Tag: M.W=100-200

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 22483-09-6, name is 2,2-Dimethoxyethanamine belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. Safety of 2,2-Dimethoxyethanamine

Benzyl chloroformate (231.3 g, 1.3 mol) was added gradually to a mixture of aminoacetaldehyde dimethyl acetal (152.0 g, 1.3 mol) in toluene (750 mL) and aqueous NaOH (72.8 g, 1.82 mol; in 375 mL of water) at 10-20 C. After the addition was complete, the mixture was stirred at ambient temperature for 4 h. The organic layer was separated, washed with brine (2×100 mL) and concentrated to provide the title compound.

The synthetic route of 22483-09-6 has been constantly updated, and we look forward to future research findings.

Reference:
Patent; Schrimpf, Michael R.; Sippy, Kevin B.; Ji, Jianguo; Li, Tao; Pace, Jennifer M.; Briggs, Clark A.; US2005/171079; (2005); A1;,
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In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 50742-37-5, name is (3-Phenoxyphenyl)methanamine belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. SDS of cas: 50742-37-5

Typical procedure: To a stirred solution of the amine (1.0 equiv) and the aldehyde (1.0 equiv) in dichloroethane (0.2 M) was added acetic acid (5.0 equiv). The solution was stirred for 18 h, then sodium triacetoxyborohydride (1.2 equiv) was added and the mixture was stirred for 1 h. The appropriate isocyanate (1.5 equiv) was added and the mixture was stirred for an additional 4 h before being quenched with a saturated aqueous solution of sodium bicarbonate. The layers were separated and the aqueous layer was extracted three times with dichloromethane. The organic layers were combined and dried over magnesium sulfate, filtered and concentrated under reduced pressure. The crude was purified on silica gel.

The synthetic route of 50742-37-5 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Chiasson, Jean-Franois; Boulet, Louise; Brideau, Christine; Chau, Anh; Claveau, David; Cote, Bernard; Ethier, Diane; Giroux, Andre; Guay, Jocelyne; Guiral, Sebastien; Mancini, Joseph; Masse, Frederic; Methot, Nathalie; Riendeau, Denis; Roy, Patrick; Rubin, Joel; Xu, Daigen; Yu, Hongping; Ducharme, Yves; Friesen, Richard W.; Bioorganic and Medicinal Chemistry Letters; vol. 21; 5; (2011); p. 1488 – 1492;,
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Application of 592-55-2, A common heterocyclic compound, 592-55-2, name is 1-Bromo-2-ethoxyethane, molecular formula is C4H9BrO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a stirred solution of 3-hydroxybenzaldehyde 1 (15 g, 122.9 mmol) in DMSO (100 mL) and 10 % aqueous NaOH solution was added 1-bromo-2-ethoxyethane 2 (34 mL, 307.3 mmol) in DMSO (50 mL) drop wise at 80 C then stirred at same temperature for 10 h. After completion of reaction as indicated by TLC, reaction mixture was poured into 1M HCl solution (200 ml) and extracted with diethyl ether (2x 500 mL). Combined organic layers were washed with brine solution (100 mL), dried over Na2SO4 and concentrated under reduced pressure to afford 3-(2-ethoxyethoxy) benzaldehyde 3 (5.4 g, 27.83 mmol, 22 %) as a colorless oily liquid. TLC system: 30 % ethyl acetate in pet ether – Rf: 0.50; LCMS: m/z = 195.31 (M+H) +

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; COCRYSTAL PHARMA, INC.; JACOBSON, Irina, C.; LEE, Sam SK; FEESE, Michael, David; (206 pag.)WO2020/23813; (2020); A1;,
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Application of 111-95-5, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 111-95-5 as follows.

EXAMPLE 17 Bis-(2-methoxy-ethyl)-prop-2-ynyl-amine Propargyl bromide (17.8 g, 150 mmol) was added dropwise to a mixture of bis(2-methoxy-ethyl)amine (20 g, 150 mmol) and cesium carbonate (49 g, 150 mmol) in 350 mL of acetone. The mixture was stirred overnight under nitrogen at room temperature. The inorganic salts were then filtered off, and the solvent was removed. The residue was dissolved in saturated sodium bicarbonate solution and extracted with ethyl acetate. The organic extracts were then evaporated to give 20 g of bis-(2-methoxy-ethyl)-prop-2-ynyl-amine: mass spectrum (m/e): M+H 172.

According to the analysis of related databases, 111-95-5, the application of this compound in the production field has become more and more popular.

Reference:
Patent; American Cyanamid Company; US6288082; (2001); B1;,
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Synthetic Route of 171290-52-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 171290-52-1, name is 3,5-Dimethoxyphenylacetylene, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: A mixture of 2 (0.50 g, 1.40 mmol), dichlorobis(triphenylphosphine)palladium(II) (0.05 g, 0.07 mmol), copper(I) iodide (0.03 g,0.14 mmol), triphenylphosphine (0.02 g, 0.08 mmol) and triethylamine(0.17 g, 1.68 mmol) in 4:1 DMF-water (v/v, 20 mL) was placed in a two necked round-bottomed flask equipped with a stirrer bar, condenser and a rubber septum. The mixture was flushed with argon gas for30 min and a solution of phenylacetylene derivative (1.2 equiv.) in DMF(2 mL) was introduced via a rubber septum by means of a syringe. A balloon filled with argon was connected to the top of the condenser andthe mixture was left to stir at 70 C for 2 h. The mixture was allowed to cool and then poured into crushed ice. The product was extracted into chloroform and the combined organic phases were washed with water and dried over anhydrous MgSO4. The salt was filtered off and the solvent was evaporated under reduced pressure on a rotary evaporator.The residue was purified by column chromatography on using silica gelusing 9:1 toluene-ethyl acetate mixture (v/v) as an eluent. The following compounds were prepared in this fashion.

The chemical industry reduces the impact on the environment during synthesis 3,5-Dimethoxyphenylacetylene. I believe this compound will play a more active role in future production and life.

Reference:
Article; Olomola, Temitope O.; Mphahlele, Malose J.; Journal of Fluorine Chemistry; vol. 229; (2020);,
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Application of 6298-96-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6298-96-0, name is 1-(4-Methoxyphenyl)ethylamine belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

EXAMPLE 6.1(S)-2-((3-(3,5-dimethoxyphenyl)-1,4-dimethyl-1H-pyrazolo[3,4-b]pyridin-6-yl)oxy)-N-(1-(4-methoxyphenyl)ethyl)acetamide To a solution of [3-(3,5-Dimethoxy-phenyl)-1,4-dimethyl-1H-pyrazolo[3,4-b]pyridin-6-yloxy]-acetic acid (building block A1, 100 mg, 0.28 mmol) in CH2Cl2 were added HOBt×H2O (64 mg, 0.42 mmol), EDC×HCl (80 mg, 0.42 mmol) and NEt3 (0.12 ml, 0.84 mmol). After stirring at rt for 5 min, (S)-1-(4-methoxyphenyl)ethanamine (64 mg, 0.42 mmol) was added and stirring continued for 18 h. Then, water was added and the mixture extracted 3 times with DCM. The organic phases were dried over Na2SO4 and the solvent removed under reduced pressure. Purification by reverse phase HPLC (Sunfire C18 OBD column) followed by liberation of the free base (SPE cartridge SCX-1, eluent 7M NH3 in methanol) yielded the title compound (17 mg, 12%). [1H-NMR (DMSO-d6, 600 MHz) delta 8.48 (d, 1H), 7.21 (d, 2H), 6.82 (d, 2H), 6.70 (s, 1H), 6.58 (s, 1H), 5.00-4.88 (m, 1H), 4.87 (d, 1H), 4.83 (d, 1H), 3.85 (s, 3H), 3.78 (s, 6H), 3.70 (s, 3H), 2.37 (s, 3H), 1.37 (d, 3H); UPLC-MS RtJ=1.14 min; [M+H]+=491.2]

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 1-(4-Methoxyphenyl)ethylamine, other downstream synthetic routes, hurry up and to see.

Reference:
Patent; NOVARTIS AG; US2012/258973; (2012); A1;,
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Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 6298-96-0, name is 1-(4-Methoxyphenyl)ethylamine, This compound has unique chemical properties. The synthetic route is as follows., Application In Synthesis of 1-(4-Methoxyphenyl)ethylamine

To a solution of [3-(3,5-Dimethoxy-phenyl)-1 ,4-dimethyl-1 H-pyrazolo[3,4-b]pyridin-6-yloxy]- acetic acid (building block A1 , 100 mg, 0.28 mmol) in CH2CI2 were added HOBt x H20 (64 mg, 0.42 mmol), EDC x HCI (80 mg, 0.42 mmol) and NEt3 (0.12 ml, 0.84 mmol). After stirring at rt for 5 min, (S)-1-(4-methoxyphenyl)ethanamine (64 mg, 0.42 mmol) was added andstirring continued for 18 h. Then, water was added and the mixture extracted 3 times withDCM. The organic phases were dried over Na2S04 and the solvent removed under reduced pressure. Purification by reverse phase HPLC (Sunfire C18 OBD column) followed byliberation of the free base (SPE cartridge SCX-1 , eluent 7M NH3 in methanol) yielded the title compound (17 mg, 12%). [1 H-NMR (DMSO-d6, 600 MHz) delta 8.48 (d, 1 H), 7.21 (d, 2H),6.82 (d, 2H), 6.70 (s, 1 H), 6.58 (s, 1 H), 5.00-4.88 (m, 1 H), 4.87 (d, 1 H), 4.83 (d, 1 H), 3.85 (s, 3H), 3.78 (s, 6H), 3.70 (s, 3H), 2.37 (s, 3H), 1.37 (d, 3H); UPLC-MS Rtj = 1.14 min; [M+H]+ = 491.2]

According to the analysis of related databases, 6298-96-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; NOVARTIS AG; BADIGER, Sangamesch; BEHNKE, Dirk; BETSCHART, Claudia; CHAUDHARI, Vinod; CHEBROLU, Murali; COSTESTA, Simona; HINTERMANN, Samuel; MEYER, Arndt; PANDIT, Chetan; WO2011/76744; (2011); A1;,
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Related Products of 93919-56-3,Some common heterocyclic compound, 93919-56-3, name is (4-(Trifluoromethoxy)phenyl)methanamine, molecular formula is C8H8F3NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: To a solution of 4 (290mg, 1.02mmol) in DMF (1.5mL), CDI (198mg, 1.23mmol) was added under N2 protection. The resulting reaction was stirred 50C. After 2h, the mixture was cooled to room temperature, and the corresponding benzylamine (1.53mmol) was added. The resulting reaction was stirred 50C under N2 protection overnight. Then the mixture was cooled to room temperature, quenched with 1M hydrochloric acid, diluted with water (50mL), and extracted with CH2Cl2 (60mL×3). The combined organic layer were washed with saturated solution of NaCl (60mL×3), dried over MgSO4, concentrated and purified by flash chromatography eluting with 5-50% ethyl acetate in petroleum ether, to provide the desired products 5a-5d.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route (4-(Trifluoromethoxy)phenyl)methanamine, its application will become more common.

Reference:
Article; Liu, Siming; Jiang, Ying; Yan, Ruohong; Li, Zhonghuang; Wan, Shanhe; Zhang, Tingting; Wu, Xiaoyun; Hou, Ju; Zhu, Zhengguang; Tian, Yuanxin; Zhang, Jiajie; European Journal of Medicinal Chemistry; vol. 179; (2019); p. 358 – 375;,
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Related Products of 2398-37-0, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 2398-37-0 as follows.

The advantageous effect of adding zinc chloride to an amination reaction was demonstrated in the amination reaction of 3-bromoanisole. the results of which are summarized in Table 10. When 3-bromoanisole was reacted under the standard lithium amide amination conditions, using lithium amide (10 eq.) in the presence of (CyPF-^-Bu)PdCl2 (1 mol%) in DME gave a complicated mixture of products was obtained (Table 10, Entry 1). When conducted in the presence of zinc chloride and TMEDA, however, the reaction could successfully gave the desired monoarylation product, 3-methoxyaniline, although at high concentrationsN,N-dimethyl-3-methoxyaniline was formed in a significant amount as a by- product (Table 10, Entries 3 and 4). Under optimized conditions (Table 10, Entries 8 and 9), 3-methoxyaniline was formed selectively in good yield.

According to the analysis of related databases, 2398-37-0, the application of this compound in the production field has become more and more popular.

Reference:
Patent; YALE UNIVERSITY; WO2007/109365; (2007); A2;,
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Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 6298-96-0, name is 1-(4-Methoxyphenyl)ethylamine, A new synthetic method of this compound is introduced below., Product Details of 6298-96-0

General procedure: The appropriate amine derivative was dissolved in the appropriate solvent (ethanol or pyridine) after which CS2 was added. The mixture was refluxed overnight under N2. Next, the solution was concentrated by evaporating the solvent and then cooled to give aprecipitate. The precipitated product was isolated by vacuum filtration. The crude N,N’-bis-thiourea was purified by recrystallizationfrom ethanol.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Tuncel, Senel Teke; Gunal, Sule Erol; Ekizoglu, Melike; Gokhan Kelekci, Nesrin; Erdem, Safiye S.; Bulak, Ece; Frey, Wolfgang; Dogan, Ilknur; Journal of Molecular Structure; vol. 1179; (2019); p. 40 – 56;,
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