In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 35822-58-3, name is 2-Bromobenzaldehyde diethyl acetal belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Product Details of 35822-58-3
To a mechanically stirred solution of 1-bromo-2-(diethoxymethyl)benzene (266 g) in dry diethyl ether (1.5 L) cooled to -70 0C under nitrogen was added a 2.5M solution of n-butyl lithium in hexanes (414 ml.) dropwise over 30 min. The reaction mixture was stirred at a temperature less than -60 0C for 45 min then a solution of 4-bromo-2- fluorobenzaldehyde in dry diethyl ether (1.5 L) was added dropwise over 1 h maintaining the low temperature. The cooling bath was removed allowing the reaction to warm to +10 0C over 3 h. The reaction was quenched by the addition of water (500 mL). Organic layer was separated and the aqueous layer washed with ethyl acetate (2 x 500 mL). Combined organic layers were washed with brine then dried over anhydrous sodium sulfate and evaporated to yield the title product (371.1 g) as a yellow oil.
The synthetic route of 35822-58-3 has been constantly updated, and we look forward to future research findings.