Ding, Yun published the artcileDesign and Synthesis of Biaryl DNA-Encoded Libraries, Name: (3-Methoxy-5-methylphenyl)boronic acid, the publication is ACS Combinatorial Science (2016), 18(10), 625-629, database is CAplus and MEDLINE.
DNA-encoded library technol. (ELT) is a powerful tool for the discovery of new small-mol. ligands to various protein targets. Here we report the design and synthesis of biaryl DNA-encoded libraries based on the scaffold of 5-formyl 3-iodobenzoic acid. Three reactions on DNA template, acylation, Suzuki-Miyaura coupling and reductive amination, were applied in the library synthesis. The three cycle library of 3.5 million diversity has delivered potent hits for phosphoinositide 3-kinase α (PI3Kα).
ACS Combinatorial Science published new progress about 725251-81-0. 725251-81-0 belongs to ethers-buliding-blocks, auxiliary class Boronic acid and ester,Benzene,Ether,Boronic Acids,Boronic acid and ester, name is (3-Methoxy-5-methylphenyl)boronic acid, and the molecular formula is C8H11BO3, Name: (3-Methoxy-5-methylphenyl)boronic acid.
Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem