In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 50742-37-5, name is (3-Phenoxyphenyl)methanamine belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. SDS of cas: 50742-37-5
Typical procedure: To a stirred solution of the amine (1.0 equiv) and the aldehyde (1.0 equiv) in dichloroethane (0.2 M) was added acetic acid (5.0 equiv). The solution was stirred for 18 h, then sodium triacetoxyborohydride (1.2 equiv) was added and the mixture was stirred for 1 h. The appropriate isocyanate (1.5 equiv) was added and the mixture was stirred for an additional 4 h before being quenched with a saturated aqueous solution of sodium bicarbonate. The layers were separated and the aqueous layer was extracted three times with dichloromethane. The organic layers were combined and dried over magnesium sulfate, filtered and concentrated under reduced pressure. The crude was purified on silica gel.
The synthetic route of 50742-37-5 has been constantly updated, and we look forward to future research findings.
Reference:
Article; Chiasson, Jean-Franois; Boulet, Louise; Brideau, Christine; Chau, Anh; Claveau, David; Cote, Bernard; Ethier, Diane; Giroux, Andre; Guay, Jocelyne; Guiral, Sebastien; Mancini, Joseph; Masse, Frederic; Methot, Nathalie; Riendeau, Denis; Roy, Patrick; Rubin, Joel; Xu, Daigen; Yu, Hongping; Ducharme, Yves; Friesen, Richard W.; Bioorganic and Medicinal Chemistry Letters; vol. 21; 5; (2011); p. 1488 – 1492;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem