Month: October 2022

Choi, Hosam; Jang, Hanho; Choi, Joohee; Lee, Kiyoun published their research in Molecules in 2021. The article was titled 《Stereoselective synthesis of oxazolidin-2-ones via an asymmetric aldol/Curtius reaction: concise total synthesis of (-)-cytoxazone》.COA of Formula: C9H10O2 The article contains the following contents:

An efficient approach toward the synthesis of 4,5-disubstituted oxazolidin-2-one scaffolds I [R1 = n-Bu, 2-thienyl, 4-ClC6H4, etc.] was reported. The developed approach was based on a combination of an asym. aldol and a modified Curtius protocol, which used an effective intramol. ring closure to rapidly access a range of oxazolidin-2-one building blocks. This strategy also permited a straightforward and concise asym. total synthesis of (-)-cytoxazone. Consisting of three steps, this was one of shortest synthesis reported to date. Ultimately, this convenient platform would provide a promising method for early phases of drug discovery. In the experiment, the researchers used many compounds, for example, 2-(Benzyloxy)acetaldehyde(cas: 60656-87-3COA of Formula: C9H10O2)

2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) is a non-natural aldehyde. It undergoes enantioselective Mukaiyama aldol reaction with silylketene acetal nucleophiles in the presence of C2-symmetric bis(oxazolinyl)pyridine Cu(II) complex (catalyst).COA of Formula: C9H10O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2022,Wang, Zichen; Hao, Mingtian; Li, Xiaoyu; Zhang, Beibei; Jiao, Mingyang; Chen, Bo-Zhen published an article in iScience. The title of the article was 《Promising and efficient lignin degradation versatile strategy based on DFT calculations》.COA of Formula: C9H10O2 The author mentioned the following in the article:

The extraction of higher-value products from lignin degradations under mild conditions is a challenge. Previous research reported efficient two-step oxidation and reduction strategies for lignin degradation, which has great significance to lignin degradation In this paper, the mechanism about the C-O bond cleavage of lignin with and without Cα oxidations has been studied systematically. Our calculation results show that the degradation of anionized lignin with Cα oxidations is kinetically and thermodynamically feasible. In addition, the calculations predict that the anionized lignin compounds without Cα oxidation also could be degraded under mild conditions. Moreover, we propose special lignin catalytic degradation systems containing the characteristic structure of “”double hydrogen bonds””. The double hydrogen bonds structure could further decrease the energy barriers of the C-O bond cleavage reaction. This provides a versatile strategy to design novel lignin degradation In the experiment, the researchers used many compounds, for example, 2-(Benzyloxy)acetaldehyde(cas: 60656-87-3COA of Formula: C9H10O2)

2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) is a non-natural aldehyde. It undergoes enantioselective Mukaiyama aldol reaction with silylketene acetal nucleophiles in the presence of C2-symmetric bis(oxazolinyl)pyridine Cu(II) complex (catalyst).COA of Formula: C9H10O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2022,Zhao, Bin; Liu, Jianwen; Feng, Renfei; Wang, Lei; Zhang, Jiujun; Luo, Jing-Li; Fu, Xian-Zhu published an article in Small Methods. The title of the article was 《Less-Energy Consumed Hydrogen Evolution Coupled with Electrocatalytic Removal of Ethanolamine Pollutant in Saline Water over Ni@Ni3S2/CNT Nano-Heterostructured Electrocatalysts》.Category: ethers-buliding-blocks The author mentioned the following in the article:

Energy crises, environmental pollution, and freshwater deficiency are critical issues on the planet. Electrolytic hydrogen generation from saline water, particularly from salt-contained hazardous wastewater, is significant to both environment and energy concerns but still challenging due to the high energy cost, severe corrosion, and the absence of competent electrocatalysts. Herein, a novel strategy is proposed for energy-efficient hydrogen production coupled with electro-oxidation removal of ethanolamine pollutant in saline water. To achieve this, an active and durable heterostructured electrocatalyst is developed by in situ growing Ni@Ni3S2 core@shell nanoparticles in cross-linked 3D carbon nanotubes’ (CNTs) network, achieving high dispersibility and metallic property, low packing d., and enriched exposed active sites to facilitate fast electron/mass diffusion. The unique Ni@Ni3S2/CNTs nano-heterostructures are competent for long-term stably electro-oxidizing environmental-unfriendly ethanolamine at a high c.d. of 100 mA cm-2 in saline water, which not only suppresses oxygen and chloride evolution reactions but also decreases the energy consumption to boost hydrogen production Associated with exptl. results, d. functional theory studies indicate that the collaborative adsorption of electrolyte ions and ethanolamine mols. can synergistically modulate the adsorption/desorption properties of catalytic active centers on Ni@Ni3S2/CNTs surface, leading to long-term stabilized electrocatalysis for efficient ethanolamine oxidation removal and less-energy hydrogen simultaneous production in saline water. The results came from multiple reactions, including the reaction of 1,2-Diphenyldisulfane(cas: 882-33-7Category: ethers-buliding-blocks)

1,2-Diphenyldisulfane(cas: 882-33-7) belongs to ethers.Oxygen is more electronegative than carbon, thus the alpha hydrogens of ethers are more acidic than those of simple hydrocarbons. They are far less acidic than alpha hydrogens of carbonyl groups (such as in ketones or aldehydes), however. Category: ethers-buliding-blocks

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthetic Route of C8H8O3In 2021 ,《A ratiometric fluorescent probe for the rapid and specific detection of HSO3- in water samples》 appeared in Luminescence. The author of the article were Mu, Xinyue; Zhu, Jinbiao; Yan, Liqiang; Tang, Ningli. The article conveys some information:

Hydrosulphite (HSO3-), as a common and important chem. reagent, is widely used in everyday life, however excessive use and abuse of HSO3- can cause potential harmful effects on the environment and in biol. health. In this paper, we describe the design and preparation of a colorimetric and ratiometric fluorescence probe for the visual detection of HSO3- (excitation wavelengths were, resp., 336 nm and 520 nm). This method showed some advantages including simple preparation, high selectivity, fast response, and significant color and fluorescence ratio (F450/F594) changes in the presence of HSO3-. In addition, this probe was used successfully for the detection of HSO3- in real water samples and showed a good recovery rate range. In the experimental materials used by the author, we found 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Synthetic Route of C8H8O3)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is the main component of root bark essential oil of Periploca sepium Bunge. It is a potential tyrosinase inhibitor present in African medicinal plants. 2-Hydroxy-4-methoxybenzaldehyde was used in the synthesis of Schiff base ligand.Synthetic Route of C8H8O3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Reference of 1,2-DiphenyldisulfaneIn 2020 ,《Sulphur-doped activated carbon as a metal-free catalyst for acetylene hydrochlorination》 was published in RSC Advances. The article was written by Qi, Xueyan; Chen, Weifeng; Zhang, Jinli. The article contains the following contents:

A series of sulfur-doped spherical activated carbon (SAC) catalysts were prepared with Ph disulfide (C12H10S2) as a sulfur source for acetylene hydrochlorination. The S-doped catalyst exhibits preferable catalytic performance compared to that of the blank carrier with the reaction conditions of GHSV of 90 h-1 and at 180°C. The catalysts were characterized by N2 adsorption/desorption (BET), elemental anal. (EA), thermogravimetric anal. (TG), temperature-programmed desorption (TPD), Raman spectrum (Raman) and XPS. The results indicate that the presence of sulfur species is favorable to promote the ability of reactant adsorption and inhibit carbon deposition. In addition, the electronic and chem. properties of catalysts were investigated by d. functional theory (DFT) simulation. It is illustrated that the introduction of sulfur species can not only change the spin d. and charge d. but also create more active sites on a carrier. The single sulfur doped carbon material catalysts were designed for the first time and the desirable results make it a green catalyst for the industrial application of acetylene hydrochlorination. In the experiment, the researchers used 1,2-Diphenyldisulfane(cas: 882-33-7Reference of 1,2-Diphenyldisulfane)

1,2-Diphenyldisulfane(cas: 882-33-7) belongs to ethers.The C-O bonds that comprise simple ethers are strong. They are unreactive toward all but the strongest bases. Although generally of low chemical reactivity, they are more reactive than alkanes. Reference of 1,2-Diphenyldisulfane

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Application of ultrasound-mediated adapalene-coated lysozyme-shelled microbubbles in UVA-induced skin photoaging》 was written by Liao, Ai-Ho; Cai, You-Lin; Chuang, Ho-Chaio; Lee, Cheng-Ying; Lin, Yu-Chun; Chiang, Chien-Ping. Synthetic Route of C28H28O3This research focused onultrasound adapalene lysozyme microbubble skin photoaging. The article conveys some information:

Photoaging, the premature aging of skin induced by UV rays, is characterized by wrinkling, roughness, laxity, and pigmentary changes. Various natural and synthetic retinoids have been explored for the treatment of aging. Among retinoids, adapalene (Ada, 0.3%) is one of the most potent and widely used drugs to treat photoaging. However, it causes irritant reactions that limit its acceptance by patients. Several studies have shown the applicability of Lysozyme (Lys)-shelled microbubbles (MBs) for drug delivery through sonophoresis, and recently we have shown its efficiency to treat inflammatory skin disease. An acoustic power d. of 3 W/cm2 for 1 min revealing maximum penetration depth of LysMBs was optimized for further in vitro and in vivo studies of Ada-LysMBs. It was observed that in vitro Ada release from Ada-LysMBs at 6 h after ultrasound (US) treatment was more rapid at pH 7.4 (82%) than at pH 5.5 (73%). Franz diffusion experiments on isolated porcine skin indicated that US approx. doubled Ada delivery by Ada-LysMBs and Ada + LysMBs at 12 h and six-fold Lys permeation by LysMBs at 6 h, compared to these treatments alone. A 5-wk in vivo study in mice identified significant wrinkle reduction in animals treated with US plus Ada-LysMBs. Our findings indicate that US may be used with Ada-LysMBs in the water phase to treat photoaging by normalizing hyperkeratinization and promoting collagen synthesis. In the part of experimental materials, we found many familiar compounds, such as 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas: 106685-40-9Synthetic Route of C28H28O3)

6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas:106685-40-9) is a third-generation synthetic retinoid and a highly lipophilic compound derived from naphthoic acid. It is widely used in the treatment of acne.Synthetic Route of C28H28O3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2019,ACS Omega included an article by Huang, Wenhua; Zhong, Chun-Hong. Computed Properties of C7H7BrO. The article was titled 《Metal-Free Synthesis of Aryltriphenylphosphonium Bromides by the Reaction of Triphenylphosphine with Aryl Bromides in Refluxing Phenol》. The information in the text is summarized as follows:

A metal-free synthesis of aryltriphenylphosphonium bromides by the reaction of triphenylphosphine with aryl bromides in refluxing phenol is developed. This reaction tolerates hydroxymethyl, hydroxyphenyl, and carboxyl groups in aryl bromides, allowing to synthesize multifunctional aryltriphenylphosphonium bromides, from which facile access to multifunctional aryldiphenylphosphines and their oxides by hydrolysis and subsequent reduction is exemplified. A two-step addition-elimination mechanism with the elimination step being a fast step is also proposed. After reading the article, we found that the author used 1-Bromo-3-methoxybenzene(cas: 2398-37-0Computed Properties of C7H7BrO)

1-Bromo-3-methoxybenzene(cas: 2398-37-0) is a compound useful in organic synthesis and other chemical processes. It is an intermediate used for pharmaceuticals, perfumes and agrochemicals.Computed Properties of C7H7BrO

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2019,RSC Advances included an article by Sakai, Rika; Iguchi, Hiroki; Maruyama, Tatsuo. Formula: C8H8O3. The article was titled 《Quantification of azide groups on a material surface and a biomolecule using a clickable and cleavable fluorescent compound》. The information in the text is summarized as follows:

Here, we propose a novel method for quantifying azide groups on a solid surface and a protein using a clickable and cleavable fluorescent compound The clickable and cleavable fluorescent compound conjugates with the azide groups on the material surface and the fluorophore is then liberated into the solvent via a cleavage reaction, which can be simply quantified with a conventional fluorometer. In the experimental materials used by the author, we found 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Formula: C8H8O3)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is employed in the synthesis of Schiff base ligand. It is applied as a reactant in the synthesis of LPA1R antagonists used in the inhibition of LPA-induced proliferation and contraction of normal human lung fibroblasts. Also used in the synthesis of tyrosine kinase 6 proteinase inhibitors.Formula: C8H8O3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2019,RSC Advances included an article by Wang, Tao; Guo, Jiarui; Wang, Xiaojuan; Guo, Han; Jia, Dingli; Wang, Hengjin; Liu, Lantao. Quality Control of 3-Methoxyphenylboronic acid. The article was titled 《Cross coupling of benzylammonium salts with boronic acids using a well-defined N-heterocyclic carbene-palladium(II) precatalyst》. The information in the text is summarized as follows:

N-heterocyclic carbene-palladium(II)-catalyzed cross-coupling of benzylammonium salts with arylboronic acids for the synthesis of diarylmethane derivatives via C-N bond activation were developed. Notably, in the presence of the easily prepared and bench-stable Pd-PEPPSI precatalyst, the Csp3-N bond activation of the benzylammonium salt even proceeded smoothly in isopropanol at room temperature The experimental part of the paper was very detailed, including the reaction process of 3-Methoxyphenylboronic acid(cas: 10365-98-7Quality Control of 3-Methoxyphenylboronic acid)

3-Methoxyphenylboronic acid(cas: 10365-98-7) belongs to boronic acids. Boronic acids are mild Lewis acids which are generally stable and easy to handle, making them important to organic synthesis.Quality Control of 3-Methoxyphenylboronic acid

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2019,RSC Advances included an article by Xue, Feng; Liu, Qibin; Zhu, Yong; Qing, Yunfei; Wan, Boshun. Recommanded Product: 10365-98-7. The article was titled 《Chiral benzene backbone-based sulfoxide-olefin ligands for highly enantioselective Rh-catalyzed addition of arylboronic acids to N-tosylarylimines》. The information in the text is summarized as follows:

An efficient Rh-catalyzed addition of arylboronic acids RB(OH)2 (R = Ph, 1-naphthyl, 4-BrC6H4, etc.) to N-tosylarylimines R1CH=NTs (R1 = Ph, 1-naphthyl, 4-BrC6H4, etc.) has been developed with chiral benzene backbone-based sulfoxide-olefin ligands, where 2-methoxy-1-naphthyl sulfinyl functionalized olefin ligands have shown to be more effective. The versatile method tolerates a wide range of functional groups and shows broad scope without regard to electronic or steric substitution pattern, allowing access to a broad range of chiral diarylmethylamines R1CH(R)NTs in high yields (up to 99%) with excellent enantioselectivities (up to 99% ee). After reading the article, we found that the author used 3-Methoxyphenylboronic acid(cas: 10365-98-7Recommanded Product: 10365-98-7)

3-Methoxyphenylboronic acid(cas: 10365-98-7) belongs to boronic acids. Boronic acids are mild Lewis acids which are generally stable and easy to handle, making them important to organic synthesis.Recommanded Product: 10365-98-7

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem