Tag: 200-300

Catalytic transfer hydrogenolysis of lignin α-O-4 model compound 4-(benzyloxy)phenol and lignin over Pt/HNbWO₆/CNTs catalyst was written by Guan, Weixiang;Chen, Xiao;Zhang, Jie;Hu, Haoquan;Liang, Changhai. And the article was included in Renewable Energy in 2020.Related Products of 103-16-2 The following contents are mentioned in the article:

Cleavage of C-O bonds in aryl ether through the catalytic transfer hydrogenolysis (CTH) is an encouraging method for the valorization of lignin into fine chems. and liquid fuels. In this contribution, the CTH of typical lignin α-O-4 model compound 4-(benzyloxy)phenol (BOP) and lignin extracted from ash wood have been explored over 0.45 wt% Pt/HNbWO₆/CNTs catalyst. The effect of solvents was elaborated and the highest catalytic activity was achieved in the CTH of BOP using isopropanol as the solvent (98.1%). This was because isopropanol can provide more hydrogen atoms to promote CTH reaction due to the weakest interaction between isopropanol and BOP among all H-donor solvents. The favorable results obtained in the model compound study inspired us to afford Pt/HNbWO₆/CNTs catalyst in the CTH of lignin. The relative oxygen content of lignin was sharply decreased after the CTH process, and the higher heating value (HHV) significantly increased from 21.4 MJ/kg to 30.8 MJ/kg. GPC, FT-IR, GC-MS, and 2D-NMR results revealed that lignin was successfully depolymerized into small mol. compounds over Pt/HNbWO₆/CNTs catalyst through the CTH process. Thereinto, phenolic compounds were the major components in the liquid products in which most of them were monophenols. The results obtained in this work shed light on that Pt/HNbWO₆/CNTs was a favorable catalyst in the depolymerization of lignin into valuable phenolic compounds via the CTH method. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Related Products of 103-16-2).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Related Products of 103-16-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Catalytic transfer hydrogenolysis of lignin α-O-4 model compound 4-(benzyloxy)phenol and lignin over Pt/HNbWO₆/CNTs catalyst was written by Guan, Weixiang;Chen, Xiao;Zhang, Jie;Hu, Haoquan;Liang, Changhai. And the article was included in Renewable Energy in 2020.Safety of 4-Benzyloxyphenol The following contents are mentioned in the article:

Cleavage of C-O bonds in aryl ether through the catalytic transfer hydrogenolysis (CTH) is an encouraging method for the valorization of lignin into fine chems. and liquid fuels. In this contribution, the CTH of typical lignin α-O-4 model compound 4-(benzyloxy)phenol (BOP) and lignin extracted from ash wood have been explored over 0.45 wt% Pt/HNbWO₆/CNTs catalyst. The effect of solvents was elaborated and the highest catalytic activity was achieved in the CTH of BOP using isopropanol as the solvent (98.1%). This was because isopropanol can provide more hydrogen atoms to promote CTH reaction due to the weakest interaction between isopropanol and BOP among all H-donor solvents. The favorable results obtained in the model compound study inspired us to afford Pt/HNbWO₆/CNTs catalyst in the CTH of lignin. The relative oxygen content of lignin was sharply decreased after the CTH process, and the higher heating value (HHV) significantly increased from 21.4 MJ/kg to 30.8 MJ/kg. GPC, FT-IR, GC-MS, and 2D-NMR results revealed that lignin was successfully depolymerized into small mol. compounds over Pt/HNbWO₆/CNTs catalyst through the CTH process. Thereinto, phenolic compounds were the major components in the liquid products in which most of them were monophenols. The results obtained in this work shed light on that Pt/HNbWO₆/CNTs was a favorable catalyst in the depolymerization of lignin into valuable phenolic compounds via the CTH method. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Safety of 4-Benzyloxyphenol).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Because of their lack of hydrogen-bond-donating ability, esters do not self-associate. Consequently, esters are more volatile than carboxylic acids of similar molecular weight.Safety of 4-Benzyloxyphenol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Design and synthesis of novel benzothiophene analogs as selective estrogen receptor covalent antagonists against breast cancer was written by Bai, Chengfeng;Ren, Shengnan;Wu, Shuangjie;Zhu, Meiqi;Luo, Guoshun;Xiang, Hua. And the article was included in European Journal of Medicinal Chemistry in 2021.Recommanded Product: 4-Benzyloxyphenol The following contents are mentioned in the article:

Endocrine therapy (ET) has benefited patients with estrogen receptor alpha (ERα) pos. breast cancer for decades. Selective estrogen receptor modulator (SERM) such as Tamoxifen represents the clin. standard of care (SoC). Despite the therapeutic importance of current SoC agents, 30-50% of prolonged treatment patients inevitably generated resistant tumor cells, usually eventually suffered tumor relapse and developed into metastatic breast cancer (MBC), which was the leading cause of female cancer-related mortality. Among these, most resistant tumors remained dependent on ERα signaling, which reignited the need for the next generation of ERα related agents. Authors hypothesized that selective estrogen receptor covalent antagonists targeting ERα would provide a therapeutic alternative. In the current work, series of novel benzothiophene hybrids I (R₁ = H, Me; R₂ = Me; R₁R₂ = (CH₂)₃, (CH₂)₅, etc.) II, III (R₃ = R₄ = H, Me) and IV bearing electrophile moieties were synthesized and biol. evaluated. The representative analog I (R₁R₂ = (CH₂)₃) exhibited potent anti-proliferative effect in MCF-7 cell lines in vitro, and further mechanism studies confirmed the necessity of covalent bonding. More importantly, I could attenuate the expression of TFF-1, GREB-1 and down-regulate the levels of cellular ERα protein. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Recommanded Product: 4-Benzyloxyphenol).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Recommanded Product: 4-Benzyloxyphenol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Identification of p53 Activators in a Human Microarray Compendium was written by Corton, J. Christopher;Witt, Kristine L.;Yauk, Carole L.. And the article was included in Chemical Research in Toxicology in 2019.Application In Synthesis of 4-Benzyloxyphenol The following contents are mentioned in the article:

Biomarkers predictive of mol. and toxicol. effects are needed to interpret emerging high-throughput transcriptomic data streams. The previously characterized 63 gene TGx-DDI biomarker that includes 20 genes known to be regulated by p53 was previously shown to accurately predict DNA damage in chem.-treated cells. The authors comprehensively evaluated whether the mol. basis of the DDI predictions was based on a p53-dependent response. The biomarker was compared to microarray data in a compendium derived from human cells using the Running Fisher test, a nonparametric correlation test. Using the biomarker, the authors identified conditions that led to p53 activation, including exposure to the chem. nutlin-3 which disrupts interactions between p53 and the neg. regulator MDM2 or by knockdown of MDM2. The expression of most of the genes in the biomarker (75%) were found to depend on p53 activation status based on gene behavior after TP53 overexpression or knockdown. The biomarker identified DDI chems. that were strong inducers of p53 in wild-type cells; these p53 responses were decreased or abolished in cells after p53 knockdown by siRNAs. Using the biomarker, the authors screened ∼1950 chems. in ∼9800 human cell line chem. vs. control comparisons and identified ∼100 chems. that caused p53 activation. Among the pos. chems. were many that are known to activate p53 through direct and indirect DNA damaging mechanisms. These results contribute to the evidence that the TGx-DDI biomarker is useful for identifying chems. that cause DDI and activate p53. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Application In Synthesis of 4-Benzyloxyphenol).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Application In Synthesis of 4-Benzyloxyphenol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Structure-activity relationship of novel (benzoylaminophenoxy)phenol derivatives as anti-prostate cancer agents was written by Kazui, Yuko;Fujii, Shinya;Yamada, Ayumi;Ishigami-Yuasa, Mari;Kagechika, Hiroyuki;Tanatani, Aya. And the article was included in Bioorganic & Medicinal Chemistry in 2018.Application of 103-16-2 The following contents are mentioned in the article:

The androgen receptor (AR) is a ligand-inducible transcription factor belonging to the nuclear receptor superfamily, and is a target mol. for development of drugs to treat prostate cancer. However, AR antagonists in clin. use, such as flutamide (3a) and bicalutamide (4), encounter resistance after several years of hormone therapy, predominantly due to mutations of AR. Thus, although some new-generation AR antagonists have been developed, novel types of AR antagonists are still required to treat drug-resistant prostate cancer. We previously reported a novel (benzoylaminophenoxy)phenol derivative 10a, which is structurally distinct from conventional AR antagonists. Here, we systematically examined the structure-activity relationship of (benzoylaminophenoxy)phenol derivatives on the inhibitory activity on the prostate cancer cell proliferations. We found that the 4-[4-(benzoylamino)phenoxy]phenol backbone is important for anti-prostate cancer activity. Introduction of a small substituent at the 2 position of the central benzene ring (B ring) increases the activity. Among the synthesized compounds, 19a and 19b exhibited the most potent inhibitory activity toward dihydrotestosterone-induced proliferation of several androgen-dependent cell lines, SC-3 (wild-type AR), LNCaP (T877A AR), and 22Rv1 (H874Y AR), but interestingly also inhibited proliferation of AR-independent PC-3 cells. These compounds, which have a different pharmacophore from conventional AR antagonists, are promising drug candidates for the treatment of prostate cancer. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Application of 103-16-2).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Application of 103-16-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Discovery of novel brain permeable and G protein-biased beta-1 adrenergic receptor partial agonists for the treatment of neurocognitive disorders was written by Yi, Bitna;Jahangir, Alam;Evans, Andrew K.;Briggs, Denise;Ravina, Kristine;Ernest, Jacqueline;Farimani, Amir B.;Sun, Wenchao;Rajadas, Jayakumar;Green, Michael;Feinberg, Evan N.;Pande, Vijay S.;Shamloo, Mehrdad. And the article was included in PLoS One in 2017.Product Details of 100927-02-4 The following contents are mentioned in the article:

The beta-1 adrenergic receptor (ADRB1) is a promising therapeutic target intrinsically involved in the cognitive deficits and pathol. features associated with Alzheimer’s disease (AD). Evidence indicates that ADRB1 plays an important role in regulating neuroinflammatory processes, and activation of ADRB1 may produce neuroprotective effects in neuroinflammatory diseases. Novel small mol. modulators of ADRB1, engineered to be highly brain permeable and functionally selective for the G protein with partial agonistic activity, could have tremendous value both as pharmacol. tools and potential lead mols. for further preclin. development. The present study describes our ongoing efforts toward the discovery of functionally selective partial agonists of ADRB1 that have potential therapeutic value for AD and neuroinflammatory disorders, which has led to the identification of the mol. STD-101-D1. As a functionally selective agonist of ADRB1, STD-101-D1 produces partial agonistic activity on G protein signaling with an EC50 value in the low nanomolar range, but engages very little beta-arrestin recruitment compared to the unbiased agonist isoproterenol. STD-101-D1 also inhibits the tumor necrosis factor α (TNFα) response induced by lipopolysaccharide (LPS) both in vitro and in vivo, and shows high brain penetration. Other than the therapeutic role, this newly identified, functionally selective, partial agonist of ADRB1 is an invaluable research tool to study mechanisms of G protein-coupled receptor signal transduction. This study involved multiple reactions and reactants, such as 4-(Benzyloxy)-3-methylphenol (cas: 100927-02-4Product Details of 100927-02-4).

4-(Benzyloxy)-3-methylphenol (cas: 100927-02-4) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Product Details of 100927-02-4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The recovery of strontium from acidic medium using novel strontium selective extractant: an experimental and DFT study was written by Khan, Pasupati Nath;Bhattacharyya, A.;Sharma, J. N.;Manohar, S.. And the article was included in Journal of Hazardous Materials in 2020.Recommanded Product: 103-16-2 The following contents are mentioned in the article:

In view of the limited solvent system known for the Sr²⁺ extraction from acidic media, extraction and recovery of ⁹⁰Sr from acidic medium using novel Octabenzyloxyoctakis[[[((N,N-diethylamino)carbonyl)]methyl]oxy]calix[8]arene (BOC8A) extractant in nitro alkane medium are presented.. BOC8A and nitro alkanes have been synthesized and characterized by ¹H NMR, ¹³C NMR, FTIR and GC-MS techniques. Solvent composition of 0.01 M BOC8A in nitro octane (NO) has been optimized for substantial amount of extraction of strontium from feed acidity of 3.5-4 M nitric acid, (D_{3.5-4 M HNO3} = 7.1-7.8). Poor extraction of Pu⁴⁺, Ba²⁺, Na⁺ and UO₂⁺² and negligible extraction of Am³⁺, Cs⁺, Ru³⁺, Nd³⁺, Zr²⁺ and trivalent lanthanides are observed Ion dissociation mechanism was found to be operative involving an extractable complex having Sr²⁺, BOC8A and HNO₃ in a ratio of 1:1:2. About 99% of Sr²⁺ from the loaded solvent was recovered with 0.01 M HNO₃. DFT calculations were used to predict the structures of free, protonated BOC8A and its complex with Sr²⁺. DFT result showed reorientation in conformation of BOC8A due to protonation resulting in the Sr²⁺ extraction from acidic medium with significantly high interaction energy between Sr²⁺ and diprotonated form of BOC8A. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Recommanded Product: 103-16-2).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters typically have a pleasant smell; those of low molecular weight are commonly used as fragrances and are found in essential oils and pheromones. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Recommanded Product: 103-16-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The recovery of strontium from acidic medium using novel strontium selective extractant: an experimental and DFT study was written by Khan, Pasupati Nath;Bhattacharyya, A.;Sharma, J. N.;Manohar, S.. And the article was included in Journal of Hazardous Materials in 2020.Category: ethers-buliding-blocks The following contents are mentioned in the article:

In view of the limited solvent system known for the Sr²⁺ extraction from acidic media, extraction and recovery of ⁹⁰Sr from acidic medium using novel Octabenzyloxyoctakis[[[((N,N-diethylamino)carbonyl)]methyl]oxy]calix[8]arene (BOC8A) extractant in nitro alkane medium are presented.. BOC8A and nitro alkanes have been synthesized and characterized by ¹H NMR, ¹³C NMR, FTIR and GC-MS techniques. Solvent composition of 0.01 M BOC8A in nitro octane (NO) has been optimized for substantial amount of extraction of strontium from feed acidity of 3.5-4 M nitric acid, (D_{3.5-4 M HNO3} = 7.1-7.8). Poor extraction of Pu⁴⁺, Ba²⁺, Na⁺ and UO₂⁺² and negligible extraction of Am³⁺, Cs⁺, Ru³⁺, Nd³⁺, Zr²⁺ and trivalent lanthanides are observed Ion dissociation mechanism was found to be operative involving an extractable complex having Sr²⁺, BOC8A and HNO₃ in a ratio of 1:1:2. About 99% of Sr²⁺ from the loaded solvent was recovered with 0.01 M HNO₃. DFT calculations were used to predict the structures of free, protonated BOC8A and its complex with Sr²⁺. DFT result showed reorientation in conformation of BOC8A due to protonation resulting in the Sr²⁺ extraction from acidic medium with significantly high interaction energy between Sr²⁺ and diprotonated form of BOC8A. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2Category: ethers-buliding-blocks).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Towards supramolecular nanostructured materials: control of the self-assembly of ionic bent-core amphiphiles was written by Castillo-Valles, Martin;Cano, Miguel;Bermejo-Sanz, Ana;Gimeno, Nelida;Ros, M. Blanca. And the article was included in Journal of Materials Chemistry in 2020.COA of Formula: C13H12O2 The following contents are mentioned in the article:

Control of the bottom-up self-assembly of ionic bent-core dendrimers has been systematically studied by mol. design. This process gave rise to architectures with diverse packing, shapes and dimensions to construct structured materials at the nanoscale. The compact organization of the mols. achieved in bent-core mesophases was transferred or induced to self-assemblies in the presence of water – even in the case of non-mesogenic dendrimers. The subtle balance of mol.-mol. and mol.-solvent interactions regulated the morphol. of the aggregates and these ranged from rods, non-twisted or twisted fibers, helical ribbons and nanotubes. The structure obtained was dependent on the choice of dendritic nucleus, the bent-core structure (from 5 to 3 aromatic ring systems), the lateral moiety and the length of the outer flexible tails. The rigid nature of the chem. structure controlled the type of mol. packing in the layers and allowed mol. conformational chirality to be transmitted to the supramol. aggregates, despite achiral mols. being used. The short/long terminal chain lengths determined the type of curvature of the ribbons. Some of these self-assemblies are proposed as alternatives to the attractive and widely applied helical nanofilaments formed by bent-core mesogens, but, thanks to their amphiphilic nature, the novel compounds can be processed from solution Moreover, the self-assembly process was studied in an effort to elucidate the aggregation mechanism of these bent-shaped amphiphiles and to define exptl. protocols to provide high quality and homogeneous aggregates. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2COA of Formula: C13H12O2).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.COA of Formula: C13H12O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Towards supramolecular nanostructured materials: control of the self-assembly of ionic bent-core amphiphiles was written by Castillo-Valles, Martin;Cano, Miguel;Bermejo-Sanz, Ana;Gimeno, Nelida;Ros, M. Blanca. And the article was included in Journal of Materials Chemistry in 2020.COA of Formula: C13H12O2 The following contents are mentioned in the article:

Control of the bottom-up self-assembly of ionic bent-core dendrimers has been systematically studied by mol. design. This process gave rise to architectures with diverse packing, shapes and dimensions to construct structured materials at the nanoscale. The compact organization of the mols. achieved in bent-core mesophases was transferred or induced to self-assemblies in the presence of water – even in the case of non-mesogenic dendrimers. The subtle balance of mol.-mol. and mol.-solvent interactions regulated the morphol. of the aggregates and these ranged from rods, non-twisted or twisted fibers, helical ribbons and nanotubes. The structure obtained was dependent on the choice of dendritic nucleus, the bent-core structure (from 5 to 3 aromatic ring systems), the lateral moiety and the length of the outer flexible tails. The rigid nature of the chem. structure controlled the type of mol. packing in the layers and allowed mol. conformational chirality to be transmitted to the supramol. aggregates, despite achiral mols. being used. The short/long terminal chain lengths determined the type of curvature of the ribbons. Some of these self-assemblies are proposed as alternatives to the attractive and widely applied helical nanofilaments formed by bent-core mesogens, but, thanks to their amphiphilic nature, the novel compounds can be processed from solution Moreover, the self-assembly process was studied in an effort to elucidate the aggregation mechanism of these bent-shaped amphiphiles and to define exptl. protocols to provide high quality and homogeneous aggregates. This study involved multiple reactions and reactants, such as 4-Benzyloxyphenol (cas: 103-16-2COA of Formula: C13H12O2).

4-Benzyloxyphenol (cas: 103-16-2) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.COA of Formula: C13H12O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem