Kurata, Haruto’s team published research in Journal of Medicinal Chemistry in 2017 | CAS: 33797-34-1

(3-Methoxy-2-methylphenyl)methanol(cas: 33797-34-1) belongs to ethers.Ethers do have nonbonding electron pairs on their oxygen atoms, and they can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. Product Details of 33797-34-1 The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.

Kurata, Haruto; Kusumi, Kensuke; Otsuki, Kazuhiro; Suzuki, Ryo; Kurono, Masakuni; Komiya, Takaki; Hagiya, Hiroshi; Mizuno, Hirotaka; Shioya, Hiroki; Ono, Takeji; Takada, Yuka; Maeda, Tatsuo; Matsunaga, Norikazu; Kondo, Tetsu; Tominaga, Sachiko; Nunoya, Ken-ici; Kiyoshi, Hidekazu; Komeno, Masaharu; Nakade, Shinji; Habashita, Hiromu published their research in Journal of Medicinal Chemistry on December 14 ,2017. The article was titled 《Discovery of a 1-Methyl-3,4-dihydronaphthalene-Based Sphingosine-1-Phosphate (S1P) Receptor Agonist Ceralifimod (ONO-4641). A S1P1 and S1P5 Selective Agonist for the Treatment of Autoimmune Diseases》.Product Details of 33797-34-1 The article contains the following contents:

The discovery of 1-({6-[(2-methoxy-4-propylbenzyl)oxy]-1-methyl-3,4-dihydronaphthalen-2-yl}methyl)azetidine3-carboxylic acid (I) (13n, ceralifimod, ONO-4641), a sphingosine-1-phosphate (S1P) receptor agonist selective for S1P1 and S1P5, is described. While it has been revealed that the modulation of the S1P1 receptor is an effective way to treat autoimmune diseases such as relapsing-remitting multiple sclerosis (RRMS), it was also reported that activation of the S1P3 receptor is implicated in some undesirable effects. The authors carried out a structure-activity relationship (SAR) study of hit compound 6 with an amino acid moiety in the hydrophilic head region. Following identification of a lead compound with a dihydronaphthalene central core by inducing conformational constraint, optimization of the lipophilic tail region led to the discovery of I as a clin. candidate that exhibited >30 000-fold selectivity for S1P1 over S1P3 and was potent in a peripheral lymphocyte lowering (PLL) test in mice (ED50 = 0.029 mg/kg, 24 h after oral dosing). In the experimental materials used by the author, we found (3-Methoxy-2-methylphenyl)methanol(cas: 33797-34-1Product Details of 33797-34-1)

(3-Methoxy-2-methylphenyl)methanol(cas: 33797-34-1) belongs to ethers.Ethers do have nonbonding electron pairs on their oxygen atoms, and they can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. Product Details of 33797-34-1 The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem