Tag: M.W=150-200

Oikonomou, Adriana published the artcileDefence against Bremia lactucae conferred by the resistance gene Dm7 in lettuce is broken by treatment with dichloroisonicotinic acid, Name: 4-Hydroxy-3,5-dimethoxybenzaldehyde, the publication is Plant Pathology (2022), 71(3), 611-620, database is CAplus.

The effect of inducers of systemic acquired resistance, dichloroisonicotinic acid (DCINA) and acibenzolar-S-Me (BION), on compatible interactions between Bremia lactucae and lettuce were examined using a detached cotyledon infection assay. Treatment with both activators caused a reduction in sporulation on susceptible cultivars Cobham Green challenged with isolate CL9W and Diana inoculated with isolate Tv, with DCINA being more effective than BION on an equimolar basis. Unexpectedly, treatment with both compounds suppressed the resistance conferred by the Dm7 gene in cv. Diana challenged by isolate CL9W (A7). The frequency of sporulation was greatly increased by DCINA in the incompatible interaction. The suppression of defense was associated with a delay in the onset of the Dm7-based hypersensitive reaction as indicated by the extended viability of penetrated epidermal cells, and reductions in both the accumulation of the phytoalexin lettucenin A and the deposition of autofluorescent phenolics such as syringaldehyde on plant and oomycete cell walls. The anal. of DCINA homologues indicated that 2-chloroisonicotinic acid was as effective as the dichloro-derivative in suppressing resistance in cv. Diana, whereas the absence of the carboxyl group rendered 2,6-dichloropyridine inactive. Infection of cotyledons by Botrytis cinerea was also found to be enhanced by DCINA treatment. Based on our results, we discuss the possibility that DCINA reduces Dm7 transcription through an epigenetic mechanism, as is supported by bioinformatic analyses of the resistance gene, and that it suppresses jasmonate-dependent resistance to B. cinerea.

Plant Pathology published new progress about 134-96-3. 134-96-3 belongs to ethers-buliding-blocks, auxiliary class Immunology/Inflammation,COX,Natural product, name is 4-Hydroxy-3,5-dimethoxybenzaldehyde, and the molecular formula is C9H10O4, Name: 4-Hydroxy-3,5-dimethoxybenzaldehyde.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Lopez-Arencibia, Atteneri published the artcileNew phenalenone analogues with improved activity against Leishmania species, Product Details of C11H10O, the publication is Biomedicine & Pharmacotherapy (2020), 110814, database is CAplus and MEDLINE.

The in vitro activity against Leishmania spp. of five novel designed compounds, phenalenone derivatives, is described in this study. Previous works have shown that some phenalenones present leishmanicidal activity, some of which could induce programmed cell death events in L. amazonensis parasites. In this research, we focused on the determination of the programmed cell death evidence by detecting the characteristic features of the apoptosis-like process, such as phosphatidylserine exposure and mitochondrial membrane potential, among others. The results showed that the new derivatives have comparable or better activity and selectivity than the commonly prescribed anti-leishmanial drug. This result was obtained by inducing stronger mitochondrial depolarization or more intense phosphatidylserine exposure than miltefosine, highlighting compound 8 with moreover 9-times better selectivity index. In addition, the new five mols. activated the apoptosis-like process in the parasite. All the signals observed were indicative of the death process that the parasites were undergoing.

Biomedicine & Pharmacotherapy published new progress about 93-04-9. 93-04-9 belongs to ethers-buliding-blocks, auxiliary class Naphthalene,Ether, name is 2-Methoxynaphthalene, and the molecular formula is C11H10O, Product Details of C11H10O.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Bhattacharyya, A. C. published the artcileGas chromatography of monohydric phenols via O-methylation, Related Products of ethers-buliding-blocks, the publication is Analytical Chemistry (1968), 40(12), 1873-6, database is CAplus.

Monohydric phenols were determined by gas chromatog., after conventional O-methylation, on an 8% Apiezon L/celite column at 140° or a 10% Apiezon L/celite column at 180°. N carrier gas and a flame ionization detector were used. The aryl Me ether was chromatographed as a 0.2-μl. aliquot of a concentrated Et2O solution The procedure gave quant. etherification of 34 phenols. A 8-component synthetic mixture of phenols was analyzed, using the column at 140° [component, weight % present (as phenol), weight % found (as phenol), given]: 3-methylanisole, 13.87, 13.39; 2,6-dimethylanisole, 6.53, 7.38; 2,5-dimethylanisole, 11.84, 11.80; 3,5-dimethylanisole, 23.70, 23.60; 2,4,6-trimethylanisole, 8.62, 9.58; 2-methyl-4-ethylanisole, 9.63, 8.36; 4-tert-butylanisole and 2,3,5-trimethylanisole, 22.07, 22.35; 2,3,4-trimethylanisole, 3.74, 3.54. The anal. was applied to distillates of tar acids obtained from hydrogenation experiments of Assam coal and from a com. high-temperature carbonization plant.

Analytical Chemistry published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C10H14O, Related Products of ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Ghosal, Manuka published the artcileTotal synthesis of (±)-shonanyl methyl ether and (±)-ferruginyl methyl ether, Related Products of ethers-buliding-blocks, the publication is Tetrahedron Letters (1989), 30(26), 3469-70, database is CAplus.

An efficient reductive methylation of the tricyclic ketone I in anhydrous NH₃ provided the β,γ-unsaturated ketone II in high yield which was subsequently converted into (±)-shonanyl Me ether (III) and (±)-ferruginyl Me ether (IV).

Tetrahedron Letters published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C10H14O, Related Products of ethers-buliding-blocks.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Huang, Lin published the artcileRuthenium-Catalyzed Dehydrogenation Through an Intermolecular Hydrogen Atom Transfer Mechanism, Safety of 2-Methoxynaphthalene, the publication is Angewandte Chemie, International Edition (2021), 60(13), 7290-7296, database is CAplus and MEDLINE.

The direct dehydrogenation of alkanes is among the most efficient ways to access valuable alkene products. Although several catalysts have been designed to promote this transformation, they have unfortunately found limited applications in fine chem. synthesis. Here, we report a conceptually novel strategy for the catalytic, intermol. dehydrogenation of alkanes using a ruthenium catalyst. The combination of a redox-active ligand and a sterically hindered aryl radical intermediate has unleashed this novel strategy. Importantly, mechanistic investigations have been performed to provide a conceptual framework for the further development of this new catalytic dehydrogenation system.

Angewandte Chemie, International Edition published new progress about 93-04-9. 93-04-9 belongs to ethers-buliding-blocks, auxiliary class Naphthalene,Ether, name is 2-Methoxynaphthalene, and the molecular formula is C11H10O, Safety of 2-Methoxynaphthalene.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Dubois, Jacques Emile published the artcileElectrophilic aromatic substitution. Bromination of methoxybenzenes. Evaluation of steric effect of bulky alkyl substituents, Synthetic Route of 2944-47-0, the publication is Nouveau Journal de Chimie (1981), 5(1), 33-8, database is CAplus.

Bulky alkyl group steric effects on substituted methoxybenzenes are quant. determined as the difference between exptl. bromination rate constants and those calculated by taking into account electronic effects only. Two kinds of results are observed For di- or trisubstituted compounds, no steric inhibition to the transmission of Me or MeO group electronic effects is observed when these substituents are flanked in a vicinal position by an Me₂CH or Me₃C group. In contrast, important steric effects are observed for 4,5,2-Me₂(Me₂CH)C₆H₂OMe and for the ortho position (to the OMe group) in o-Me₃C C₆H₄OMe.

Nouveau Journal de Chimie published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C10H14O, Synthetic Route of 2944-47-0.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Mastral, Ana Maria published the artcileFriedel-Crafts reaction. Comparative study of alkylation of anisole with diverse alkylation agents, Synthetic Route of 2944-47-0, the publication is Afinidad (1979), 36(363), 401-4, database is CAplus.

Alkylation of anisole was carried out with MeCH:CH₂, PrCl, PrOH, or ROCHMeCH₂HgBr (R = H, Me, Ac) in the presence AlCl₃, FeCl₃, or BF₃.Et₂O. Best results were achieved using the organomercury compounds, which gave mainly o– or p-MeOC₆H₄CH₂CHMeOR.

Afinidad published new progress about 2944-47-0. 2944-47-0 belongs to ethers-buliding-blocks, auxiliary class Benzene,Ether, name is 2-Isopropylanisole, and the molecular formula is C10H14O, Synthetic Route of 2944-47-0.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Favalli, Nicholas published the artcileLarge screening of DNA-compatible reaction conditions for Suzuki and Sonogashira cross-coupling reactions and for reverse amide bond formation, HPLC of Formula: 947533-23-5, the publication is Bioorganic & Medicinal Chemistry (2021), 116206, database is CAplus and MEDLINE.

Progress in DNA-encoded chem. library synthesis and screening crucially relies on the availability of DNA-compatible reactions, which proceed with high yields and excellent purity for a large number of possible building blocks. In the past, exptl. conditions have been presented for the execution of Suzuki and Sonogashira cross-coupling reactions on-DNA. In this article, our aim was to optimize Suzuki and Sonogashira reactions, comparing our results to previously published procedures. We have tested the performance of improved conditions using 606 building blocks (including boronic acids, pinacol boranes and terminal alkynes), achieving >70% conversion for 84% of the tested mols. Moreover, we describe efficient exptl. conditions for the on-DNA synthesis of amide bonds, starting from DNA derivatives carrying a carboxylic acid moiety and 300 primary, secondary and aromatic amines, as amide bonds are frequently found in DNA-encoded chem. libraries thanks to their excellent DNA compatibility.

Bioorganic & Medicinal Chemistry published new progress about 947533-23-5. 947533-23-5 belongs to ethers-buliding-blocks, auxiliary class Nitrile,Boronic acid and ester,Benzene,Ether,Boronic Acids,Boronic Acids,Boronic acid and ester,, name is (4-(Cyanomethoxy)phenyl)boronic acid, and the molecular formula is C8H8BNO3, HPLC of Formula: 947533-23-5.

Referemce:
https://en.wikipedia.org/wiki/Ether,
Ether | (C2H5)2O – PubChem

Garino, Cedrik published the artcileNew 2-bromomethyl-8-substituted-benzo[c]chromen-6-ones. Synthesis and biological properties, Related Products of ethers-buliding-blocks, the main research area is bromomethyl benzochromenone preparation enzyme inhibitor.

New 2-bromomethyl-8-substituted-benzo[c]chromen-6-ones have been synthesized and their bioactive properties have been evaluated on different enzymic models: serine proteases (trypsin and α-chymotrypsin), HIV aspartyl protease, nitric oxide synthase and a panel of protein kinases. These new derivatives can provide upon chem. or enzymic attack, very reactive quinonimine methide intermediates, which could be utilized for the design of enzyme inhibitors. We found that some of these new derivatives exhibit modest inhibitory activities on the studied enzyme models, but it could be improved after structure optimization.

Bioorganic & Medicinal Chemistry Letters published new progress about bromomethyl benzochromenone preparation enzyme inhibitor. 127972-00-3 belongs to class ethers-buliding-blocks, name is 2-Methoxy-5-methylphenylboronic acid, and the molecular formula is C8H11BO3, Related Products of ethers-buliding-blocks.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Gluska, Hadar published the artcilePostpartum Depression in COVID-19 Days: Longitudinal Study of Risk and Protective Factors, Recommanded Product: 4-Hydroxy-3-tert-butylanisole, the main research area is COVID-19; EPDS; birth; post-partum depression.

COVID-19 impacted the childbirth experience and increased the rates of postpartum depression (PPD). We assessed the longitudinal effects of the pandemic on the rates of PPD and evaluated the PPD causes and symptoms among women who delivered during the first COVID-19 quarantine in Israel. The participants completed online questionnaires 3 (T1) and 6 mo (T2) following delivery. We used the ‘COVID-19 exposure’ questionnaire, while PPD symptoms, situational anxiety, and social support were evaluated with the EPDS, STAI, and MSPSS questionnaires. The mean EPDS scores increased between T1 and T2 (6.31 ± 5.6 vs. 6.92 ± 5.9, mean difference -0.64 ± 4.59 (95% CI (-1.21)-(-0.06)); t (244) = -2.17, p = 0.031), and the STAI scores decreased (45.35 ± 16.4 vs. 41.47 ± 14.0, t(234) = 4.39, p = 0.000). Despite the exposure to an increased number of COVID-19 events (3.63 ± 1.8 vs. (6.34 ± 2.3)), the impact of exposure decreased between T1 and T2 (8.91 ± 4.6 vs. 7.47 ± 4.1), p < 0.001). In the MSPSS, significant differences were noted on the family scale between the T1 (6.10 ± 1.3) and T2 (5.91 ± 1.4) scores; t (216) = 2.68, p = 0.0008. A regression anal. showed three statistically significant variables that correlated with increased EPDS scores: the MSPSS family subscale (F (1212.00) = 4.308, p = 0.039), the STAI scores (F (1212.00) = 31.988, p = 0.000), and the impact of exposure to COVID-19 (F (1212.00) = 5.038, p = 0.026). The rates of PPD increased for women who delivered during the first COVID-19 lockdown. Further research is warranted to help reduce PPD among these women. Journal of Clinical Medicine published new progress about COVID-19; EPDS; birth; post-partum depression. 121-00-6 belongs to class ethers-buliding-blocks, name is 4-Hydroxy-3-tert-butylanisole, and the molecular formula is C11H16O2, Recommanded Product: 4-Hydroxy-3-tert-butylanisole.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem