Garino, Cedrik published the artcileNew 2-bromomethyl-8-substituted-benzo[c]chromen-6-ones. Synthesis and biological properties, Related Products of ethers-buliding-blocks, the main research area is bromomethyl benzochromenone preparation enzyme inhibitor.
New 2-bromomethyl-8-substituted-benzo[c]chromen-6-ones have been synthesized and their bioactive properties have been evaluated on different enzymic models: serine proteases (trypsin and α-chymotrypsin), HIV aspartyl protease, nitric oxide synthase and a panel of protein kinases. These new derivatives can provide upon chem. or enzymic attack, very reactive quinonimine methide intermediates, which could be utilized for the design of enzyme inhibitors. We found that some of these new derivatives exhibit modest inhibitory activities on the studied enzyme models, but it could be improved after structure optimization.
Bioorganic & Medicinal Chemistry Letters published new progress about bromomethyl benzochromenone preparation enzyme inhibitor. 127972-00-3 belongs to class ethers-buliding-blocks, name is 2-Methoxy-5-methylphenylboronic acid, and the molecular formula is C8H11BO3, Related Products of ethers-buliding-blocks.
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem