Tag: 200-300

Model Compounds Study for the Mechanism of Horseradish Peroxidase-Catalyzed Lignin Modification was written by Yang, Dongjie;Wang, Yalin;Huang, Wenjing;Li, Zhixian;Qiu, Xueqing. And the article was included in Applied Biochemistry and Biotechnology in 2020.Application of 103-16-2 The following contents are mentioned in the article:

Horseradish peroxidase (HRP) has demonstrated high activity for the modification of lignin. In this paper, several lignin model compounds with different functional groups and linkages are selected to investigate the reactivity of HRP-catalyzed lignin modification. The phenolic groups of lignin model compounds are indispensable for the HRP-catalyzed modification process. The introduction of the sulfomethylated Me group or methoxyl group could facilitate or inhibit the modification, resp. The oxidative coupling activity of α-O-4 lignin model compounds is higher than that of β-O-4 compounds Meanwhile, the free energy obtained by d. functional theory (DFT) is used to verify the results of the exptl. study, and the order of preference for linkages is β-5 > β-β > β-O-4 in most cases. In addition, electron cloud d. and steric hindrance of lignin model compounds have crucial effects on the oxidation and modification processes. Finally, the mechanism of HRP-catalyzed lignin modification is proposed. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Application of 103-16-2).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Application of 103-16-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Model Compounds Study for the Mechanism of Horseradish Peroxidase-Catalyzed Lignin Modification was written by Yang, Dongjie;Wang, Yalin;Huang, Wenjing;Li, Zhixian;Qiu, Xueqing. And the article was included in Applied Biochemistry and Biotechnology in 2020.Application of 103-16-2 The following contents are mentioned in the article:

Horseradish peroxidase (HRP) has demonstrated high activity for the modification of lignin. In this paper, several lignin model compounds with different functional groups and linkages are selected to investigate the reactivity of HRP-catalyzed lignin modification. The phenolic groups of lignin model compounds are indispensable for the HRP-catalyzed modification process. The introduction of the sulfomethylated Me group or methoxyl group could facilitate or inhibit the modification, resp. The oxidative coupling activity of α-O-4 lignin model compounds is higher than that of β-O-4 compounds Meanwhile, the free energy obtained by d. functional theory (DFT) is used to verify the results of the exptl. study, and the order of preference for linkages is β-5 > β-β > β-O-4 in most cases. In addition, electron cloud d. and steric hindrance of lignin model compounds have crucial effects on the oxidation and modification processes. Finally, the mechanism of HRP-catalyzed lignin modification is proposed. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Application of 103-16-2).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Application of 103-16-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthesis and biological evaluation of 4-phenoxy-phenyl isoxazoles as novel acetyl-CoA carboxylase inhibitors was written by Wu, Xin;Yu, Yongbo;Huang, Tonghui. And the article was included in Journal of Enzyme Inhibition and Medicinal Chemistry in 2021.Category: ethers-buliding-blocks The following contents are mentioned in the article:

Acetyl-CoA carboxylase (ACC) is a crucial enzyme in fatty acid metabolism, which plays a major role in the occurrence and development of certain tumors. Herein, one potential ACC inhibitor () was identified through high-throughput virtual screening (HTVS), and a series of 4-phenoxy-Ph isoxazoles were synthesized for structure-activity relationship (SAR) studies. Among these compounds, exhibited the most potent ACC inhibitory activity (IC50=99.8 nM), which was comparable to that of CP-640186. Moreover, the antiproliferation assay revealed that compound exhibited the strongest cytotoxicity, with IC50 values of 0.22μM (A549), 0.26μM (HepG2), and 0.21μM (MDA-MB-231), resp. The preliminary mechanistic studies on and suggested that the compounds decreased the malonyl-CoA levels, arrested the cell cycle at the G0/G1 phase, and induced apoptosis in MDA-MB-231 cells. Overall, these results indicated that the 4-phenoxy-Ph isoxazoles are potential for further study in cancer therapeutics as ACC inhibitors. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Category: ethers-buliding-blocks).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Many esters have the potential for conformational isomerism, but they tend to adopt an s-cis (or Z) conformation rather than the s-trans (or E) alternative, due to a combination of hyperconjugation and dipole minimization effects. The preference for the Z conformation is influenced by the nature of the substituents and solvent, if present. Lactones with small rings are restricted to the s-trans (i.e. E) conformation due to their cyclic structure.Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthesis and biological evaluation of 4-phenoxy-phenyl isoxazoles as novel acetyl-CoA carboxylase inhibitors was written by Wu, Xin;Yu, Yongbo;Huang, Tonghui. And the article was included in Journal of Enzyme Inhibition and Medicinal Chemistry in 2021.Reference of 103-16-2 The following contents are mentioned in the article:

Acetyl-CoA carboxylase (ACC) is a crucial enzyme in fatty acid metabolism, which plays a major role in the occurrence and development of certain tumors. Herein, one potential ACC inhibitor () was identified through high-throughput virtual screening (HTVS), and a series of 4-phenoxy-Ph isoxazoles were synthesized for structure-activity relationship (SAR) studies. Among these compounds, exhibited the most potent ACC inhibitory activity (IC50=99.8 nM), which was comparable to that of CP-640186. Moreover, the antiproliferation assay revealed that compound exhibited the strongest cytotoxicity, with IC50 values of 0.22μM (A549), 0.26μM (HepG2), and 0.21μM (MDA-MB-231), resp. The preliminary mechanistic studies on and suggested that the compounds decreased the malonyl-CoA levels, arrested the cell cycle at the G0/G1 phase, and induced apoptosis in MDA-MB-231 cells. Overall, these results indicated that the 4-phenoxy-Ph isoxazoles are potential for further study in cancer therapeutics as ACC inhibitors. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Reference of 103-16-2).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Reference of 103-16-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Nucleophilic Thiols Reductively Cleave Ether Linkages in Lignin Model Polymers and Lignin was written by Klinger, Grace E.;Zhou, Yuting;Foote, Juliet A.;Wester, Abby M.;Cui, Yanbin;Alherech, Manar;Stahl, Shannon S.;Jackson, James E.;Hegg, Eric L.. And the article was included in ChemSusChem in 2020.Related Products of 103-16-2 The following contents are mentioned in the article:

Lignin may serve as a renewable feedstock for the production of chems. and fuels if mild, scalable processes for its depolymerization can be devised. The use of small organic thiols represents a bioinspired strategy to cleave the β-O-4 bond, the most common linkage in lignin. In the present study, synthetic β-O-4 linked polymers were treated with organic thiols, yielding up to 90% cleaved monomer products. Lignin extracted from poplar was also treated with organic thiols resulting in mol. weight reductions as high as 65% (M_n) in oxidized lignin. Thiol-based cleavage of other lignin linkages was also explored in small-mol. model systems to uncover addnl. potential pathways by which thiols might depolymerize lignin. The success of thiol-mediated cleavage on model dimers, polymers, and biomass-derived lignin illustrates the potential utility of small redox-active mols. to penetrate complex polymer matrixes for depolymerization and subsequent valorization of lignin into fuels and chems. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Related Products of 103-16-2).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Related Products of 103-16-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Nucleophilic Thiols Reductively Cleave Ether Linkages in Lignin Model Polymers and Lignin was written by Klinger, Grace E.;Zhou, Yuting;Foote, Juliet A.;Wester, Abby M.;Cui, Yanbin;Alherech, Manar;Stahl, Shannon S.;Jackson, James E.;Hegg, Eric L.. And the article was included in ChemSusChem in 2020.Synthetic Route of C13H12O2 The following contents are mentioned in the article:

Lignin may serve as a renewable feedstock for the production of chems. and fuels if mild, scalable processes for its depolymerization can be devised. The use of small organic thiols represents a bioinspired strategy to cleave the β-O-4 bond, the most common linkage in lignin. In the present study, synthetic β-O-4 linked polymers were treated with organic thiols, yielding up to 90% cleaved monomer products. Lignin extracted from poplar was also treated with organic thiols resulting in mol. weight reductions as high as 65% (M_n) in oxidized lignin. Thiol-based cleavage of other lignin linkages was also explored in small-mol. model systems to uncover addnl. potential pathways by which thiols might depolymerize lignin. The success of thiol-mediated cleavage on model dimers, polymers, and biomass-derived lignin illustrates the potential utility of small redox-active mols. to penetrate complex polymer matrixes for depolymerization and subsequent valorization of lignin into fuels and chems. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Synthetic Route of C13H12O2).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Synthetic Route of C13H12O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Chemo- and regioselective benzylic C(sp³)-H oxidation bridging the gap between hetero- and homogeneous copper catalysis was written by Nandi, Shantanu;Mondal, Shuvam;Jana, Ranjan. And the article was included in iScience in 2022.Recommanded Product: 4-Benzyloxyphenol The following contents are mentioned in the article:

An expedient synthesis of privileged seven-membered lactones, dibenzo[c,e]oxepin-5(7H)-one through a highly chemoselective benzylic C(sp³)-H activation was disclosed. Remarkably, the formation of widely explored six-membered lactone via C(sp²)-H activation was suppressed under the present conditions. The reaction proceeded smoothly on use of inexpensive metallic copper catalyst and di-tert-Bu peroxide (DTBP). Owing to the hazards of stoichiometric DTBP, further, a sustainable metallic copper/rose bengal dual catalytic system coupled with mol. oxygen replacing DTBP was developed. A 1,5-aryl migration through Smiles rearrangement was realized from the corresponding diaryl ether substrates instead of expected eight-membered lactones. The present methodol. was scalable, applied to the total synthesis of cytotoxic and neuroprotective natural product alterlactone. The catalyst was recyclable and the reaction could be performed in a copper bottle without any added catalyst. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Recommanded Product: 4-Benzyloxyphenol).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Recommanded Product: 4-Benzyloxyphenol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Chemo- and regioselective benzylic C(sp³)-H oxidation bridging the gap between hetero- and homogeneous copper catalysis was written by Nandi, Shantanu;Mondal, Shuvam;Jana, Ranjan. And the article was included in iScience in 2022.Application of 103-16-2 The following contents are mentioned in the article:

An expedient synthesis of privileged seven-membered lactones, dibenzo[c,e]oxepin-5(7H)-one through a highly chemoselective benzylic C(sp³)-H activation was disclosed. Remarkably, the formation of widely explored six-membered lactone via C(sp²)-H activation was suppressed under the present conditions. The reaction proceeded smoothly on use of inexpensive metallic copper catalyst and di-tert-Bu peroxide (DTBP). Owing to the hazards of stoichiometric DTBP, further, a sustainable metallic copper/rose bengal dual catalytic system coupled with mol. oxygen replacing DTBP was developed. A 1,5-aryl migration through Smiles rearrangement was realized from the corresponding diaryl ether substrates instead of expected eight-membered lactones. The present methodol. was scalable, applied to the total synthesis of cytotoxic and neuroprotective natural product alterlactone. The catalyst was recyclable and the reaction could be performed in a copper bottle without any added catalyst. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Application of 103-16-2).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Application of 103-16-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Design and Synthesis of Basic Selective Estrogen Receptor Degraders for Endocrine Therapy Resistant Breast Cancer was written by Lu, Yunlong;Gutgesell, Lauren M.;Xiong, Rui;Zhao, Jiong;Li, Yangfeng;Rosales, Carlo I.;Hollas, Michael;Shen, Zhengnan;Gordon-Blake, Jesse;Dye, Katherine;Wang, Yueting;Lee, Sue;Chen, Hu;He, Donghong;Dubrovyskyii, Oleksii;Zhao, Huiping;Huang, Fei;Lasek, Amy W.;Tonetti, Debra A.;Thatcher, Gregory R. J.. And the article was included in Journal of Medicinal Chemistry in 2019.Application In Synthesis of 4-Benzyloxyphenol The following contents are mentioned in the article:

The clin. steroidal selective estrogen receptor (ER) degrader (SERD), fulvestrant, is effective in metastatic breast cancer, but limited by poor pharmacokinetics, prompting the development of orally bioavailable, nonsteroidal SERDs, currently in clin. trials. These trials address local breast cancer as well as peripheral metastases, but patients with brain metastases are generally excluded because of the lack of blood-brain barrier penetration. A novel family of benzothiophene SERDs with a basic amino side arm (B-SERDs) was synthesized. Proteasomal degradation of ERα was induced by B-SERDs that achieved the objectives of oral and brain bioavailability, while maintaining high affinity binding to ERα and both potency and efficacy comparable to fulvestrant in cell lines resistant to endocrine therapy or bearing ESR1 mutations. A novel 3-oxyazetidine side chain was designed, leading to 37d, a B-SERD that caused endocrine-resistant ER+ tumors to regress in a mouse orthotopic xenograft model. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Application In Synthesis of 4-Benzyloxyphenol).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Application In Synthesis of 4-Benzyloxyphenol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Design and synthesis of aminothiazole based Hepatitis B Virus (HBV) capsid inhibitors was written by Pan, Ting;Ding, Yanchao;Wu, Liyang;Liang, Liting;He, Xin;Li, Qianwen;Bai, Chuan;Zhang, Hui. And the article was included in European Journal of Medicinal Chemistry in 2019.Related Products of 103-16-2 The following contents are mentioned in the article:

The capsid assembly is an essential step for Hepatitis B Virus (HBV) life cycle and is an important target for anti-HBV drug development. In this report, we identified a hit compound with aminothiazole structure by the high throughput screening (HTS) which inhibited the interaction of HBV capsid protein within the cells. The structure hopping and SAR studies of the hit compound afforded compound 79 with potent anti-HBV replication activity and good basic drug-like properties. The working mechanism studies showed that compound 79 could bind to the similar binding site of known HBV capsid inhibitor with heteroaryldihydropyrimidine (HAP) scaffold, through similar hydrophobic interactions but with a different hydrogen bond. This compound exerted potent inhibitory effect upon HBV production, either in cell culture or in mice with no obvious acute toxicity. We propose that further development of this compound could lead to novel potent anti-HBV inhibitors that target HBV capsid assembly. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Related Products of 103-16-2).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Related Products of 103-16-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem