Month: October 2022

In 2022,Wang, Zheng-Hai; Wang, Dong-Hui published an article in Organic Letters. The title of the article was 《Cu-Catalyzed Synthesis of Benzoxazole with Phenol and Cyclic Oxime》.Electric Literature of C7H8O2 The author mentioned the following in the article:

A Cu-catalyzed straightforward synthesis of benzoxazoles I [R = 5-iPr, 5-NHAc, 7-Bn, etc.; Ar = Ph, 1-naphthyl, 2-furyl, etc.] from free phenols and cyclic oxime esters was reported. The mild reaction conditions tolerate various electron-withdrawing and electron-donating functional groups on both substrates, affording benzoxazoles in moderate to good yields. With this protocol, large-scale syntheses of Ezutromid and Flunoxaprofe in one or two steps were demonstrated. A catalytic mechanism, which included Cu-catalyzed amination via inner-sphere electron transfer and consequent annulation, was proposed. In addition to this study using m-Methoxyphenol, there are many other studies that have used m-Methoxyphenol(cas: 150-19-6Electric Literature of C7H8O2) was used in this study.

m-Methoxyphenol(cas: 150-19-6) may be used in synthesis of:C(4) symmetric calix[4]resorcinarene, 2-nitroso-5-methoxyphenol, 6-methoxy-2(3H)-benzoxazoloneElectric Literature of C7H8O2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2022,Xie, Huilin; Lin, Chuankai; Wang, Ruixiang; Liu, Jin-Biao published an article in Tetrahedron Letters. The title of the article was 《Synthesis of salicylates from anionically activated aromatic trifluoromethyl group》.Application of 150-19-6 The author mentioned the following in the article:

An efficient approach to salicylates via a novel transformation of anionically activated aromatic trifluoromethyl group is described. 2-(Trifluoromethyl)phenol reacts with phenols/alcs. under alk. conditions to afford the corresponding aryl/alkyl salicylates in high yields. Mechanism studies indicated that the carbonyl oxygen atom of ester is from the H2O in the solvent. The experimental process involved the reaction of m-Methoxyphenol(cas: 150-19-6Application of 150-19-6)

m-Methoxyphenol(cas: 150-19-6) may be used as an analytical standard for the determination of the analyte in wine, coffee beans, wood samples, and mainstream smoke by gas chromatography (GC) based techniques.Application of 150-19-6

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

In 2022,Hadsarung, Rungsima; Thongnest, Sanit; Oekchuae, Sittisak; Chaiyaveij, Duangduan; Boonsombat, Jutatip; Ruchirawat, Somsak published an article in Tetrahedron. The title of the article was 《Facile synthesis of 1-substituted 4-H phthalazine, a versatile scaffold for chemically diverse phthalazines》.SDS of cas: 673-22-3 The author mentioned the following in the article:

An improved synthetic strategy for 1-substituted 4-H phthalazines using a convenient, three-step reaction sequence under mild conditions is described. The protocol involves condensation of hydrazine hydrate with o-ketobenzaldehydes derived through the Pb(OAc)4 oxidation of the N-acylhydrazones of salicylaldehydes. This pathway is of high practical value since a wide variety of substituted acylhydrazides and salicylaldehydes, the substrates for N-acylhydrazones, are com. available. In addition, the three-step sequence could be scaled up without the need for intermediate purification affording a broad range of products in high yield. 1-Ph 4-H phthalazine was a versatile compound providing ready access to multiple phthalazine analogs, including the vasodilating agent MY5445.2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3SDS of cas: 673-22-3) was used in this study.

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is the main component of root bark essential oil of Periploca sepium Bunge. It is a potential tyrosinase inhibitor present in African medicinal plants. 2-Hydroxy-4-methoxybenzaldehyde was used in the synthesis of Schiff base ligand.SDS of cas: 673-22-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Electric Literature of C5H13NO2In 2019 ,《Synthesis and antimicrobial evaluation of novel pyrazolopyrimidines incorporated with mono- and diphenylsulfonyl groups》 appeared in Molecules. The author of the article were Alsaedi, Amani M. R.; Farghaly, Thoraya. A.; Shaaban, Mohamed R.. The article conveys some information:

A novel series of pyrazolo[1,5-a]pyrimidine ring systems containing phenylsulfonyl moiety I (Ar = C6H5, 3-H3CC6H4, 2-ClC6H4, etc.) have been synthesized via the reaction of 2-(phenylsulfonyl)-1-(4-(phenylsulfonyl)phenyl)ethan-1-one, 2-benzenesulfonyl-1-(4-benzenesulfonyl-phenyl)-3-dimethylamino-propenone and 3-(dimethylamino)-1-(4-(phenylsulfonyl)phenyl)prop-2-en-1-one each with various substituted aminoazopyrazole derivatives in one pot reaction strategy. The proposed structure as well as the mechanism of their reactions were discussed and proved with all possible spectral data. The results of antimicrobial activities of the new sulfone derivatives revealed that several derivatives showed activity exceeding the activity of reference drug. Contrary to expectations, derivatives containing one sulfonyl group are more effective against all bacteria and fungi than those containing two sulfonyl groups. The experimental process involved the reaction of N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Electric Literature of C5H13NO2)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime.Typically the presence of an amine functional group is deduced by a combination of techniques, including mass spectrometry as well as NMR and IR spectroscopies. 1H NMR signals for amines disappear upon treatment of the sample with D2O. In their infrared spectrum primary amines exhibit two N-H bands, whereas secondary amines exhibit only one.Electric Literature of C5H13NO2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Synthetic Route of C8H8O3In 2020 ,《Rhodium-Catalyzed Ring-Opening Hydroacylation of Alkylidenecyclopropanes with Chelating Aldehydes for the Synthesis of γ,δ-Unsaturated Ketones》 was published in Organic Letters. The article was written by Li, Hong-Shuang; Lu, Shi-Chao; Chang, Zhi-Xin; Hao, Liqiang; Li, Fu-Rong; Xia, Chengcai. The article contains the following contents:

The first intermol. ring-opening hydroacylation of alkylidenecyclopropanes with chelating aldehydes through a rhodium-catalyzed acrylamide-promoted protocol is reported. This highly efficient catalytic system enables the direct synthesis of a diverse range of linear γ,δ-unsaturated ketones. Good functional group compatibility is demonstrated for the completely atom-economical and remarkably selective proximal C-C bond cleavage process. Mechanistic studies reveal that the bidentate coordination of N,N-dimethylmethacrylamide (L1) to the acylrhodium intermediates might facilitate the cyclopropane ring fragmentation and isomerization. In the experimental materials used by the author, we found 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Synthetic Route of C8H8O3)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is the main component of root bark essential oil of Periploca sepium Bunge. It is a potential tyrosinase inhibitor present in African medicinal plants. 2-Hydroxy-4-methoxybenzaldehyde was used in the synthesis of Schiff base ligand.Synthetic Route of C8H8O3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Product Details of 60656-87-3In 2022 ,《Access to Sulfoxides under NHC/Photocatalysis via a Radical Pathway》 was published in Organic Letters. The article was written by Wang, Xuefeng; Tang, Yulian; Ye, Shengqing; Zhang, Jun; Kuang, Yunyan; Wu, Jie. The article contains the following contents:

A photocatalyzed transformation from sulfinic acids to sulfoxides under visible-light irradiation in the presence of N-heterocyclic carbene is established. Various alkyl groups from four-substituted Hantzsch esters or Meyer nitriles are smoothly converted to the corresponding sulfoxides through a radical coupling pathway in the presence of 1,1-carbonyldiimidazole. This method allows sulfoxide synthesis to refrain from relying on the oxidation of sulfides and provides an alternative route for the preparation of sulfoxides. In the experiment, the researchers used 2-(Benzyloxy)acetaldehyde(cas: 60656-87-3Product Details of 60656-87-3)

2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) is a non-natural aldehyde. It undergoes enantioselective Mukaiyama aldol reaction with silylketene acetal nucleophiles in the presence of C2-symmetric bis(oxazolinyl)pyridine Cu(II) complex (catalyst).Product Details of 60656-87-3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Application In Synthesis of 1-Iodo-2-methoxybenzeneIn 2019 ,《Sulfenamide-enabled ortho thiolation of aryl iodides via palladium/norbornene cooperative catalysis》 was published in Nature Communications. The article was written by Li, Renhe; Zhou, Yun; Yoon, Ki-Young; Dong, Zhe; Dong, Guangbin. The article contains the following contents:

A general ortho thiolation of common aryl and heteroaryl iodides RI (R = 2-methylphenyl, 1-naphthyl, quinolin-5-yl, etc.) via palladium-norbornene cooperative catalysis is reported. Using this approach, an aryl or alky sulfur moiety can be site-selectively introduced at the arene ortho position without using sterically or electronically biased substrates. The arene ipso functionalization is simultaneously achieved through Heck, Suzuki or Sonogashira termination. The reaction is enabled by a unique class of electrophiles in palladium-norbornene cooperative catalysis, which are sulfenamides such as N-phenyl-N-(phenylsulfanyl)formamide, 1-(phenylsulfanyl)pyrrolidin-2-one, 1-(phenylsulfanyl)azepan-2-one, etc. derived from seven-membered lactams. The broad substrates scope and high chemoselectivity could make this method attractive for synthesis of complex sulfur-containing aromatic compounds, e.g., I. The experimental part of the paper was very detailed, including the reaction process of 1-Iodo-2-methoxybenzene(cas: 529-28-2Application In Synthesis of 1-Iodo-2-methoxybenzene)

1-Iodo-2-methoxybenzene(cas: 529-28-2) participates in palladium catalyzed enantioselective Heck arylation of 2,3-dihydrofuran in the presence of chiral ionic liquids containing L-prolinate and L-lactate anions and non-chiral quaternary ammonium cations.Application In Synthesis of 1-Iodo-2-methoxybenzene

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Synthesis and antiplasmodial activity of 1,2,3-triazole-naphthoquinone conjugates》 was written by Oramas-Royo, Sandra; Lopez-Rojas, Priscila; Amesty, Angel; Gutierrez, David; Flores, Ninoska; Martin-Rodriguez, Patricia; Fernandez-Prrez, Leandro; Estevez-Braun, Ana. SDS of cas: 10365-98-7This research focused ontriazole naphthoquinones copper catalyzed cycloaddition mol docking Plasmodium malaria; 1,2,3-triazole-naphthoquinones; Plasmodium falciparum; copper-catalyzed cycloaddition; docking; malaria. The article conveys some information:

A series of 34 1,2,3-triazole-naphthoquinone conjugates were synthesized via copper-catalyzed cycloaddition (CuAAC). They were evaluated for their in vitro antimalarial activity against chloroquine-sensitive strains of Plasmodium falciparum and against three different tumor cell lines (SKBr-3, MCF-7, HEL). The most active antimalarial compounds showed a low antiproliferative activity. Simplified analogs were also obtained and some structure-activity relationships were outlined. The best activity was obtained by compounds 3s and 3j, having IC50 of 0.8 and 1.2 μM, resp. Mol. dockings were also carried on Plasmodium falciparum enzyme dihydroorotate dehydrogenase (PfDHODH) in order to rationalize the results. In the experimental materials used by the author, we found 3-Methoxyphenylboronic acid(cas: 10365-98-7SDS of cas: 10365-98-7)

3-Methoxyphenylboronic acid(cas: 10365-98-7) belongs to boronic acids. Boronic acids are mild Lewis acids which are generally stable and easy to handle, making them important to organic synthesis.SDS of cas: 10365-98-7

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《Synthesis, Characterization, and Substituent Effects of Binuclear Ruthenium Vinyl Complexes [RuCl(CO)(PMe3)3]2(μ-CH:CH-Ar-CH:CH)》 was written by Wu, Xiang Hua; Jin, Shan; Liang, Jin Hua; Li, Zi Yong; Yu, Guang-ao; Liu, Sheng Hua. Application In Synthesis of 1,4-Diethynyl-2,5-dimethoxybenzene And the article was included in Organometallics on April 27 ,2009. The article conveys some information:

Reactions of 1,4-diethenylbenzene derivatives with Ru(H)(Cl)(CO)(PPh3)2 followed by PMe3 to give binuclear Ru divinylbenzene complexes [RuCl(CO)(PMe3)3]2(μ-CH:CH-Ar-CH:CH) (Ar = C6H4 (6a), C6H3CH3 (6b), C6H3OCH3 (6c), C6H3F (6d), C6H3Cl (6e), C6H3Br (6f), C6H3CN (6g), C6H3NO2 (6h), C6H2Me2-2,5 (6i), C6H2(OCH3)2-2,5 (6j), C6H2(F)2-2,5 (6k), C6H2(CF3)2-2,5 (6l), and C6H3CF3 (6m)). The resp. products were characterized by elemental analyses, NMR spectrometry, and UV/visible spectrophotometry. The structures of 6h, 6i, and 6j were established by x-ray crystallog. Electrochem. studies revealed that intermetallic electron communication between the two Ru centers may be fine-tuned by modification of the bridging spacers, i.e., by introducing one or two substituent groups on the 1,4-diethenylphenylene bridge. Electron-releasing substituents facilitate electron communication between the two metal centers. In the experiment, the researchers used many compounds, for example, 1,4-Diethynyl-2,5-dimethoxybenzene(cas: 74029-40-6Application In Synthesis of 1,4-Diethynyl-2,5-dimethoxybenzene)

1,4-Diethynyl-2,5-dimethoxybenzene(cas: 74029-40-6) belongs to ethers.The C-O bonds that comprise simple ethers are strong. They are unreactive toward all but the strongest bases. Although generally of low chemical reactivity, they are more reactive than alkanes. Application In Synthesis of 1,4-Diethynyl-2,5-dimethoxybenzene

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

《TSA-CRAFT: A Free Software for Automatic and Robust Thermal Shift Assay Data Analysis》 was written by Lee, Po-Hsien; Huang, Xi Xiao; Teh, Bin Tean; Ng, Ley-Moy. COA of Formula: C28H28O3This research focused onTSA CRAFT software boltzmann equation; automatic Tm analysis; differential scanning fluorimetry; high-throughput ligand screening; thermal shift assay; thermofluor. The article conveys some information:

Thermal shift assay (TSA) is an increasingly popular technique used for identifying protein stabilizing conditions or interacting ligands in X-ray crystallog. and drug discovery applications. Although the setting up and running of TSA reactions is a relatively simple process, the subsequent anal. of TSA data, especially in high-throughput format, requires substantial amount of effort if conducted manually. We therefore developed the Thermal Shift Assay-Curve Rapid and Automatic Fitting Tool (TSA-CRAFT), a freely available software that enable automatic anal. of TSA data of any throughput. TSA-CRAFT directly reads real-time PCR instrument data files and displays the analyzed results in a web browser. This software features streamlined data processing and Boltzmann equation fitting, which is demonstrated in this study to provide more accurate data anal. than the commonly used first-derivative method. TSA-CRAFT is freely available as a cross-operating system-compatible standalone tool and also as a freely accessible web. In the part of experimental materials, we found many familiar compounds, such as 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas: 106685-40-9COA of Formula: C28H28O3)

6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas:106685-40-9) is a third-generation synthetic retinoid and a highly lipophilic compound derived from naphthoic acid. It is widely used in the treatment of acne.COA of Formula: C28H28O3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem