Tag: M.W=150-200

Bowie, John H. published the artcileSolvent effects in nuclear magnetic resonance spectroscopy. X. Solvent shifts induced by benzene in ortho-and meta-substituted methoxybenzenes, Product Details of C10H14O, the publication is Journal of the Chemical Society [Section] B: Physical Organic (1967), 535-40, database is CAplus.

Solvent shifts (Δ = δCCl4-δC6H6 ppm.) for the methoxyl protons of meta-substituted anisoles correlate with σm of the substituent, but for ortho-substituted anisoles a better correlation between Δ and the dipole moment is found. The effect of introducing a methoxyl group ortho to a substituent in a benzene ring is to make the Δ values for protons in that substituent more neg. In the compounds examined, protons α to the benzene ring (Ar-CH) and attached to a substituent situated between two o-methoxyl groups are only shielded (0.4-0.6 ppm.) in benzene relative to CCl4. On the basis of the observed shifts the orientating effect of an aromatic methoxyl function in a solute upon benzene solvent mols. may be surmised.

Journal of the Chemical Society [Section] B: Physical Organic published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C10H14O, Product Details of C10H14O.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Makowski, Philippe published the artcileChlorine borrowing: An efficient method for an easier use of alcohols as alkylation agents, Recommanded Product: 2-Isopropylanisole, the publication is Green Chemistry (2009), 11(1), 34-37, database is CAplus.

Chlorine functionalized tin dioxide nanoparticles proved able to partially convert alcs. into the corresponding chlorides, which act as alkylation agents with an increased electrophilicity, as evidenced on ether formation and Friedel-Crafts reactions.

Green Chemistry published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C10H14O, Recommanded Product: 2-Isopropylanisole.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Hwang, Jimin published the artcileSynthesis and evaluation of RNase L-binding 2-aminothiophenes as anticancer agents, Application of 4-Hydroxy-3,5-dimethoxybenzaldehyde, the publication is Bioorganic & Medicinal Chemistry (2022), 116653, database is CAplus and MEDLINE.

Aminothiophene is a scaffold that is widely present in drugs and biol. active small mols. as chem. probes. In this study, 43 compounds sharing a 2-aminothiophenone-3-carboxylate (ATPC) scaffold, known to activate the RNase L (RNase L), were synthesized and selected ATPCs showed enhancement of thermal stability of RNase L upon binding. Screening of antiproliferation activities against human cancer cell lines revealed that ATPCs represented by compounds 4l and 50 showed potent single-digit micromolar antiproliferation activity against human cancer cell lines. Compounds 4l and 50 exhibited time- and dose-dependent proliferation inhibition, induced cellular apoptosis measured by cleaved PARP and via flow cytometry, inhibited cell migration, and inhibited cell colony formation. Combining the results reported in this work, ATPCs were evaluated as potential anticancer agents mediated by RNase L-binding and apoptosis induction. The work contributes to the study on the polypharmacol. properties of aminothiophene-containing small mols.

Bioorganic & Medicinal Chemistry published new progress about 134-96-3. 134-96-3 belongs to ethers-buliding-blocks, auxiliary class Immunology/Inflammation,COX,Natural product, name is 4-Hydroxy-3,5-dimethoxybenzaldehyde, and the molecular formula is C9H10O4, Application of 4-Hydroxy-3,5-dimethoxybenzaldehyde.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Bhar, Shanta S. published the artcileAnnulation strategy for the biomimetic synthesis of cis-fused diterpenoids, Safety of 2-Isopropylanisole, the publication is Tetrahedron Letters (2006), 47(44), 7805-7807, database is CAplus.

Concise and efficient formal syntheses of the A/B cis-fused ring C-aromatic tricyclic diterpenes, xanthoperol, and cis-A/B-coleon V are reported, via the application of domino reactions followed by a novel annulation method, in which the highly substituted target mols. are assembled from an acyclic precursor, namely the easily accessible monoterpene, citral.

Tetrahedron Letters published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C10H14O, Safety of 2-Isopropylanisole.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Cobo-Golpe, M. published the artcilePortable dehumidifiers condensed water: A novel matrix for the screening of semi-volatile compounds in indoor air, Name: 2-Methoxynaphthalene, the publication is Chemosphere (2020), 126346, database is CAplus and MEDLINE.

The comprehensive identification of organic species existing in indoor environments is a key issue to understand their impact in human health. This study proposes the anal. of condensed water samples, collected with portable dehumidifiers, to characterize semi-volatile compounds in the gas phase of confined areas. Water samples are concentrated by solid-phase extraction (SPE). The obtained extracts are analyzed by gas chromatog. (GC) time-of-flight mass spectrometry (TOF-MS), following a non-target screening data mining approach. In first term, spectra of deconvoluted compounds are compared with those in NIST low resolution library; thereafter, tentative identifications are verified using an inhouse database of accurate electron ionization (EI) MS spectra. Chromatog. (retention index) and spectral data are combined for unambiguous species identification. The potential of condensed water samples to reflect changes in the composition of indoor atmospheres, the match between data obtained using different dehumidifiers, and the relative concentration efficiency of condensed water compared to that attained by active sampling of moderate air volumes are discussed. A total of 141 semi-volatile compounds were identified (98 confirmed against authentic standards) in a set of 21 samples obtained from different homes and working places. This list contains more than 40 fragrances (including several potential allergens), solvents and intermediates in the production of polymeric materials, plasticizers and flame retardants.

Chemosphere published new progress about 93-04-9. 93-04-9 belongs to ethers-buliding-blocks, auxiliary class Naphthalene,Ether, name is 2-Methoxynaphthalene, and the molecular formula is C11H10O, Name: 2-Methoxynaphthalene.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Dominguez-Rodriguez, Gloria published the artcileComposition of Nonextractable Polyphenols from Sweet Cherry Pomace Determined by DART-Orbitrap-HRMS and Their In Vitro and In Vivo Potential Antioxidant, Antiaging, and Neuroprotective Activities, Related Products of ethers-buliding-blocks, the publication is Journal of Agricultural and Food Chemistry (2022), 70(26), 7993-8009, database is CAplus and MEDLINE.

Sweet cherry pomace is an important source of phenolic compounds with beneficial health properties. As after the extraction of phenolic compounds, a phenolic fraction called nonextractable polyphenols (NEPs) remains usually retained in the extraction residue, alk. and acid hydrolyzes and enzymic-assisted extraction (EAE) were carried out in this work to recover NEPs from the residue of conventional extraction from sweet cherry pomace. In vitro and in vivo evaluation of the antioxidant, antihypertensive, antiaging, and neuroprotective capacities employing Caenorhabditis elegans was achieved for the first time. Extractable phenolic compounds and NEPs were separated and identified by families by high-performance thin-layer chromatog. (HPTLC) with UV/Vis detection. A total of 39 phenolic compounds were tentatively identified in all extracts by direct anal. in real-time high-resolution mass spectrometry (DART-Orbitrap-HRMS). EAE extracts presented the highest in vitro and in vivo antioxidant capacity as well as the highest in vivo antiaging and neuroprotective capacities. These results showed that NEPs with interesting biol. properties are retained in the extraction residue, being usually underestimated and discarded.

Journal of Agricultural and Food Chemistry published new progress about 134-96-3. 134-96-3 belongs to ethers-buliding-blocks, auxiliary class Immunology/Inflammation,COX,Natural product, name is 4-Hydroxy-3,5-dimethoxybenzaldehyde, and the molecular formula is C9H10O4, Related Products of ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Gurram, Venkateshwarlu published the artcileC-C Cross-Coupling Reactions of O⁶-Alkyl-2-Haloinosine Derivatives and a One-Pot Cross-Coupling/O⁶-Deprotection Procedure, Synthetic Route of 947533-23-5, the publication is Chemistry – An Asian Journal (2012), 7(8), 1853-1861, S1853/1-S1853/41, database is CAplus and MEDLINE.

Reaction conditions for the C-C cross-coupling of O⁶-alkyl-2-bromo- and 2-chloroinosine derivatives with aryl-, heteroaryl-, and alkylboronic acids were studied. Optimization experiments with silyl-protected 2-bromo-O⁶-methylinosine led to the identification of [PdCl₂(dcpf)]/K₃PO₄ in 1,4-dioxane as the best conditions for these reactions (dcpf=1,1′-bis(dicyclohexylphosphino)ferrocene). Attempted O⁶-demethylation, as well as the replacement of the C-6 methoxy group by amines, was unsuccessful, which led to the consideration of Pd-cleavable groups such that C-C cross-coupling and O⁶-deprotection could be accomplished in a single step. Thus, inosine 2-chloro-O⁶-allylinosine was chosen as the substrate and, after re-evaluation of the cross-coupling conditions with 2-chloro-O⁶-methylinosine as a model substrate, one-step C-C cross-coupling/deprotection reactions were performed with the O⁶-allyl analog. These reactions are the first such examples of a one-pot procedure for the modification and deprotection of purine nucleosides under C-C cross-coupling conditions.

Chemistry – An Asian Journal published new progress about 947533-23-5. 947533-23-5 belongs to ethers-buliding-blocks, auxiliary class Nitrile,Boronic acid and ester,Benzene,Ether,Boronic Acids,Boronic Acids,Boronic acid and ester,, name is (4-(Cyanomethoxy)phenyl)boronic acid, and the molecular formula is C8H8BNO3, Synthetic Route of 947533-23-5.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Sardashti, A. R. published the artcileChemical composition of the essential oil of A. kermanensis from Taftan area by GC/MS technique, Product Details of C10H14O, the publication is International Journal of Agriculture and Crop Sciences (2012), 4(9), 561-563, 3 pp., database is CAplus.

The aerial parts of A. Kermanensis were subjected to hydro distillation by a Clevenger-type apparatus to produce an oil in 1.87% weight/weight yield. It was then analyzed by GC/MS. Identification of the compounds was carried out by comparison of their mass spectra with those of authentic sample together with the relative retention indexes. 37 Components were identified representing 97.04% of the oil. It contained mainly oxygenated monoterpenes (71.68%) with 1,8 cineole (56.55%), Borneol (5.28%) Geranyl perpionate (4.05%), camphor (4.48%), beta Thujone (2.84%), 4-Terpineol (2.77%) and unknown compound (2.94%) as the major constituents. The amount of Sesquiterpenes were representing (1.30% weight/weight) of the total oil. The results clearly showed the richness of oil in monoterpenes, which may be due to the collection of plant material during the flowering period.

International Journal of Agriculture and Crop Sciences published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C10H14O, Product Details of C10H14O.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Fu, Xiangkai published the artcilePerfluorooctanesulfonic acid catalyzed Friedel-Crafts alkylation with olefins in gas-liquid phase, Application In Synthesis of 2944-47-0, the publication is Chinese Chemical Letters (1993), 4(4), 307-10, database is CAplus.

Solid superacid perfluorooctanesulfonic acid (POSA) catalyzed Friedel-Crafts alkylation of aromatic hydrocarbons with olefins in gas-liquid phase. The alkylations gave good yields with simple operation and easy work up. The amount of the catalyst used in the reactions was small and could be reused. The optimum temperature of the reactions and the effect of the amount of the catalyst used in the reactions are also discussed.

Chinese Chemical Letters published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C10H14O, Application In Synthesis of 2944-47-0.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Liu, Luo-Yan published the artcilemeta C-H Arylation of Electron-Rich Arenes: Reversing the Conventional Site Selectivity, Recommanded Product: 2-Isopropylanisole, the publication is Journal of the American Chemical Society (2019), 141(37), 14870-14877, database is CAplus and MEDLINE.

Controlling site selectivity of C-H activation without using a directing group remains a significant challenge. While Pd(II) catalysts modulated by a mutually repulsive pyridine-type ligand have been shown to favor the relatively electron-rich carbon centers of arenes, reversing the selectivity to favor palladation at the relatively electron-deficient positions has not been possible. Herein we report the first catalytic system that effectively performs meta C-H arylation of a variety of alkoxy aromatics including 2,3-dihydrobenzofuran and chroman with exclusive meta site selectivity, thus reversing the conventional site selectivity governed by native electronic effects. The identification of an effective ligand and modified norbornene (NBE-CO₂Me), as well as taking advantage of the statistics, are essential for achieving the exclusive meta selectivity.

Journal of the American Chemical Society published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C10H14O, Recommanded Product: 2-Isopropylanisole.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem