Tag: M.W=100-200

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 10075-63-5, name is 1,5-Dimethoxynaphthalene, A new synthetic method of this compound is introduced below., Recommanded Product: 10075-63-5

70% Nitric acid (4.5 mL) in acetic acid (4.5 mL) was added slowly to a stirred suspension of 1,5-dimethoxynaphthalene(3.76 g, 20 mmol) in acetic acid (50 mL)at room temperature. Upon stirring overnight at ambienttemperature, the precipitate was filtered off,washed with water, recrystallized from methanol, anddried. Light yellow solid, yield 82%. 1H NMRspectrum, delta, ppm: 3.91 s (6H), 7.31 d (J = 8.5 Hz, 2H), 8.01 d (J = 8.5 Hz, 2H). 13C NMR spectrum, delta, ppm:57.45, 107.87, 116.85, 124.51, 140.69, 155.01.

The synthetic route of 10075-63-5 has been constantly updated, and we look forward to future research findings.

Reference:
Article; Dong; Zhang; Huang; Meng; Li; Russian Journal of General Chemistry; vol. 87; 4; (2017); p. 837 – 841; Zh. Obshch. Khim.; vol. 87; 4; (2017); p. 837 – 841,5;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 2338-54-7, name is 4-Fluoro-3-methylanisole, A new synthetic method of this compound is introduced below., COA of Formula: C8H9FO

6-Fluoro-3-methoxybenzoic acid 4-Fluoro-3-methylanisol (1.0 g, 7.1 mmol) was dissolved in a mixture of pyridine (16 mL) and water (32 mL). Potassium permanganate (3.4 g, 21 mmol) was added and the reaction mixture was refluxed for 3 h and then left at room temperature over night. After filtration and extraction with CH2 Cl2 the aqueous phase was acidified with HCl precipitating the product (440 mg). 1 NMR (CD3 OD): delta7.44-7.47 (m, 1H), 7.18-7.16 (m, 2H), 3.86 (s, 3H); 13 C NMR (CD3 OD): delta167.55, 158.35 (d, J=192 Hz), 156.30, 121.65 (d, J=8.7 Hz), 120.63 (d), 118.94 (d, J=24.4 Hz), 117.03, 56.59.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Aktiebolaget Astra; Cornell Research Foundation, Inc.; The University of Maryland at Baltimore; US5523475; (1996); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Adding a certain compound to certain chemical reactions, such as: 870563-60-3, name is (4-Fluoro-2-methoxyphenyl)methanamine, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 870563-60-3, COA of Formula: C8H10FNO

General procedure: Spirothiazamenthane 3 (1.0 eq) was dissolved in toluene (0.1 M concentration) in a microwave vial and the solution was treated with amine (10 eq) and PTSA (20 mol %). This mixture was heated at 150 C using microwaves for 4 h. After cooling, the solvents were removed by evaporation and the resulting residue was taken up in 1:1 Et2O/2M NaOH. The layers were separated and the aqueous layer was extracted 2 × with Et2O. The organic layers were combined, dried over Na2SO4, filtered and concentrated. The resulting crude products were purified as described below. Variations in reaction conditions are also noted below.

If you are interested in these compounds, you can also browse my other articles.Thank you for taking the time to read this article. I hope you enjoyed it.

Reference:
Article; Arns, Steve; Balgi, Aruna D.; Shimizu, Yoko; Pfeifer, Tom A.; Kumar, Nag; Shidmoossavee, Fahimeh S.; Sun, Sharon; Tai, Sheldon S.-H.; Agafitei, Olga; Jaquith, James B.; Bourque, Elyse; Niikura, Masahiro; Roberge, Michel; European Journal of Medicinal Chemistry; vol. 120; (2016); p. 64 – 73;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthetic Route of 126940-10-1, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 126940-10-1, name is 1-Fluoro-3-(methoxymethoxy)benzene, This compound has unique chemical properties. The synthetic route is as follows.

To a solution of compound 2 (25 g, 130.2mmol, 1 .Oeq) in dry THF (250ml_) and dry cyclohexane (40ml_) was added sec-BuLi (121.82ml_, 195.3mmol, 1.5eq) drop wise at -78 C under argon. The mixture was stirred for 2h at the same temperature, then compound 3 (62ml_, 520.3mmol, 4. Oeq) was added with sitrring for 10mins at the same temperature. TLC analysis indicated formation of a polar spot then the reaction mass was quenched with satd. NH4CI solution; the reaction mixture was dissolved in ether (2X500mL) and washed with brine (2 x 200mL) & water (2x200mL). The separated organic layer was dried over Na2S04 and concentrated under reduced pressure to give a crude product; which was purified by column chromatography (silica gel 100- 200mesh) using 1 % EtOAc petroleum ether as an eluent to give compound 4 ( 20g, 45.1 % ) as a pale yellow color liquid.

The chemical industry reduces the impact on the environment during synthesis 1-Fluoro-3-(methoxymethoxy)benzene. I believe this compound will play a more active role in future production and life.

Reference:
Patent; ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR); AL-AWAR, Rima; ISAAC, Methvin; CHAU, Anh My; MAMAI, Ahmed; WATSON, Iain; PODA, Gennady; SUBRAMANIAN, Pandiaraju; WILSON, Brian; UEHLING, David; PRAKESCH, Michael; JOSEPH, Babu; MORIN, Justin-Alexander; (441 pag.)WO2019/153080; (2019); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 10075-63-5, name is 1,5-Dimethoxynaphthalene, A new synthetic method of this compound is introduced below., HPLC of Formula: C12H12O2

70% Nitric acid (1.5 mL) in acetic acid (1.5 mL) was addedslowly to a stirred suspension of 1,5-dimethoxynaphthalene(3.76 g, 20 mmol) in acetic acid (50 mL) at room temperature. Upon stirring overnight atambient temperature, the precipitate was filtered offand washed with water. The crude product wasrecrystallized from methanol and dried. Light yellowsolid, yield 85%. 1H NMR spectrum, delta, ppm: 3.92 s(3H), 4.03 s (3H), 6.74 d (J = 8.3 Hz, 1H), 7.01 d (J =7.8 Hz, 1H), 7.44-7.53 m (2H), 7.90 d (J = 8.5 Hz,1H). 13C NMR spectrum, delta, ppm: 56.03, 56.06, 102.24,108.31, 114.68, 117.16, 121.65, 127.15, 127.21,141.18, 153.64, 157.04.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Article; Dong; Zhang; Huang; Meng; Li; Russian Journal of General Chemistry; vol. 87; 4; (2017); p. 837 – 841; Zh. Obshch. Khim.; vol. 87; 4; (2017); p. 837 – 841,5;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Related Products of 2338-54-7, These common heterocyclic compound, 2338-54-7, name is 4-Fluoro-3-methylanisole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a vigorously stirred mixture [OF 4-FLUORO-3-METHYLANISOLE] (12.0 g, 85.6 mmol) and pyri- dine (41.7 g, 527 mmol) in water (170 mL) at [50C] was added portion-wise potassium per- manganate (44.65 g, mmol) and then maintained at this temperature for 2 h. The resulting mixture was then allowed to cool to RT and allowed to stand overnight and then heated for a further 5 h at [50C.] Then the mixture was filtered over celite and then the residue was washed with sulfuric acid (conc. 100 mL). The combined filtrates were then [HALF-EVAPORA-] ted and neutralised with potasssium carbonate. Then the mixture was washed with diethyl ether and then the aqueous layer was acidified with hydrochloric acid (conc.) and the pro- duct extracted with diethyl ether. The combined extracts were then dried over sodium sul- phate. After filtration and evaporation the crude solid was [RECRYSTALLISED] from 1,2,-di- chloroethane to afford the title compound (4.4 g, 30%) as a light pink solid. MS [M/E =] 168.9 (M-H). Alternatively, a solution of 4-fluoroanisole (500 mg, 4.0 mmol) in THF (10 mL) was added to a cooled [SOLUTION (-78C) OF 2,] 2,6, 6-tetramethylpiperidine (1.1 g, 7.9 mmol) and BuLi (5 mL, 1.6 M in hexanes, 7.9 mmol) in THF (10 mL) at a slow rate to maintain the tempera- ture [BELOW-70C.] The mixture was maintained at this temperature for 12 h, and then dry C02 gas was passed into the solution. The resulting mixture was allowed to warm up to 0C and then HCl (1 M, 10 mL) was added and the product was extracted with diethyl ether. The combined organic extracts were then dried over sodium sulfate, washed with water and brine, filtered and evaporated. The crude solid was then partioned between sodium hydroxide [(1] M, 10 mL) and diethyl ether. The aqueous phase was then acidified with HCl (1 M) and the product extracted with diethyl ether. Evaporation afforded the title compound (268 mg, 40%) as a white solid. MS m/e = 168.9 (M-H).

Statistics shows that 4-Fluoro-3-methylanisole is playing an increasingly important role. we look forward to future research findings about 2338-54-7.

Reference:
Patent; F. HOFFMANN-LA ROCHE AG; WO2004/14856; (2004); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

These common heterocyclic compound, 40515-89-7, name is Phenethoxybenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. category: ethers-buliding-blocks

General procedure: etherCatalytic decomposition of phenethyl phenyl ether (PPE) to aro-matics was carried out in a stainless steel autoclave reactor (25 mL)under hydrogen atmosphere. Prior to the reaction, each catalystwas reduced using an ex-situ reduction system at 450C for 4 hunder 5% H2/N2flow (50 mL/min). 50 mg of reduced catalyst, 0.25 gof phenethyl phenyl ether (Frinton Laboratory, a reactant), and 9 mLof hexadecane (Sigma-Aldrich, a solvent) were charged into thereactor at room temperature. The reactor was purged with nitro-gen several times in order to remove air. The catalytic reaction wasperformed at 250C and 10 bar (H2) for 3 h with agitation speed of250 rpm. After the reaction, reaction products were analyzed usinga gas chromatograph (Younglin, YL6100) equipped with a DB-1 col-umn and a flame ionization detector (FID). Conversion of phenethylphenyl ether and selectivity for aromatic product (benzene, phe-nol, or ethylbenzene) were calculated according to the followingequations on the basis of mole balance. Yield for aromatic product(benzene, phenol, or ethylbenzene) was calculated by multiplyingconversion of phenethyl phenyl ether and corresponding productselectivity

The synthetic route of Phenethoxybenzene has been constantly updated, and we look forward to future research findings.

Reference:
Article; Kim, Jeong Kwon; Lee, Jong Kwon; Kang, Ki Hyuk; Lee, Jong Won; Song, In Kyu; Journal of Molecular Catalysis A: Chemical; vol. 410; (2015); p. 184 – 192;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthetic Route of 151414-47-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 151414-47-0, name is 2,6-Difluoro-4-methoxyaniline belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

Step A: Preparation of N-[(6-chloro-3-pyridinyl)methylene]-2,6-difluoro-4-methoxybenzenamineTo a mixture of 2,6-difluoro-4-methoxybenzenamine (0.98 g, 6.9 mmol) in toluene (20 mL) was added 6-chloro-3-pyridinecarboxaldehyde (1.0 g, 6.3 mmol). The reaction mixture was heated at reflux with the use of a Dean-Stark trap for azeotropic removal of water. After 16 h the reaction mixture was cooled to room temperature and concentrated under reduced pressure. The resulting material was dried in a vacuum oven at 55 C. overnight to provide the title compound as a light brown solid (1.66 g).1H NMR (CDCl3): delta 8.74 (s, 1H), 8.73 (d, J=2.44 Hz, 1H), 8.32 (dd, J=2.20 Hz, J=8.29 Hz, 1H), 7.44 (d, J=8.29 Hz, 1H), 6.59-6.52 (m, 2H), 3.82 (s, 3H).1F NMR (CDCl3): delta-121.48 to 121.40 (m, 2F).

The synthetic route of 2,6-Difluoro-4-methoxyaniline has been constantly updated, and we look forward to future research findings.

Reference:
Patent; E.I. Du Pont De Nemours and Company; US2011/45101; (2011); A1;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Application of 4457-67-4, A common heterocyclic compound, 4457-67-4, name is 1-Bromo-4-methoxybutane, molecular formula is C5H11BrO, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

c) 2-(4-Methoxybutoxy)-terephthalic acid dimethyl ester Alkylation of 2-hydroxy-terephthalic acid dimethyl ester (10 g) with 4-methoxybutyl bromide in anhydrous acetone in the presence of dried potassium carbonate and potassium iodide in a manner analogous to that described in Example 16a) yields the title compound, Rf (B)=0.20, in the form of a slightly yellowish oil.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Reference:
Patent; Ciba-Geigy Corporation; US5641778; (1997); A;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 121588-79-2 as follows. Recommanded Product: trans-4-Methoxycyclohexanamine

General procedure: To a suspension of 9 (26.6 g, 76.3 mmol) in N,N-dimethylformamide (380 mL) was added 1-amino-2-methyl-propan-2-ol (8.16 g, 91.5 mmol) and triethylamine (31.9 mL, 228 mmol) at 0 C. The reaction mixture was stirred at room temperature for 5.5 h. Then the reaction mixture was diluted with cold water (1000 mL) and the mixture was stirred at room temperature for 1 h. The resulting precipitate was collected and washed with water. The precipitate was triturated with a mixture of diethyl ether and diisopropyl ether (1:1, 60 mL) to give the title compound (27.7 g, 83%) as a tan colored powder.

According to the analysis of related databases, 121588-79-2, the application of this compound in the production field has become more and more popular.

Reference:
Article; Koizumi; Tanaka, Yoshihito; Matsumura, Takehiko; Kadoh, Yoichi; Miyoshi, Haruko; Hongu, Mitsuya; Takedomi, Kei; Kotera, Jun; Sasaki, Takashi; Taniguchi, Hiroyuki; Watanabe, Yumi; Takakuwa; Kojima, Koki; Baba, Nobuyuki; Nakamura, Itsuko; Kawanishi, Eiji; Bioorganic and Medicinal Chemistry; vol. 27; 15; (2019); p. 3440 – 3450;,
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem