Tag: M.W=150-200

Morimoto, Koji published the artcileCyclic Hypervalent Iodine-Induced Oxidative Phenol and Aniline Couplings with Phenothiazines, Safety of 4-Hydroxy-3-tert-butylanisole, the main research area is phenothiazineyl phenol chemoselective preparation; phenol phenothiazine cross coupling cyclic hypervalent iodine induced; amine phenothiazinyl chemoselective preparation; phenothiazine aryl amine cross coupling cyclic hypervalent iodine induced.

In this study, cyclic hypervalent iodine-induced metal-free cross-dehydrogenative coupling of phenols/amines with phenothiazines to afford (10H-phenothiazinyl)phenols I [R = 4,5-dimethoxy-2-phenolyl, 6-Br-4-OMe-2-phenolyl, 4-naphthalenolyl, etc.; R1 = H, OMe, Cl, CF3; X = O,S] and (10H-phenothiazinyl)amines II [R2 = N,N-diethyl-4-aniline, N,N-dimethyl-4-aniline, N-ethyl-2-methyl-4-aniline, etc.; R3 = H, Me, Cl, etc.; Y = O,S] was reported. This method afforded selective amination products I and II under mild conditions and in moderate-to-high yields. Aniline amination proceeded efficiently at 20°C, a previously unreported phenomenon.

Organic Letters published new progress about Amination. 121-00-6 belongs to class ethers-buliding-blocks, name is 4-Hydroxy-3-tert-butylanisole, and the molecular formula is C11H16O2, Safety of 4-Hydroxy-3-tert-butylanisole.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Nantaba, Florence published the artcileTemporal dynamics and ecotoxicological risk assessment of personal care products, phthalate ester plasticizers, and organophosphorus flame retardants in water from Lake Victoria, Uganda, COA of Formula: C11H16O2, the main research area is ecotoxicol risk assessment water pollution Lake Victoria Uganda; East africa; Flame retardants; Lake victoria; Personal care products; Plasticizers; Risk assessment.

For the first time the occurrence of 25 organic micropollutants (OMPs) including, eleven personal care products (PCPs), six phthalate ester plasticizers (PEPs) and eight organophosphorus flame retardants (OPFRs) was investigated in 72 water samples obtained from five bays in the Uganda sector of Lake Victoria. In addition, an assessment of the potential ecotoxic risk of the target OMPs to aquatic organisms was conducted. Water samples were analyzed for the target OMPs using gas chromatog. coupled with GC/MS. All the target PCPs were found in all the water samples with the exception of musk ketone and 2,6-di-tert-butylphenol. Triclosan, benzophenone, and 4-methylbenzylidine camphor were the most predominant PCPs. All the six plasticizers were found in all the water samples with di-Bu phthalate, and bis-(2-ethylhexyl) phthalate detected at the highest concentrations Tricresyl phosphate, tris-(2-chloroethyl) phosphate and tri-Ph phosphate were the most dominant OPFRs. The highest concentrations of OMPs were recorded in Murchison and Thurston Bays, presumably due to industrial wastewater effluents from the highly industrialized localities of the two Bays. Ecotoxicol. risk assessment showed that PCPs (triclosan, musk ketone, and 4-MBC), plasticizers (di-Bu phthalate, bis-(2-ethylhexyl) adipate and bis-(2-ethylhexyl) phthalate) and OPFRs (tricresyl phosphate, tri-Ph phosphate and tris-(2-chloroethyl) phosphate) pose a high ecotoxic risk to lives of aquatic organisms.

Chemosphere published new progress about Alkalinity. 121-00-6 belongs to class ethers-buliding-blocks, name is 4-Hydroxy-3-tert-butylanisole, and the molecular formula is C11H16O2, COA of Formula: C11H16O2.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Hu, Xiaomei published the artcileModification of thionucleobases in ionic liquids, SDS of cas: 622-86-6, the main research area is ionic liquid catalyst thioalkylation nucleobase preparation thionucleobase.

A simple method was established for the preparation of thio-substituted thionucleobases using room temperature ionic liquids (RTILs) such as 1-butyl-3-methylimidazolium trifluoroacetate [BMIM]+[CF3COO]- and 1-methoxyethyl-3-methylimidazolium trifluoroacetate [MeOEtMIM]+[CF3COO]- as solvents and catalysts without any other catalyst. These reactions proceeded efficiently in RTILs with excellent yield of products. RTILs can be recycled and reused effectively without further purification

Journal of Chemistry published new progress about Alkylation. 622-86-6 belongs to class ethers-buliding-blocks, name is (2-Chloroethoxy)benzene, and the molecular formula is C8H9ClO, SDS of cas: 622-86-6.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Demuner, Antonio Jacinto published the artcileThe Fungal Phytotoxin Alternariol 9-Methyl Ether and Some of Its Synthetic Analogues Inhibit the Photosynthetic Electron Transport Chain, SDS of cas: 127972-00-3, the main research area is Alternaria phytotoxin alternariol methyl ether analog preparation inhibition photosynthesis.

