Discovery of 1-(4-Methoxyphenyl)ethylamine

The synthetic route of 6298-96-0 has been constantly updated, and we look forward to future research findings.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 6298-96-0, name is 1-(4-Methoxyphenyl)ethylamine, A new synthetic method of this compound is introduced below., Recommanded Product: 6298-96-0

A mixture of (S)-1-(4-methoxyphenyl)-ethylamine (475 mg) and 6-chloropurine riboside (300 mg) in PrOH (70 ml) was heated to 70C and reacted for 8 h. After evaporation of the reaction mixture, the residue was separated by column chromatography over Sephadex LH-20 gel and eluted with ethanol to yield N6-[(S)-1-(4-methoxyphenyl)-ethyl]-adenosine(345 mg) as a white solid: positive ESIMS m/z 402 [M + H]+ and 424 [M + Na]+; 1H NMR (300 MHz, DMSO-d6): the adenosine moiety delta 8.38 (1H, s, H-2), 8.23 (1H, brs, -NH), 8.18 (1H, s, H-8), 5.90 (1H, d, J= 6.3 Hz, H-1′), 5.46 (1H, d, J= 6.3 Hz, -OH), 5.42 (1H, m, -OH), 5.20 (1H, d, J= 4.5 Hz, -OH), 4.61 (1H, m, H-2′), 4.16 (1H, m, H-3′), 3.98 (1H, m, H-4′), 3.66 (1H, m, H-5’a), 3.54 (1H, m, H-5’b); the (S)-1-(4-methoxyphenyl)-ethyl moiety delta 7.35 (1H, d, J = 8.4 Hz, H-2′, H-6′), 6.84 (1H, d, J = 8.4 Hz, H-3′, H-5′), 5.48 (1H, m, H-7′), 3.71 (3H, s, -OCH3), 1.51 (3H, d, 7.2Hz, H-8′); 13C NMR (75 MHz, DMSO-d6): the adenosine moiety delta,153.9 (s, C-6), 152.3 (d, C-2), 148.6 (s, C-4), 139.8 (d, C-8), 119.7 (s, C-5), 88.0 (d, C-1′), 85.9 (d, C-4′), 73.6 (d, C-2′), 70.7 (d, C-3′), 61.7 (t, C-5′); the (S)-1-(4-methoxyphenyl)-ethyl moiety delta 158.0 (s, C-4′), 137.1 (s, C-1′), 127.3 (d, C-2′, C-6′), 113.6 (d, C-3′, C-5′), 55.0 (q, -OCH3), 48.2 (d, C-7′), 22.5 (q, C-8′)o

The synthetic route of 6298-96-0 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; INSTITUTE OF MATERIA MEDICA, CHINESE ACADEMY OF MEDICAL SCIENCES; EP2511283; (2012); A1;,
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Introduction of a new synthetic route about C7H17NO3

Statistics shows that 2-(2-(2-Methoxyethoxy)ethoxy)ethanamine is playing an increasingly important role. we look forward to future research findings about 74654-07-2.

Synthetic Route of 74654-07-2, These common heterocyclic compound, 74654-07-2, name is 2-(2-(2-Methoxyethoxy)ethoxy)ethanamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

A solution of cyanoacetic acid (621 mg, 7.3 mmol) in anhydrous DCM (15 mL) was cooled to 0 C. Separately, a solution of hydroxybenzothiazole (HOBt) (1.48 g, 10.97 mmol) and 2-(2-(2-methoxyethoxy)ethoxy)ethanamine (A2, 1.79 g, 10.97 mmol) was prepared in DCM (10 mL); this solution was then added dropwise to the cooled solution of cyanoacetic acid. The resulting solution was allowed to stir for 10 minutes at 0 C., upon which 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide (EDC) (2.1 g, 10.97 mmol) was added in one portion and the reaction stirred under argon at 0 C. for 12 hours. The reaction was then concentrated and purified by silica gel chromatography (0-2% MeOH/DCM) to obtain 2-cyano-N-(2-(2-(2-methoxyethoxy)ethoxy)ethyl)acetamide A3 as a yellow oil in 83% yield.

Statistics shows that 2-(2-(2-Methoxyethoxy)ethoxy)ethanamine is playing an increasingly important role. we look forward to future research findings about 74654-07-2.

Reference:
Patent; The Regents of the University of California; Amydis, Inc.; Yang, Jerry; Theodorakis, Emmanuel A.; Sarraf, Stella; US2018/327373; (2018); A1;,
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Research on new synthetic routes about 1,11-Diamino-3,6,9-trioxaundecane

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,11-Diamino-3,6,9-trioxaundecane, other downstream synthetic routes, hurry up and to see.

Adding a certain compound to certain chemical reactions, such as: 929-75-9, name is 1,11-Diamino-3,6,9-trioxaundecane, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 929-75-9, Formula: C8H20N2O3

To 4-carboxymethyl-7-[1-(4,4,5,5,6,6,7,7,8,8,9,9,10,10,11,11,11-heptadecafluoroundecyl)-1H-1,2,3-triazol-4-yl]-2H-chromen-2-one (7a, 200 mg, 0.273 mmol) and 1,11-diamino-3,6,9-trioxaundecane (8c, 53 mg, 0.273 mmol) in THF (10 mL) at room temperature was added benzotriazole-1-yl-oxytris(dimethylamino)phosphonium hexafluorophosphate (121 mg, 0.273 mmol), and the mixture was stirred at the same temperature for 1 h. The solvent was removed, and the resulting slurry was diluted with saturated aqueous NaHCO3 and extracted with methylene chloride several times. The combined organic layer was washed with brine, dried over magnesium sulfate, and evaporated in vacuo. The residue was chromatographed on a silica gel column with methylene chloride and MeOH (7:1) to give the desired product 10e (113 mg, 46%). Mp 303.9+/-0.7 C; 1H NMR (500 MHz, DMF-d7): delta=8.92 (s, 1H), 8.44 (br t, J=5.6 Hz, 1H), 7.99 (d, J=8.3 Hz, 1H), 7.94 (dd, J=8.3 and 1.5 Hz, 1H), 7.89 (d, J=1.5 Hz, 1H), 6.52 (s, 1H), 4.74 (t, J=7.0 Hz, 2H), 3.92 (s, 2H), 3.78 (m, 2H), 3.63-3.67(m, 2H), 3.60-3.63 (m, 2H), 3.57-3.60 (m, 4H), 3.55 (t, J=5.6 Hz, 2H), 3.40 (q, J=5.6 Hz, 2H), 3.24-3.33 (m, 2H), 2.43-2.56 (m, 2H), 2.31-2.31 ppm (m, 2H); 13C NMR (125 MHz, DMF-d7): delta=168.4, 160.2, 154.4, 151.1, 145.7, 135.0, 126.6, 123.2, 121.3, 119.1, 116.0, 112.9, 70.35, 70.27, 70.21, 70.18, 69.5, 67.2, 49.1, 40.1, 39.94, 39.91, 39.7, 39.6, 39.5, 39.4, 39.2, 27.8 (t, J=19.2 Hz), 21.6 ppm (t, J=3.5 Hz); IR (ATR, neat): nu=2925, 1719 (CO), 1654 (CO), 1622, 1238, 1203, 1147, 1056, 1027, 1009, 1004, 832, 823, 763 cm-1; MS (ESI): m/z: 906 [M+H+]; HRMS (EI): m/z calcd for C32H32F17N5O6: 905.2081 [M+]; [M+] not found.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1,11-Diamino-3,6,9-trioxaundecane, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Jeon, Moon-Kook; Kang, Myoung-Ku; Park, Koon Ha; Tetrahedron; vol. 68; 30; (2012); p. 6038 – 6053;,
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The important role of 2,6-Dimethoxyaniline

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,6-Dimethoxyaniline, other downstream synthetic routes, hurry up and to see.

Adding a certain compound to certain chemical reactions, such as: 2734-70-5, name is 2,6-Dimethoxyaniline, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2734-70-5, Recommanded Product: 2,6-Dimethoxyaniline

General procedure: To a solution of aniline (0.93 g,10 mmol) in 10% HCl (50 mL) cooled in an ice-bath was added NaNO2 (0.74 g,10.7 mmol). The mixture was stirred at 0 C for 0.5 h and followed by the addition of NaN3 (0.72 g,11 mmol). The mixture was stirred at 0 C for 0.5 h and the aqueous layer was extracted by EtOAc (3×50 mL). The organic layer was dried over MgSO4 overnight. After filtration, EtOAc was evaporated to give 20a as yellow oil (1.09 g, yield 92%), which was used directly in the next reaction without further purification. Compounds 20b-20z and 20aa were prepared from compounds19b-19z and 19aa in a similar manner as described for compound 20a, respectively.

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2,6-Dimethoxyaniline, other downstream synthetic routes, hurry up and to see.

Reference:
Article; Cao, Jiangying; Zang, Jie; Kong, Xiujie; Zhao, Chunlong; Chen, Ting; Ran, Yingying; Dong, Hang; Xu, Wenfang; Zhang, Yingjie; Bioorganic and Medicinal Chemistry; vol. 27; 6; (2019); p. 978 – 990;,
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Research on new synthetic routes about 4-Isopropoxyaniline

The synthetic route of 4-Isopropoxyaniline has been constantly updated, and we look forward to future research findings.

Synthetic Route of 7664-66-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 7664-66-6, name is 4-Isopropoxyaniline belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

[Example 45] Preparation of 1-(4-chlorobenzyl)-2-(4-isopropoxyphenylimino)-dihydro-pyrimidine-4,6-dion (I-322) To a mixture of 4-isopropoxyaniline (15 g, 99 mmol) and acetonitrile (150 mL) was added gradually benzoylisothiocyanate (13.4 mL, 99 mmol) under ice-cooling, and the resulting mixture was stirred at room temperature for 50 minutes. To the reaction mixture were added gradually 4-chlorobenzylamine (12.1 mL, 99 mmol), triethylamine (13.8 mL, 99 mmol), and 1-ethyl-3-(3-dimethyl-aminopropyl) carbodiimide hydrochloride (20.9 g, 109 mmol) under ice-cooling, and the resulting mixture was stirred at room temperature for 2.5 hours. To the reaction mixture was added water (200 mL), and the mixture was extracted with toluene (300 mL). The extract was washed by brine (100 mL), dried over anhydrous magnesium sulfate, and concentrated in vacuo. The resulting residue was precipitated by toluene and hexane to give N-((4-chlorobenzylamino)(4-isopropoxyanilino)methylene)benzamide (38.1 g, Yield: 91%) as white powder. 1H-NMR (delta ppm TMS/CDCl3): 1.34 (6H, d, J=6.0 Hz), 4.52 (1H, sept, J=6.0 Hz), 4.72 (2H, d, J=6.2 Hz), 5.09 (1H, brs), 6.87-6.92 (2H, m), 7.13-7.18 (2H, m), 7.24-7.31 (4H, m), 7.36-7.48 (3H, m), 8.21-8.25 (2H, m), 11.9 (1H, brs).

The synthetic route of 4-Isopropoxyaniline has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Shionogi & Co., Ltd.; KAI, Hiroyuki; ENDOH, Takeshi; JIKIHARA, Sae; ASAHI, Kentaro; HORIGUCHI, Tohru; EP2604260; (2013); A1;,
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Extended knowledge of C5H11BrO2

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 54149-17-6.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 54149-17-6, name is 1-Bromo-2-(2-methoxyethoxy)ethane, This compound has unique chemical properties. The synthetic route is as follows., Product Details of 54149-17-6

Example 1.2.1 4-Bromo-3,5-dimethylphenol (10.05 g, 50.0 mmol) and K2CO3 (9.0 g, 65.2 mmol) were stirred for 10 minutes in DMF (25 mL). 1-Bromo-2-(2-methoxyethoxy)ethane was added, and the reaction mixture was heated at 45 C. overnight under argon. After cooling to room temperature, the reaction mixture was poured into ~300 mL DCM; filtered off white solids. Flash column (silica; 100% hexane) gave 12.95 g (85% yield) of product 5.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 54149-17-6.

Reference:
Patent; Nitto Denko Corporaton; US2010/308310; (2010); A1;,
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Share a compound : 54149-17-6

The synthetic route of 54149-17-6 has been constantly updated, and we look forward to future research findings.

54149-17-6, name is 1-Bromo-2-(2-methoxyethoxy)ethane, belongs to ethers-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. category: ethers-buliding-blocks

l-Bromo-2-(2-methoxyethoxy)ethane (1.83 g, 10 mmol, diluted in 10 mL of dried DMF) was added dropwise to a stirred mixture of tert- butyl 4-hydroxyphenethylcarbamate (2.61 g, 11 mmol) and NaH (0.44 g, 11 mmol, 60% dispersion in mineral oil) in dry DMF (40 mL) under N2 at 0 C. The reaction was stirred at room temperature for 14 h. After this time, the reaction mixture was stirred at 60 C for 8 h. The reaction was quenched with ice-water and extracted with ethyl acetate. The organic layer was washed with water and brine, dried over sodium sulfate and concentrated in vacuo. The crude product was purified by column chromatography to afford the title compound as colorless oil (2.311 g, 68% yield). NMR (500 MHz, CDCb) S: 7.19- 7.01 (m, 2H), 6.93-6.81 (m, 2H), 4.58 (s, 1H), 4.13 (dd, J= 9.8, 4.9 Hz, 2H), 3.86 (dd, J= 9.5, 5.1 Hz, 2H), 3.79-3.67 (m, 2H), 3.65-3.53 (m, 2H), 3.40 (dd, J= 4.0, 1.8 Hz, 3H), 3.34 (s, 2H), 2.73 (s, 2H), 1.44 (s, 9H).

The synthetic route of 54149-17-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; ZHEJIANG VIMGREEN PHARMACEUTICALS, LTD; SUN, Sanxing; ZHAO, Long; HU, Chongbo; CHEN, Zhengshu; YE, Jinqi; (0 pag.)WO2020/2969; (2020); A1;,
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Discovery of 1-(3-Methoxyphenyl)-N-methylmethanamine

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-(3-Methoxyphenyl)-N-methylmethanamine, its application will become more common.

Related Products of 41789-95-1,Some common heterocyclic compound, 41789-95-1, name is 1-(3-Methoxyphenyl)-N-methylmethanamine, molecular formula is C9H13NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: A mixture of 2.73 mmol appropriate alkyl halide (i.e., 17a-c, or18a-c), 0.6 g K2CO3 (4.34 mmol), and 0.6 g NaI (4.00 mmol) in ACN(12 mL) was mixed for 5 min in a 30 mL microwave reaction vessel.Then, 8.2 mmol appropriate amine derivative (i.e., 1-6, as shown inScheme 3) was added and the resulting content was mixed foradditional 2 min. The reaction vessel was capped, and insertedinside the microwave instrument (i.e., A CEM Model Single ModeMicrowave Instrument) and heated for 32 min at 105 C at thedynamic mode of the instrument automatically calibrating theradiation and temperature balance with respect to the change inpressure. Then, acetonitrile was distilled out under vacuum andthe residue thus obtained was mixed with 20 mL of K2CO3 solution(5.0%) and this mixture was heated at 60 C for 1 h. Then the mixturewas cooled down to room temperature and the aqueous phasewas extracted 3 times with 20 mL of ethylacetate. Combinedorganic extracts were dried over MgSO4 and concentrated underreduced pressure to give the product (i.e., free base). The free basewas dissolved in 10 mL acetone and HCl gas was continuouslypassed until HCl salt precipitation took place.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 1-(3-Methoxyphenyl)-N-methylmethanamine, its application will become more common.

Reference:
Article; Gulcan, Hayrettin Ozan; Unlu, Serdar; Esiringu, Ilker; Ercetin, Tugba; Sahin, Yasemin; Oz, Demet; Sahin, Mustafa Fethi; Bioorganic and Medicinal Chemistry; vol. 22; 19; (2014); p. 5141 – 5154;,
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Some tips on C9H13NO

According to the analysis of related databases, 41789-95-1, the application of this compound in the production field has become more and more popular.

Reference of 41789-95-1, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 41789-95-1 as follows.

General procedure: To a solution of 2,6-bis(chloromethyl)pyridine (1 mmol) in anhydrous acetonitrile (10 mL) was added cesium carbonate (3 mmol) and the corresponding secondary amine (2.2 mmol). The reaction mixture was heated at reflux for 5 h. The resulting mixture was diluted with water (20 mL) and extracted with ethyl acetate (15 mL) three times. The combined organic layers were washed with brine, dried over anhydrous sodium sulfate, and concentrated in vacuo. The crude was purified by column chromatography with methanol/dichloromethane (100:1, v/v) to give the title compound as a colorless liquid or a white solid.

According to the analysis of related databases, 41789-95-1, the application of this compound in the production field has become more and more popular.

Reference:
Article; Bai, Renren; Liang, Zhongxing; Yoon, Younghyoun; Liu, Shuangping; Gaines, Theresa; Oum, Yoonhyeun; Shi, Qi; Mooring, Suazette Reid; Shim, Hyunsuk; European Journal of Medicinal Chemistry; vol. 118; (2016); p. 340 – 350;,
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Analyzing the synthesis route of 7-Methoxy-3,4,5,6-tetrahydro-2H-azepine

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2525-16-8, name is 7-Methoxy-3,4,5,6-tetrahydro-2H-azepine, A new synthetic method of this compound is introduced below., Application In Synthesis of 7-Methoxy-3,4,5,6-tetrahydro-2H-azepine

I. 3-Methyl-7,8,9,10-tetrahydroazepino[2,1-b]quinazolin-12(6H)-one 25 g 2-bromo-4-methylbenzoic acid was treated with 150 mL of 28% aqueous ammonia, 50 g gaseous ammonia, 1 g CuSO4 at 140 C. for 12 hours in an autoclave, then concentrated in vacuo, dissolved in a minimal amount of water, pH adjusted to 6 with 4N HCl. The precipitate was filtered, washed with ice cold water, and dried at 60 C. The residue was extracted with THF and concentrated in vacuo, giving a light brown crystalline solid. Yield of combined material: 14 g 4-methylanthranilic acid. 6.4 g of this acid was suspended with stirring in 100 mL toluene. 11 mL 1-Aza-2-methoxy-1-cycloheptene (1) (Aldrich) were added and the mixture was refluxed under a Dean-Stark trap for 12 hours. Then the toluene was removed by distillation in vacuo, followed by removal of excess (1) in vacuo (11 mm Hg) at 140 C. The dark brown residue crystallized. It was purified by column chromatography (6:1 chloroformethyl acetate) followed by recrystallization from hexane-ethyl acetate to give 7.1 g of pure 3-methyl-7,8,9,10-tetrahydroazepino[2,1-b]quinazolin-12(6H)-one as white, shiny crystals.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Warner-Lambert Company; US5486512; (1996); A;,
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