Choi, Hosam; Jang, Hanho; Choi, Joohee; Lee, Kiyoun published their research in Molecules in 2021. The article was titled 《Stereoselective synthesis of oxazolidin-2-ones via an asymmetric aldol/Curtius reaction: concise total synthesis of (-)-cytoxazone》.COA of Formula: C9H10O2 The article contains the following contents:
An efficient approach toward the synthesis of 4,5-disubstituted oxazolidin-2-one scaffolds I [R1 = n-Bu, 2-thienyl, 4-ClC6H4, etc.] was reported. The developed approach was based on a combination of an asym. aldol and a modified Curtius protocol, which used an effective intramol. ring closure to rapidly access a range of oxazolidin-2-one building blocks. This strategy also permited a straightforward and concise asym. total synthesis of (-)-cytoxazone. Consisting of three steps, this was one of shortest synthesis reported to date. Ultimately, this convenient platform would provide a promising method for early phases of drug discovery. In the experiment, the researchers used many compounds, for example, 2-(Benzyloxy)acetaldehyde(cas: 60656-87-3COA of Formula: C9H10O2)
2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) is a non-natural aldehyde. It undergoes enantioselective Mukaiyama aldol reaction with silylketene acetal nucleophiles in the presence of C2-symmetric bis(oxazolinyl)pyridine Cu(II) complex (catalyst).COA of Formula: C9H10O2
Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem