Tamura, Yasumitsu; Fujita, Masanobu; Chen, Ling-Ching; Inoue, Minako; Kita, Yasuyuki published their research in Journal of Organic Chemistry on August 14 ,1981. The article was titled 《Regioselective metalation of the 4-position of pyridine. New and convenient alkylation and acylation of 3-amino-5-methoxypyridine》.Name: 5-Methoxy-4-methylpyridin-3-amine The article contains the following contents:
The reaction of 3-methoxy-5-pivaloylaminopyridine with BuLi at low temperature in THF gives the 4-lithiopyridines, which react with various electrophiles to give the corresponding 4-substituted 3-methoxy-5-pivaloylaminopyridines. The conversion of the 5-pivaloylamino group to other substituents via the pyridyl radical was also examined In the experiment, the researchers used 5-Methoxy-4-methylpyridin-3-amine(cas: 77903-28-7Name: 5-Methoxy-4-methylpyridin-3-amine)
5-Methoxy-4-methylpyridin-3-amine(cas: 77903-28-7) belongs to anime. Acylation is one of the most important reactions of primary and secondary amines; a hydrogen atom is replaced by an acyl group (a group derived from an acid, such as RCOOH or RSO3H, by removal of ―OH, such as RC(=O)―, RS(O)2―, and so on). Reagents may be acid chlorides (RCOC1, RSO2C1), anhydrides ((RCO)2O), or even esters (RCOOR′); the products are amides of the corresponding acids.Name: 5-Methoxy-4-methylpyridin-3-amine
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem