Month: November 2022

Ruthenium-Catalyzed α-(Hetero)Arylation of Saturated Cyclic Amines: Reaction Scope and Mechanism was written by Peschiulli, Aldo;Smout, Veerle;Storr, Thomas E.;Mitchell, Emily A.;Elias, Zdenek;Herrebout, Wouter;Berthelot, Didier;Meerpoel, Lieven;Maes, Bert U. W.. And the article was included in Chemistry – A European Journal in 2013.COA of Formula: C12H17BO3 The following contents are mentioned in the article:

Transition-metal-catalyzed sp³ C-H activation has emerged as a powerful approach to functionalize saturated cyclic amines. Our group recently disclosed a direct catalytic arylation reaction of piperidines at the α position to the nitrogen atom. 1-(Pyridin-2-yl)piperidine could be smoothly α-arylated if treated with an arylboronic ester in the presence of a catalytic amount of [Ru₃(CO)₁₂] and one equivalent of 3-ethyl-3-pentanol. A systematic study on the substrate and reagent scope of this transformation is disclosed in this paper. The effect of substitution on both the piperidine ring and the arylboronic ester has been investigated. Smaller (pyrrolidine) and larger (azepane) saturated ring systems, as well as benzoannulated derivatives, were found to be compatible substrates with the α-arylation protocol. The successful use of a variety of heteroarylboronic esters as coupling partners further proved the power of this direct functionalization method. Mechanistic studies have allowed for a better understanding of the catalytic cycle of this remarkable transformation featuring an unprecedented direct transmetalation on a Ru^II-H species. This study involved multiple reactions and reactants, such as 2-(3-Methoxyphenyl)-5,5-dimethyl-1,3,2-dioxaborinane (cas: 1003858-50-1COA of Formula: C12H17BO3).

2-(3-Methoxyphenyl)-5,5-dimethyl-1,3,2-dioxaborinane (cas: 1003858-50-1) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Esters are more polar than ethers but less polar than alcohols. They participate in hydrogen bonds as hydrogen-bond acceptors, but cannot act as hydrogen-bond donors, unlike their parent alcohols. This ability to participate in hydrogen bonding confers some water-solubility.COA of Formula: C12H17BO3

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Preparation of Highly Reactive Pyridine- and Pyrimidine-Containing Diarylamine Antioxidants was written by Hanthorn, Jason J.;Valgimigli, Luca;Pratt, Derek A.. And the article was included in Journal of Organic Chemistry in 2012.Related Products of 562085-85-2 The following contents are mentioned in the article:

We recently reported a preliminary account of our efforts to develop novel diarylamine radical-trapping antioxidants wherein we demonstrated that the incorporation of ring nitrogens into diphenylamines affords compounds which display a compromise between H-atom transfer reactivity to peroxyl radicals and stability to one-electron oxidation Herein we provide the details of the synthetic efforts associated with that report, which have been substantially expanded to produce a library of substituted heterocyclic diarylamines that we have used to provide further insight into the structure-reactivity relationships of these compounds as antioxidants. The diarylamines were prepared in short, modular sequences from 2-aminopyridine and 2-aminopyrimidine wherein aminations of intermediate pyri(mi)dyl bromides and then Pd-catalyzed cross-coupling reactions of the amines and precursor bromides were the key steps to yield the diarylamines. The cross-coupling reactions were found to proceed best with Pd(η³-1-PhC₃H₄)(η⁵-C₅H₅) as precatalyst, which gave higher yields than the conventional Pd source, Pd₂(dba)₃. This study involved multiple reactions and reactants, such as N-(4-Methoxyphenyl)pyridin-3-amine (cas: 562085-85-2Related Products of 562085-85-2).

N-(4-Methoxyphenyl)pyridin-3-amine (cas: 562085-85-2) belongs to ethers. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Related Products of 562085-85-2

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Molecular modeling of the standard state heat of formation was written by Bagheri, Mehdi;Yerramsetty, Krishna;Gasem, Khaled A. M.;Neely, Brian J.. And the article was included in Energy Conversion and Management in 2013.Application In Synthesis of 2-(2-(Hexyloxy)ethoxy)ethanol The following contents are mentioned in the article:

The standard heat of formation is a basic thermophys. property required in determining enthalpies of reaction and in thermodn. stability analyses. Further, the enthalpies of formation are important in investigating bond energies, resonance energies and the nature of chem. bonds. Therefore, the development of accurate structure-based estimation methods for large varieties of chem. species is greatly beneficial in enhancing capability in process and product development. In this work, quant. structure-property relationship (QSPR) models were developed for a structurally diverse DIPPR dataset of standard heats of formation comprising 1765 pure compounds involving 82 chem. classes. We have employed both linear and nonlinear QSPR modeling techniques. The linear approach involves the use of constricted binary particle swarm optimization (BPSO) for feature selection and multiple-linear regression. In the nonlinear approach, the optimum network architecture and its associated inputs are identified using a wrapper-based feature selection algorithm combining differential evolution and artificial neural networks. Model predictions for the root-mean-square error of the BPSO and nonlinear approaches were 138 and 97 kJ/mol, resp. This study involved multiple reactions and reactants, such as 2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4Application In Synthesis of 2-(2-(Hexyloxy)ethoxy)ethanol).

2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4) belongs to ethers. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Application In Synthesis of 2-(2-(Hexyloxy)ethoxy)ethanol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

On microemulsion phase behavior and the monomeric solubility of surfactant was written by Burauer, Stefan;Sachert, Thomas;Sottmann, Thomas;Strey, Reinhard. And the article was included in Physical Chemistry Chemical Physics in 1999.Related Products of 112-59-4 The following contents are mentioned in the article:

The authors highlight the advantageous features of both short- and long-chain surfactant systems in determining the most important properties of 3-phase bodies and genuine microemulsions. To this end 1st the phase behavior of the simple system H₂O-n-dodecane-C₄E₁ (Bu monoglycol ether) is discussed. From temperature-concentration sections through the phase prism at various H₂O-to-oil ratios, a number of isothermal Gibbs triangles are constructed, which can quant. be compared with theories. Also, the critical tie-lines of the 3-phase body were precisely determined From these measurements it is evident that there is a nonnegligible monomeric solubility of the surfactant in the excess phases. For long-chain surfactant systems, the more efficient the surfactant, the larger is the size of the microstructure of the microemulsion. The authors report a striking correlation between the efficiency of a surfactant and its monomeric solubility in the excess phases for 23 systems H₂O-n-alkane-C_iE_j. Probably the monomeric solubility of the surfactant in oil and H₂O might be the key to describing the main features of these microemulsion systems. This study involved multiple reactions and reactants, such as 2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4Related Products of 112-59-4).

2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Related Products of 112-59-4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Study of concentration dependent curcumin interaction with serum biomolecules using ATR-FTIR spectroscopy combined with Principal Component Analysis (PCA) and Partial Least Square Regression (PLS-R) was written by Perera, Kalindu D. C.;Weragoda, Geethika K.;Haputhanthri, Rukshani;Rodrigo, Sanjeewa K.. And the article was included in Vibrational Spectroscopy in 2021.Product Details of 33171-05-0 The following contents are mentioned in the article:

The binding of curcumin with biomols. in biol. fluids can affect the activity, distribution, rate of excretion, and toxicity of pharmaceutical agents in the body. It is said that interaction of curcumin with bio mols. such as protein can increase its bioavailability. A simpler alternative to current methods for study of curcumin interaction with biomols. in biol. fluids and the quantification of the interacted curcumin is therefore useful. Herein we demonstrated a method based on ATR-FTIR spectroscopy combined with multivariate anal. for concentration dependent curcumin interaction with serum biomols. as a model. ATR-FTIR spectra of curcumin-spiked serum samples were acquired and data were processed with two different multivariate methods namely, Principal Component Anal. (PCA) and Partial Least-Squares Regression (PLS-R). PCA of the protein region (1701-1304 cm-1) shows a separation into groups based on the concentration of curcumin with no overlaps indicating the curcumin interaction is highest with serum proteins other than lipids and carbohydrates. PLS-R was employed to construct a calibration plot in carbohydrate, protein and lipid regions. The limit of detection of the interaction for all three regions was 10 ppm. This study involved multiple reactions and reactants, such as Bisdemethoxycurcumin (cas: 33171-05-0Product Details of 33171-05-0).

Bisdemethoxycurcumin (cas: 33171-05-0) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits. Esters contain a carbonyl center, which gives rise to 120° C–C–O and O–C–O angles. Unlike amides, esters are structurally flexible functional groups because rotation about the C–O–C bonds has a low barrier. Their flexibility and low polarity is manifested in their physical properties; they tend to be less rigid (lower melting point) and more volatile (lower boiling point) than the corresponding amides. Product Details of 33171-05-0

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

A simple approach to the determination of three curcuminoids with similar chemical structures in different substrates was written by Li, Sha Sha;Lu, Shao Hua;Zhai, Hong Lin;Yin, Bo;Mi, Jia Ying. And the article was included in Journal of Food Science and Technology in 2021.Recommanded Product: 33171-05-0 The following contents are mentioned in the article:

Abstract: The determination of curcuminoids in mixtures is more difficult due to their similar chem. structures as well as serious interferences, thus the complex pretreatments of samples and the optimization of exptl. conditions are often required. Here, owing to the math. separation of chem. signals by Tchebichef image moments, a simple and effective approach to the simultaneous quant. anal. was proposed, and applied to the determination of the three curcuminoids in turmeric and curry based on their raw fluorescence 3D spectra. For the established linear models, the leave-one-out correlation coefficients (Rloo-cv) were more than 0.9816 within the linear ranges, and the predictive correlation coefficients (Rp) for the external independent samples were more than 0.9897. The intra- and inter-day precision (less than 6.82%, RSD), average spiked recovery (89.9% ∼ 100.8%), LOD (less than 0.07μg/mL) and LOQ (less than 0.23μg/mL) suggest that the proposed approach is accurate and reliable. Compared with N-PLS and MCR-ALS methods, our method can obtain more satisfactory results. This study provides a convenient pathway for the rapid anal. of multi-target components with similar chem. structures in mixture of different substrates. This study involved multiple reactions and reactants, such as Bisdemethoxycurcumin (cas: 33171-05-0Recommanded Product: 33171-05-0).

Bisdemethoxycurcumin (cas: 33171-05-0) belongs to ethers. Esters perform as high-grade solvents for a broad array of plastics, plasticizers, resins, and lacquers, and are one of the largest classes of synthetic lubricants on the commercial market. Polyesters are important plastics, with monomers linked by ester moieties. Acyl chlorides and acid anhydrides alcoholysis is another way to produce esters. Acyl chlorides and acid anhydrides react with alcohols to produce esters. Anydrous conditions are recommended since both acyl chlorides and acid anhydrides react with water.Recommanded Product: 33171-05-0

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Shape similarities of ultra-low interfacial tension curves in ternary microemulsion systems of the water-alkane-C_iE_j type was written by Sottmann, T.;Strey, R.. And the article was included in Berichte der Bunsen-Gesellschaft in 1996.Application of 112-59-4 The following contents are mentioned in the article:

The interfacial tensions between water- and oil-rich phases in microemulsion systems were measured for a series of ternary water-alkane-C_iE_j systems. Interfacial tensions vary over orders of magnitude with temperature displaying a pronounced min. for each surfactant. The center of the 3-phase temperature interval, T_u-T_l, i.e. the phase inversion temperature (PIT), corresponds to the temperature T_m of the min. in interfacial tension. Increasing the surfactant chain length the min. value decreases by 3 orders of magnitude for a change of i from 6 to 12. Interestingly, all interfacial tension curves have a similar shape. Centering the curves around T_m and reducing the temperature scale by T_u-T_l permits determining the factors by which the individual interfacial tension curves differ. The factors are be proportional, resp., to square of the maximum length scale ζ or the inverse surfactant volume fraction ϕ^–_c,i in the interface. Accordingly, plotting σ_ab/ϕ_c,i² vs. 2(T-T_m)/(T_u-T₁) an almost perfect superposition of all interfacial tension curves is observed This study involved multiple reactions and reactants, such as 2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4Application of 112-59-4).

2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4) belongs to ethers. Volatile esters with characteristic odours are used in synthetic flavours, perfumes, and cosmetics. Certain volatile esters are used as solvents for lacquers, paints, and varnishes. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Application of 112-59-4

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Demethoxycurcumin induces apoptosis in HER2 overexpressing bladder cancer cells through degradation of HER2 and inhibiting the PI3K /Akt pathway was written by Kao, Chien-Chang;Cheng, Yi-Ching;Yang, Ming-Hsin;Cha, Tai-Lung;Sun, Guang-Huan;Ho, Chi-Tang;Lin, Ying-Chao;Wang, Hao-Kuang;Wu, Sheng-Tang;Way, Tzong-Der. And the article was included in Environmental Toxicology in 2021.Quality Control of Bisdemethoxycurcumin The following contents are mentioned in the article:

Bladder cancer is the most common malignancy of the urinary tract and arising from the epithelial lining of the urinary bladder. Resistance to cytotoxic therapies is associated with overexpression of oncogenic proteins; including HER2, and Akt in chemotherapy resistance of bladder cancer. Various studies demonstrated that curcuminoids, the most important active phenolic compounds of turmeric (Curcuma longa), have anti-tumor activities in a wide range of human malignant cell lines. The aim of this study is to evaluate whether curcuminoids (curcumin, demethoxycurcumin (DMC), and bisdemethoxycurcumin) could repress the expression of HER2 in HER2-overexpressing bladder cancer cells. Among the test compounds, DMC significantly suppressed the expression of HER2, and preferentially inhibited cell proliferation and induced apoptosis in HER2-overexpressing bladder cancer cells. DMC decreases HER2 level through inhibiting the interaction of HER2 and Hsp90. Our study also indicated that DMC showed additive activity in combination with chemotherapeutic agents, including paclitaxel and cisplatin. These findings show that DMC should be developed further as a new antitumor drug candidate for treatment of HER2-overexpressing bladder cancer. This study involved multiple reactions and reactants, such as Bisdemethoxycurcumin (cas: 33171-05-0Quality Control of Bisdemethoxycurcumin).

Bisdemethoxycurcumin (cas: 33171-05-0) belongs to ethers. Esters are also usually derived from carboxylic acids. It may also be obtained by reaction of acid anhydride or acid halides with alcohols or by the reaction of salts of carboxylic acids with alkyl halides. Cyclic esters are called lactones, regardless of whether they are derived from an organic or inorganic acid. One example of an organic lactone is γ-valerolactone.Quality Control of Bisdemethoxycurcumin

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Evaluation of microemulsions of cationic surfactants and a polyoxyethylene cosurfactant for electrolytic dechlorinations of chlorobiphenyls was written by Zhang, Shiping;Rusling, James F.. And the article was included in Journal of Colloid and Interface Science in 1996.Name: 2-(2-(Hexyloxy)ethoxy)ethanol The following contents are mentioned in the article:

Three microemulsions containing cosurfactant 2-(2-hexyloxyethoxy)ethanol, 1% aqueous KBr, dodecane, and either didodecyldimethylammonium bromide (DDAB) or cetyltrimethylammonium bromide (CTAB) with conductivities and viscosities appropriate for electrolytic applications were prepared These fluids were characterized further by measuring diffusion coefficients of electrochem. probes and pyrene fluorescence peak ratios characteristic of polarity and viscosity of the oil phase. A microemulsion of DDAB/2-(2-hexyloxyethoxy)ethanol/1% aqueous KBr/dodecane (7.3/36/22.7/34 by weight) had the highest conductivity and lowest viscosity and gave the most pos. reduction potential for 4,4′-dichlorobiphenyl of the four-component fluids examined Electrochem. catalytic reduction of 4,4′-dichlorobiphenyl was done with this fluid, a lead electrode, and zinc phthalocyanine as catalyst with only a small loss of current efficiency compared to a previously used 3-component 21% DDAB microemulsion. The four-component 7.3% DDAB microemulsion was prepared at half the cost of the three-component 21% DDAB microemulsion. On the basis of diffusion, conductivity, and fluorescence studies, the structure of the 7.3% DDAB microemulsion is probably bicontinuous. This study involved multiple reactions and reactants, such as 2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4Name: 2-(2-(Hexyloxy)ethoxy)ethanol).

2-(2-(Hexyloxy)ethoxy)ethanol (cas: 112-59-4) belongs to ethers. Carboxylic acid esters of low molecular weight are colourless, volatile liquids with pleasant odours, slightly soluble in water. Esterification is the general name for a chemical reaction in which two reactants (typically an alcohol and an acid) form an ester as the reaction product. Esters are common in organic chemistry and biological materials.Name: 2-(2-(Hexyloxy)ethoxy)ethanol

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem

Highly Reactive, General and Long-Lived Catalysts for Palladium-Catalyzed Amination of Heteroaryl and Aryl Chlorides, Bromides, and Iodides: Scope and Structure-Activity Relationships was written by Shen, Qilong;Ogata, Tokutaro;Hartwig, John F.. And the article was included in Journal of the American Chemical Society in 2008.Name: N-(4-Methoxyphenyl)pyridin-3-amine The following contents are mentioned in the article:

The authors describe a systematic study of the scope and relation between ligand structure and activity for a highly efficient and selective class of catalysts containing sterically hindered chelating alkylphosphines for the amination of heteroaryl and aryl chlorides, bromides, and iodides. In the presence of this catalyst, aryl and heteroaryl chlorides, bromides, and iodides react with many primary amines in high yields with part-per-million quantities of palladium precursor and ligand. Many reactions of primary amines with both heteroaryl and aryl chlorides, bromides, and iodides occur to completion with 0.0005-0.05 mol % catalyst. A comparison of the reactivity of this catalyst for the coupling of primary amines at these loadings is made with catalysts generated from hindered monophosphines and carbenes, and these data illustrate the benefits of chelation. Studies on structural variants of the most active catalyst indicate that a rigid backbone in the bidentate structure, strong electron donation, and severe hindrance all contribute to its high reactivity. Thus, these complexes constitute a fourth-generation catalyst for the amination of aryl halides, whose activity complements catalysts based on monophosphines and carbenes. This study involved multiple reactions and reactants, such as N-(4-Methoxyphenyl)pyridin-3-amine (cas: 562085-85-2Name: N-(4-Methoxyphenyl)pyridin-3-amine).

N-(4-Methoxyphenyl)pyridin-3-amine (cas: 562085-85-2) belongs to ethers. Esters are widespread in nature and are widely used in industry. In nature, fats are in general triesters derived from glycerol and fatty acids. Esters are responsible for the aroma of many fruits, including apples, durians, pears, bananas, pineapples, and strawberries. Liquid esters of low volatility serve as softening agents for resins and plastics. Esters also include many industrially important polymers. Polymethyl methacrylate is a glass substitute sold under the names Lucite and Plexiglas; polyethylene terephthalate is used as a film (Mylar) and as textile fibres sold as Terylene, Fortrel, and Dacron.Name: N-(4-Methoxyphenyl)pyridin-3-amine

Referemce:
Ether – Wikipedia,
Ether | (C2H5)2O – PubChem