Tag: M.W=100-200

Application of 352-67-0, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 352-67-0, name is 1-Fluoro-4-(trifluoromethoxy)benzene belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

A. 1 -Fluoro-2-nitro-4-trifluoromethoxy-benzene and 4-Fluoro-2-nitro-1 – trifluoromethoxy-benzeneTo a mixture of 1-fluoro-4-trifluoromethoxy-benzene (31.57 g, 0.18 mol) in cone. H2SO4 (100 ml_) at 0C is added cone. HNO3 (30 ml_) dropwise over a 10 min period. After the mixture is stirred at 0 C for 1 h, it was poured into ice. The mixture is extracted with EtOAc. The organic extract is washed with H2O (3x) and brine, dried over MgSO4, filtered, and concentrated in vacuo to yield 38 g (96%) of the product as a mixture of 1 -fluoro-2-nitro-4-trifluoromethoxy-benzene and 4-fluoro-2-nitro-1 – trifluoromethoxy-benzene (-30/70, based upon 19F NMR). 1H NMR (CDCI3): delta 8.00- 7.90 and 7.80-7.65 (m, 1 H), 7.60-7.25 (m, 2H); 19 F NMR (CDCI3) delta -57.59 and -58.11 (s, 3F), -109.07 and -117.90 (t, J = 6.2 and d, J = 6.2, 1 F).B. 2-Fluoro-5-trifluoromethoxy-phenylamine and 5-Fluoro-2-trifluoromethoxy- phenvlamine A mixture of 1 -fluoro-2-nitro-4-trifluoromethoxy-benzene and 4-fluoro-2-nitro-1 – trifluoromethoxy-benzene and Raney Ni (2800) in MeOH (250 ml_) is hydrogenated at 40 psi for 5 h (or until no more H2 is consumed). The catalyst is filtered off, and the filtrate is concentrated in vacuo. The residue is redissolved in CH2CI2, dried over MgSO4, filtered, and concentrated in vacuo to yield 27.4 g of the product (dark brown liquid) as a mixture of 2-fluoro-5-trifluoromethoxy-phenylamine and 5-fluoro-2- trifluoromethoxy-phenylamine (-30/70, based upon 19F NMR). 1H NMR (CDCI3): delta 7.15-6.90 (m, 1 H), 6.70-6.30 (m, 2H), 3.60-4.25 (br m, 1 H); 19 F NMR (CDCI3) delta -57.77 and -57.86 (s, 3F), -113.83 and -137.09 (1 H); MS 196 (M+1 , 100%).

The synthetic route of 1-Fluoro-4-(trifluoromethoxy)benzene has been constantly updated, and we look forward to future research findings.

Synthetic Route of 7664-66-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 7664-66-6, name is 4-Isopropoxyaniline belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

The compound obtained in Step 3 (60 mg) was dissolved in acetonitrile (1.5 mL), 4-isopropoxy aniline (40 mg) was added and stirred for 30 minutes under microwave irradiation under 180 C. It extracted three times with chloroform. After addition of a saturated aqueous sodium hydrogen carbonate solution to the reaction solution. Then, the organic layer was concentrated and dried over sodium sulfate. The resulting residue to give the title compound purified by silica gel column chromatography (82mg, 100%).

The synthetic route of 4-Isopropoxyaniline has been constantly updated, and we look forward to future research findings.

Some common heterocyclic compound, 658-89-9, name is 4-(Trifluoromethoxy)benzene-1,2-diamine, molecular formula is C7H7F3N2O, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. COA of Formula: C7H7F3N2O

A mixture of S-bromo-lH-pyrazoloP^-bjpyridine-S-carboxyric acid Compound Ic (0.68 g, 1.93 mmol), Compound 16b (0.373 g, 1.93 mmol), HATU (0.73 g, 1.9 mmol) and DIPEA (1 mL, 5.8 mmol) in DMF (30 mL) was stirred at room temperature overnight. The solvent was removed under vacuum and the resulting yellow residue was mixed with AcOEt, sequentially washed with saturated aqueous NH4Cl, IM HCl, water and saturated aqueous NaHCO3, then dried over Na2SO4. The solvent was evaporated to dryness to provide 5-bromo-lH-pyrazolo[3,4-b]pyridine-3- carboxylic acid (2-amino-4-trifluoromethoxy-phenyl)-amide Compound 16c (0.67 g, 83% yield) as a yellow solid. LC-MS major peak 3.03 min, MS (ESI) m/z 416.0 (M+)/417.0 (M+H+).

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 658-89-9, its application will become more common.

Application of 102-52-3, In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 102-52-3 as follows.

Preparation of 5-(3-methoxy-4-(1H-pyrazol-1-yl)phenyl)oxazole (IIe) To a suspension of intermediate IId (1.834 g, 8.94 mmol) in EtOH (30 ml) were added malonaldehyde bis(dimethyl acetal) (1.63 ml, 9.84 mmol) and conc.HCl (1 ml). The reaction mixture was stirred at 70 C. for 2 hours. The cooled mixture was evaporated to dryness, diluted saturated solution of NaHCO3 and extracted with EtOAc twice. The combined organics were washed with water, with saturated solution of NaCl, dried over MgSO4, filtered and evaporated. The final product was purified by silica gel chromatography using 0 to 30% EtOAc/cyclohexane as eluent to give intermediate IIe (1.380 g, 64%). 1H NMR (500 MHz, CDCl3) delta 8.12 (d, J=2.1 Hz, 1H), 7.94 (s, 1H), 7.85 (d, J=8.3 Hz, 1H), 7.72 (d, J=1.4 Hz, 1H), 7.40 (s, 1H), 7.36 (dd, J=8.3, 1.8 Hz, 1H), 7.32 (d, J=1.7 Hz, 1H), 6.46-6.43 (m, 1H), 3.97 (s, 3H).

According to the analysis of related databases, 102-52-3, the application of this compound in the production field has become more and more popular.

Application of 645-36-3, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 645-36-3 name is 2,2-Diethoxyethanamine, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

To a stirred solution of 2-bromo-5-(trifluoromethyl)benzoic acid (5 g, 18.59 mmol) in 50 mL DMF at 0 C was added HATU (10.60 g, 27.9 mmol) and triethylamine (3.89 ml, 27.9 mmol). The reaction mixture was stirred for 15 min. and then 2, 2-diethoxyethanamine (4.05 ml, 27.9 mmol) was added to it and the reaction mixture was slowly warmed to room temperature and stirred for 12 h. The reaction mixture was diluted with ice cold water, and the precipitate obtained was filtered and the residue was dissolved in ethyl acetate, dried over sodium sulphate and concentrated to get the product as white solid. (Yield = 6 g, 85%). NMR (400 MHz, Chloroform-if) delta 7.82 (d, J = 2.8 Hz, 1H), 7.76 (d, J = 8.3 Hz, 1H), 7.55 (d, J = 8.3 Hz, 1H), 6.33 (s, 1H), 4.69 (dd, J = 6.0, 3.6 Hz, 1H), 3.83 – 3.72 (m, 2H), 3.68 – 3.57 (m, 4H), 1.30 – 1.18 (m, 6H). LCMS (ESI) : m/z 406.07 & 408.07(M+Na)+

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 2,2-Diethoxyethanamine, and friends who are interested can also refer to it.

Electric Literature of 20781-20-8,Some common heterocyclic compound, 20781-20-8, name is (2,4-Dimethoxyphenyl)methanamine, molecular formula is C9H13NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a solution of 2,4- dimethoxybenzaldehyde (Sigma-Aldrich, 5.00 g, 30.1 mmol) in MeOH (100 mL) was added 2,4-dimethoxybenzylamine (Sigma-Aldrich, 5.53 mL, 33.1 mmol). The resulting mixture was stirred at RT for 1 h and then sodium borohydride (1.30 g, 34.3 mmol) was added slowly. Gas evolution was observed. After stirring at RT overnight, the reaction was quenched with water and then partially concentrated to remove MeOH in vacuo. The residue was extracted with EtOAc (3X). The combined organic layers were washed with brine (1X), dried over anhydrous magnesium sulfate and concentrated in vacuo to afford 98.1 as a colorless oil. The product was used directly in the next step. LCMS-ESI (pos.) m/z: 318.2 (M+H)+.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route (2,4-Dimethoxyphenyl)methanamine, its application will become more common.

Some common heterocyclic compound, 171290-52-1, name is 3,5-Dimethoxyphenylacetylene, molecular formula is C10H10O2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route. Safety of 3,5-Dimethoxyphenylacetylene

General procedure: To a solution of an alkyne 2 (1.2 equiv) in anhydrous toluene (3 mL) under an argon atmosphere, KOtBu (1.0 equiv) was added, and the mixture was stirred for 10-15 min. Then, an N-protected isatin 1 (1.0 equiv) was added to the reaction mixture, which was stirred for 30 min to 3 h until all the isatin was consumed (confirmed by TLC). The reaction was finally quenched with a few drops of 1 N HCl and the resulting mixture was extracted with CH2Cl2 (2 × 15 mL). The combined organic phases were washed with a saturated aqueous solution of sodium chloride, dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. The crude residue was then purified by column chromatography on silica gel (EtOAc-hexane,10:90 to 30:70) to give compounds 3.

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route 171290-52-1, its application will become more common.

Related Products of 82830-49-7, The chemical industry reduces the impact on the environment during synthesis 82830-49-7, name is 2-Fluoro-1,4-dimethoxybenzene, I believe this compound will play a more active role in future production and life.

To a solution of 2-fluoro-1,4-dimethoxybenzene (2.56 g, 0.0 16 mol) in dry THF (100 mL) at -78 C was added n-BuLi (2.5 M, 7 mL, 0.0 17 mol) dropwise under a N2 atmosphere. The reaction was stuffed at -78 C for 1 h and then ethyl chloroformate (1.8 g, 0.0 17 mol) inTHF (50 mL) was added dropwise at -78 C. The reaction mixture was stirred at -78 C for another 1 h. The reaction was warmed slowly to room temperature and quenched with a saturated aqueous NH4C1 solution (100 mL). The reaction mixture was extracted with ethyl acetate (100 mL x 3). The combined organic phases were dried with MgSO4 and concentrated to afford the crude material which was purified by column chromatography on silica gel(petroleum ether/ethyl acetate 1:10 to 1:5) to afford pure methyl 2-fluoro-3,6- dimethoxybenzoate (2.28 g, 65% yield).

In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles, 2-Fluoro-1,4-dimethoxybenzene, other downstream synthetic routes, hurry up and to see.

Electric Literature of 4393-09-3,Some common heterocyclic compound, 4393-09-3, name is (2,3-Dimethoxyphenyl)methanamine, molecular formula is C9H13NO2, traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

8-Chloro-2,2-dimethyl-5-(pyrrolidin-1 -yl)-1 ,4-dihydro-2/-/- pyrano[4″,3″:4l,5′]pyrido[3′,2′:4,5]thieno[3,2-c/]pyrimidine (O.Odeltag, 0.21 mmol, see Preparation 24) is suspended in ethanol (5 ml) and (2,3-dimethoxybenzyl)amine (0.16 ml, 1.07 mmol) is added. The mixture is refluxed for 24h and then allowed to cool to room temperature. The solvent is evaporated under vacuum and the residue is purified by chromatography, eluting first with CH2CI2 and then with CH2CI2:Me0H 99:1. 85 mg of the desired final product are obtained. Yield= 79%. m.p. 166.0-167.50C1 H NMR (300 MHz, DMSO-D6) delta ppm 1.32 (s,6 H) 1.88 (m, 4 H) 3.33 (d, J=7.02 Hz, 3 H) 3.60 (m, 4 H) 3.78 (m, 6 H) 4.74 (d, J=5.80 Hz, 2 H) 4.83 (s, 2 H) 6.83 (dd, J=7.17, 1.98 Hz, 1 H) 6.96 (m, 1 H) 8.01 (t, J=5.80 Hz, 1 H) 8.48 (s, 1 H)

These compound has a wide range of applications. It is believed that with the continuous development of the source of the synthetic route (2,3-Dimethoxyphenyl)methanamine, its application will become more common.

Related Products of 54149-17-6, As we all know, there are many different methods for the synthesis of a compound, and people can choose the synthesis method that suits their own laboratory according to the actual situation. 54149-17-6 name is 1-Bromo-2-(2-methoxyethoxy)ethane, This compound is widely used in many fields, so it is necessary to find a new synthetic route. The downstream synthesis method of this compound is introduced below.

Under a nitrogen atmosphere, 2.00 g of the compound represented by the formula (C-7-1) and 20 mL of N,N-dimethylformamide were placed in a reaction vessel.While ice-cooling, 1.49 g of tertiary potassium butoxide was added, and the mixture was stirred at room temperature for 1 hour.While cooling with ice, a solution obtained by dissolving 2.44 g of the compound represented by the formula (C-7-2) in 3 mL of N,N-dimethylformamide was added dropwise.After stirring at room temperature for 5 hours, it was diluted with 100 mL of dichloromethane and poured into water.The organic layer was washed with brine and dried over sodium sulfate, and the solvent was evaporated.By subjecting column chromatography (alumina, dichloromethane) and recrystallization (dichloromethane/hexane), 3.04 g of the compound of formula (C-7) was obtained.The yield of the compound represented by the formula (C-7-1) was 94%.The reaction solution after the reaction showed a light coloration.

At the same time, in my other blogs, there are other synthetic methods of this type of compound, 1-Bromo-2-(2-methoxyethoxy)ethane, and friends who are interested can also refer to it.