Alternariol and monomethylalternariol are natural phytotoxins produced by some fungal strains, such as Nimbya and Alternaria. These substances confer virulence to phytopathogens, yet no information is available concerning their mode of action. Here it is shown that in the micromolar range alternariol 9-Me ether is able to inhibit the electron transport chain (IC50 = 29.1 ± 6.5 μM) in isolated spinach chloroplasts. Since its effectiveness is limited by poor solubility in water, several alternariol analogs were synthesized using different aromatic aldehydes. The synthesized 6H-benzo-[c]-cromen-6-ones, 5H-chromene-[4,3-b]-pyridin-5-one, and 5H-chromene-[4,3-c]-pyridin-5-one also showed inhibitory properties, and three 6H-benzo-[c]-cromen-6-ones were more effective (IC50 = 12.8-22.8 μM) than the lead compound Their addition to the culture medium of a cyanobacterial model strain was found to inhibit algal growth, with a relative effectiveness that was consistent with their activity in vitro. In contrast, the growth of a nonphotosynthetic plant cell culture was poorly affected. These compounds may represent a novel lead for the development of new active principles targeting photosynthesis.

Journal of Natural Products published new progress about Alternaria. 127972-00-3 belongs to class ethers-buliding-blocks, name is 2-Methoxy-5-methylphenylboronic acid, and the molecular formula is C8H11BO3, SDS of cas: 127972-00-3.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Rausaria, Smita published the artcileManganese(III) Complexes of Bis(hydroxyphenyl)dipyrromethenes Are Potent Orally Active Peroxynitrite Scavengers, SDS of cas: 127972-00-3, the main research area is manganese chelate biscyclohexano fused bishydroxyphenyldipyrromethene preparation crystal structure; oral analgesic activity manganese chelate biscyclohexano fused bishydroxyphenyldipyrromethene; peroxynitrite scavenger manganese chelate biscyclohexano fused bishydroxyphenyldipyrromethene.

The authors report biscyclohexano-fused Mn(III) complexes of bis(hydroxyphenyl)dipyrromethenes, complexes I (R1 = H, Me, or F, 4a-c, resp.,) as potent and orally active peroxynitrite scavengers. Complexes 4a-c reduce peroxynitrite through a two-electron mechanism, thereby forming the corresponding Mn(V)O species, which were characterized by UV, NMR, and LC-MS methods. Mn(III) complex 4b and its strained boron (BODIPY) analog 9b were analyzed by x-ray crystallog. Finally, complex 4a is an orally active and potent analgesic in a model carrageenan-induced hyperalgesia known to be driven by the over-production of peroxynitrite.

Journal of the American Chemical Society published new progress about Analgesics. 127972-00-3 belongs to class ethers-buliding-blocks, name is 2-Methoxy-5-methylphenylboronic acid, and the molecular formula is C8H11BO3, SDS of cas: 127972-00-3.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Nikl, Joachim published the artcileDirect Metal- and Reagent-Free Sulfonylation of Phenols with Sodium Sulfinates by Electrosynthesis, COA of Formula: C11H16O2, the main research area is hydroxyarylsulfone preparation electrochem green chem; phenol sodium benzenesulfinate anodization cross coupling sulfonylation; C−H activation; cross-coupling; electrochemistry; oxidation; sustainable chemistry.

A novel electrochem. strategy for the synthesis of arylsulfones R1SO2R2 (R1 = 3-tert-butyl-2-hydroxy-5-methoxyphenyl, 2-hydroxy-5-methoxy-3-methylphenyl, 4-hydroxy-3,5-dimethoxyphenyl, 2-hydroxy-3-methoxy-5-methylphenyl; R2 = Me, Ph, 4-fluorophenyl, etc.) by direct sulfonylation of phenols with sodium sulfinates NaOS(O)R2 has been developed. The C,S-coupling products are of particular interest for chem. synthesis, material sciences and pharmaceutical sciences. By using this metal- and reagent-free electrochem. method, aryl and diaryl sulfones can be obtained directly in good yields. The established one-step protocol is easy to perform, scalable, and inherently safe, and enables a broad scope, which is not limited by quinoid-forming substrates.

Chemistry – A European Journal published new progress about Anodization. 121-00-6 belongs to class ethers-buliding-blocks, name is 4-Hydroxy-3-tert-butylanisole, and the molecular formula is C11H16O2, COA of Formula: C11H16O2.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ben Jrad, Amani published the artcileSalen/salan metallic complexes as redox labels for electrochemical aptasensors, Category: ethers-buliding-blocks, the main research area is salen salan metallic complex electrochem aptasensor.

This work presents the synthesis and characterization of salen/salan metal complexes for their future application as electrochem. labels in affinity sensors. Due to its stability and electrochem. properties, an oxovanadium salan complex was selected and coupled to an estradiol-specific aptamer. The response of the resulting aptasensor was shown to decrease with increasing estradiol concentration

Chemical Communications (Cambridge, United Kingdom) published new progress about Aptasensors. 121-00-6 belongs to class ethers-buliding-blocks, name is 4-Hydroxy-3-tert-butylanisole, and the molecular formula is C11H16O2, Category: ethers-buliding-blocks.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Yang, Huibin published the artcileDesign and synthesis of thiazolylhydrazone derivatives as inhibitors of chitinolytic N-acetyl-β-D-hexosaminidase, Related Products of ethers-buliding-blocks, the main research area is thiazolylhydrazone derivative acetylhexosaminidase inhibitor mol docking.

N-acetyl-β-D-hexosaminidase (Hex) is potential target for pesticide design. Here, a series of thiazolylhydrazone derivatives were designed, synthesized and evaluated as competitive inhibitors of OfHex1, a Hex from the agricultural pest Ostrinia furnacalis. The derivative 3k, with a (benzyloxy)methyl group at the N3 atom, demonstrated greater potency with a Ki of 10.2 μM. Mol. docking anal. indicated that the (benzyloxy)methyl group of 3k was bound to a previously unexplored pocket formed by Loop 478-496. Then further optimization around naphthalene ring led to find the more potency substituent Ph. The derivative 7, with phenoxyethyl group at R1 and a Ph group at R2, demonstrated an augmented potency with a Ki of 2.1 μM. Mol. docking anal. indicated that 7 was bound to the active pocket of OfHex1 more favorably than 3k. This work suggests a novel scaffold for developing specific Hex inhibitors.

Bioorganic & Medicinal Chemistry published new progress about Drug design. 622-86-6 belongs to class ethers-buliding-blocks, name is (2-Chloroethoxy)benzene, and the molecular formula is C8H9ClO, Related Products of ethers-buliding-blocks.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Ram, Siya published the artcileSynthesis of potential antifilarial agents. 2. Methyl 2-substituted purine 8-carbamates and related compounds, Quality Control of 622-86-6, the main research area is purinecarbamate preparation inactive filaricide; methoxycarbonylthioureidopyrimidine preparation inactive filaricide.

Purinecarbamates I [R = (un)substituted alkyl, benzyl] were prepared from 2-mercapto-4,5-pyrimidinediamine. Some methoxycarbonylthioureidopyrimidines were also prepared The compounds were tested against the filarial infection, Brugia pahangi, in Meriones ungericulatus malis. None of the compounds demonstrated antifilarial activity.

Journal of Heterocyclic Chemistry published new progress about Filaricides. 622-86-6 belongs to class ethers-buliding-blocks, name is (2-Chloroethoxy)benzene, and the molecular formula is C8H9ClO, Quality Control of 622-86-6.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Li, Yongtao published the artcileBuilding a Chemical Toolbox for Human Pregnane X Receptor Research: Discovery of Agonists, Inverse Agonists, and Antagonists Among Analogs Based on the Unique Chemical Scaffold of SPA70, Formula: C8H11BO3, the main research area is pregnane X receptor agonist antagonist inverse agonist SPA70 analog.

Pregnane X receptor (PXR) plays roles in detoxification and other physiol. processes. PXR activation may enhance drug metabolism (leading to adverse drug reactions) or inhibit inflammation. Therefore, PXR agonists, antagonists, and inverse agonists may serve as research tools and drug candidates. However, a specific PXR modulator with an associated structure-activity relationship is lacking. Based on the scaffold of specific human PXR (hPXR) antagonist SPA70 (10), we developed 81 SPA70 analogs and evaluated their receptor-binding and cellular activities. Interestingly, analogs with subtle structural differences displayed divergent cellular activities, including agonistic, dual inverse agonistic and antagonistic, antagonistic, and partial agonistic/partial antagonistic activities (as in compounds 111, 10, 97, and 42, resp.). We generated a pharmacophore model that represents 81 SPA70 analogs, and docking models that correlate strong interactions between the compounds and residues in the AF-2 helix with agonistic activity. These compounds are novel chem. tools for studying hPXR.

Journal of Medicinal Chemistry published new progress about Cytotoxicity. 127972-00-3 belongs to class ethers-buliding-blocks, name is 2-Methoxy-5-methylphenylboronic acid, and the molecular formula is C8H11BO3, Formula: C8H11BO3.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem