Month: October 2022

Reference of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamateIn 2019 ,《endo-Hydroxamic Acid Monomers for the Assembly of a Suite of Non-native Dimeric Macrocyclic Siderophores Using Metal-Templated Synthesis》 appeared in Inorganic Chemistry. The author of the article were Brown, Christopher J. M.; Gotsbacher, Michael P.; Holland, Jason P.; Codd, Rachel. The article conveys some information:

An expedited synthesis of endo-hydroxamic acid aminocarboxylic acid (endo-HXA) compounds was developed. These monomeric ligands are relevant to the synthesis of metal-macrocycle complexes using metal-templated synthesis (MTS), and the downstream production of apomacrocycles. Macrocycles can display useful drug properties and be used as ligands for radiometals in medical imaging applications, which supports methodol. advances in accessing this class of mol. Six endo-HXA ligands were prepared that contained methylene groups, ether atoms, or thioether atoms in different regions of the monomer (1-6). MTS using a 1:2 Fe(III)/ligand ratio furnished six dimeric hydroxamic acid macrocycles complexed with Fe(III) (1a-6a). The corresponding apomacrocycles (1b-6b) were produced upon treatment with diethylenetriaminepentaacetic acid (DTPA). Constitutional isomers of the apomacrocycles that contained one ether oxygen atom in the diamine-containing (2b) or dicarboxylic acid-containing (3b) region were well resolved by reverse-phase HPLC (RP-HPLC). D. functional theory calculations were used to compute the structures and solvated mol. properties of 1b-6b and showed that the orientation of the amide bonds relative to the pseudo-C2 axis was close to parallel in 1b, 2b, and 4b-6b but tended toward perpendicular in 3b. This conformational constraint in 3b reduced the polarity compared with 2b, consistent with the exptl. trend in polarity observed using RP-HPLC. The improved synthesis of endo-HXA ligands allows expanded structural diversity in MTS-derived macrocycles and the ability to modulate macrocycle properties. The results came from multiple reactions, including the reaction of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Reference of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.Oxygen is more electronegative than carbon, thus the alpha hydrogens of ethers are more acidic than those of simple hydrocarbons. They are far less acidic than alpha hydrogens of carbonyl groups (such as in ketones or aldehydes), however. Reference of tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate

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Ether – Wikipedia,
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Product Details of 139115-91-6In 2018 ,《Tracking down protein-protein interactions via a FRET-system using site-specific thiol-labeling》 appeared in Organic & Biomolecular Chemistry. The author of the article were Soveges, B.; Imre, T.; Poti, A. L.; Sok, P.; Kele, Zs.; Alexa, A.; Kele, P.; Nemeth, K.. The article conveys some information:

Forster resonance energy transfer is among the most popular tools to follow protein-protein interactions. Although limited to certain cases, site-specific fluorescent labeling of proteins via natural functions by chem. manipulations can redeem laborious protein engineering techniques. Herein the authors report on the synthesis of a heterobifunctional tag and its use in site-specific protein labeling studies aiming at exploring protein-protein interactions. The oxadiazole-methylsulfonyl functionality serves as a thiol specific warhead that enables easy and selective installation of fluorescent labels through a bioorthogonal motif. Mitogen activated protein kinase (MAPK14) and its substrate mitogen activated protein kinase activated kinase (MAPKAP2) or its docking motif, a 22 amino acid-long peptide fragment, were labeled with a donor and an acceptor, resp. Evolution of strong FRET signals upon protein-protein interactions supported the specific communication between the partners. Using an efficient FRET pair allowed the estimation of dissociation constants for protein-protein and peptide-protein interactions (145 nM and 240 nM, resp.). In the experimental materials used by the author, we found tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6Product Details of 139115-91-6)

tert-Butyl (2-(2-hydroxyethoxy)ethyl)carbamate(cas: 139115-91-6) belongs to ethers.Product Details of 139115-91-6Although ethers resist hydrolysis, they are cleaved by hydrobromic acid and hydroiodic acid. Hydrogen chloride cleaves ethers only slowly.

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

HPLC of Formula: 135-02-4In 2019 ,《1,1′-Butylenebis(3-sulfo-3H-imidazol-1-ium) hydrogensulfate: a versatile task-specific ionic liquid catalyst for the synthesis of 4H-pyran scaffolds through non-conventional process》 appeared in Monatshefte fuer Chemie. The author of the article were Khaligh, Nader Ghaffari; Ling, Ong Chiu; Mihankhah, Taraneh; Johan, Mohd Rafie; Ching, Juan Joon. The article conveys some information:

In the present study, the catalytic efficiency of 1,1′-butylenebis(3-sulfo-3H-imidazol-1-ium)hydrogensulfate (BBSI-HSO4) as a versatile sulfonic acid-functionalized ionic liquid was demonstrated for the one-pot mechanosynthesis of pyrano[4,3-b]-pyrans I (R = C6H5, 4-FC6H4, 2-MeOC6H4, etc.) using planetary ball mill at room temperature under solvent-free conditions. This efficient mechanosynthesis approach to the 4H-pyran scaffolds displays a combination of the structure-activity relationship of ionic liquids with ecol. benefits of a mechanocatalytic procedure. The ionic liquid was easily recycled and reused several times with no significant loss of its catalytic activity.2-Methoxybenzaldehyde(cas: 135-02-4HPLC of Formula: 135-02-4) was used in this study.

2-Methoxybenzaldehyde(cas: 135-02-4) is found in cassia oil, cinnamon bark, and cinnamon bark oil. It is a clear colorless liquid with a strong aroma. It has been used to examine the acaricidal activity of Periploca sepium oil and its active component against Tyrophagus putrescentiae.HPLC of Formula: 135-02-4

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Ether – Wikipedia,
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Recommanded Product: 4637-24-5In 2020 ,《Synthesis of novel pyrido[2,1-b]benzothiazole and N-substituted 2-pyridylbenzothiazole derivatives showing remarkable fluorescence and biological activities》 appeared in Journal of Molecular Structure. The author of the article were Azzam, Rasha A.; Elgemeie, Galal H.; Osman, Rokia R.. The article conveys some information:

The synthesis of novel pyrido[2,1-b]benzothiazole and pyrido[2,1-b]benzoimidazole derivatives was achieved via the reaction of N-aryl-2-cyano-3,3-bis(methylthio)acrylamide with benzothiazoleylacetonitrile and benzoimidazoleylacetonitrile, resp., while N-substituted 2-pyridylbenzothiazole derivatives were synthesized by reacting 2-(benzo[d]thiazol-2-yl)-3-(dimethylamino)acrylonitrile with either cyanoacetamide, aryl cyanoacetamides or 2-cyano-N’-(4-substituted benzylidene)acetohydrazide. Based on the steady state fluorescence measurements, the newly synthesized N-substituted 2-pyridylbenzothiazole derivatives exhibited remarkable fluorescence properties with considerably high quantum yields (0.25-0.29). In addition, the antimicrobial and antiviral activities were evaluated for all the newly synthesized derivatives The antimicrobial examination revealed that triazolo-pyridone I (Ar = 4-FC6H4, 4-ClC6H4, 4-MeOC6H4, 4-MeC6H4) had the highest potency among all tested compounds against Escherichia coli, Klebsiella pneumonia and Staphylococcus aureus while pyrido[2,1-b]benzoimidazole derivatives II (Ar = 4-ClC6H4, 4-MeC6H4, 3-MeC6H4) had the highest potency over other compounds against Candida albicans fungus. The results came from multiple reactions, including the reaction of N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Recommanded Product: 4637-24-5)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Amine, any member of a family of nitrogen-containing organic compounds that is derived, either in principle or in practice, from ammonia (NH3). Naturally occurring amines include the alkaloids, which are present in certain plants; the catecholamine neurotransmitters (i.e., dopamine, epinephrine, and norepinephrine); and a local chemical mediator, histamine, that occurs in most animal tissues.Recommanded Product: 4637-24-5

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Ether – Wikipedia,
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Name: N,N-Dimethylformamide Dimethyl AcetalIn 2020 ,《Pyrrolo[2′,3′:3,4]cyclohepta[1,2-d][1,2]oxazoles, a New Class of Antimitotic Agents Active against Multiple Malignant Cell Types》 appeared in Journal of Medicinal Chemistry. The author of the article were Spano, Virginia; Rocca, Roberta; Barreca, Marilia; Giallombardo, Daniele; Montalbano, Alessandra; Carbone, Anna; Raimondi, Maria Valeria; Gaudio, Eugenio; Bortolozzi, Roberta; Bai, Ruoli; Tassone, Pierfrancesco; Alcaro, Stefano; Hamel, Ernest; Viola, Giampietro; Bertoni, Francesco; Barraja, Paola. The article conveys some information:

A new class of pyrrolo[2′,3′:3,4]cyclohepta[1,2-d][1,2]oxazoles, e.g. was synthesized for the treatment of hyperproliferative pathologies, including neoplasms. The new compounds were screened in the 60 human cancer cell lines of the NCI drug screen and showed potent activity with GI50 values reaching the nanomolar level, with mean graph midpoints of 0.08-0.41μM. All compounds were further tested on six lymphoma cell lines, and eight showed potent growth inhibitory effects with IC50 values lower than 500 nM. Mechanism of action studies showed the ability of the new [1,2]oxazoles to arrest cells in the G2/M phase in a concentration dependent manner and to induce apoptosis through the mitochondrial pathway. The most active compounds inhibited tubulin polymerization, with IC50 values of 1.9-8.2μM, and appeared to bind to the colchicine site. The G2/M arrest was accompanied by apoptosis, mitochondrial depolarization, generation of reactive oxygen species, and PARP cleavage. After reading the article, we found that the author used N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Name: N,N-Dimethylformamide Dimethyl Acetal)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Aniline, ethanolamines, and several other amines are major industrial commodities used in making rubber, dyes, pharmaceuticals, and synthetic resins and fibres and for a host of other applications. Most of the numerous methods for the preparation of amines may be broadly divided into two groups: (1) chemical reduction (replacement of oxygen with hydrogen atoms in the molecule) of members of several other classes of organic nitrogen compounds and (2) reactions of ammonia or amines with organic compounds.Name: N,N-Dimethylformamide Dimethyl Acetal

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Ether – Wikipedia,
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Name: m-MethoxyphenolIn 2020 ,《Spirosteroids and α-glucosidase inhibitory norlignans from Asparagus racemosus Willd. roots》 was published in Phytochemistry (Elsevier). The article was written by Tantapakul, Cholpisut; Chaiyosang, Boonyanoot; Promgool, Trinop; Somteds, Apisara; Suthiphasilp, Virayu; Kanokmedhakul, Kwanjai; Laphookhieo, Surat; Andersen, Raymond J.; Patrick, Brian O.; Kanokmedhakul, Somdej. The article contains the following contents:

Three undescribed spirosteroids, asparacemosones A-C, an undescribed spiro-21-norsteroid, asparacemosone D, along with seven known compounds were isolated from Thai herbal plant Asparagus racemosus Willd. roots. Their structures were elucidated by spectroscopic anal. including NMR, UV, IR and mass spectrometry. The absolute configurations of asparacemosones A, B, and D were determined by single crystal X-ray diffraction using CuKα radiation. Among the isolated compounds, the norlignan nyasol and three acetylenic norlignans demonstrated potent α-glucosidase inhibition, with IC50 values ranging from 0.003 to 0.004 μM which is 5 x 104 fold more potent than the standard acarbose. In the part of experimental materials, we found many familiar compounds, such as m-Methoxyphenol(cas: 150-19-6Name: m-Methoxyphenol)

m-Methoxyphenol(cas: 150-19-6) may be used as an analytical standard for the determination of the analyte in wine, coffee beans, wood samples, and mainstream smoke by gas chromatography (GC) based techniques.Name: m-Methoxyphenol

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Ether – Wikipedia,
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COA of Formula: C5H13NO2In 2021 ,《Design, synthesis, X-ray analysis, and biological screening of new oxime and enaminone thiazoline-2-thione derivatives》 was published in Journal of Molecular Structure. The article was written by Asiri, Yahya I.; Muhsinah, Abdullatif Bin; Alsayari, Abdulrhman; Ghabbour, Hazem A.; Almarhoon, Zainab M.; Al-aizari, Faiz A.; Venkatesan, Kumar; Tasqeeruddin, Syed; Sulthana, Syeda Shaheen; Mabkhot, Yahia N.. The article contains the following contents:

A series of 12 new thiazoline-2-thione derivatives (oxime and enaminone) I (R = Me, hydroxy, 4-chlorophenyl, carbamoyl, etc.; R1 = H, Me), II (R2 = hydroxy, 2-phenylhydrazin-1-yl, hydrazinyl) and III. were synthesized using an appropriate synthetic route. The characterization of the newly synthesized compounds I, II and III was performed using X-ray single-crystal diffractometry, elemental anal., 1H NMR, 13C NMR, IR, and MS techniques. These compounds I, II and III were then evaluated for their biol. activities against a variety of microbes and human cancer cell lines. These results revealed that the prepared thiazoline derivatives I (R = hydroxy, 4-chlorophenyl; R1 = H), II (R2 = 2-phenylhydrazin-1-yl, hydrazinyl) and III showed potent antifungal activity against Aspergillus fumigatus, comparable to the standard drugs. Addnl., all the thiazoline derivatives, I, II and III except compound II (R2 = hydrazinyl), were effective against Candida albicans. The tested thiazolines also demonstrated potent antibacterial activity comparable to the standard drugs for all tested Gram-pos. and Gram-neg. bacterial species. The cytotoxicity evaluation of synthesized compounds II (R2 = hydroxy), I (R = azanyl; R1 = H) and III against two cancer cell lines (HCT-116 and HepG-2) revealed that they had moderate cytotoxic activities, with compound I (R = azanyl; R1 = H) showing the best cytotoxic activity against the HCT-116 (IC50 = 79μg/mL) and HepG-2 (IC50 = 49μg/mL) cell lines. These findings open the pathway for the development of new lead compounds with chemotherapeutic properties. The experimental process involved the reaction of N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5COA of Formula: C5H13NO2)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Amines characteristically form salts with acids; a hydrogen ion, H+, adds to the nitrogen. With the strong mineral acids (e.g., H2SO4, HNO3, and HCl), the reaction is vigorous. Salt formation is instantly reversed by strong bases such as NaOH. Neutral electrophiles (compounds attracted to regions of negative charge) also react with amines; alkyl halides (R′X) and analogous alkylating agents are important examples of electrophilic reagents.COA of Formula: C5H13NO2

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Ether – Wikipedia,
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Synthetic Route of C5H13NO2In 2019 ,《Synthesis and photochromism of some mono and bis (thienyl) substituted oxathiine 2,2-dioxides》 was published in Organic & Biomolecular Chemistry. The article was written by Aiken, Stuart; Gabbutt, Christopher D.; Heron, B. Mark; Rice, Craig R.; Zonidis, Dimitrios. The article contains the following contents:

1,2-Oxathiine 2,2-dioxides have been obtained from their resp. 3,4-dihydro-4-dimethylamino precursors, for the first time, by a mild Cope elimination of the 4-dimethylamino function. The application of the 1,2-oxathiine 2,2-dioxide scaffold in materials chem. is exemplified by the efficient P-type photochromism of the 5,6-bis(2,5-dimethyl-3-thienyl) substituted oxathiine 2,2-dioxides. In the experiment, the researchers used N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Synthetic Route of C5H13NO2)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.Synthetic Route of C5H13NO2

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Ether – Wikipedia,
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Reference of (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-sulfophenyl)propanoic acidOn June 13, 2019, Gambini, Luca; Baggio, Carlo; Udompholkul, Parima; Jossart, Jennifer; Salem, Ahmed F.; Perry, J. Jefferson P.; Pellecchia, Maurizio published an article in Journal of Medicinal Chemistry. The article was 《Covalent Inhibitors of Protein-Protein Interactions Targeting Lysine, Tyrosine, or Histidine Residues》. The article mentions the following:

We have recently reported a series of Lys-covalent agents targeting the BIR3 domain of the X-linked inhibitor of apoptosis protein (XIAP) using a benzamide-sulfonyl fluoride warhead. Using XIAP as a model system, we further investigated a variety of addnl. warheads that can be easily incorporated into binding peptides and analyzed their ability to form covalent adducts with lysine and other amino acids, including tyrosine, histidine, serine, and threonine, using biochem. and biophys. assays. Moreover, we tested aqueous, plasma stability, cell permeability, and cellular efficacy of the most effective agents. These studies identified aryl-fluoro sulfates as likely the most suitable electrophiles to effectively form covalent adducts with Lys, Tyr, and His residues, given that these agents were cell permeable and stable in aqueous buffer and in plasma. Our studies contain a number of general findings that open new possible avenues for the design of potent covalent protein-protein interaction antagonists. In the experimental materials used by the author, we found (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-sulfophenyl)propanoic acid(cas: 138472-22-7Reference of (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-sulfophenyl)propanoic acid)

(S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-sulfophenyl)propanoic acid(cas: 138472-22-7) belongs to ethers.The C-O bonds that comprise simple ethers are strong. They are unreactive toward all but the strongest bases. Although generally of low chemical reactivity, they are more reactive than alkanes. Reference of (S)-2-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)-3-(4-sulfophenyl)propanoic acid

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Kurata, Haruto; Kusumi, Kensuke; Otsuki, Kazuhiro; Suzuki, Ryo; Kurono, Masakuni; Komiya, Takaki; Hagiya, Hiroshi; Mizuno, Hirotaka; Shioya, Hiroki; Ono, Takeji; Takada, Yuka; Maeda, Tatsuo; Matsunaga, Norikazu; Kondo, Tetsu; Tominaga, Sachiko; Nunoya, Ken-ici; Kiyoshi, Hidekazu; Komeno, Masaharu; Nakade, Shinji; Habashita, Hiromu published their research in Journal of Medicinal Chemistry on December 14 ,2017. The article was titled 《Discovery of a 1-Methyl-3,4-dihydronaphthalene-Based Sphingosine-1-Phosphate (S1P) Receptor Agonist Ceralifimod (ONO-4641). A S1P1 and S1P5 Selective Agonist for the Treatment of Autoimmune Diseases》.Product Details of 33797-34-1 The article contains the following contents:

The discovery of 1-({6-[(2-methoxy-4-propylbenzyl)oxy]-1-methyl-3,4-dihydronaphthalen-2-yl}methyl)azetidine3-carboxylic acid (I) (13n, ceralifimod, ONO-4641), a sphingosine-1-phosphate (S1P) receptor agonist selective for S1P1 and S1P5, is described. While it has been revealed that the modulation of the S1P1 receptor is an effective way to treat autoimmune diseases such as relapsing-remitting multiple sclerosis (RRMS), it was also reported that activation of the S1P3 receptor is implicated in some undesirable effects. The authors carried out a structure-activity relationship (SAR) study of hit compound 6 with an amino acid moiety in the hydrophilic head region. Following identification of a lead compound with a dihydronaphthalene central core by inducing conformational constraint, optimization of the lipophilic tail region led to the discovery of I as a clin. candidate that exhibited >30 000-fold selectivity for S1P1 over S1P3 and was potent in a peripheral lymphocyte lowering (PLL) test in mice (ED50 = 0.029 mg/kg, 24 h after oral dosing). In the experimental materials used by the author, we found (3-Methoxy-2-methylphenyl)methanol(cas: 33797-34-1Product Details of 33797-34-1)

(3-Methoxy-2-methylphenyl)methanol(cas: 33797-34-1) belongs to ethers.Ethers do have nonbonding electron pairs on their oxygen atoms, and they can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. Product Details of 33797-34-1 The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.

Referemce:
Ether – Wikipedia,
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