Tag: M.W=150-200

Dickschat, Jeroen S.; Wang, Tao; Stadler, Marc published the artcile< Volatiles from the xylarialean fungus Hypoxylon invadens>, Electric Literature of 56724-03-9, the main research area is Hypoxylon fungal volatile natural product constitutional isomer; constitutional isomerism; gas chromatography; mass spectrometry; natural products; volatiles.

The volatiles emitted by agar plate cultures of the xylarialean fungus Hypoxylon invadens were investigated by use of a closed loop stripping apparatus in combination with GC-MS. Several aromatic compounds were found that could only be identified by comparison to all possible constitutional isomers with different ring substitution patterns. For the set of identified compounds a plausible biosynthetic scheme was suggested that gives further support for the assigned structures.

Beilstein Journal of Organic Chemistry published new progress about Aromatic compounds Role: BSU (Biological Study, Unclassified), BIOL (Biological Study). 56724-03-9 belongs to class ethers-buliding-blocks, and the molecular formula is C9H10O2, Electric Literature of 56724-03-9.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Shang, Gao; Liu, Duan; Allen, Scott E.; Yang, Qin; Zhang, Xumu published the artcile< Asymmetric hydrogenation of α-primary and secondary amino ketones: efficient asymmetric syntheses of (-)-arbutamine and (-)-denopamine>, Product Details of C11H16O2, the main research area is asym hydrogenation amino ketone rhodium catalyst; alc amino chiral preparation rhodium catalyst.

Two β-receptor agonists (-)-denopamine (I) and (-)-arbutamine (II) were prepared in good yields and enantioselectivities by asym. hydrogenation of unprotected amino ketones for the first time by using Rh catalysts bearing electron-donating phosphine ligands. A series of α-primary and secondary amino ketones, e.g. ArCOCH2NHR (Ar = Ph, 2-MeOC6H4, 2-naphthyl, R = Me; Ar = Ph, R = Et), were synthesized and hydrogenated to produce various 1,2-amino alcs., e.g. ArCH(OH)CH2NHR, in good yields and with good enantioselectivities. This Rh electron-donating phosphine-catalyzed asym. hydrogenation rep- resents one of the most promising and convenient approaches towards the asym. synthesis of chiral amino alcs.

Chemistry – A European Journal published new progress about Amines, keto Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Product Details of C11H16O2.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Jeon, Heechol; Jo, Nam Hyun; Yoo, Kyung Ho; Choi, Joung-Hoon; Cho, Heeyeong; Cho, Jung-Hyuck; Oh, Chang-Hyun published the artcile< Synthesis and antibacterial evaluation of 1β-methyl-2-[5-(1-methoxyimino-2-substituted sulfonamide ethyl)pyrrolidin-3-ylthio]carbapenems and their related compounds>, Computed Properties of 10305-42-7, the main research area is carbapenem sulfonamide pyrrolidinyl preparation antibacterial structure activity relationship.

The synthesis of a new series of 1β-methylcarbapenems, I (R = SO2Me, SO2Et, SO2NHEt, SO2NMe2, SO2NH-n-Pr, COMe, H, CONH2) having methoxyimine and substituted sulfonamide moieties is described. Their in vitro antibacterial activities against both Gram-pos. and Gram-neg. bacteria were tested and the effect of substituents on the pyrrolidine ring was investigated. A particular compound I (R = SO2NHMe) having (methylamino)sulfonamide moiety showed the most potent antibacterial activity.

European Journal of Medicinal Chemistry published new progress about Antibacterial agents. 10305-42-7 belongs to class ethers-buliding-blocks, and the molecular formula is C3H8ClNO2S, Computed Properties of 10305-42-7.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Baricelli, Pablo J.; Rodriguez, Mariandry; Melean, Luis G.; Borusiak, Margarita; Crespo, Isis; Pereira, Juan C.; Rosales, Merlin published the artcile< Hydroformylation of natural olefins with the [Rh(COD)(μ-OMe)]2/TPPTS complex in BMI-BF4/toluene biphasic medium: observations on the interfacial role of CTAB in reactive systems>, HPLC of Formula: 52244-70-9, the main research area is aldehyde preparation hydroformylation natural olefin rhodium catalyst ionic liquid.

The complex [Rh(COD)(μ-OMe)]2 in presence of TPPTS (TPPTS = triphenylphosphinetrisulfonate) was evaluated as catalyst precursor for the in situ hydroformylation of natural olefins (eugenol, estragole and safrole) in biphasic media BMIm-BF4/toluene. Under moderate reaction conditions, the substrates showed the following reactivity order: eugenol > estragole > safrole. The rhodium system showed a high activity and selectivity towards the desired aldehydes. It was found that the use of cetyltrimethylammoniun bromide (CTAB) as phase transfer agent inhibits the hydroformylation reaction. The catalytic phase can be recycled up to four times without evident loss of activity or selectivity. In this work we report the use of an ionic liquid with hydrophilic character, without using water in the reaction medium.

Molecular Catalysis published new progress about Aldehydes Role: SPN (Synthetic Preparation), PREP (Preparation). 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, HPLC of Formula: 52244-70-9.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Duan, Jicheng; Du, Yun-Fei; Pang, Xiaobo; Shu, Xing-Zhong published the artcile< Ni-catalyzed cross-electrophile coupling between vinyl/aryl and alkyl sulfonates: synthesis of cycloalkenes and modification of peptides>, Synthetic Route of 52244-70-9, the main research area is vinyl triflate alkyl sulfonate Nickel catalyst reductive cross coupling; peptide alkyl tosylate Nickel catalyst cross coupling.

The coupling reactions between vinyl/aryl and alkyl C-O electrophiles that can be derived from chem. feedstocks and naturally occurring functional groups was reported. This method provided an efficient approach to the synthesis of a wide range of functionalized, and/or secondary alkyl substituted cycloalkenes that are difficult to synthesize by conventional methods. The reaction proceeded with broad substrate scope, and tolerated various functional groups such as alc., aldehyde, ketone, ester, amide, alkene, alkyne, heterocycles, organotin and organosilicon compounds The synthetic utility of this method was demonstrated by providing facile access to important building blocks. The possibility to apply this method for late-stage modification of peptides was also demonstrated. A broad range of functionalized alkyl groups was selectively introduced into tyrosine in peptides via C-C bond formation, which was a challenge to the existing procedures.

Chemical Science published new progress about Alkanesulfonates Role: RCT (Reactant), RACT (Reactant or Reagent). 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Synthetic Route of 52244-70-9.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

King, Frank D.; Aliev, Abil E.; Caddick, Stephen; Tocher, D. A. published the artcile< A novel synthesis of (di)-benzazocinones via an endocyclic N-acyliminium ion cyclization>, Category: ethers-buliding-blocks, the main research area is benzazocinone preparation; acyliminium cyclization.

The triflic acid-mediated endocyclic N-acyliminium ion cyclization provides a facile synthesis of (di)-benzazocinones, e.g. I (R = H, 14-Cl, 15-Br, etc.). On reduction of the 10-Ph derivative, an unusually nonpolar tertiary alkylamine II was obtained.

Organic & Biomolecular Chemistry published new progress about Cyclization. 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Category: ethers-buliding-blocks.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Gyulavari, Pal; Szokol, Balint; Szabadkai, Istvan; Brauswetter, Diana; Banhegyi, Peter; Varga, Attila; Marko, Peter; Boros, Sandor; Illyes, Eszter; Szantai-Kis, Csaba; Kreko, Marcell; Czudor, Zsofia; Orfi, Laszlo published the artcile< Discovery and optimization of novel benzothiophene-3-carboxamides as highly potent inhibitors of Aurora kinases A and B>, Safety of n-Propylsulphamoyl chloride, the main research area is benzothiophene carboxamide derivative preparation Aurora kinase inhibitor cancer; Aurora kinase; Benzothiophene-3-carboxamide; Cancer; Kinase inhibitor; Targeted therapy.

Aurora kinases as regulators of cell division have become promising therapeutic targets recently. Here we report novel, low mol. weight benzothiophene-3-carboxamide derivatives designed and optimized for inhibiting Aurora kinases. The most effective compound 36 inhibits Aurora kinases in vitro in the nanomolar range and diminishes HCT 116 cell viability blocking cytokinesis and inducing apoptosis. According to western blot anal., the lead mol. inhibits Aurora kinases equipotently to VX-680 (Tozasertib) and similarly synergizes with other targeted drugs.

Bioorganic & Medicinal Chemistry Letters published new progress about Antitumor agents (drug potential as). 10305-42-7 belongs to class ethers-buliding-blocks, and the molecular formula is C3H8ClNO2S, Safety of n-Propylsulphamoyl chloride.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Zha, Gao-Feng; Fang, Wan-Yin; Li, You-Gui; Leng, Jing; Chen, Xing; Qin, Hua-Li published the artcile< SO2F2-Mediated Oxidative Dehydrogenation and Dehydration of Alcohols to Alkynes>, Quality Control of 52244-70-9, the main research area is alkyne chemoselective preparation; phenyltriazole phenylacetylene preparation; sulfuryl fluoride DMSO mediated oxidative dehydrogenation elimination alc; beta hydroxy amide secondary alc oxidative elimination sulfuryl fluoride; sequential oxidative elimination primary alc azide alkyne cycloaddition azidobenzene; oxidative elimination primary alc Sonogashira coupling iodobenzene.

Terminal and internal alkynes were prepared directly from primary alcs. and secondary alcs. and β-hydroxyamides by oxidative dehydrogenation and dehydration using sulfuryl fluoride as the leaving group source and DMSO as oxidant; the method does not require transition metal reagents or catalysts. The method was used in one-pot preparations of phenyltriazoles and phenylacetylenes using the oxidative dehydrogenation/elimination reaction in sequence with azide-alkyne cycloaddition with Ph azide and Sonogashira coupling with iodobenzene.

Journal of the American Chemical Society published new progress about Alkynes, aryl Role: RCT (Reactant), SPN (Synthetic Preparation), RACT (Reactant or Reagent), PREP (Preparation). 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Quality Control of 52244-70-9.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Mohamed, Salah E. N.; Whiting, Donald A. published the artcile< Synthesis of meta,meta-bridged biaryls [7,0-metacyclophanes] via aryl-aryl coupling: factors affecting the cyclization>, Name: 4-(4-Methoxyphenyl)-1-butanol, the main research area is iodoarylheptane cyclization; metacycloptane.

Isoxazoline I and 3,4-I(MeO)C6H3(CH2)4CH(OAc)(CH2)2C6H3(OMe)I-4,3 were prepared; on treatment with (Ph3P)4Ni in DMF at 55-65° for 48 h these compounds cyclized to the [7.0]metacyclophanes II and III, resp., in 31 and 49% yield, resp. The analog 3,4-I(MeO)C6H3(CH2)4SO2(CH2)3C6H3(OMe)I-4,3 was also prepared; it failed to cyclize. Steric effects at the coupling site are more important than torsional strain in the products in determination of the product yield.

Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1972-1999) published new progress about Cyclocondensation reaction, intramolecular. 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Name: 4-(4-Methoxyphenyl)-1-butanol.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Zhao, Xiaoyong; Poon, Zhiyong; Engler, Amanda C.; Bonner, Daniel K.; Hammond, Paula T. published the artcile< Enhanced Stability of Polymeric Micelles Based on Postfunctionalized Poly(ethylene glycol)-b-poly(γ-propargyl L-glutamate): The Substituent Effect>, Quality Control of 52244-70-9, the main research area is block copolymer polymeric micelle polyethylene glycol propargyl glutamate stability.

One of the major obstacles that delay the clin. translation of polymeric micelle drug delivery systems is whether these self-assembled micelles can retain their integrity in blood following i.v. injection. The objective of this study was to evaluate the impact of core functionalization on the thermodn. and kinetic stability of polymeric micelles. The combination of ring-opening polymerization of N-carboxyanhydride (NCA) with highly efficient “”click”” coupling has enabled easy and quick access to a family of poly(ethylene glycol)-block-poly(γ-R-glutamate)s with exactly the same block lengths, for which the substituent “”R”” is tuned. The structures of these copolymers were carefully characterized by 1H NMR, FT-IR, and GPC. When pyrene is used as the fluorescence probe, the critical micelle concentrations (CMCs) of these polymers were found to be in the range of 10-7-10-6 M, which indicates good thermodn. stability for the self-assembled micelles. The incorporation of polar side groups in the micelle core leads to high CMC values; however, micelles prepared from these copolymers are kinetically more stable in the presence of serum and upon SDS disturbance. It was also observed that these polymers could effectively encapsulate paclitaxel (PTX) as a model anticancer drug, and the micelles possessing better kinetic stability showed better suppression of the initial “”burst”” release and exhibited more sustained release of PTX. These PTX-loaded micelles exerted comparable cytotoxicity against HeLa cells as the clin. approved Cremophor PTX formulation, while the block copolymers showed much lower toxicity compared to the cremophor-ethanol mixture The present work demonstrated that the PEG-b-PPLG can be a uniform block copolymer platform toward development of polymeric micelle delivery systems for different drugs through the facile modification of the PPLG block.

Biomacromolecules published new progress about Blood. 52244-70-9 belongs to class ethers-buliding-blocks, and the molecular formula is C11H16O2, Quality Control of 52244-70-9.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem