Adding a certain compound to certain chemical reactions, such as: 2741-16-4, name is Isopropoxybenzene, belongs to ethers-buliding-blocks compound, can increase the reaction rate and produce products with better performance than those obtained under traditional synthetic methods. Here is a downstream synthesis route of the compound 2741-16-4, Recommanded Product: 2741-16-4
(1) O-isopropylphenol (1.0 g, 7.3 mmol) and allyl bromide (14.6 mmol) were successively added to a 25 mL round bottom flask and dissolved in dichloromethane. (0107) (2) Benzyl tributyl ammonium bromide (0.26 g, 0.73 mmol) was added to another 50 mL flask and dissolved in a 1 M NaOH solution. (0108) (3) The solution obtained in (1) was added slowly to the solution obtained in (2) at room temperature and stirred at room temperature for 2 h. The organic phase was separated, and the aqueous phase was extracted with dichloromethane. The organic phases were combined, washed with water and saturated sodium chloride, dried over anhydrous sodium sulfate, and concentrated to give a colorless liquid. The liquid was heated under nitrogen at 250 C. for 2 h, cooled and purified with column chromatography to give a colorless liquid. The colorless liquid was dissolved in absolute ethanol and reduced by addition of Pd/C to give 2-isopropyl-6-propylphenol: 1H NMR (400 MHz, CDCl3) delta 7.06 (dd, J=7.6, 1.6 Hz, 1H), 6.97 (dd, J=7.5, 1.6 Hz, 1H), 6.85 (t, J=7.6 Hz, 1H), 4.75 (s, 1H), 3.22-3.13 (m, 1H), 2.59-2.54 (m, 2H), 1.72-1.59 (m, 2H), 1.26 (d, J=6.9 Hz, 6H), 0.99 (t, J=7.3 Hz, 3H). (0109) (4) The obtained liquid (1.0 g, 5.6 mmol) was dissolved in 20 mL of dichloromethane, into which the catalyst Cu(OH)Cl.TMEDA (50 mg, 0.1 mmol) was added, and stirred at room temperature to give a red solid quinone which was then reduced with sodium hydrosulfite to give 4,4?-dihydroxy-3,3?-diisopropyl-5,5?-dipropylbiphenyl (1.1 g, 55.5%). (0110) 4,4?-dihydroxy-3,3?-diisopropyl-5,5?-dipropylbiphenyl: 1H NMR (300 MHz, CDCl3) delta 7.29 (s, 4H), 6.52 (s, 2H), 3.13-3.08 (m, 2H), 2.43-2.40 (m, 4H), 1.51-1.43 (m, 4H), 1.03 (d, 12H), 0.84-0.81 (m, 6H).
In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, Isopropoxybenzene, other downstream synthetic routes, hurry up and to see.