Tag: M.W=150-200

Pawar, Gaurav published the artcileCu(I)-Catalyzed Microwave-Assisted Multicomponent Reaction Towards Synthesis of Diverse Fluorescent Quinazolino[4,3-b]quinazolin-8-ones and Their Photophysical Study, Related Products of ethers-buliding-blocks, the publication is ChemistrySelect (2022), 7(14), e202200500, database is CAplus.

A novel, base- and ligand-free one pot protocol for the synthesis of fused-quinazolinone under microwave irradiation using environmentally friendly PEG-400 as a solvent has been developed. Besides benzaldehyde, various benzyl alcs. and Me arenes were used in this protocol, which extend its synthetic applicability. Photophys. study of this highly fluorescent framework was studied by fluorescent study. DFT and ESI/MS studies were carried out to justify the proposed mechanism.

ChemistrySelect published new progress about 134-96-3. 134-96-3 belongs to ethers-buliding-blocks, auxiliary class Immunology/Inflammation,COX,Natural product, name is 4-Hydroxy-3,5-dimethoxybenzaldehyde, and the molecular formula is C9H10O4, Related Products of ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Koparan, Arzu published the artcileA Validated Method for Separation and Determination of Codeine Phosphate Hemihydrate Impurities in Bilayer Tablet Dosage Form of Naproxen Sodium and Codeine Phosphate by Using UHPLC, Safety of 2-Methoxynaphthalene, the publication is Current Pharmaceutical Analysis (2021), 17(6), 748-760, database is CAplus.

Apranax Plus is a new bilayer tablet dosage form, which combines two active pharmaceutical ingredients: naproxen sodium and codeine phosphate. The purpose of this work was to develop an Ultra-High-Performance Liquid Chromatog. (UHPLC) method for the separation and determination of codeine phosphate hemihydrate impurities in a bilayer tablet dosage form. The separation and determination of codeine phosphate hemihydrate and its impurities, methylcodeine, morphine, codeine dimer, 10-hydroxycodeine, 14-hydroxycodeine, thebaine and codeinone were achieved by using reversed-phase liquid chromatog. with TUV (Tunable UV Detector) and PDA (Photodiode Array Detector) detection by UHPLC. The new proposed method utilized by the Waters Acquity UHPLC TUV and PDA systems using a UHPLC column Waters Acquity, BEH, C18, 2.1×100 mm, 1.7μm particle size with a mixture of component A and acetonitrile in a gradient mode at a flow rate of 0.3mL/min, at 25°C with a load of 5μL. The detection for all eluted compounds was carried out at 245nm. The codeine phosphate hemihydrate and peaks of its impurities were adequately obtained, thus proving the stability-indicating power of the method. The developed method was validated as per the ICH guidelines with respect to parameters such as precision, accuracy, linearity, Limit of Detection (LOD), Limit of Quantification (LOQ) and robustness. It was verified as being adequate for all the mentioned impurities of codeine phosphate hemihydrate. The described method was found to be useful for routine purity testing and was also found suitable for the anal. of the stability samples of the drug product.

Current Pharmaceutical Analysis published new progress about 93-04-9. 93-04-9 belongs to ethers-buliding-blocks, auxiliary class Naphthalene,Ether, name is 2-Methoxynaphthalene, and the molecular formula is C11H10O, Safety of 2-Methoxynaphthalene.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Chen, Shuotong published the artcilePool complexity and molecular diversity shaped topsoil organic matter accumulation following decadal forest restoration in a karst terrain, Quality Control of 134-96-3, the publication is Soil Biology & Biochemistry (2022), 108553, database is CAplus.

Fast accumulation of soil organic matter (SOM) following forest restoration shifted from cropland has been widely reported, but how the pools and mol. composition change across soil aggregate fractions remains unclear. In this study, undisturbed topsoil (0-10 cm) samples were collected across a decadal chronosequence of forest stands (RL10, RL20 and RL40) restored for 10, 20 and 40 years following maize cropland (CL) abandonment in a karst terrain of Guizhou, Southwest China. SOM changes were explored using the size and d. fractionation of water-stable aggregates, 13C isotopic signalling and biomarker analyses as well as 13C solid-state NMR assays. Compared to that of CL, SOM content was increased by 24%, 79% and 181%, mass proportion of macroaggregates increased by 136%, 179% and 250%, and particulate organic matter (POM) increased by 13%, 108% and 382%, resp. at RL10, RL20 and RL40. With biomarker analyses, the relative abundances of plant-derived organics (lignin, cutin, suberin, wax and phytosterols), mostly protected in aggregates, increased, while those of microbe-derived OC, predominantly mineral bound, decreased in response to prolonged forest restoration. Calculated as per the Shannon diversity index (H’), changes in SOM pool complexity and mol. diversity were parallel to the SOM accumulation trend. The pool size ratio of POM to MAOM (mineral-associated organic matter) and the mol. abundance ratio of PL (plant-derived lipids) to ML (microbe-derived lipids) appeared to be indicative of SOM accumulation following forest restoration. With prolonged forest restoration, the topsoil OM shifted from microbial MAOM dominance to plant-derived POM dominance. Furthermore, the great topsoil OM enhancement in restored forest stands was shaped by pool complexity and mol. diversity changes with the complex interactions among plant-microbial-mineral assemblages in the karst topsoil. Both the pool complexity and mol. diversity of SOM should be considered in addressing carbon sequestration with forest restoration concerning the functioning of soil ecosystems and services under global change pressures.

Soil Biology & Biochemistry published new progress about 134-96-3. 134-96-3 belongs to ethers-buliding-blocks, auxiliary class Immunology/Inflammation,COX,Natural product, name is 4-Hydroxy-3,5-dimethoxybenzaldehyde, and the molecular formula is C9H10O4, Quality Control of 134-96-3.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Vicente, Estela D. published the artcileCytotoxicity and mutagenicity of particulate matter from the open burning of pruning wastes, Safety of 4-Hydroxy-3,5-dimethoxybenzaldehyde, the publication is Air Quality, Atmosphere & Health (2022), 15(2), 299-310, database is CAplus.

Burning vegetative debris is a worldwide long-standing practice. The current study was designed to examine the cytotoxicity and mutagenicity of particulate matter with an aerodynamic diameter below 10 μm (PM10) released from the burning of pruning residues common in Portugal and other countries of the Mediterranean region. Field measurements were conducted to collect PM10 samples from open burning of vines, olive, willow and acacia pruning branches. To assess the cytotoxicity of the PM10 total organic extract, the A549 cell line, representative of the alveolar type II pneumocytes of the human lung, was used. The cytotoxicity was checked using two complementary methods: water-soluble tetrazolium (WST-8) test to evaluate the cell metabolic activity and lactate dehydrogenase (LDH) activity assay to assess the loss of cell membrane integrity. The mutagenicity of the PM10-bound polycyclic aromatic hydrocarbons (PAHs) was screened through the Ames test. PM10 organic extracts induced LDH release in a dose-dependent manner. Regarding the cellular metabolic activity, dose-dependency was lacking for the majority of the samples. Combined WST-8 and LDH data indicate that PM10 exposure induce a necrotic cell death pathway in which the cell membrane integrity is lost. Direct and indirect mutagenicity towards the TA98 Salmonella strain has been recorded for the PAH extracts of PM10 collected from combustion of vine and willow branches during the ignition/flaming combustion stage. Significant correlations were found between the cytotoxic responses (WST-8 and LDH) and the PM10 organic component.

Air Quality, Atmosphere & Health published new progress about 134-96-3. 134-96-3 belongs to ethers-buliding-blocks, auxiliary class Immunology/Inflammation,COX,Natural product, name is 4-Hydroxy-3,5-dimethoxybenzaldehyde, and the molecular formula is C12H25Br, Safety of 4-Hydroxy-3,5-dimethoxybenzaldehyde.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Anthis, Jeffrey W. published the artcileA New Route to Chelating Bis(aryloxide) Ligands and Their Applications to Tantalum and Titanium Organometallic Compounds, Product Details of C10H14O, the publication is Inorganic Chemistry (2004), 43(2), 716-724, database is CAplus and MEDLINE.

A new route to sterically tuned, chelating bis(aryloxide) ligands is described and demonstrated by the synthesis of 2,2′-ethylenebis(6-isopropylphenol) (1, H₂BIPP) and transition metal complexes of its dianion. The utility of these ligands in titanium and tantalum organometallic chem. is shown in the alkylation of (BIPP)TiCl₂ (7) to form (BIPP)TiMe₂ (8) and (BIPP)Ti(CH₂Ph)₂ (9) and in the alkylation of (BIPP)TaCl₃ (10) and its base adducts to form (BIPP)TaMe₃ (14) and (BIPP)Ta(CH₂Ph)₃ (13). Structural comparisons of the chelating 2,2′-ethylenebis(6-isopropylphenoxide) (BIPP) ligand with its analogous, nonchelating bis(2,6-dialkylaryloxide) ligand set are examined in the x-ray diffraction studies of (BIPP)TaCl₃(THF)·THF and (BIPP)Ta(CH₂C₆H₅)₃.

Inorganic Chemistry published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C10H14O, Product Details of C10H14O.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Hungerford, Natasha L. published the artcileOccurrence of environmental contaminants (pesticides, herbicides, PAHs) in Australian/Queensland Apis mellifera honey, Safety of 2-Methoxynaphthalene, the publication is Food Additives & Contaminants, Part B: Surveillance (2021), 14(3), 193-205, database is CAplus and MEDLINE.

Honey is a popular agricultural product containing mostly sugars and water, but due to its nutritious components and natural production by honeybees (Apis mellifera) from floral nectar, it is marketed as a premium health food item. As environmental monitors, honeybees can potentially transfer environmental contaminants to honey. While pesticides can have ubiquitous presence in agricultural and urban areas, polycyclic aromatic hydrocarbons (PAHs) can be more prevalent in higher d. urban/industrial environments. Australian beehives are customarily located in rural areas/forests, but it is increasingly popular to keep hives in urban areas. This study assessed the levels of environmental contaminants in honeys (n = 212) from Queensland/Australian sources including rural, peri-urban and urban areas. Honey samples were analyzed by LC-MS/MS and GC-MS/MS for 53 herbicides, 83 pesticides, 18 breakdown products (for certain pesticides/herbicides) and 33 PAHs and showed low/negligible pesticide, herbicide and PAHs contamination, consistent regardless of honey origins.

Food Additives & Contaminants, Part B: Surveillance published new progress about 93-04-9. 93-04-9 belongs to ethers-buliding-blocks, auxiliary class Naphthalene,Ether, name is 2-Methoxynaphthalene, and the molecular formula is C11H10O, Safety of 2-Methoxynaphthalene.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Ding, Yun published the artcileDesign and Synthesis of Biaryl DNA-Encoded Libraries, Name: (3-Methoxy-5-methylphenyl)boronic acid, the publication is ACS Combinatorial Science (2016), 18(10), 625-629, database is CAplus and MEDLINE.

DNA-encoded library technol. (ELT) is a powerful tool for the discovery of new small-mol. ligands to various protein targets. Here we report the design and synthesis of biaryl DNA-encoded libraries based on the scaffold of 5-formyl 3-iodobenzoic acid. Three reactions on DNA template, acylation, Suzuki-Miyaura coupling and reductive amination, were applied in the library synthesis. The three cycle library of 3.5 million diversity has delivered potent hits for phosphoinositide 3-kinase α (PI3Kα).

ACS Combinatorial Science published new progress about 725251-81-0. 725251-81-0 belongs to ethers-buliding-blocks, auxiliary class Boronic acid and ester,Benzene,Ether,Boronic Acids,Boronic acid and ester, name is (3-Methoxy-5-methylphenyl)boronic acid, and the molecular formula is C8H11BO3, Name: (3-Methoxy-5-methylphenyl)boronic acid.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Pompeo, Matthew published the artcilePd-PEPPSI-IPent^Cl: A Highly Effective Catalyst for the Selective Cross-Coupling of Secondary Organozinc Reagents, Safety of 2-Isopropylanisole, the publication is Angewandte Chemie, International Edition (2012), 51(45), 11354-11357, database is CAplus and MEDLINE.

A series of Pd-PEPPSI complexes with various substitution pattern on the heterocyclic carbene backbone were designed, prepared and studied as catalysts in Negishi cross-coupling reactions of aryl and heteroaryl halides or triflates with secondary organozinc nucleophiles. In all the cases, the selectivity for the normal, non-rearranged products was observed Computational studies revealed that the relative barrier difference between reductive elimination and β-hydride elimination correlate well with observed selectivities. The best results were shown by the Pd-PEPPSI-IPent^cl complex which demonstrated unprecedented selectivity leading to virtually one (desired) isomer for reactions of a wide selection of alkylzincs and highly functionalized (hetero)aromatic halides and triflates.

Angewandte Chemie, International Edition published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C10H14O, Safety of 2-Isopropylanisole.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Cody, Robert B. published the artcileIntegrated data analysis making use of the total information from gas chromatography and high-resolution time-of-flight mass spectrometry to identify qualitative differences between two whisky samples, Name: 4-Hydroxy-3,5-dimethoxybenzaldehyde, the publication is Rapid Communications in Mass Spectrometry (2022), 36(3), e9225, database is CAplus and MEDLINE.

Anal. of complex mixtures with gas chromatog. coupled with high-resolution time-of-flight mass spectrometry (GC/HRTOFMS) can produce a large amount of data. A new software program was recently reported that integrates all of the available mass spectrometric information from GC/HRTOFMS anal. into a concise report. New capabilities have now been added to the software to incorporate retention index data and to identify differences between two samples. Two Scotch whisky samples were sampled by solid-phase microextraction (SPME) and analyzed by GC/HRTOFMS. One of the two whisky samples (Sample B) was identical to the other sample (Sample A) except for an addnl. 6-mo storage in sherry casks. Both electron ionization (EI) and chem. ionization (CI) data were obtained using a new GC/TOFMS system (JEOL AccuTOF GC-Alpha) with enhanced resolving power and mass accuracy. Statistical anal. of replicate measurements of the whisky samples was carried out with a new software program (msFineAnal. version 3.2) to identify and assign differences between the samples. There were 124 peaks detected in the two whiskies. Thirteen compounds were detected with a relative peak area greater than 0.05% that were present in greater amounts in the whisky that had been stored in sherry casks for an addnl. 6 mo. Ten of these compounds were identified by the software with high confidence, two were identified as isomers with close retention indexes, and one was identified interactively. The software identified small differences between the two samples that resulted from sherry cask aging. Because all of the information available from the hard and soft ionization analyses for each compound is summarized in a concise integrated report, the operator can rapidly determine the level of confidence for each assignment and inspect the information for compounds that are not present in the database.

Rapid Communications in Mass Spectrometry published new progress about 134-96-3. 134-96-3 belongs to ethers-buliding-blocks, auxiliary class Immunology/Inflammation,COX,Natural product, name is 4-Hydroxy-3,5-dimethoxybenzaldehyde, and the molecular formula is C9H10O4, Name: 4-Hydroxy-3,5-dimethoxybenzaldehyde.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Kanemoto, Kazuya published the artcileAcid-Mediated Sulfonylthiolation of Arenes via Selective Activation of SS-Morpholino Dithiosulfonate, Product Details of C11H10O, the publication is Organic Letters (2021), 23(5), 1582-1587, database is CAplus and MEDLINE.

A trifluoroacetic-acid-mediated desulfurilative sulfonylthiolation of arenes RH (R = 4-methoxyphenyl, thiophen-2-yl, 6-bromo-2-hydroxynaphthalen-1-yl, etc.) using SS-morpholino 4-toluene(dithioperoxo)sulfonate is described. This system is based on selective activation of the morpholino group over the tosyl group of the doubly transformable sulfur surrogate. Mechanistic studies suggested that the reaction proceeds through electrophilic aromatic substitution followed by sulfur extrusion. The wide substrate scope of this reaction and the transformability of the resulting thiosulfonates RSTs enable expeditious access to divergent multifunctionalized sulfides.

Organic Letters published new progress about 93-04-9. 93-04-9 belongs to ethers-buliding-blocks, auxiliary class Naphthalene,Ether, name is 2-Methoxynaphthalene, and the molecular formula is C11H10O, Product Details of C11H10O.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem