Tag: M.W=100-200

Electric Literature of 349-65-5,Some common heterocyclic compound, 349-65-5, name is 2-Methoxy-5-(trifluoromethyl)aniline, molecular formula is C8H8F3NO, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

B3b. General Method for the Reaction of an Aryl Amine with Phosgene with Isolation of the Isocyanate, Followed by Reaction with a Second Aryl Amine; [] Step 1. 2-Methoxy-5-trifluoromethylphenyl Isocyanate: To a solution of phosgene (1.93 M in toluene; 16 mL, 31.4 mmol) in CH2Cl2 (120 mL) at 0 C was added a solution of 2-methoxy-5-(trifluoromethyl)aniline (3.0 g, 15.7 mmol) and pyridine (2.3 mL, 47.1 mmol) in CH2Cl2 (30 mL) dropwise. The resulting mixture was stirred at 0 C for 30 min and at room temp for 3 h, then concentrated under reduced pressure. The residue was diluted with toluene (30 mL), concentrated under reduced pressure, and treated with Et2O. The resulting precipitate (pyridinium hydrochloride) was removed and the filtrate was concentrated under redeuced pressure to give the title compound as a yellow oil (3.0 g) which crystallized upon standing at room temp. for a few days.

The synthetic route of 349-65-5 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 2741-16-4, name is Isopropoxybenzene, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2741-16-4, Recommanded Product: 2741-16-4

(1) O-isopropylphenol (1.0 g, 7.3 mmol) and allyl bromide (14.6 mmol) were successively added to a 25 mL round bottom flask and dissolved in dichloromethane. (0107) (2) Benzyl tributyl ammonium bromide (0.26 g, 0.73 mmol) was added to another 50 mL flask and dissolved in a 1 M NaOH solution. (0108) (3) The solution obtained in (1) was added slowly to the solution obtained in (2) at room temperature and stirred at room temperature for 2 h. The organic phase was separated, and the aqueous phase was extracted with dichloromethane. The organic phases were combined, washed with water and saturated sodium chloride, dried over anhydrous sodium sulfate, and concentrated to give a colorless liquid. The liquid was heated under nitrogen at 250 C. for 2 h, cooled and purified with column chromatography to give a colorless liquid. The colorless liquid was dissolved in absolute ethanol and reduced by addition of Pd/C to give 2-isopropyl-6-propylphenol: 1H NMR (400 MHz, CDCl3) delta 7.06 (dd, J=7.6, 1.6 Hz, 1H), 6.97 (dd, J=7.5, 1.6 Hz, 1H), 6.85 (t, J=7.6 Hz, 1H), 4.75 (s, 1H), 3.22-3.13 (m, 1H), 2.59-2.54 (m, 2H), 1.72-1.59 (m, 2H), 1.26 (d, J=6.9 Hz, 6H), 0.99 (t, J=7.3 Hz, 3H). (0109) (4) The obtained liquid (1.0 g, 5.6 mmol) was dissolved in 20 mL of dichloromethane, into which the catalyst Cu(OH)Cl.TMEDA (50 mg, 0.1 mmol) was added, and stirred at room temperature to give a red solid quinone which was then reduced with sodium hydrosulfite to give 4,4?-dihydroxy-3,3?-diisopropyl-5,5?-dipropylbiphenyl (1.1 g, 55.5%). (0110) 4,4?-dihydroxy-3,3?-diisopropyl-5,5?-dipropylbiphenyl: 1H NMR (300 MHz, CDCl3) delta 7.29 (s, 4H), 6.52 (s, 2H), 3.13-3.08 (m, 2H), 2.43-2.40 (m, 4H), 1.51-1.43 (m, 4H), 1.03 (d, 12H), 0.84-0.81 (m, 6H).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Isopropoxybenzene, other downstream synthetic routes, hurry up and to see.

Synthetic Route of 592-55-2, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 592-55-2 as follows.

