Month: October 2022

Computed Properties of C8H8O2In 2019 ,《Synthesis of New 6-[4-(2-Fluorophenylpiperazin-1-yl)]-3(2H)-Pyridazinone-2-Acetyl-2- (Substituted benzal)Hydrazone Derivatives and Evaluation of Their Cytotoxic Effects in Liver and Colon Cancer Cell Lines》 appeared in Pharmaceutical Chemistry Journal. The author of the article were Ozdemir, Zeynep; Basak-Turkmen, Nese; Ayhan, Idris; Ciftci, Osman; Uysal, Mehtap. The article conveys some information:

In this study, seven new 3(2H)-pyridazinone derivatives I (R = H, 2-Cl, 4-NMe2, 4-Me, 4-Cl, 4-Br, 2-MeO) expected to show cytotoxic activity in liver and colon cancer cell lines were synthesized. Compounds I were tested on HEP3B (liver cancer) and HTC116 (colon cancer) cell lines for cytotoxicity by using MTS [3-(4,5-dimethylthiazol-2-yl)-5-(3-carboxymethoxyphenyl)-2-(4-sulfophenyl)-2H-tetrazolium] proliferation assay. Human fibroblast cells were used as a safety control in these tests. Compound I (R = 2-Cl) was the most active agent with respect to HEP3B and HTC116 cell lines. In the experiment, the researchers used 2-Methoxybenzaldehyde(cas: 135-02-4Computed Properties of C8H8O2)

2-Methoxybenzaldehyde(cas: 135-02-4) is found in cassia oil, cinnamon bark, and cinnamon bark oil. It is a clear colorless liquid with a strong aroma. It has been used to examine the acaricidal activity of Periploca sepium oil and its active component against Tyrophagus putrescentiae.Computed Properties of C8H8O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Electric Literature of C8H8O2In 2019 ,《Green one-pot multicomponent synthesis of pyrrolidinones using planetary ball milling process under solvent-free conditions》 appeared in Synthetic Communications. The author of the article were Khaligh, Nader Ghaffari; Mihankhah, Taraneh; Johan, Mohd Rafie. The article conveys some information:

A novel and efficient protocol was presented for the synthesis of pyrrolidinones I [R1 = H, 2-NO2, 4-Cl, etc.; R2 = Et, Me; R3 = H, 4-Me, 4-OMe, 4-NO2] via multicomponent condensation of benzaldehydes, dialkyl butynedioates and anilines using catalytic loading of 1,1′-butylene-bis(3-sulfo-3H-imidazol-1-ium)hydrogen sulfate as recyclable Bronsted acid ionic liquid through ball milling process at room temperature under solvent-free conditions. The developed method provided good to excellent yields of various pyrrolidinones in environmentally friendly conditions. Furthermore, this efficient protocol displayed a combination of the synthetic advantage of one-pot multicomponent reaction with ecol. benefits and convenience of a mechanochem. procedure. The results came from multiple reactions, including the reaction of 2-Methoxybenzaldehyde(cas: 135-02-4Electric Literature of C8H8O2)

2-Methoxybenzaldehyde(cas: 135-02-4) is found in cassia oil, cinnamon bark, and cinnamon bark oil. It is a clear colorless liquid with a strong aroma. It has been used to examine the acaricidal activity of Periploca sepium oil and its active component against Tyrophagus putrescentiae.Electric Literature of C8H8O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Recommanded Product: 135-02-4In 2019 ,《Introduction of piperazine-1,4-diium dihydrogen phosphate as a new and highly efficient dicationic Bronsted acidic ionic salt for the synthesis of (thio)barbituric acid derivatives in water》 appeared in Journal of Molecular Structure. The author of the article were Darvishzad, Shila; Daneshvar, Nader; Shirini, Farhad; Tajik, Hassan. The article conveys some information:

A new piperazine-based dicationic Bronsted acidic ionic salt named as piperazine-1,4-diium dihydrogen phosphate was prepared After characterization by FT-IR, Mass and NMR spectroscopy, it was used as an efficient and reusable catalyst for the synthesis of 5-arylidenepyrimidine-2,4,6(1H,3H,5H)-trione and pyrano[2,3-d]pyrimidinone (thione) derivatives Some of the advantages of this method were utilization of low amount of the catalyst, ease of work-up, short reaction times, excellent yields and acceptable reusability of the catalyst. In the experiment, the researchers used many compounds, for example, 2-Methoxybenzaldehyde(cas: 135-02-4Recommanded Product: 135-02-4)

2-Methoxybenzaldehyde(cas: 135-02-4) is found in cassia oil, cinnamon bark, and cinnamon bark oil. It is a clear colorless liquid with a strong aroma. It has been used to examine the acaricidal activity of Periploca sepium oil and its active component against Tyrophagus putrescentiae.Recommanded Product: 135-02-4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Reference of 1,2-DiphenyldisulfaneIn 2020 ,《C-N, C-S and S-S Bond Cleavage by Rhodium PCcarbeneP Pincer Complexes》 was published in Chemistry – An Asian Journal. The article was written by Tinnermann, Hendrik; Young, Rowan D.. The article contains the following contents:

Rhodium carbene pincer complexes I·BArF4 [1-L, L = PPh3, PPh2(C6F5)] react with isothiocyanate, carbodiimide and disulfide to enable C-S, C-N and S-S bond cleavage. The cleaved mols. are sequestered by the metal center and the pincer alkylidene linkage, forming η2-coordinated sulfide or imide centered pincer complexes. When a C-S or S-S bond is cleaved, the resulting complexes can bridge two rhodium centers through sulfur forming dimeric complexes and eliminating a monodentate phosphine ligand. In the part of experimental materials, we found many familiar compounds, such as 1,2-Diphenyldisulfane(cas: 882-33-7Reference of 1,2-Diphenyldisulfane)

1,2-Diphenyldisulfane(cas: 882-33-7) belongs to ethers.Ethers do have nonbonding electron pairs on their oxygen atoms, and they can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. Reference of 1,2-Diphenyldisulfane The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

HPLC of Formula: 2398-37-0In 2022 ,《Synthesis of selenopyrano[2,3-b]indol-4(9H)-ones and their C H arylation》 was published in Journal of Heterocyclic Chemistry. The article was written by Woo-Jin, Choi; Jalani, Hitesh B.; Jeong, Jin-Hyun. The article contains the following contents:

Herein, authors disclose the synthesis of selenopyrano[2,3-b]indol-4(9H)-ones and their aryl derivatives using seleno-pyran ring formation via an in situ-generated selenide reacting directly with α-halo-β-ynones of substituted indoles providing selenopyrano[2,3-b]indol-4(9H)-ones. Subsequent direct CH arylation of the these compounds by palladium-catalyzed Heck reaction enables the incorporation of aryl substituents on the selenopyrano[2,3-b]indol-4(9H)-ones scaffolds with moderate yields. This new chemo-type incorporating an indole ring may be useful for the biol. screenings. After reading the article, we found that the author used 1-Bromo-3-methoxybenzene(cas: 2398-37-0HPLC of Formula: 2398-37-0)

1-Bromo-3-methoxybenzene(cas: 2398-37-0) can be used in chemical reaction as intermediates to obtain target materials such as dyes, pharmaceuticals, perfumes, photoinitiators and agrochemicals.HPLC of Formula: 2398-37-0

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Related Products of 135-02-4In 2019 ,《Novel Fe3O4/SiO2/PPA Magnetic Nanoparticles: Preparation, Characterization, and First Catalytic Application to the Solvent- Free Synthesis of Tetrahydrobenzo[a]xanthene-11-ones》 was published in Russian Journal of Organic Chemistry. The article was written by Amarloo, F.; Zhiani, R.; Mehrzad, J.. The article contains the following contents:

Novel Fe3O4/SiO2/PPA nanoparticles were used as solid acid support in the solvent-free synthesis of 12-aryl-9,9-dimethyl-8,9,10,12-tetrahydro-11H-benzo[a]xanthen-11-ones I (R = H, 4-Me, 2-MeO, 4-MeO, 2-Cl, 4-Cl) via multicomponent condensation of aromatic aldehydes with naphthalen-2-ol and 5,5-dimethylcyclohexane-1,3-dione. The target products were obtained in good to high yields. The Fe3O4/SiO2/PPA nanoparticles were thoroughly characterized by SEM, transmission electron microscopy, Fourier-transform IR spectroscopy, and energy-dispersive C-ray spectroscopy. The new catalyst has a high activity and is environmentally friendly, heterogeneous, easily recoverable, and recyclable without loss of catalytic activity. In the experimental materials used by the author, we found 2-Methoxybenzaldehyde(cas: 135-02-4Related Products of 135-02-4)

2-Methoxybenzaldehyde(cas: 135-02-4) is found in cassia oil, cinnamon bark, and cinnamon bark oil. It is a clear colorless liquid with a strong aroma. It has been used to examine the acaricidal activity of Periploca sepium oil and its active component against Tyrophagus putrescentiae.Related Products of 135-02-4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Recommanded Product: 101-70-2In 2021 ,《Tetraphenylethylene-Arylamine Derivatives as Hole Transporting Materials for Perovskite Solar Cells》 was published in ACS Applied Materials & Interfaces. The article was written by Zhang, Xianfu; Liu, Xuepeng; Ghadari, Rahim; Li, Maohui; Zhou, Zi’an; Ding, Yong; Cai, Molang; Dai, Songyuan. The article contains the following contents:

A series of hole transporting materials (HTMs) with fused tetraphenylethylene cores (9,9′-bifluorenylidene and dibenzo[g,p]chrysene) as well as different substitution positions of arylamine side arms has been designed and synthesized. A reference HTM with a non-fused tetraphenylethylene core is also prepared for a comparative study. It is noted that fused tetraphenylethylene mols. show a bathochromic spectral shift, electroneg. character, and lower reorganization energies than the non-fused ones. Furthermore, the mols. with side arms located on the meta-position on the tetraphenylethylene core in terms of a double bond exhibit a deeper HOMO level than those of the para-position-based ones whether tetraphenylethylene is fused or not. Moreover, the reorganization energies of fused meta-position-based HTMs are lower than those of para-position-based HTMs. Fused tetraphenylethylene HTMs own a better hole-extraction capability than the non-fused ones. When used in perovskite solar cells, all devices with fused tetraphenylethylene HTMs display better performance than those of the non-fused ones. The HTMs based on dibenzo[g,p]chrysene exhibit better performance than those of bifluorenylidene. Moreover, the devices with HTMs with side arms located on the meta-position on the tetraphenylethylene core display higher power conversion efficiency than those of the para-position-based ones. The results give some new insight and reference to develop ideal HTMs for perovskite solar cells. In the experiment, the researchers used Bis(4-methoxyphenyl)amine(cas: 101-70-2Recommanded Product: 101-70-2)

Bis(4-methoxyphenyl)amine(cas: 101-70-2) is a diphenylamine derivative used as a chemical additive for cured rubber.Bis(4-methoxyphenyl)amine is highly toxic and may potentially induce chromosome abberation.Recommanded Product: 101-70-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Application In Synthesis of 2-Methoxy-5-(trifluoromethoxy)anilineOn March 23, 2017, Deng, Yonghong; Sun, Cuixiang; Hunt, Diana K.; Fyfe, Corey; Chen, Chi-Li; Grossman, Trudy H.; Sutcliffe, Joyce A.; Xiao, Xiao-Yi published an article in Journal of Medicinal Chemistry. The article was 《Heterocyclyl Tetracyclines. 1. 7-Trifluoromethyl-8-Pyrrolidinyltetracyclines: Potent, Broad Spectrum Antibacterial Agents with Enhanced Activity against Pseudomonas aeruginosa》. The article mentions the following:

Utilizing a total synthesis approach, the first 8-heterocyclyltetracyclines were designed, synthesized, and evaluated against panels of tetracycline- and multidrug-resistant Gram-pos. and Gram-neg. pathogens. Several compounds with balanced, highly potent in vitro activity against a broad range of bacterial isolates were identified through structure-activity relationships (SAR) studies. One compound I demonstrated the best antibacterial activity against Pseudomonas aeruginosa both in vitro and in vivo for tetracyclines reported to date. The experimental part of the paper was very detailed, including the reaction process of 2-Methoxy-5-(trifluoromethoxy)aniline(cas: 660848-57-7Application In Synthesis of 2-Methoxy-5-(trifluoromethoxy)aniline)

2-Methoxy-5-(trifluoromethoxy)aniline(cas: 660848-57-7) belongs to anime. Nitrous acid converts secondary amines (aliphatic or aromatic) to N-nitroso compounds (nitrosamines): R2NH + HNO2 → R2N―NO. Some nitrosamines are potent cancer-inducing substances, and their possible formation is a serious consideration when nitrites, which are salts of nitrous acid, are present in foods or pharmaceutical preparations. Tertiary amines give rise to nitrosamines more slowly; an alkyl group is eliminated as an aldehyde or ketone, along with nitrous oxide, N2O.Application In Synthesis of 2-Methoxy-5-(trifluoromethoxy)aniline

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Tamura, Yasumitsu; Fujita, Masanobu; Chen, Ling-Ching; Inoue, Minako; Kita, Yasuyuki published their research in Journal of Organic Chemistry on August 14 ,1981. The article was titled 《Regioselective metalation of the 4-position of pyridine. New and convenient alkylation and acylation of 3-amino-5-methoxypyridine》.Name: 5-Methoxy-4-methylpyridin-3-amine The article contains the following contents:

The reaction of 3-methoxy-5-pivaloylaminopyridine with BuLi at low temperature in THF gives the 4-lithiopyridines, which react with various electrophiles to give the corresponding 4-substituted 3-methoxy-5-pivaloylaminopyridines. The conversion of the 5-pivaloylamino group to other substituents via the pyridyl radical was also examined In the experiment, the researchers used 5-Methoxy-4-methylpyridin-3-amine(cas: 77903-28-7Name: 5-Methoxy-4-methylpyridin-3-amine)

5-Methoxy-4-methylpyridin-3-amine(cas: 77903-28-7) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.Name: 5-Methoxy-4-methylpyridin-3-amine

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

The author of 《Quantum Dots Arrangement and Energy Transfer Control via Charge-Transfer Complex Achieved on Poly(Phenylene Ethynylene)/Schizophyllan Nanowires》 were Shiraki, Tomohiro; Haraguchi, Shuichi; Tsuchiya, Youichi; Shinkai, Seiji. And the article was published in Chemistry – An Asian Journal in 2009. Category: ethers-buliding-blocks The author mentioned the following in the article:

Assemblies of organic and inorganic compounds in the nanoscale region have contributed to the development of novel functional materials toward future applications, including sensors and opto-electronics. The authors succeed in fabricating hybrid nanowires composed of a conjugated polymer and semiconductor quantum dots (QDs) by a supramol. assembly technique. The 1-dimensional fashion of the nanowire structure was obtained by the polymer wrapping of cationic poly(phenylene ethynylene) (PPE) with helix-forming polysaccharide schizophyllan (SPG). The electrostatic interaction between cationic PPE and anionic QDs affords the nanowires decorated with QDs. Upon addition of an acceptor mol., tetranitrofluorenone (TNF), the charge-transfer (CT) complex between PPE and TNF is formed, resulting in energy transfer from the QDs to PPE arising from the induced spectral overlap. Also, the employment of the conjugated polymer allows highly sensitive quenching of the QD’s emission by raising the transmission efficiency to the CT complexed electron deficient sites along the polymer backbone. In the experiment, the researchers used many compounds, for example, 1,4-Diethynyl-2,5-dimethoxybenzene(cas: 74029-40-6Category: ethers-buliding-blocks)

1,4-Diethynyl-2,5-dimethoxybenzene(cas: 74029-40-6) belongs to ethers.Category: ethers-buliding-blocksAlthough ethers resist hydrolysis, they are cleaved by hydrobromic acid and hydroiodic acid. Hydrogen chloride cleaves ethers only slowly.

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem