Month: October 2022

In 2022,Li, Xiang; Shen, Yang; Zhang, Guodong; Zheng, Xin; Zhao, Qing; Song, Zihe published an article in Organic Letters. The title of the article was 《Ru(II)-Catalyzed Decarbonylative Alkylation and Annulations of Benzaldehydes with Iodonium Ylides under Chelation Assistance》.Safety of 2-Hydroxy-4-methoxybenzaldehyde The author mentioned the following in the article:

A Ru(II)-catalyzed decarbonylative alkylation and annulation of salicylaldehydes and 2-aminobenzaldehydes with iodonium ylides has been developed for the synthesis of dibenzo[b,d]furans and NH-free carbazolones. The reaction proceeds smoothly under mild conditions with a low catalyst loading and a broad substrate compatibility. Notably, hydroxy and free amino groups were demonstrated to be the effective directing groups, enabling the successful aldehyde C-H bond activation and subsequent decarbonylation and annulation under the inexpensive Ru(II) catalyst. The experimental process involved the reaction of 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Safety of 2-Hydroxy-4-methoxybenzaldehyde)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is employed in the synthesis of Schiff base ligand. It is applied as a reactant in the synthesis of LPA1R antagonists used in the inhibition of LPA-induced proliferation and contraction of normal human lung fibroblasts. Also used in the synthesis of tyrosine kinase 6 proteinase inhibitors.Safety of 2-Hydroxy-4-methoxybenzaldehyde

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthetic Route of C8H8O2In 2019 ,《One-pot synthesis of 2-amino-4H-chromene derivatives by MNPs@Cu as an effective and reusable magnetic nanocatalyst》 was published in RSC Advances. The article was written by Ma, Wanzheng; Ebadi, Abdol Ghaffar; sabil, Mostafa shahbazi; Javahershenas, Ramin; Jimenez, Giorgos. The article contains the following contents:

In this research, MNPs@Cu as an effective and recyclable nanocatalyst was prepared and characterized using different methods including FT-IR, TGA, VSM, SEM, EDX and XRD. After the characterization of this new nanocatalyst, it was efficiently used for one-pot synthesis of 2-amino-4H-chromene derivatives I [R = Ph, 4-MeOC6H4, 4-ClC6H4, etc.], II and III [X = NH, O] via one-pot three-component Knoevenagel condensation of enolizable compounds, malononitrile and benzaldehydes under solvent-free conditions. The procedure gave the desired products I, II and III in high-to-excellent yields in short reaction times. Also this catalyst, because of its magnetic nature, could be simply restored by a permanent magnetic field and comfortably reused several times without any significant loss of its catalytic activity. The results came from multiple reactions, including the reaction of 2-Methoxybenzaldehyde(cas: 135-02-4Synthetic Route of C8H8O2)

2-Methoxybenzaldehyde(cas: 135-02-4) is found in cassia oil, cinnamon bark, and cinnamon bark oil. It is a clear colorless liquid with a strong aroma. It has been used to examine the acaricidal activity of Periploca sepium oil and its active component against Tyrophagus putrescentiae.Synthetic Route of C8H8O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Application of 135-02-4In 2020 ,《Ag nanoparticles stabilized on cyclodextrin polymer decorated with multi-nitrogen atom containing polymer: an efficient catalyst for the synthesis of xanthenes》 was published in Molecules. The article was written by Sadjadi, Samahe; Kahangi, Fatemeh Ghoreyshi; Dorraj, Masoumeh; Heravi, Majid M.. The article contains the following contents:

In attempt to broaden the use of cyclodextrin polymer for catalytic purposes, a novel covalent hybrid system was prepared through growth of multi-nitrogen atom containing polymer (PMelamine) derived from reaction of ethylenediamine and 2,4,6-trichloro-1,3,5-triazine on the functionalized cyclodextrin polymer (CDNS). The resulting hybrid system was then utilized as a catalyst support for the immobilization of silver nanoparticles through using Cuscuta epithymum extract as a naturally-derived reducing agent. The catalytic activity of the catalyst,Ag@CDNS-N/PMelamine, for the synthesis of xanthenes through reaction of aldehydes and dimedone in aqueous media was examined The results showed high catalytic activity and recyclability of the catalyst. It was believed that cyclodextrin in the backbone of the catalyst could act both as a capping agent for Ag nanoparticles and phase transfer agent to bring the hydrophobic substrates in the vicinity of the catalytic active sites and accelerate the reaction rate. Multi-nitrogen atoms on the polymer, on the other hand, could improve the Ag NPs anchoring and suppress their leaching. In the experimental materials used by the author, we found 2-Methoxybenzaldehyde(cas: 135-02-4Application of 135-02-4)

2-Methoxybenzaldehyde(cas: 135-02-4) is found in cassia oil, cinnamon bark, and cinnamon bark oil. It is a clear colorless liquid with a strong aroma. It has been used to examine the acaricidal activity of Periploca sepium oil and its active component against Tyrophagus putrescentiae.Application of 135-02-4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Application of 882-33-7In 2021 ,《Rhodium-Catalyzed Twofold Unsymmetrical C-H Alkenylation-Annulation/Thiolation Reaction To Access Thiobenzofurans》 was published in Organic Letters. The article was written by Lin, Jian; Hu, Liuyu; Chen, Chao; Feng, Huijin; Yu, Yang; Yang, Yaxi; Zhou, Bing. The article contains the following contents:

A Rh(III)-catalyzed twofold unsym. C-H alkenylation-annulation/thiolation reaction was developed, enabling the straightforward and efficient synthesis of various thiobenzofurans I [R1 = Me, Et, Ph, CH2CH2OBn; R2 = H, Me; R3 = n-Pr, Ph, 2-thienyl, etc.; R4 = H, OMe, F, OBn; R5 = H, Me, Br, etc.; R4R5 = OCH2O, OCH2CH2O] in one step. This robust protocol proceeded with a broad substrate scope and good functional group tolerance under relatively mild reaction conditions. In addition to this study using 1,2-Diphenyldisulfane, there are many other studies that have used 1,2-Diphenyldisulfane(cas: 882-33-7Application of 882-33-7) was used in this study.

1,2-Diphenyldisulfane(cas: 882-33-7) belongs to ethers. Ethers lack the hydroxyl groups of alcohols. Without the strongly polarized O―H bond, ether molecules cannot engage in hydrogen bonding with each other. Application of 882-33-7

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Discovery of potential Q-marker of traditional Chinese medicine based on plant metabolomics and network pharmacology: Periplocae Cortex as an example》 was written by Li, Zi-ting; Zhang, Feng-xiang; Fan, Cai-lian; Ye, Meng-nan; Chen, Wei-wu; Yao, Zhi-hong; Yao, Xin-sheng; Dai, Yi. Recommanded Product: 673-22-3This research focused ontraditional Chinese medicine plant metabolomic pharmacol Periplocae; Multivariate statistical analysis; Network pharmacology; Periplocae Cortex; Q-marker; Quantification. The article conveys some information:

Quality control exerted great importance on the clin. application of drugs for ensuring effectiveness and safety. Due to chem. complexity, diversity among different producing areas and harvest seasons, as well as unintentionally mixed with non-medicinal parts, the current quality standards of traditional Chinese medicine (TCM) still faced challenges in evaluating the overall chem. consistency. We aimed to develop a new strategy to discover potential quality marker (Q-marker) of TCM by integrating plant metabolomics and network pharmacol., using Periplocae Cortex (GP, the dried root bark of Periploca sepium Bge.) as an example. First, plant metabolomics anal. was performed by UPLC/Q-TOF MS in 89 batches of samples to discover chem. markers to distinguish medicinal parts (GP) and non-medicinal parts (the dried stem bark of Periploca sepium Bge. (JP)), harvest seasons and producing region of Periplocae Cortex. Second, network pharmacol. was applied to explore the initial linkages among chem. constituents, targets and diseases. Last, potential Q-marker were selected by integrating anal. of plant metabolomics and network pharmacol., and the quantification method of Q-marker was developed by using UPLC-TQ-MS. The chem. profiling of GP and JP was investigated. Fifteen distinguishing features were designated as core chem. markers to distinguish GP and JP. Besides, the content of 4-methoxybenzaldehyde-2-O-β-D-xylopyranosyl-(1→6)-β-D-glucopyranoside could be used to identify Periplocae Cortex harvested in spring-autumn or summer. Meanwhile, a total of 15 components targeted rheumatoid arthritis were screened out based on network pharmacol. Taking absorbed constituents into consideration, 23 constituents were selected as potential Q-marker. A simultaneous quantification method (together with 11 semi-quant. anal.) was developed and applied to the anal. of 20 batches of com. Periplocae Cortex on the market. The PLS-DA model was successfully developed to distinguish GP and JP samples. In addition, the artificially mixed GP sample, which contained no less than 10% of the adulterant (JP), could also be correctly identified. Our results indicated that 9 ingredients could be considered as Q-marker of Periplocae Cortex. This study has also demonstrated that the plant metabolomics and network pharmacol. could be used as an effective approach for discovering Q-marker of TCM to fulfill the evaluation of overall chem. consistency among samples from different producing areas, harvest seasons, and even those com. crude drugs, which might be mixed with a small amount of non-medicinal parts. The experimental part of the paper was very detailed, including the reaction process of 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Recommanded Product: 673-22-3)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is the main component of root bark essential oil of Periploca sepium Bunge. It is a potential tyrosinase inhibitor present in African medicinal plants. 2-Hydroxy-4-methoxybenzaldehyde was used in the synthesis of Schiff base ligand.Recommanded Product: 673-22-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Quality Control of 1,4-Diethynyl-2,5-dimethoxybenzeneOn June 11, 2001, Dirk, S. M.; Price, D. W.; Chanteau, S.; Kosynkin, D. V.; Tour, J. M. published an article in Tetrahedron. The article was 《Accoutrements of a molecular computer: switches, memory components and alligator clips》. The article mentions the following:

Several second generation memory components consisting of oligo(phenylene ethynylene)s containing easily reducible functionalities consisting of either nitro or quinone cores have been synthesized for incorporation into mol. electronic devices. Addnl., two new types of contacts between organic compounds and a metal surface based on diazonium salts or pyridine have been synthesized and integrated into mols. for use in mol. electronic devices. In the experiment, the researchers used 1,4-Diethynyl-2,5-dimethoxybenzene(cas: 74029-40-6Quality Control of 1,4-Diethynyl-2,5-dimethoxybenzene)

1,4-Diethynyl-2,5-dimethoxybenzene(cas: 74029-40-6) belongs to ethers.Oxygen is more electronegative than carbon, thus the alpha hydrogens of ethers are more acidic than those of simple hydrocarbons. They are far less acidic than alpha hydrogens of carbonyl groups (such as in ketones or aldehydes), however. Quality Control of 1,4-Diethynyl-2,5-dimethoxybenzene

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Pelter, Andrew; Jones, D. Elfyn published an article in Perkin 1. The title of the article was 《The preparation and some properties of substituted phenylene-ethynylene and phenylenebuta-1,3-diynylene polymers》.Related Products of 74029-40-6 The author mentioned the following in the article:

Syntheses are described for the preparation of a variety of diynes which are converted to high mol. weight substituted arylenebuta-1,3-diynylene polymers by oxidative coupling and to high mol. weight substituted arylene-ethynylene polymers by Pd(II) catalyzed cross coupling reactions. The products tend to be insoluble in normal organic solvents. Doping with ferric chloride produces significant changes in conductivity but these are less than those produced on equivalently substituted thienylene-phenylene polymers.1,4-Diethynyl-2,5-dimethoxybenzene(cas: 74029-40-6Related Products of 74029-40-6) was used in this study.

1,4-Diethynyl-2,5-dimethoxybenzene(cas: 74029-40-6) belongs to ethers.Although ethers resist hydrolysis, they are cleaved by hydrobromic acid and hydroiodic acid. Hydrogen chloride cleaves ethers only slowly. Related Products of 74029-40-6

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2019,ACS Catalysis included an article by Hamasaka, Go; Roy, David; Tazawa, Aya; Uozumi, Yasuhiro. Recommanded Product: 1-Iodo-2-methoxybenzene. The article was titled 《Arylation of Terminal Alkynes by Aryl Iodides Catalyzed by a Parts-per-Million Loading of Palladium Acetate》. The information in the text is summarized as follows:

Arylation of terminal alkynes (16 varieties) by aryl iodides (28 varieties) was achieved with a mol ppm loading level of palladium catalyst, where a variety of functional groups including heteroarenes were tolerated. Thus, the arylations were carried out in the presence of palladium acetate at ppm loadings and potassium carbonate in ethanol at 80° to give the corresponding internal alkynes in good to excellent yields. Synthesis of 2-phenyl-3-(phenylalkynyl)benzofuran was achieved by iterative use of the alkyne arylation under mol ppm catalytic conditions. Reaction-rate anal., transmission electron microscopic ex-amination of the reaction mixture, and mercury-amalgamation test were performed to gain insight into the active species of the highly active ppm catalytic species. Transmission electron microscopic (TEM) examination of the reaction mixture revealed that palladium nanoparticles were generated in situ under the reaction conditions, and their cluster size was variable during the catalytic reaction. A variation in size of palladium particles suggested that the composition-decomposition process of Pd aggregates should take place in situ via monomeric palladium(0) species and/or fine palladium(0) clusters which might be real catalytic species in this reaction. The experimental part of the paper was very detailed, including the reaction process of 1-Iodo-2-methoxybenzene(cas: 529-28-2Recommanded Product: 1-Iodo-2-methoxybenzene)

1-Iodo-2-methoxybenzene(cas: 529-28-2) is a useful synthetic intermediate. It can be used in the synthesis of piperidinyl diaminopyrimidines as cyclin-dependent kinase inhibitors with antitumor activity and polysubstituted benzofuran derivatives as novel inhibitors of parasitic growth.Recommanded Product: 1-Iodo-2-methoxybenzene

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2019,Organic Letters included an article by Lv, Weiwei; Chen, Yanhui; Zhao, Zemin; Wen, Si; Cheng, Guolin. Reference of 1-Iodo-2-methoxybenzene. The article was titled 《Palladium-Catalyzed Regioselective Heck Coupling of Alkynes with Aryl Iodides for the Synthesis of Trisubstituted Allenes》. The information in the text is summarized as follows:

A utility approach toward trisubstituted allenes through Pd-catalyzed alkynyl Heck coupling reaction of alkynes and aryl iodides is reported. This process proceeded via regioselective carbopalladation of 1-aryl-1-alkynes to give alkenyl palladium species, which undergo β-hydride elimination to provide 1,1-diarylallenes in 25-71% yields. This method features unique regioselectivity and high functional group compatibility. In the part of experimental materials, we found many familiar compounds, such as 1-Iodo-2-methoxybenzene(cas: 529-28-2Reference of 1-Iodo-2-methoxybenzene)

1-Iodo-2-methoxybenzene(cas: 529-28-2) is a useful synthetic intermediate. It can be used in the synthesis of piperidinyl diaminopyrimidines as cyclin-dependent kinase inhibitors with antitumor activity and polysubstituted benzofuran derivatives as novel inhibitors of parasitic growth.Reference of 1-Iodo-2-methoxybenzene

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2019,ACS Omega included an article by Gautam, Prashant; Tiwari, Neelam J.; Bhanage, Bhalchandra M.. Application of 529-28-2. The article was titled 《Aminophosphine Palladium Pincer-Catalyzed Carbonylative Sonogashira and Suzuki-Miyaura Cross-Coupling with High Catalytic Turnovers》. The information in the text is summarized as follows:

In the presence of palladium pincer complex I, aryl iodides underwent carbonylative Sonogashira and Suzuki coupling reactions with aryl alkynes and cyclopropylacetylene and arylboronic acids mediated by K2CO3 in propylene carbonate to yield aryl alkynones and diaryl ketones, resp. Using I, the carbonylative Sonogashira and Suzuki coupling reactions were carried out at 10-4 mol% and 10-6 mol%, resp. Palladium nanoparticles generated from I were characterized. The results came from multiple reactions, including the reaction of 1-Iodo-2-methoxybenzene(cas: 529-28-2Application of 529-28-2)

1-Iodo-2-methoxybenzene(cas: 529-28-2) is a useful synthetic intermediate. It can be used in the synthesis of piperidinyl diaminopyrimidines as cyclin-dependent kinase inhibitors with antitumor activity and polysubstituted benzofuran derivatives as novel inhibitors of parasitic growth.Application of 529-28-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem