Tag: 200-300

Gold-Catalyzed Oxidative Biaryl Cross-Coupling of Organometallics was written by Liu, Kai;Li, Nian;Ning, Yunyun;Zhu, Chengjian;Xie, Jin. And the article was included in Chem in 2019.Application In Synthesis of 2-(3-Methoxyphenyl)-5,5-dimethyl-1,3,2-dioxaborinane The following contents are mentioned in the article:

A general dimeric gold-catalyzed oxidative cross-coupling of arylboronates ArB(-OCH₂C(CH₃)₂CH₂O-) (Ar = 3-methoxyphenyl, naphthalen-2-yl, 8-thiatricyclo[7.4.0.0(2,7)]trideca-1(13),2(7),3,5,9,11-hexaen-6-yl, etc.) and arylsilanes Ar¹Si(CH₃)₃ (Ar¹ = 4-iodophenyl, 4-(trifluoromethanesulfonyloxy)phenyl, 2,3-dimethylphenyl, etc.) without an external base for the synthesis, with excellent functional-group tolerance of asym. biaryls ArAr¹ was reported. Both coupling partners are readily available, bench-stable, and non-toxic. A broad array of (pseudo)halogenated and borylated coupling partners can be successfully applied to this site-specific biaryl coupling with unprecedented versatility. Its synthetic value has been substantiated by concise preparation of several π-conjugated organic materials and pharmacophores. This study involved multiple reactions and reactants, such as 2-(3-Methoxyphenyl)-5,5-dimethyl-1,3,2-dioxaborinane (cas: 1003858-50-1Application In Synthesis of 2-(3-Methoxyphenyl)-5,5-dimethyl-1,3,2-dioxaborinane).

2-(3-Methoxyphenyl)-5,5-dimethyl-1,3,2-dioxaborinane (cas: 1003858-50-1) belongs to ethers. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Application In Synthesis of 2-(3-Methoxyphenyl)-5,5-dimethyl-1,3,2-dioxaborinane

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Boric Acid as a Novel Homogeneous Catalyst Coupled with Ru/C for Hydrodeoxygenation of Phenolic Compounds and Raw Lignin Oil was written by Luo, Bowen;Li, Rongxuan;Shu, Riyang;Wang, Chao;Zhang, Jingtao;Chen, Ying. And the article was included in Industrial & Engineering Chemistry Research in 2020.HPLC of Formula: 103-16-2 The following contents are mentioned in the article:

Simple and efficient catalytic routes have been explored to upgrade the raw lignin oil. Though homogeneous catalysis is easy to operate and possesses a high reaction rate, it also suffers from the difficulty of product separation In this work, we used H₃BO₃ as a novel homogeneous catalyst coupled with Ru/C to overcome the separation problem and carry out the hydrodeoxygenation (HDO) of phenolic compounds and raw lignin oil. H₃BO₃ showed an outstanding performance over the liquid organic and mineral acids, with a good catalyst recyclability. Phenolic model compounds including monomers and dimers can be efficiently converted into cycloalkanes with yields close to 100%. Moreover, the raw lignin oil also had a good HDO result by using this bifunctional catalyst (H₃BO₃ and Ru/C). The content of hydrocarbons increased from 7.9% to 93.1% at 260°C, which promoted the upgraded lignin oil capable to be used as fuel directly. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2HPLC of Formula: 103-16-2).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.HPLC of Formula: 103-16-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Boric Acid as a Novel Homogeneous Catalyst Coupled with Ru/C for Hydrodeoxygenation of Phenolic Compounds and Raw Lignin Oil was written by Luo, Bowen;Li, Rongxuan;Shu, Riyang;Wang, Chao;Zhang, Jingtao;Chen, Ying. And the article was included in Industrial & Engineering Chemistry Research in 2020.Application of 103-16-2 The following contents are mentioned in the article:

Simple and efficient catalytic routes have been explored to upgrade the raw lignin oil. Though homogeneous catalysis is easy to operate and possesses a high reaction rate, it also suffers from the difficulty of product separation In this work, we used H₃BO₃ as a novel homogeneous catalyst coupled with Ru/C to overcome the separation problem and carry out the hydrodeoxygenation (HDO) of phenolic compounds and raw lignin oil. H₃BO₃ showed an outstanding performance over the liquid organic and mineral acids, with a good catalyst recyclability. Phenolic model compounds including monomers and dimers can be efficiently converted into cycloalkanes with yields close to 100%. Moreover, the raw lignin oil also had a good HDO result by using this bifunctional catalyst (H₃BO₃ and Ru/C). The content of hydrocarbons increased from 7.9% to 93.1% at 260°C, which promoted the upgraded lignin oil capable to be used as fuel directly. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Application of 103-16-2).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Application of 103-16-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Discovery of 5-bromo-4-phenoxy-N-phenylpyrimidin-2-amine derivatives as novel ULK1 inhibitors that block autophagy and induce apoptosis in non-small cell lung cancer was written by Sun, Dejuan;Yang, Zijian;Zhen, Yongqi;Yang, Yushang;Chen, Yanmei;Yuan, Yong;Zhang, Lan;Zeng, Xiaoxi;Chen, Lixia. And the article was included in European Journal of Medicinal Chemistry in 2020.Recommanded Product: 4-Benzyloxyphenol The following contents are mentioned in the article:

5-Bromo-4-phenoxy-N-phenylpyrimidin-2-amine derivatives were synthesized and evaluated as ULK1 inhibitors in non-small cell lung cancer. Among all the obtained ULK1 inhibitors, 5-bromo-4-(2-fluoro-4-nitrophenoxy)-N-(3,4,5-trimethoxyphenyl) pyrimidin-2-amine, was the most active one. The docking anal. was conducted to compare 5-bromo-4-(2-fluoro-4-nitrophenoxy)-N-(3,4,5-trimethoxyphenyl) pyrimidin-2-amine and SBI-0206965, which further elucidated the roles of the H-bond donor. This compound inhibited the proliferation of A549 cells and showed strong inhibitory activity against ULK1 kinase. Moreover, we found that 5-bromo-4-(2-fluoro-4-nitrophenoxy)-N-(3,4,5-trimethoxyphenyl) pyrimidin-2-amine could induce apoptosis while simultaneously blocking autophagy. Collectively, these findings shed new light on 5-bromo-4-(2-fluoro-4-nitrophenoxy)-N-(3,4,5-trimethoxyphenyl) pyrimidin-2-amine that would be utilized as a promising candidate drug for the future NSCLC therapy. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Recommanded Product: 4-Benzyloxyphenol).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Recommanded Product: 4-Benzyloxyphenol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Discovery of 5-bromo-4-phenoxy-N-phenylpyrimidin-2-amine derivatives as novel ULK1 inhibitors that block autophagy and induce apoptosis in non-small cell lung cancer was written by Sun, Dejuan;Yang, Zijian;Zhen, Yongqi;Yang, Yushang;Chen, Yanmei;Yuan, Yong;Zhang, Lan;Zeng, Xiaoxi;Chen, Lixia. And the article was included in European Journal of Medicinal Chemistry in 2020.Recommanded Product: 4-Benzyloxyphenol The following contents are mentioned in the article:

5-Bromo-4-phenoxy-N-phenylpyrimidin-2-amine derivatives were synthesized and evaluated as ULK1 inhibitors in non-small cell lung cancer. Among all the obtained ULK1 inhibitors, 5-bromo-4-(2-fluoro-4-nitrophenoxy)-N-(3,4,5-trimethoxyphenyl) pyrimidin-2-amine, was the most active one. The docking anal. was conducted to compare 5-bromo-4-(2-fluoro-4-nitrophenoxy)-N-(3,4,5-trimethoxyphenyl) pyrimidin-2-amine and SBI-0206965, which further elucidated the roles of the H-bond donor. This compound inhibited the proliferation of A549 cells and showed strong inhibitory activity against ULK1 kinase. Moreover, we found that 5-bromo-4-(2-fluoro-4-nitrophenoxy)-N-(3,4,5-trimethoxyphenyl) pyrimidin-2-amine could induce apoptosis while simultaneously blocking autophagy. Collectively, these findings shed new light on 5-bromo-4-(2-fluoro-4-nitrophenoxy)-N-(3,4,5-trimethoxyphenyl) pyrimidin-2-amine that would be utilized as a promising candidate drug for the future NSCLC therapy. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Recommanded Product: 4-Benzyloxyphenol).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Recommanded Product: 4-Benzyloxyphenol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Nickel Dual Photoredox Catalysis for the Synthesis of Aryl Amines was written by Key, Ryan J.;Vannucci, Aaron K.. And the article was included in Organometallics in 2018.Electric Literature of C12H12N2O The following contents are mentioned in the article:

In this work, a new dual photoredox nickel catalysis system has been utilized for the synthesize of aryl amines. Previously, our group has shown that a nickel catalyst in conjunction with a photosensitizer and a sacrificial electron donor can cross-couple C-C bonds via photoredox-assisted reductive coupling. Here we have built upon that system to develop a redox-neutral cross-coupling system for the formation of C-N bonds. The catalytic system is composed of just a nickel cross-coupling catalyst, a Ru photocatalyst, and base and is capable of coupling amines with aryl halides in good to excellent yields. Furthermore, it was found that these reactions are functional under ambient conditions with catalyst loadings of 1 mol %. Spectroscopic studies provide support that this amination mechanism proceeds via a nitrogen-based radical intermediate. This N-radical mechanism offers direct synthetic access to di- and triaryl amines from nickel photocatalysis. This study involved multiple reactions and reactants, such as N-(4-Methoxyphenyl)pyridin-3-amine (cas: 562085-85-2Electric Literature of C12H12N2O).

N-(4-Methoxyphenyl)pyridin-3-amine (cas: 562085-85-2) belongs to ethers. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Electric Literature of C12H12N2O

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Functionalized Triphenylene Discotic Molecules: Synthesis and Mesomorphic Characterizations was written by Srinivasa, H. T.;Hariprasad, S.. And the article was included in ChemistrySelect in 2022.HPLC of Formula: 103-16-2 The following contents are mentioned in the article:

The synthesis and characterization of two sets of triphenylene derived discotic mols. with phenol, aldehyde and acid functional groups was reported. In the first set, triphenylene moiety was tethered with benzene derivatives via an ester linkage, while in the second set via an ether linkage with increased aromatic conjugation. All the mols. have triphenylene disk at one end and with benzene, biphenyl and terphenyl cores at the other end connected via flexible methylene spacers. The chem. structures of the novel compounds were confirmed by IR, NMR spectroscopy and CHN anal. methods. Thermal and liquid crystal texture properties were determined using differential scanning calorimetry, polarized optical microscope and X-ray diffraction studies. Amongst all the novel compounds, only the terphenyl derivative displayed mesomorphism. However, their charge transfer complexes with trinitrofluorenone (TNF) an electron acceptor exhibited columnar mesophases. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2HPLC of Formula: 103-16-2).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. HPLC of Formula: 103-16-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Functionalized Triphenylene Discotic Molecules: Synthesis and Mesomorphic Characterizations was written by Srinivasa, H. T.;Hariprasad, S.. And the article was included in ChemistrySelect in 2022.HPLC of Formula: 103-16-2 The following contents are mentioned in the article:

The synthesis and characterization of two sets of triphenylene derived discotic mols. with phenol, aldehyde and acid functional groups was reported. In the first set, triphenylene moiety was tethered with benzene derivatives via an ester linkage, while in the second set via an ether linkage with increased aromatic conjugation. All the mols. have triphenylene disk at one end and with benzene, biphenyl and terphenyl cores at the other end connected via flexible methylene spacers. The chem. structures of the novel compounds were confirmed by IR, NMR spectroscopy and CHN anal. methods. Thermal and liquid crystal texture properties were determined using differential scanning calorimetry, polarized optical microscope and X-ray diffraction studies. Amongst all the novel compounds, only the terphenyl derivative displayed mesomorphism. However, their charge transfer complexes with trinitrofluorenone (TNF) an electron acceptor exhibited columnar mesophases. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2HPLC of Formula: 103-16-2).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.HPLC of Formula: 103-16-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Oxoammonium salts are catalysing efficient and selective halogenation of olefins, alkynes and aromatics was written by Wang, Weijin;Li, Xinyao;Yang, Xiaoxue;Ai, Lingsheng;Gong, Zhiwen;Jiao, Ning;Song, Song. And the article was included in Nature Communications in 2021.Category: ethers-buliding-blocks The following contents are mentioned in the article:

Herein, TEMPO (2,2,6,6-tetramethylpiperidine nitroxide) and its derivatives are disclosed as active catalysts for electrophilic halogenation of olefins e.., prop-1-en-1-ylbenzene, alkynes R¹CCR² (R¹ = octyl, Ph; R² = H, Me, n-Bu, Ph), and aromatics R³H (R³ = 3-(carboxymethyl)-4-methoxybenzen-1-yl, 2-[ethoxy(oxo)methane]-1H-indol-3-yl, 5-phenylthiophen-2-yl, etc.). These catalysts are stable, readily available, and reactive enough to activate haleniums including Br⁺, I⁺ and even Cl⁺ reagents. This catalytic system is applicable to various halogenations including haloarylation of olefins or dibromination of alkynes, which were rarely realized in previous Lewis base catalysis or Lewis acid catalysis. The high catalytic ability is attributed to a synergistic activation model of electrophilic halogenating reagents, where the carbonyl group and the halogen atom are both activated by present TEMPO catalysis. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Category: ethers-buliding-blocks).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Oxoammonium salts are catalysing efficient and selective halogenation of olefins, alkynes and aromatics was written by Wang, Weijin;Li, Xinyao;Yang, Xiaoxue;Ai, Lingsheng;Gong, Zhiwen;Jiao, Ning;Song, Song. And the article was included in Nature Communications in 2021.Recommanded Product: 103-16-2 The following contents are mentioned in the article:

Herein, TEMPO (2,2,6,6-tetramethylpiperidine nitroxide) and its derivatives are disclosed as active catalysts for electrophilic halogenation of olefins e.., prop-1-en-1-ylbenzene, alkynes R¹CCR² (R¹ = octyl, Ph; R² = H, Me, n-Bu, Ph), and aromatics R³H (R³ = 3-(carboxymethyl)-4-methoxybenzen-1-yl, 2-[ethoxy(oxo)methane]-1H-indol-3-yl, 5-phenylthiophen-2-yl, etc.). These catalysts are stable, readily available, and reactive enough to activate haleniums including Br⁺, I⁺ and even Cl⁺ reagents. This catalytic system is applicable to various halogenations including haloarylation of olefins or dibromination of alkynes, which were rarely realized in previous Lewis base catalysis or Lewis acid catalysis. The high catalytic ability is attributed to a synergistic activation model of electrophilic halogenating reagents, where the carbonyl group and the halogen atom are both activated by present TEMPO catalysis. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Recommanded Product: 103-16-2).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Recommanded Product: 103-16-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem