-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Photoconductive bent-core liquid crystalline radicals with a paramagnetic polar switchable phase was written by Shivakumar, Kilingaru I.;Pociecha, Damian;Szczytko, Jacek;Kapuscinski, Szymon;Monobe, Hirosato;Kaszynski, Piotr. And the article was included in Journal of Materials Chemistry in 2020.Product Details of 103-16-2 The following contents are mentioned in the article:

A series of self-organizing bent-core derivatives 1[12,n] (I; n = 10, 12, 14, 16) containing a highly π-delocalized stable radical as the central angular structural element, is described. The planarity of the open-shell core permits efficient π-π stacking, which results in the formation of B2 and soft crystalline phases above 100°C. Optical, XRD and dielec. analyses of 1[12,12] indicate that the ground state of the observed B2 phase is polar antiferroelec. of type SmC_AP_A exhibiting tristable electro-optical switching. SQUID and EPR measurements revealed strong antiferromagnetic spin-spin exchange interactions below the isotropic phase, which have been estimated at θ = -46 cm^-1 with the Curie-Weiss law. Transient photoconductivity was observed in the B2 phase with a hole carrier mobility μ_h of 1.4 × 10^-4 cm² V^-1 s^-1. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Product Details of 103-16-2).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Product Details of 103-16-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthesis and activity of BNF15 against drug-resistant Mycobacterium tuberculosis was written by Mahmud, Hafij Al;Seo, Hoonhee;Kim, Sukyung;Islam, Imtiazul Md;Sultana, Omme Fatema;Nam, Kung-Woo;Lee, Byung-Eui;Sadu, Venkata S.;Lee, Kee-In;Song, Ho-Yeon. And the article was included in Future Medicinal Chemistry in 2021.Synthetic Route of C13H12O2 The following contents are mentioned in the article:

Tuberculosis is the leading cause of mortality among infectious diseases worldwide. Finding a new competent anti tubercular therapy is essential. We screened thousands of compounds and evaluated their efficacy against Mycobacterium tuberculosis. Initially, 2- nitronaphtho[2,3-b]benzofuran-6,11-dione was active against M. tuberculosis. Next, among 15 newly synthesized derivatives, BNF15 showed promising effect against all drug-sensitive and drug-resistant M. tuberculosis (MIC: 0.02-0.78 μg/mL). BNF15 effectively killed intracellular M. tuberculosis and nontuberculous mycobacteria. BNF15 exhibited a prolonged post antibiotic effect superior to isoniazid, streptomycin, and ethambutol and synergistic interaction with rifampicin. In acute oral toxicity test, BNF15 did not show toxic effect at a concentration up to 2000 mg/kg. These results highlight the perspective of BNF15 to treat drug-resistant M. tuberculosis. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Synthetic Route of C13H12O2).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Synthetic Route of C13H12O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthesis and activity of BNF15 against drug-resistant Mycobacterium tuberculosis was written by Mahmud, Hafij Al;Seo, Hoonhee;Kim, Sukyung;Islam, Imtiazul Md;Sultana, Omme Fatema;Nam, Kung-Woo;Lee, Byung-Eui;Sadu, Venkata S.;Lee, Kee-In;Song, Ho-Yeon. And the article was included in Future Medicinal Chemistry in 2021.Name: 4-Benzyloxyphenol The following contents are mentioned in the article:

Tuberculosis is the leading cause of mortality among infectious diseases worldwide. Finding a new competent anti tubercular therapy is essential. We screened thousands of compounds and evaluated their efficacy against Mycobacterium tuberculosis. Initially, 2- nitronaphtho[2,3-b]benzofuran-6,11-dione was active against M. tuberculosis. Next, among 15 newly synthesized derivatives, BNF15 showed promising effect against all drug-sensitive and drug-resistant M. tuberculosis (MIC: 0.02-0.78 μg/mL). BNF15 effectively killed intracellular M. tuberculosis and nontuberculous mycobacteria. BNF15 exhibited a prolonged post antibiotic effect superior to isoniazid, streptomycin, and ethambutol and synergistic interaction with rifampicin. In acute oral toxicity test, BNF15 did not show toxic effect at a concentration up to 2000 mg/kg. These results highlight the perspective of BNF15 to treat drug-resistant M. tuberculosis. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Name: 4-Benzyloxyphenol).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Name: 4-Benzyloxyphenol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Cobalt-Catalyzed C(sp²)-C(sp³) Suzuki-Miyaura Cross-Coupling Enabled by Well-Defined Precatalysts with L,X-Type Ligands was written by Mills, L. Reginald;Gygi, David;Ludwig, Jacob R.;Simmons, Eric M.;Wisniewski, Steven R.;Kim, Junho;Chirik, Paul J.. And the article was included in ACS Catalysis in 2022.Category: ethers-buliding-blocks The following contents are mentioned in the article:

Cobalt(II) halides in combination with phenoxyimine (FI) ligands generated efficient precatalysts in situ for the C(sp²)-C(sp³) Suzuki-Miyaura cross-coupling between alkyl bromides and neopentylglycol (hetero)arylboronic esters. The protocol enabled efficient C-C bond formation with a host of nucleophiles and electrophiles (36 examples, 34-95%) with precatalyst loadings of 5 mol %. Studies with alkyl halide electrophiles that function as radical clocks support the intermediacy of alkyl radicals during the course of the catalytic reaction. The improved performance of the FI-cobalt catalyst was correlated with decreased lifetimes of cage-escaped radicals as compared to those of diamine-type ligands. Studies of the phenoxy(imine)-cobalt coordination chem. validate the L,X interaction leading to the discovery of an optimal, well-defined, air-stable mono-FI-cobalt(II) precatalyst structure. This study involved multiple reactions and reactants, such as 2-(3-Methoxyphenyl)-5,5-dimethyl-1,3,2-dioxaborinane (cas: 1003858-50-1Category: ethers-buliding-blocks).

2-(3-Methoxyphenyl)-5,5-dimethyl-1,3,2-dioxaborinane (cas: 1003858-50-1) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem