Month: October 2022

In 2022,Liu, Zhenfeng; Ai, Jing; Zhu, Zhenlai; Huang, Lixia; Yi, Zhen; Wu, Linshan; Xu, Yunjing; Zhu, Dingheng; Li, Huizhong; Yan, Yunling; Zhang, Lichun; Zhong, Xinyi; Yang, Bin published an article in Dermatologic Therapy. The title of the article was 《Chemical peeling with 35% glycolic acid for the treatment of disseminated facial verruca plana: A randomized, split-face, evaluator-blinded trial》.Recommanded Product: 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid The author mentioned the following in the article:

Disseminated facial verruca plana is a chronic disorder that causes significant psychol. distress. However, safe and effective treatment is lacking. This study aimed to explore the efficacy and safety of 35% glycolic acid (GA) for the treatment of disseminated facial verruca plana. A split-face clin. trial was conducted to explore the efficacy and safety of using chem. peeling with 35% GA for the treatment of disseminated facial verruca plana. One side of the face was applied with 35% GA once every fortnight for a total of three times. Adapalene gel was applied every night to the other side of the face as the control. The clearance rate of lesions was evaluated at different time points. Between June 2020 and Dec. 2020, 30 patients with disseminated verruca plana who visited the Dermatol. Hospital of Southern Medical University were enrolled. After three chem. peelings with 35% GA that was applied at 2-wk intervals, 15 (50%) patients achieved >70% lesion reduction The same effective rate in the adapalene gel-treated side of the face was documented in eight patients. Subgroup anal. showed a higher clearance rate in patients with a shorter disease duration. Moreover, concurrent improvements in facial roughness were observed in the 35% GA-treated group. Adverse effects including mild erythema and desquamation were observed during chem. peeling with 35% GA. In conclusion, chem. peeling with 35% GA could be a safe and effective option for treating disseminated facial verruca plana, especially for those who desire skin improvement.6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas: 106685-40-9Recommanded Product: 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid) was used in this study.

6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas:106685-40-9) is a third-generation synthetic retinoid and a highly lipophilic compound derived from naphthoic acid. It is widely used in the treatment of acne.Recommanded Product: 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Category: ethers-buliding-blocksIn 2022 ,《Greener synthesis of pyranopyrazole derivatives catalyzed by CaO nanoparticles》 appeared in Rasayan Journal of Chemistry. The author of the article were Sangeeta; Singh, Har Lal; Chahar, Mamta; Sahal, Saloni; Khaturia, Sarita. The article conveys some information:

The development of a novel green synthetic protocol for the series of pyrano-pyrazole derivatives I (R = CN, COOEt; X = H, 4-Cl, 2-OH-4-OMe, 4-NO2, etc.) in a one-pot multi-component method using CaO nanoparticles as the heterogeneous catalyst was reported. The CaO nanoparticles were synthesized by a greener route using an economic and efficient alternative i.e. papaya leaf extract and exhibited excellent catalytic activity, and this plant-mediated synthesis of CaO nanoparticles is a very promising area of research. CaO nanoparticles can be efficiently used in the synthesis of pyrano-pyrazoles I and this catalytic approach can deliver the appropriate products in a rapid reaction time with a high yield (85-91%). The current protocol has various advantages, including a short reaction time, a high percent yield, a clean reaction, a simple separation technique, and a recoverable catalyst that retains its catalytic activity when utilized in subsequent reactions. Characterization of synthesized pyrano-pyrazole derivatives I were wdone by IR, 1H and 13C NMR spectral data as well as HOMO-LUMO calculations In the part of experimental materials, we found many familiar compounds, such as 2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3Category: ethers-buliding-blocks)

2-Hydroxy-4-methoxybenzaldehyde(cas: 673-22-3) is the main component of root bark essential oil of Periploca sepium Bunge. It is a potential tyrosinase inhibitor present in African medicinal plants. 2-Hydroxy-4-methoxybenzaldehyde was used in the synthesis of Schiff base ligand.Category: ethers-buliding-blocks

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Product Details of 101-70-2In 2019 ,《Quinoxaline based amines as blue-orange emitters: Effect of modulating donor system on optoelectrochemical and theoretical properties》 appeared in Dyes and Pigments. The author of the article were Kanekar, Deepali N.; Chacko, Sajeev; Kamble, Rajesh M.. The article conveys some information:

A series of eight novel donor-acceptor based quinoxaline-amine derivatives 2-9 were prepared by modulating donor species on quinoxaline core with Buchwald-Hartwig coupling amination reaction. The synthesized mols. were fully characterized and studied for impact of D-A interaction on optoelectrochem. properties of derivatives Absorption spectra of 2-9 display intramol. charge transfer (ICT) transitions in the range of 377-456 nm. Dyes 2-9 show pos. solvatochromism in emission and emit in blue-orange region with emission maxima 472-592 nm on excitation at their resp. ICT maxima in toluene, chloroform, DCM and neat solid film. Herein, dyes 2, 3 and 7 which possess intense emission in solid state were further studied for Aggregation Induced Emission (AIE) effect. The HOMO and LUMO energy level for compound 2-9 obtained by CV were found in the range of -5.23 to -5.83 eV and -3.55 to -3.74 eV. Theor. studies of mols. were also carried out by using TD-DFT calculations The comparable HOMO and LUMO energy level of 2-9 with reported ambipolar materials and efficient solid state emission make synthesized compounds potential candidate for solid state emissive, ambipolar materials in organic electronics. The experimental part of the paper was very detailed, including the reaction process of Bis(4-methoxyphenyl)amine(cas: 101-70-2Product Details of 101-70-2)

Bis(4-methoxyphenyl)amine(cas: 101-70-2) is a diphenylamine derivative used as a chemical additive for cured rubber.Bis(4-methoxyphenyl)amine is highly toxic and may potentially induce chromosome abberation.Product Details of 101-70-2

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Category: ethers-buliding-blocksIn 2020 ,《Synthesis of 4,4-Disubstituted 1,2-Thiazinane-5-one 1,1-Dioxides via the CSIC[#] Reaction Strategy》 was published in ChemistrySelect. The article was written by Dyachenko, Maksim S.; Kochetkov, Artem O.; Dobrydnev, Alexey V.; Milokhov, Demyd S.; Shishkina, Svitlana V.; Konovalova, Irina S.; Omelchenko, Irina V.; Volovenko, Yulian M.. The article contains the following contents:

A series of sp3-enriched 2,2-disubstituted 1,2-thiazinane-5-one 1,1-dioxides (including spirocyclic derivatives) I (R1 = R2 = Me, Et, -(CH2)4-, -(CH2)5-, etc.), II (R1 = R2 = Me; R3 = NH2, Me, phenyl) and III (R1 = R2 = Me) has been synthesized through the CSIC [Carbanion mediated Sulfonate (Sulfonamido) Intramol. Cyclization] reaction strategy. In particular, 2,2-disubstituted alkyl 3-aminopropanoates C(R1)(R2)(CO2R4)CH2NH3+Cl- (R4 = Me, Et) were subsequently sulfonylated with mesyl chloride followed by alkylation with Me iodide to give the key precursor 2,2-disubstituted Me 3-(methylsulfonamido)propanoates C(R1)(R2)(CO2R4)CH2N(Me)SO2Me. The latter were treated with sodium hydride and underwent the intramol. sulfa-Dieckmann cyclization yielding the target 4,4-disubstituted 1,2-thiazinane-5-one 1,1-dioxides (so-called β-keto-δ-sultams) I. The structure of the target compounds was confirmed by an X-ray diffraction study. The results came from multiple reactions, including the reaction of N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5Category: ethers-buliding-blocks)

N,N-Dimethylformamide Dimethyl Acetal(cas: 4637-24-5) belongs to anime. Large quantities of aliphatic amines are made synthetically. The most widely used industrial method is the reaction of alcohols with ammonia at a high temperature, catalyzed by metals or metal oxide catalysts (e.g., nickel or copper). Mixtures of primary, secondary, and tertiary amines are thereby produced.Category: ethers-buliding-blocks

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Ether – Wikipedia,
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《An efficient approach to access 1,1,2-triarylethanes enabled by the organo-photoredox-catalyzed decarboxylative addition reaction》 was written by Guo, Jing; Huang, Gong-Bin; Wu, Qiao-Lei; Xie, Ying; Weng, Jiang; Lu, Gui. Related Products of 135-02-4This research focused ontriarylethane diarylethylamine preparation green chem; carboxylic acid para quinone methide decarboxylative conjugate addition; photoredox organocatalyst. The article conveys some information:

An efficient protocol for the synthesis of 1,1,2-triarylethanes I (R1 is 4-OH-3,5-(t-Bu)2 and 4-OH-3,5-(i-Pr)2; R2 is H, 2-OMe, 4-CN, etc.; R3 is 2-Me, 3,4-(OMe)2, 4-Br, etc.) and 2,2-diarylethylamines II (R4 is NH(Boc); R5 is H, i-Pr, Bn, etc; R4R5 is (CH2)2N(Boc)(CH2)2 and (CH2)2O(CH2)2) with biol. and pharmacol. potential via organo-photoredox-catalyzed decarboxylative 1,6-conjugate addition of carboxylic acids to para-quinone methides has been developed. Different from the traditional transition-metal catalyzed multi-step synthetic strategy, this process involves a photoredox-promoted free radical pathway. A variety of structurally diverse products can be easily obtained under metal-free conditions in good to excellent yields (38 examples, up to 98% yield) in one step.2-Methoxybenzaldehyde(cas: 135-02-4Related Products of 135-02-4) was used in this study.

2-Methoxybenzaldehyde(cas: 135-02-4) is found in cassia oil, cinnamon bark, and cinnamon bark oil. It is a clear colorless liquid with a strong aroma. It has been used to examine the acaricidal activity of Periploca sepium oil and its active component against Tyrophagus putrescentiae.Related Products of 135-02-4

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《Catalytic Ynone-Amidine Formal [4 + 2]-Cycloaddition for the Regioselective Synthesis of Tricyclic Azepines》 was written by Reddy, T. Prabhakar; Gujral, Jagjeet; Roy, Pritam; Ramachary, Dhevalapally B.. COA of Formula: C9H10O2This research focused onynone amidine calcium cycloaddition catalyst; azepine tricyclic stereoselective preparation. The article conveys some information:

A Ca(OTf)2- and self-promoted ynone-amidine atom-economic formal [4 + 2]-cycloaddition of various ynones with amidines is reported for the construction of highly functionalized tricyclic azepines. High reaction rate, ease of operation, and high product selectivity with wide substrate scope are the key advantages of the present annulation protocol. The experimental part of the paper was very detailed, including the reaction process of 2-(Benzyloxy)acetaldehyde(cas: 60656-87-3COA of Formula: C9H10O2)

2-(Benzyloxy)acetaldehyde(cas: 60656-87-3) is a non-natural aldehyde. It undergoes enantioselective Mukaiyama aldol reaction with silylketene acetal nucleophiles in the presence of C2-symmetric bis(oxazolinyl)pyridine Cu(II) complex (catalyst).COA of Formula: C9H10O2

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Ether – Wikipedia,
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《Development and Investigation of Vitamin C-Enriched Adapalene-Loaded Transfersome Gel: a Collegial Approach for the Treatment of Acne Vulgaris》 was written by Vasanth, Sandhya; Dubey, Akhilesh; Ravi, G. S.; Lewis, Shaila A.; Ghate, Vivek M.; El-Zahaby, Sally A.; Hebbar, Srinivas. Application In Synthesis of 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acidThis research focused onvitamin C adapalene transfersome gel delivery acne vulgaris; Transfersomes; adapalene; cosmetics; topical; vitamin C. The article conveys some information:

Adapalene-loaded transfersome gel containing vitamin C as a combination therapy for the management of acne vulgaris was developed in the present study. The transfersome was prepared by reverse-phase evaporation, and the effect of various process parameters were investigated by the Design of Experiment (DOE) approach and optimized based on the particle size (PS), polydispersity index (PDI), zeta potential (ZP), and entrapment efficiency (EE). The selected tranfersomes were further evaluated for their thermal behavior and morphol. by transmission electron microscopy and turbidity measurements and incorporated into a gel with/without vitamin C. The gel was evaluated and compared with the marketed product (Adiff gel) for various physicochem. parameters, and in vivo studies in testosterone-induced rat models of acne. The prepared transfersomes had PS in the range of 280 to 400 nm, PDI values of 0.416 to 0.8, ZP of – 38 to – 20 mV, and % EE of 32 to 70%. DSC studies confirmed a pos. interaction of the components in the transfersome. Surface morphol. confirmed that the vesicles were spherical, unilamellar, and discrete. A relative deformability study showed higher elasticity of the transfersomes compared with Adiff aqs gel. Ascorbyl-6-palmitate in adapalene-loaded transfersome gel containing vitamin C (ADVTG) was found to have a good antioxidant free radical-scavenging activity. An in vitro drug release study showed that the sustained release of the transfersomal formulations was attributed to the flexibility of the vesicles by which penetration was increased. ADVTG was found to be promising in treating acne compared with the marketed product. The experimental part of the paper was very detailed, including the reaction process of 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas: 106685-40-9Application In Synthesis of 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid)

6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid(cas:106685-40-9) is a third-generation synthetic retinoid and a highly lipophilic compound derived from naphthoic acid. It is widely used in the treatment of acne.Application In Synthesis of 6-(3-(Adamantan-1-yl)-4-methoxyphenyl)-2-naphthoic acid

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Computed Properties of C12H10O2On November 5, 2021 ,《Effects of side alkoxy groups on the arylacetylene unit on properties of Poly(silylene arylacetylene)s》 appeared in European Polymer Journal. The author of the article were Li, Jixian; Gong, Changjun; Lv, Shuaikang; Huang, Farong. The article conveys some information:

A series of poly(dimethylsilylene arylacetylene)s with different side alkoxy groups on the arylacetylene unit (named as PSA-(AO) resins), including methoxy (MO), ethoxy (EO), pentyloxy (PO), and decyloxy (DO), were synthesized from corresponding disubstituted diethynylbenzene and dichlorodimethylsilane. The processability, heat resistance and mech. properties, and the effects of side alkoxy groups were investigated. The results show the processability of PSA-(AO) resins is improved, while the flexural properties and heat resistance of the relative cured resins decrease with the increase in the length of side alkoxy groups. The flexural strength and degradation temperature of 5% weight loss for the cured PSA-(EO) resin with side ethoxy groups reach 20.8 MPa and 415°, resp. In the experiment, the researchers used 1,4-Diethynyl-2,5-dimethoxybenzene(cas: 74029-40-6Computed Properties of C12H10O2)

1,4-Diethynyl-2,5-dimethoxybenzene(cas: 74029-40-6) belongs to ethers.Although ethers resist hydrolysis, they are cleaved by hydrobromic acid and hydroiodic acid. Hydrogen chloride cleaves ethers only slowly. Computed Properties of C12H10O2

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Category: ethers-buliding-blocksOn March 31, 2020, Albano, Gianluigi; Colli, Tony; Nucci, Luigi; Charaf, Rima; Biver, Tarita; Pucci, Andrea; Aronica, Laura Antonella published an article in Dyes and Pigments. The article was 《Synthesis of new bis[1-(thiophenyl)propynones] as potential organic dyes for colorless luminescent solar concentrators (LSCs)》. The article mentions the following:

New luminophores having different aryl nuclei and propynones moieties have been obtained via Sonogashira reactions. Their optical properties were evaluated and indicated that carbonyl groups are responsible for significant bathochromic effects and high Stokes shifts. The insertion of -OMe groups on the central benzene unit gives to the fluorophore high optical efficiency (7.7%) when homogeneously dispersed in a poly(cyclohexyl methacrylate) (PCMA) film and connected to a PV cell. In the experiment, the researchers used many compounds, for example, 1,4-Diethynyl-2,5-dimethoxybenzene(cas: 74029-40-6Category: ethers-buliding-blocks)

1,4-Diethynyl-2,5-dimethoxybenzene(cas: 74029-40-6) belongs to ethers.Ethers do have nonbonding electron pairs on their oxygen atoms, and they can form hydrogen bonds with other molecules (alcohols, amines, etc.) that have O―H or N―H bonds. Category: ethers-buliding-blocks The ability to form hydrogen bonds with other compounds makes ethers particularly good solvents for a wide variety of organic compounds and a surprisingly large number of inorganic compounds.

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Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Kim, Wan Shin; Shalit, Zachary A.; Nguyen, Sidney M.; Schoepke, Emmalie; Eastman, Alan; Burris, Thomas P.; Gaur, Arti B.; Micalizio, Glenn C. published their research in Nature Communications on December 31 ,2019. The article was titled 《A synthesis strategy for tetracyclic terpenoids leads to agonists of ERβ》.Name: (3-Methoxy-2-methylphenyl)methanol The article contains the following contents:

A concise asym. route to forging natural and unnatural (enantiomeric) C19 and C20 tetracyclic terpenoid skeletons (1S,13S,15R)/(1R,13R,15S)/(1S,13R,15S)/(1R,13S,15R)-I (R = H, Me) and (2S,13S,15R)/(2R,13R,15S)-II (R1 = H, Me) suitable to drive medicinal exploration was reported. While efforts have been focused on establishing the chem. science, early investigations reveal that the emerging chem. technol. can deliver compositions of matter that are potent and selective agonists of the estrogen receptor beta, and that are selectively cytotoxic in two different glioblastoma cell lines (U251 and U87). In the experiment, the researchers used many compounds, for example, (3-Methoxy-2-methylphenyl)methanol(cas: 33797-34-1Name: (3-Methoxy-2-methylphenyl)methanol)

(3-Methoxy-2-methylphenyl)methanol(cas: 33797-34-1) belongs to ethers.Oxygen is more electronegative than carbon, thus the alpha hydrogens of ethers are more acidic than those of simple hydrocarbons. They are far less acidic than alpha hydrogens of carbonyl groups (such as in ketones or aldehydes), however. Name: (3-Methoxy-2-methylphenyl)methanol

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Ether – Wikipedia,
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