Tag: M.W=200-300

Electric Literature of 202865-80-3, These common heterocyclic compound, 202865-80-3, name is 4-Bromo-2-fluoro-1-isopropoxybenzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

To a mixture of 2-amino-5-ethyl-3-(4-methylphenoxy)pyrazine (55.0 mg, 0.240 mmol) and dioxane (1 mL) were added 4-bromo-2-fluoro-1-isopropoxybenzene (61 mg, 0.26 mmol), tris(dibenzylideneacetone)(0) (2.8 mg, 0.0030 mmol), 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene (4.2 mg, 0.0072 mmol) and sodium phenoxide trihydrate (61 mg, 0.36 mmol), and the resulting mixture was heated at reflux for 4 hours. To the reaction mixture was added saturated aqueous sodium bicarbonate, and the mixture was extracted with ethyl acetate. The extract was washed by brine, dried over anhydrous sodium sulphate, and concentrated in vacuo. The resulting residue was purified by reversed-phase HPLC (0.3% formic acid/acetonitrile) to give 5-ethyl-2-(3-fluoro-4-isopropoxyphenylamino)-3-(4-methylphenoxy)pyrazine (17 mg, Yield: 18%)as pale brown solid. 1H-NMR (delta ppm TMS/DMSO-d6): 1.05 (3H, t, J = 7.5 Hz), 1.26 (6H, d, J = 5.8 Hz), 2.33 (3H, s), 2.44 (2H, q, J = 7.5 Hz), 4.45-4.52 (1H, m), 7.05-7.17 (3H, m), 7.25 (2H, d, J = 8.6 Hz), 7.55-7.61 (1H, m), 7.69 (1H, s), 7.85-7.91 (1H, m), 8.93 (1H, s).

Statistics shows that 4-Bromo-2-fluoro-1-isopropoxybenzene is playing an increasingly important role. we look forward to future research findings about 202865-80-3.

Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 36805-97-7, name is 1,1-Di-tert-butoxy-N,N-dimethylmethanamine, This compound has unique chemical properties. The synthetic route is as follows., Quality Control of 1,1-Di-tert-butoxy-N,N-dimethylmethanamine

To a solution of 2,6-dichloroisonicotinic acid (2 g, 10.4 mmol) in toluene (50 mL) N,N dimethylformamide di-tert-butil acetal (15 mL, 62.5 mmol) was added under nitrogen atmosphere and mixture heated at 80 Ethyl acetate was added and organic layer was washed with water and brine, dried (MgSO4), filtered and concentrated to yield the title compound (2.34 g, 87%) as a solid.LRMS (m/z): 249 (M+1)+.1H NMR (400 MHz, CHLOROFORM-d) ppm 1.60 (s, 9 H) 7.74 (s, 2 H)

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 36805-97-7.

Reference of 1462-37-9, These common heterocyclic compound, 1462-37-9, name is ((2-Bromoethoxy)methyl)benzene, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

General procedure: alpha-Monosubstituted malonic diester 1 was synthesized according to the reported procedure as follows.3 tert-Butyl methyl malonate was purchased from Kanto Chemical, and used without further purification. The physical properties and spectral data of the new compounds, 2-(2-methylbenzyl)malonate 1g, 2-prenylmalonate 1l, and 2-(2-benzyloxyethyl)malonate 1o, are listed below. A 100 mL round-bottom flask equipped with a stirring bar was charged with tert-butyl methyl malonate (846 muL, 5.0 mmol) and DMF (10 mL). To the solution, sodium hydride (60percent oil suspension, 200 mg, 5.0 mmol) was added. The reaction was allowed to stir at 0 °C for 30 min. To the mixture, corresponding alkyl halide (5.0 mmol) was added at 0 °C and the mixture was stirred at room temperature for 24 h. To the reaction mixture, H2O was added, and the mixture was extracted with CH2Cl2 (3 * 20 mL), dried over MgSO4, and concentrated in vacuo. The remaining residue was purified by silica gel column chromatography (hexane/ethyl acetate) to afford the desired product 1.

Statistics shows that ((2-Bromoethoxy)methyl)benzene is playing an increasingly important role. we look forward to future research findings about 1462-37-9.

116557-46-1, name is 3-Bromo-2-methoxyaniline, belongs to ethers-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Product Details of 116557-46-1

To a solution of 3-bromo-2-methoxyaniline (20 g) in 1N hydrochloric acid (400 mL) was added a solution of sodium nitrite (7.2 g in 720 mL of water) at about 0 C. to about 5 C. under stirring. The reaction mixture was stirred for about 15 minutes at about 5 C. Then ethyladetoacetate (12.9 g) was added to the reaction mixture and stirred for about 15 minutes at about 0 C. to about 5 C. Sodium bicarbonate solution (27.5 g in 300 mL water) and ethanol (400 mL) was then added to the reaction mixture. The reaction mixture was allowed to warm to about room temperature and stirred for about 2 hours. The mixture was filtered, washed with water (200 mL) and dried to get yellowish solid. Yield: 33 g; Melting point: 75.9-77.1 C.; Purity (HPLC): 99.12% IR: 3421, 1706, 1684, 1517, 1215, 1093, 980 cm-1; Mass: m/z 342.88 [M+] and 344.86 [M+2] 1H NMR (300 MHz in CDCl3): delta 12.86 (s, 1H), 7.58-7.61 (d, 1H), 7.30-7.33 (d, 1H), 7.02-7.07 (m, 1H), 4.31-4.43 (q, 2H), 3.95 (s, 3H), 2.5 (s, 3H), 1.38-1.43 (t, 3H)

The synthetic route of 116557-46-1 has been constantly updated, and we look forward to future research findings.

Synthetic Route of 452-08-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 452-08-4, name is 2-Bromo-4-fluoro-1-methoxybenzene belongs to ethers-buliding-blocks compound, it is a common compound, a new synthetic route is introduced below.

EXAMPLE 107 9-Fluoro-1,2-dihydro-2,2,4-trimethyl-5-coumarino[3,4-f]quinoline (Compound 207, structure 41 of Scheme XI, where R1 =H, R2 =F). 5-Fluoro-2-methoxyphenylboronic acid (structure 37 of Scheme XI, where R1 =H, R2 =F) In a 200-mL flask, a solution of 2-bromo-4-fluoroanisole (Aldrich: 4.00 mL, 30.8 mmol) in THF (50 mL) was cooled to -78 C. (CO2 /IPA). To this solution n-BuLi (Aldrich: 2.5M in hexanes; 12.4 mL, 31 mmol, 1.0 equivuiv) was added dropwise over a 30 min period. The reaction mixture was stirred at -78 C. for 60 min and treated with trimethylborate (Aldrich: 10.5 mL, 92.4 mmol, 3.0 equivuiv). The reaction mixture was allowed to slowly warm to rt, stirred overnight (12 h), and cooled to 0 C. (ice/H2 O). The solution was treated with 5% HCl until the pH reached 6. The reaction mixture was poured into sat’d NH4 Cl (80 mL) and extracted with CH2 Cl2 (3*100 mL). The extracts were washed with sat’d NH4 Cl (1*80 mL), combined, dried (MgSO4), filtered through a pad of Celite, and concentrated to afford 4.90 g (94%) of a white semi-solid. Data for 5-fluoro-2-methoxyphenylboronic acid: 1 H NMR (400 MHz, acetone-d6): 7.47 (dd, J=8.8, 3.3, 1 H); 7.17 (m, 1 H); 7.05 (dd, J=9.0, 3.9, 1 H); 3.93 (s, 3 H).

The synthetic route of 2-Bromo-4-fluoro-1-methoxybenzene has been constantly updated, and we look forward to future research findings.

4463-59-6, name is 1-(2-Bromoethoxy)-2-methoxybenzene, belongs to ethers-buliding-blocks compound, is considered to be a conventional heterocyclic compound, which is widely used in drug synthesis. The chemical synthesis route is as follows. Computed Properties of C9H11BrO2

EXAMPLE 68 4-Benzyl-1-[2-(2-methoxyphenoxy)ethyl]piperidine STR105 From 1-(2-Bromoethoxy)-2-methoxybenzene (515 mg, 2.23 mmol) and 4-benzylpiperidine (785 mg, 4.48 mmol) there was obtained 560 mg (85%) of the amine as a yellowish oil. 1 H NMR (CDCl3): 1.27-1.40 (m, 2H), 1.47-1.58 (m, 1H), 1.62-1.66 (m,2H), 1.99-2.06 (m, 2H), 2.543 (d, 2H, J=7), 2.745 (t, 2H, J=6), 2.95-2.99 (m, 2H), 3.760 (s, 3H), 4.041 (t, 2H, J=6), 6.79-6.85 (m, 4H), 7.13-7.30 (m, 5H). The hydrochloride, mp 165-6 C.

The synthetic route of 4463-59-6 has been constantly updated, and we look forward to future research findings.

In the chemical reaction process, reaction time, type of solvent, can easily affect the result of the reaction, thereby determining the yield and properties of the reaction product. An updated downstream synthesis route of 332-48-9 as follows. SDS of cas: 332-48-9

EXAMPLE 7Synthesis of 2-(2-(2-(4-fluorophenoxy)ethyl)-2/T-tetrazol-5-yl)-4-methyl-J/V-(pyridin-3-ylmethyl)thiazole-5-carboxamide and 2-(l-(2-(4-fluorophenoxy)ethyl)-l£-r-tetrazol-5-yl)-4-methyl-lambdaf-(pyridin-3-ylmethyl)thiazole-5-carboxamideTo a mixture of 4-methyl-lambdar-(pyridin-3-ylmethyl)-2-(2//-tetrazol-5-yl)thiazole-5- carboxamide (0.10 g, 0.33 mmol) and potassium carbonate (0.069 g, 0.50 mmol) in NJV- dimethylformamide (2 mL) was added l-(2-bromoethoxy)-4-fluorobenzene (0.08 mL, 0.37 mmol). The reaction mixture was stirred at ambient temperature for 17 hours, diluted with ethyl acetate (15 mL) and washed with brine (5 mL). The organic solution was dried over anhydrous sodium sulfate, filtered and concentrated in vacuo. The residue was purified by column chromatography (ethyl acetate). Compound 2-(l-(2-(4- fluorophenoxy)ethyl)-lH-tetrazol-5-yl)-4-methyl-lambdar-(pyridin-3-ylmethyl)thiazole-5- carboxamide was first eluted from the column and isolated as a white solid (0.010 g, 7%): 1H NMR (300 MHz, CDCl3) delta 8.61-8.55 (m, 2H), 7.77-7.68 (m, IH), 7.37-7.28 (m, IH), 7.03-6.88 (m, 2H), 6.86-6.74 (m, 2H), 6.49 (t, J= 5.8 Hz, IH), 5.06 (t,J= 5.3 Hz, 2H), 4.65 (d, J= 5.8 Hz, 2H), 4.55 (t, J= 5.3 Hz, 2H), 2.79 (s, 3H); MS (ES+) m/z 440.3 (M + 1 ). Compound 2-(2-(2-(4-fluorophenoxy)ethyl)-2H-tetrazol-5-yl)-4-methyl-N-(pyridin-3- ylmethyl)thiazole-5-carboxamide was second eluted from the column and isolated as a white solid (0.02 g, 14%): mp 137-138 0C (ethyl acetate); 1H NMR (300 MHz, CDCl3) delta 8.59 (br s, IH), 8.54 (br s, IH), 7.76-7.65 (m, IH), 7.35-7.26 (m, IH), 6.94-6.86 (m, 2H), 6.72-6.66 (m, 2H), 6.58 (t, J= 5.8 Hz, IH), 5.31 (t, J= 5.4 Hz, 2H), 4.64 (d, J= 5.8 Hz, 2H), 4.45 (t,J= 5.4 Hz, 2H), 2.72 (s, 3H); 13C NMR (75 MHz, CDCl3) delta 161.3, 160.2, 157.8, 157.2, 153.8, 153.7, 153.7, 149.2, 149.2, 135.8, 127.7, 116.2, 115.9, 115.8, 65.6, 53.0, 41.8, 17.5; MS (ES+) m/z 440.3 (M + 1).

According to the analysis of related databases, 332-48-9, the application of this compound in the production field has become more and more popular.

Synthetic Route of 588-96-5, These common heterocyclic compound, 588-96-5, name is p-Bromophenetole, its traditional synthetic route has been very mature, but the traditional synthetic route has various shortcomings, such as complicated route, low yield, poor purity, etc, below Introduce a new synthetic route.

Reference Example 3 2-(4-Ethoxybenzyl)phenol A Grignard reagent was prepared from 1-bromo-4-ethoxybenzene (1.5g), magnesium (0.19g), a catalytic amount of iodine and tetrahydrofuran (2mL) in the usual manner. To the obtained Grignard reagent solution was added dropwise a solution of 2-benzyloxybenzaldehyde (1.1g) in tetrahydrofuran (15mL), and the mixture was stirred at room temperature for 30 minutes. To the reaction mixture were added a saturated aqueous ammonium chloride solution (10mL) and water (20mL), and the mixture was extracted with ethyl acetate (100mL). The extract was washed with water (20mL) and brine (20mL), and dried over anhydrous sodium sulfate. Thereafter, the solvent was removed under reduced pressure. The residue was purified by column chromatography on silica gel (eluent: hexane/ethyl acetate = 5/1) to give a diphenylmethanol compound (1.7g). The obtained diphenylmethanol compound (1.7g) was dissolved in ethanol (25mL). To the solution were added concentrated hydrochloric acid (0.42mL) and a catalytic amount of 10% palladium-carbon powder, and the mixture was stirred under a hydrogen atmosphere at room temperature for 18 hours. The catalyst was removed by filtration, and the filtrate was concentrated under reduced pressure. To the residue was added ethyl acetate (100mL), and the mixture was washed with a saturated aqueous sodium hydrogen carbonate solution (30mL) and brine (30mL). The organic layer was dried over anhydrous sodium sulfate, and the solvent was removed under reduced pressure. The residue was purified by column chromatography on silica gel (eluent: hexane/ethyl acetate = 8/1) to give 2-(4-ethoxybenzyl)phenol (0.85g). 1H-NMR (CDCl3) delta ppm: 1.39 (3H, t, J=7.1Hz), 3.93 (2H, s), 4.00 (2H, q, J=7.1Hz), 4.72 (1H, s), 6.75-6.85 (3H, m), 6.85-6.95 (1H, m), 7.05-7.20 (4H, m)

Statistics shows that p-Bromophenetole is playing an increasingly important role. we look forward to future research findings about 588-96-5.

Researchers who often do experiments know that organic synthesis is a process of preparing more complex target molecules from simple raw materials through one or more chemical reactions. Generally, it requires fewer steps, and cheap raw materials. 36449-75-9, name is 1-(2-Bromoethyl)-2-methoxybenzene, A new synthetic method of this compound is introduced below., Safety of 1-(2-Bromoethyl)-2-methoxybenzene

General procedure: General synthetic procedure for the final products.The appropriately substituted 4-phenethylpiperidine (6)(0.5 mmol) was dissolved in acetonitrile (5 mL) and K2CO3(0.75 mmol) and the appropriate phenethyl bromide (7) (0.5 mmol) added. The reaction mixture was refluxedfor 8 h.After completion of the reaction (monitored by TLC), the reaction mixture was cooled to ambient temperature and filtered through a Celite pad. The filtrate was concentrated under vacuum to obtain the desired crude product. The crude product was further purified by column chromatography (silica gel: 3-5% methanol in dichloromethane) to afford the corresponding 1,4-diphenethylpiperidine (8a-8y) in good yield (75-80 %), which was then converted to hydrochloride salt by treatment with 2M HCl in diethyl ether.Compounds12a-12dwere synthesized using the same procedure as above, except that an appropriately substituted 4-benzylpiperidine (11) was utilized in place of compound6.

The basis of chemical reaction formula synthesis, the synthesis route is composed of some specific reactions and combined according to certain logical thinking. We look forward to the emergence of more reaction modes in the future.

Electric Literature of 29578-83-4, Each compound has different characteristics, and only by selecting the characteristics of the compound suitable for a specific situation can the compound be applied on a large scale. 29578-83-4, name is 1-Bromo-3-methoxy-5-methylbenzene, This compound has unique chemical properties. The synthetic route is as follows.

To a vigorously stirred mixture of 1-Bromo-3-methoxy-5-methylbenzene (1 g, 4.97 mmol), Pyridine (3.22 ml_, 39.8 mmol) and Water (8 ml) was added in small portions KMnO 4 (3.14g, 19.89 mmol) at 105C. The mixture which turned to a black suspension was stirred 24 hours at 105C, then cooled down to RT and filtered over Hyflo. The black residue was washed several times with EtOAc. The filtrate was then diluted in EtAOc and washed with a 2M solution of HCI. The organic layer was dried over sodium sulfate, filtered and concentrated to afford the title compound (281 mg, 24% yield) as a white solid. MS: 229.1 [M+H]+, Rt (1 ) 1 .18 min.

The chemical industry reduces the impact on the environment during synthesis 1-Bromo-3-methoxy-5-methylbenzene. I believe this compound will play a more active role in future production and life.