Tag: M.W=100-200

Synthetic Route of 578-57-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 578-57-4, name is 1-Bromo-2-methoxybenzene, This compound has unique chemical properties. The synthetic route is as follows.

In a reaction tube, dissolve palladium complex [Pd] (0.03 mmol) and o-methoxybromobenzene (1.0 mmol) in 3 mL of toluene,extract and ventilate three timesin a CO2atmosphere, and connect a CO2balloonunder normal pressure. The reaction was carried out at 60 C for 8 hours. After the reaction, the reaction mixture was acidified. The reaction solution was concentrated and separated by column chromatography to obtain the corresponding product C8H8O3(yield 91%).

The chemical industry reduces the impact on the environment during synthesis 1-Bromo-2-methoxybenzene. I believe this compound will play a more active role in future production and life.

Reference:
Patent; Shanghai Institute of Technology; Yao Zijian; Chen Jing; (9 pag.)CN110483581; (2019); A;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 7252-83-7, name is 2-Bromo-1,1-dimethoxyethane, A new synthetic method of this compound is introduced below., COA of Formula: C4H9BrO2

1-(2-Amino-3-chloro-4-hydroxy-phenyl)-ethanone (15.5 g, 83.8 mmol), Cs2CO3 (54.6 g, 167 mmol) and 2-bromo-1,1-dimethoxy-ethane (14.78 mL, 126 mmol) was dissolved in DMF (125 mL) under an atmosphere of nitrogen. The reaction was heated to 65 C. for 6 hours. The reaction was determined to be complete by LC/MS. The reaction was taken up in EtOAc (500 mL) and washed with 5% LiCl(aq) (3*250 mL). Organics were dried over Na2SO4, filtered and solvent removed under reduced pressure. 1-[2-Amino-3-chloro-4-(2,2-dimethoxy-ethoxy)-phenyl]-ethanone (12.99 g, 57%) was isolated by silica gel chromatography as a white solid. LC/MS=274 (M++1)

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Gilead Sciences, Inc.; US2011/135599; (2011); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 38336-04-8, name is 2-(Benzyloxy)-1-ethanamine, A new synthetic method of this compound is introduced below., HPLC of Formula: C9H13NO

Azido-N-(2-benzyloxyethyl)acetamide, 6a A solution of 2-benzyloxyethylamine (15 g) and potassium carbonate (40 g) in acetone (400 ml) was treated dropwise with azidoacetyl chloride at 20 C. After stirring for 3 h at room temperature, the mixture was filtered and concentrated in vacuo. Dichloromethane (800 ml) was added, and the solution was washed with aq. sodium bicarbonate. The organic phase was dried over magnesium sulfate. Removal of solvent in vacuo gave a yellow oil which was filtered through silica gel with ethyl acetate. Removal of the solvent in vacuo gave 6a as a colorless oil. Yield: 22 g.

The synthetic route of 38336-04-8 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; H. Lundbeck A/S; US5703087; (1997); A;,
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Adding a certain compound to certain chemical reactions, such as: 4393-09-3, name is (2,3-Dimethoxyphenyl)methanamine, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 4393-09-3, name: (2,3-Dimethoxyphenyl)methanamine

General procedure: Under an atmosphere of N2, the appropriate amine (0.669 mmol, 1.2 equiv.) was dissolved in 1,2-dichloroethane (DCE) (1 mL) and methyl-(E)-3-(4-formylphenyl)acrylate (106 mg; 0.557 mmol, 1 equiv.) wasthen added, followed by the addition of acetic acid (64 muL, 1.11 mmol, 2 equiv.). The reaction mixture wasstirred overnight at room temperature. When the starting aldehyde had been consumed as monitored by TLC,NaBH(OAc)3 (0.836 mmol, 1.5 equiv.) was added, and the reaction mixture was stirred for 3 h at roomtemperature. The reaction was quenched by the addition of saturated NH4Cl solution (2.0 mL), and thenextracted with saturated sodium hydrogen carbonate solution (10 mL) and ethyl acetate (3 × 10 mL). Theorganic layer was washed with brine, dried over anhydrous magnesium sulfate, and filtered. The solvent wasremoved in vacuo, and the residue was dissolved in a minimal volume of dichloromethane (DCM) and purifiedby flash column chromatography (silica gel, 20-80% EtOAC:hexane).

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Article; Daniel, Lydia; Gotsbacher, Michael P.; Richardson-Sanchez, Tomas; Tieu, William; Codd, Rachel; Bioorganic and Medicinal Chemistry Letters; vol. 29; 18; (2019); p. 2581 – 2586;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 41365-75-7, name is 1-Amino-3,3-diethoxypropane, A new synthetic method of this compound is introduced below., COA of Formula: C7H17NO2

/V./V-Diisopropylethylamine (3.397 mL, 19.5 mmol) followed by 3,3-diethoxypropan-l- amine (3.154 mL, 19.5 mmol) were added to a solution of 4-chloro-l-fluoro-2- nitrobenzene (1.765 mL, 15 mmol), in iPrOH (35 mL) and heated at 80 C for 4.5 h. After cooling to rt, the reaction mixture was diluted with EtOAc (100 mL), washed successively with LLO (acidified to -pH 6 with 0.01 M aqueous HC1, 4x) and brine (1 x, 100 mL each), dried (MgS04) and the solvent removed under reduced pressure to afford the crude product as an orange solid (4.308 g, 97%). ‘H NMR (400 MHz, CDCls): d 8.29 (br s, 1H), 8.17 (d, J = 2.6 Hz, 1H), 7.37 (ddd, J = 9.2, 2.6, 0.6 Hz, 1H), 6.83 (d, J = 9.2 Hz, 1H), 4.65 (t, J = 5.0 Hz, 1H), 3.76-3.65 (m, 2H), 3.59-3.49 (m, 2H), 3.44-3.37 (m, 2H), 2.07-2.01 (m, 2H), 1.24 (t, J = 7.0 Hz, 6H). LRMS (ESI+) m/z 324.9 [M+Na]+

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; REVIRAL LIMITED; GOOD, James; (48 pag.)WO2019/122928; (2019); A1;,
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Some common heterocyclic compound, 651734-54-2, name is 2,6-Difluoro-3,5-dimethoxyaniline, molecular formula is C8H9F2NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. HPLC of Formula: C8H9F2NO2

Example 1233-{ 13-(2,6-difluoro-3,5-dimethoxyphenyl)-2,8-dioxo-2,3,4,7,8,9-hexahydro-1H- pyrrolo j3?,2?:5,6j pyrido 14,3-d jpyrimidin-1-ylj methyl}benzonitrile Step 1: N-[(4-chloro-1-{[2-(trimethylsilyl)ethoxyJmethyl}-JH-pyrrolo[2, 3-bJpyridin-5- yl)methylJ-2, 6-dijluoro-3 , 5-dimethoxyaniline To a solution of sodium triacetoxyborohydride (6.2 g, 29 mmol) in trifluoroacetic acid (10.0 mL, 1.30E2 mmol) at 0 C was added a solution of 2,6-difluoro-3,5-dimethoxyaniline (1.52 g, 8.03 mmol) in methylene chloride (10 mL), followed by a solution of 4-chloro-1-{[2-(trimethylsilyl)ethoxy]methyl} -1 H-pyrrolo[2,3 -b]pyridine-5 -carbaldehyde (Example 106, Step 1: 2.27 g, 7.30 mmol) in methylene chloride (40 mL, 700 mmol). The reaction mixture was stirred at 0 C for 1 h then poured into a cold aqueous solution of NaHCO3 and then extracted with methylene chloride. The organic phase was washed with brine then dried over Na2SO4 and concentrated. The residue was purified by flash chromatography eluted with 0 to40 % EtOAc in DCM to give the desired product as a yellow oil which solidified on standing (3.32 g, 94 %). LC-MS calculated for C22H29C1F2N3O3Si (M+H) mlz: 484.2; found: 484.1.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 651734-54-2, its application will become more common.

Reference:
Patent; INCYTE CORPORATION; WU, Liangxing; ZHANG, Colin; HE, Chunhong; SUN, Yaping; LU, Liang; QIAN, Ding-Quan; XU, Meizhong; ZHUO, Jincong; YAO, Wenqing; WO2014/7951; (2014); A2;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 929-75-9, name is 1,11-Diamino-3,6,9-trioxaundecane, This compound has unique chemical properties. The synthetic route is as follows., name: 1,11-Diamino-3,6,9-trioxaundecane

Synthesis of Intermediate J To a solution of 2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethanamine (646 mg, 3.36 mmol) in anhydrous i-PrOH (10.0 mL) was added triethylamine (255 mg, 2.52 mmol, 349 muL) and the reaction mixture cooled to 0 C. A solution of [(3S,8S,9S,10R,13R,14S,17R)-17-[(1R,4R)-4-ethyl-1,5-dimethyl-hexyl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] carbonochloridate (800 mg, 1.68 mmol) in DCM (10 mL) was added dropwise to the reaction mixture over 10 minutes. The resultant solution was stirred at 0 C. for 2 hours then warmed to room temperature and stirred another 4 hours until completion of the reaction was indicated by TLC. The reaction mixture was concentrated under reduced pressure and purified via flash chromatography with an eluent of methanol/DCM (1:4) to afford the product [(3S,8S,9S,10R,13R,14S,17R)-17-[(1R,4R)-4-ethyl-1,5-dimethyl-hexyl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-yl] N-[2-[2-[2-(2-aminoethoxy)ethoxy]ethoxy]ethyl]carbamate (823 mg, 1.30 mmol, 77.4% yield).

According to the analysis of related databases, 929-75-9, the application of this compound in the production field has become more and more popular.

Reference:
Patent; Preceres Inc.; Heidebrecht, JR., Richard Wayne; Svenson, Sonke; Wiegand, Roger; Hwang, Jungyeon; Beaudoin, Jen; Zhong, Cheng; (181 pag.)US2017/325457; (2017); A1;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 5961-59-1, name is 4-Methoxy-N-methylaniline, A new synthetic method of this compound is introduced below., HPLC of Formula: C8H11NO

General procedure: Compound 1a (0.0016g, 0.0043 mmol),HBpin (94L, 0.645 mmol), N-methylaniline (23 L, 0.215mmol), the internal standard1,3,5-trimethoxybenzene (10 mg) and CD3CN (0.4 mL) were loaded in a dried J-Young Tube under argonatmosphere. The sample was degassed using a freeze-pump-thaw method, and CO2 (approximately 45 mg)was introduced into the NMR tube at -196 oC. The reaction was monitored by NMR spectroscopy.PhMeN(CHO) 8a was purified by preparative TLC using ethyl acetate/hexane/triethylamine as eluent.Spectral data of all products are in accordance with those reported in the literature.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Wu, Di; Wang, Ruixing; Li, Yongxin; Ganguly, Rakesh; Hirao, Hajime; Kinjo, Rei; Chem; vol. 3; 1; (2017); p. 134 – 151;,
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These common heterocyclic compound, 701-56-4, name is 4-Methoxy-N,N-dimethylaniline, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of 4-Methoxy-N,N-dimethylaniline

General procedure: Under an atmosphere of N2, KOt-Bu (2.2 mmol), dioxane (0.9 mL), DMSO (1.65 mmol), tertiary amine 1 (0.55 mmol), and aryl halide 2(1.65 mmol) were successively added to a Schlenk reaction tube. The mixture was stirred vigorously at 80-120 C for 12 h. Then the mixture was diluted with EtOAc, washed with sat. brine, and dried (anhyd Na2SO4). Then the solvent was removed under reduced pressure and the residue was purified by flash column chromatography (petroleum ether and petroleum ether-EtOAc, 100:1 for the methoxy group derived products) to give pure products 3.

The synthetic route of 4-Methoxy-N,N-dimethylaniline has been constantly updated, and we look forward to future research findings.

Reference:
Article; Huang, Pei; He, Bang-Yue; Wang, Hui-Min; Lu, Jian-Mei; Synthesis; vol. 47; 2; (2015); p. 221 – 227;,
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These common heterocyclic compound, 93919-56-3, name is (4-(Trifluoromethoxy)phenyl)methanamine, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Application In Synthesis of (4-(Trifluoromethoxy)phenyl)methanamine

A mixture of 4,7-dichloro-l-methyl-lH-pyrrolo[2,3-c]pyridine (153 mg, 760 muiotaetaomicron) obtained in Reference example 2 and 4-(trifluoromethoxy)benzylamine (1.45 g, 7.60 mmol) was stirred at 200C for 6 hours under microwave irradiation. After cooling, to the reaction solution was added 1 mol/L aqueous citric acid solution, and the mixture was extracted with ethyl acetate twice. The organic layer was combined, washed with water, filtered through diatomite column, and then concentrated under reduced pressure. The resulting residue was purified by silica gel column chromatography (hexane:ethyl acetate = 19:1?1 : 1) to give 4- chloro- 1 -methyl -N- [4-(trifluoromethoxy)benzyl] – 1 H-pyrrolo [2,3 -c]pyridine-7-amine (138 mg, 51%) as a yellow viscous material.APCI-MS m/z:356/358[M+H]+.

The synthetic route of (4-(Trifluoromethoxy)phenyl)methanamine has been constantly updated, and we look forward to future research findings.

Reference:
Patent; MITSUBISHI TANABE PHARMA CORPORATION; TSUZUKI, Yasuyuki; SAWAMOTO, Daisuke; SAKAMOTO, Toshiaki; KATO, Taku; NIWA, Yasuki; AWAI, Nobumasa; WO2012/124825; (2012); A1;,
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