General procedure: A suspension of methyl 3-hydroxybenzoate (104 mg, 0.68 mmol), 2-bromoethyl ethyl ether (0.22 mL, 2.0 mmol) and K2CO3 (550 mg, 4.0 mmol) in DMF (13 mL) was stirred for 16 h at 70 C. After addition of a saturated solution of NaHCO3 the mixture was extracted with EtOAc. The organic layer was washed with brine and dried over Na2SO4. The solvent was removed under reduced pressure and the residue was purified by flash chromatography (hexane/EtOAc 5:1) to give 4a in 89% yield (136 mg).

According to the analysis of related databases, 592-55-2, the application of this compound in the production field has become more and more popular.

Synthetic Route of 171290-52-1, These common heterocyclic compound, 171290-52-1, name is 3,5-Dimethoxyphenylacetylene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

5-(Benzenesulfonyl)-2-[2-(3,5-dimethoxyphenyl)ethynyl]-5H-pyrrolo[2,3-b]pyrazine 5-(Benzenesulfonyl)-2-bromo-5H-pyrrolo[2,3-b]pyrazine (3.50 g, 10.35 mmol), copper(1+) iodide (197.1 mg, 1.03 mmol) and palladium tetrakis triphenylphospine (597.7 mg, 0.52 mmol) were dissolved in MeCN (40 ml). Reaction mixture was degassed with nitrogen for 5 mins. 1-ethynyl-3,5-dimethoxybenzene (2.52 g, 15.52 mmol) and DIPEA (8.96 ml, 51.75 mmol) were added and reaction heated to 80C, under a nitrogen atmosphere, for 2 h. Reaction mixture was allowed to cool to RT, then to 0C and left to stand overnight. The beige precipitate formed after this time was filtered off, dissolved in EtOAc, washed with water and concentrated. Crude material was re-crystallised from EtOAc to give the title compound as a yellow solid (3.16 g, 73%). 1H NMR (500 MHz, Chloroform-d) delta 8.55 (s, 1H), 8.24 – 8.13 (m, 2H), 8.04 (d, J = 3.7 Hz, 1H), 7.66 – 7.60 (m, 1H), 7.52 (t, J = 7.9 Hz, 2H), 6.82 (s, 1H), 6.77 (d, J = 2.2 Hz, 2H), 6.51 (t, J = 2.2 Hz, 1H), 3.80 (s, 6H). M/Z: 419.09, M+1: 419.95, tR= 1.59 min (System 1).

The synthetic route of 171290-52-1 has been constantly updated, and we look forward to future research findings.

Adding a certain compound to certain chemical reactions, such as: 1535-75-7, name is 2-(Trifluoromethoxy)aniline, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 1535-75-7, COA of Formula: C7H6F3NO

General procedure: Acetamides (1a-1x, 1ab, 1ac and 1ba-1bc). To a solution of 2-phenylacetic acid (7.0mmol), 2-(trifluoromethoxy)aniline (7.7mmol) in anhydrous CH2Cl2 (25mL) were added EDCI (1.745g, 9.1mmol) and DMAP (256.6mg, 2.1mmol). The reaction mixture was stirred at room temperature overnight, diluted with HCl (1M) aqueous solution, and extracted with CH2Cl2 (3×25mL). The combined organic phase was washed with saturated NaHCO3 aqueous solution and brine, dried over anhydrous Na2SO4, and concentrated under vacuum. Purification by flash chromatography (Silica gel, petroleum ether: ethyl acetate=50: 1 as eluent) gave the corresponding 2-phenyl-N-[2-(trifluoromethoxy)phenyl]acetamide compound.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2-(Trifluoromethoxy)aniline, and friends who are interested can also refer to it.

Electric Literature of 50742-37-5, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 50742-37-5 name is (3-Phenoxyphenyl)methanamine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

C) 3-oxo-2-(3-phenoxybenzyl)isoindoline-5-carbonitrile Under nitrogen atmosphere, a mixture of methyl 2-(bromomethyl)-5-cyanobenzoate (100 mg), 1-(3-phenoxyphenyl)methanamine (94 mg), DIEA (0.082 mL) and THF (7 mL) was stirred at 50C for 6 hr, and then overnight at room temperature, and the reaction mixture was concentrated under reduced pressure. To the residue was added water, and the mixture was extracted with ethyl acetate. The organic layer was washed with saturated brine, dried over anhydrous sodium sulfate, and concentrated under reduced pressure. The residue was purified by silica gel column chromatography (hexane/ethyl acetate) to give the title compound (123 mg). MS (API+), found: 341.2 (M+1)

At the same time, in my other blogs, there are other synthetic methods of this type of compound, (3-Phenoxyphenyl)methanamine, and friends who are interested can also refer to it.

Electric Literature of 1836-62-0, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 1836-62-0, name is 2-(2-Methoxyphenoxy)ethylamine, This compound has unique chemical properties. The synthetic route is as follows.

General procedure: To a solution of 2-phenoxy-ethylamine (5 eq.) or 2-(2-methoxyphenoxy-)ethylamine (5 eq.) in 2-methoxyethanol(25 mL per mmol of amine) the appropriate aliphatic chloride33-39 (1 eq.) and KI (cat.) was added. The mixturewas refluxed for18-48 h and concentrated. The residue was suspended in CHCl3and washed with 1M NaOH, brine, dried over anhydrous Na2SO4and concentrated. The crude was purified by flash chromatographyto give the titled compound.

The chemical industry reduces the impact on the environment during synthesis 2-(2-Methoxyphenoxy)ethylamine. I believe this compound will play a more active role in future production and life.

In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 134364-69-5, name is 2,3-Difluoroanisole belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below. category: ethers-buliding-blocks

Step 2) 2.Og 3-Isobutoxy-4,5,6,6a-tetrahydro-3aH-pentalen-l -one was dissolved in 40 ml DCM. 2.47g Br2 was added drop wise and the mixture was stirred at rt for 20 min. The reaction mixture was cooled to O0C and 3.12 g TEA was slowly added. The cooling bath was removed and the mixture was stirred at rt for 1 h. Filtration and concentration gave a crude product which was purified on silica using 2% MeOH in DCM to produce 2.26 g l-Bromo-2,3-difluoro-4-methoxy-benzene.

The synthetic route of 134364-69-5 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 366-99-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 366-99-4, name is 3-Fluoro-4-methoxyaniline belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

2-butanone (14.40 g, 200 mmol), Acetic acid (1.8 g, 30 mmol), and Sodium triacetoxyborohydride (6.36 g, 30 mmol) were added to a solution of 3-Fluoro-4-methoxyaniline (2.82 g, 20 mmol) in DCM (120 mL) and the mixture was stirred at RT for 12 hr. Water was added to quench the reaction and the mixture was extracted with DCM. The solvent was removed under and the residue was purified by silica gel chromatography to afford N-(sec-Butyl)-3-fluoro-4-methoxyaniline (2.6 g, 66percent yield). MS m/z=198 [M+H].

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 3-Fluoro-4-methoxyaniline, other downstream synthetic routes, hurry up and to see.

Electric Literature of 592-55-2, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 592-55-2, name is 1-Bromo-2-ethoxyethane, This compound has unique chemical properties. The synthetic route is as follows.

A solution of 2- [1- (2- {4- [1- (4,4-dimethyl-4,5-211-oxazol-2-yl) -1-methyl-ethyl] } -piperidin-4-yl] -1H-benzimidazole was dissolved in 60 mL of THF, and 620 mg of sodium methoxide was added in portions to produce a large amount of air bubbles. The solution was clouded by clarification, After 2 h of reaction, the mixture was heated to 70 C, 2032 muL 2-bromoethyl ether was added, Reaction 2 h, TLC monitoring reaction, After stopping the reaction, add a small amount of water to quench the reaction, concentrate out of THF, add methylene chloride and wash with saturated NaCl solution three times, the organic layer was concentrated with the appropriate amount of dichloromethane to dissolve it, adding n-hexane beating to obtain light yellow solid, Filtration and drying gave solid 2. 0 g, yield 90%

The chemical industry reduces the impact on the environment during synthesis 1-Bromo-2-ethoxyethane. I believe this compound will play a more active role in future production and life.